Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis

The main aim of this study is to describe the relationship between serum levels of atazanavir, renal toxicity, and lithiasis. This is a prospective observational study of patients being treated with atazanavir (ATV) at Son Espases Teaching Hospital, Palma de Mallorca, between 2011 and 2013. The study includes 98 patients. Sixteen were found to have a history of urolithiasis. During a median monitoring period of 23 months, nine patients suffered renal colic, in three of whom ATV crystals were evidenced in urine. Cumulative incidence of renal colic was 9.2 per 100 patients. The variables related to having renal colic were the presence of alkaline urine pH and lower basal creatinine clearance. The mean serum level of ATV was slightly higher in patients with renal colic—1,303 μg/L versus 1,161 μg/L—but did not reach statistical significance. Neither were any significant differences detected by analysing the levels according to the timetable for ATV dosage. Cumulative incidence of renal colic was high in patients being treated with ATV, in 33% of whom the presence of ATV crystals was evidenced in urine. We were unable to demonstrate a relationship between ATV serum levels and renal colic or progression towards renal failure.

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Socially prescribed perfectioism and personality

European Journal of Investigation in Health, Psychology and Education ◽

10.3390/ejihpe6020008 ◽

2016 ◽

Vol 6 (2) ◽

pp. 107-118

Author(s):

María Vicent ◽

Cándido J. Inglés ◽

Carolina Gonzálvez ◽

Ricardo Sanmartín ◽

José Manuel García-Fernández

Keyword(s):

Personality Traits ◽

Big Five ◽

Statistical Significance ◽

Effect Sizes ◽

Big Five Personality ◽

Primary School Students ◽

School Students ◽

Socially Prescribed Perfectionism ◽

The Mean ◽

The Relationship

The aim of this study was to examine the relationship between Socially Prescribed Perfectionism (SPP) and the Big Five personality traits in a sample of 804 Primary School students between 8 and 11 years old (M=9.57; SD=1.12). The SPP subscale of the Child and Adolescent Perfectionism Scale (CAPS) and the Big Five Questionnaire for Children (BFQ-N), which evaluate the traits of Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness, were used. The mean difference analysis showed that students with high levels of SPP scored significantly higher on Conscientiousness, Agreeableness, Extraversion and Openness, with small effect sizes for all cases. In contrast, no significant differences were observed in Neuroticism. Logistic regression analysis revealed that all personality traits, except neuroticism, whose results didn’t reach the statistical significance, significantly and positively predicted higher scores on PSP, with OR levels ranging from 1.01 (for Conscientiousness and Agreeableness) to 1.03 (for Openness and Extraversion).

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An Investigation of the Relationship between Involvement Sites in Vitiligo Patients and Autoimmune Diseases and Hematological Parameters

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol04-i10/769 ◽

2019 ◽

Vol 4 (10) ◽

Cited By ~ 1

Author(s):

Ebru KARAGUN

Keyword(s):

Hematological Parameters ◽

Fasting Blood Glucose ◽

Unknown Etiology ◽

Control Group ◽

Endocrine Disorders ◽

Positive Correlation ◽

Lymphocyte Ratio ◽

History Of ◽

The Mean ◽

The Relationship

Aim-Objectives: Vitiligo is an acquired idiopathic disease which progresses with melanocyte destruction and is clinically characterized by depigmented lesions of unknown etiology. Vitiligo may be coexistence with a autoimmune and endocrine disorders. This study examined the sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vitamin B12 and fasting blood glucose (FBG) values, and thrombocyte-to-lymphocyte ratio(TLR), neutrophil-to-lymphocyte ratio(NLR), the mean platelet volume(MPV) the correlation of depigmented lesions with the extent of body involvement sites(IS). Materials and Method: The study enrolled 67 patients aged 0‒65 who were diagnosed with non-segmental generalized vitiligo and in whom an increase in lesions had been observed in the last six months. The IS of the lesions in the patients were evaluated as IS ˂10%(1st group), 10%‒20% (2nd group), 20% - 30%(3rd group), 30% - 40%(4th group), 40% ‒50 %(5th group), and ˃50%(6th group). The control group consisted of patients who had presented to the outpatient clinic having had no history of vitiligo detected in themselves nor in their families. Results: No significant correlation was found between IS and sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vit. B12, PBG or MPV. A moderately positive correlation was found between IS and duration (p <0.05) and a mildly positive correlation between IS and NLR and TLR (p <0.05). Conclusion: This study show that every patient diagnosed with vitiligo, independent of the IS, should undergo examination for autoimmune disease. A mild positive correlation between VTA and NLO-TLO was found to be an indicator of increased inflammation in vitiligo patients as the extent of lesions increased.

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632 Family History of Children Diagnosed with Obstructive Sleep Apnea

SLEEP ◽

10.1093/sleep/zsab072.630 ◽

2021 ◽

Vol 44 (Supplement_2) ◽

pp. A248-A248

Author(s):

Kristi Porterfield-Pruss ◽

Denise Willis ◽

Beverly Spray ◽

Supriya Jambhekar

Keyword(s):

Family History ◽

Family Members ◽

Biological Father ◽

Medical Problems ◽

Obstructive Sleep ◽

Familial Association ◽

History Of ◽

The Mean ◽

Relationship Of ◽

The Relationship

Abstract Introduction Limited evidence suggests a familial association of OSA. It is not known how often children who require positive airway pressure (PAP) devices have a family member with OSA or that requires PAP. It is felt that PAP adherence in children is affected by PAP adherence in parents. We wanted to explore the relationship of OSA in children requiring PAP to OSA in immediate family members as well as the association of obesity and adherence between children and family members. Methods Caregivers of children who utilize PAP devices at home were invited to complete an electronic questionnaire regarding family history of OSA. Descriptive statistics were utilized to summarize results. Results The study was completed by 75 participants. The majority of children were male (64%, 48/75), black (47%, 35/75) and non-Hispanic (88%, 66/75). The mean age was 11.8 years (median 13) and mean BMI was 32.8 (median 29.8). The mean AHI on the diagnostic polysomnogram was 28.4 events per hour (median 15.3). Mean adherence to PAP > 4 hours per night was 56.5 (Median 68.2). Most, 87% (65/75), have other underlying medical problems. Twenty-four percent (18/75) have a biological father with OSA of whom 61% (11/18) are considered moderately/extremely obese. Of mothers, 13% (10/75) have OSA and 70% (7/10) are obese. Overall, 29% (22/75) had either a paternal (11%, 8/75) or maternal (19%, 14/75) grandfather with OSA of which 36% (8/22) are obese. For grandmothers, 31% (23/75) have OSA and 22% (5/23) are obese with more being paternal (19%, 14/75) compared to maternal (12%, 9/75). Of the 73 total family members reported to have OSA, 86% (63/73) use PAP and most (65%, 41/63) use it for > 4 hours every night. Few participants had siblings with OSA. Conclusion There were more fathers with OSA than mothers, but mothers were reported to be obese more often. Grandparents were reported to have OSA but were reported to be obese less often than parents. Maternal grandparents with OSA were reported to be obese more than paternal grandparents. The majority of family members with OSA who use CPAP report nightly use. Support (if any):

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A-41 Exploring the Influence of Referral Source on State Anxiety Levels of Concussed Patients

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acaa036.41 ◽

2020 ◽

Vol 35 (5) ◽

pp. 637-637

Author(s):

K Stephenson ◽

M N Womble ◽

R J Elbin

Keyword(s):

State Anxiety ◽

Statistical Significance ◽

Urgent Care ◽

Athletic Trainer ◽

Referral Source ◽

State Trait Anxiety Inventory ◽

Clinical Visit ◽

History Of ◽

Highly Correlated ◽

The Relationship

Abstract Objective To explore the influence of referral source on state anxiety in concussed athletes. Method One hundred thirty athletes (mean age = 16.46, SD = 1.93 yrs; 42% female) seeking care for a concussion at a specialty clinic within 30 days of injury (M = 8.83, SD = 6.12 days) were enrolled in the study. Demographic (e.g., age, sex, and history of anxiety) and referral source (e.g., emergency department/urgent care, primary care/pediatrician, and athletic trainer) information were collected, and the State-Trait Anxiety Inventory (STAI) was administered to all participants. A one-way analysis of variance (ANOVA) was conducted to compare STAI scores between referral groups, and a logistic regression (LR) was used to assess the relationship between referral sources and patients with and without clinical levels of state anxiety (STAI > 40). Statistical significance for all analyses was (p < .05). Results Approximately 25% (32/130) of patients reported a history of anxiety, and 46% (60/130) scored above clinical cutoffs for clinical anxiety. The referral groups did not differ on STAI scores (F(3, 130) = 1.12, p = .34), and the LR was not significant, (χ2(2, N = 130) = 3.75, p = 0.15). Conclusions History of anxiety was highly correlated with state anxiety at the first clinical visit; however, patients referred from different medical sources did not differ on clinical levels of anxiety at the first clinical visit following concussion.

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Socially prescribed perfectioism and personality

European Journal of Investigation in Health, Psychology and Education ◽

10.1989/ejihpe.v6i2.162 ◽

2016 ◽

Vol 6 (2) ◽

pp. 107-118

Author(s):

María Vicent ◽

Cándido J. Inglés ◽

Carolina Gonzálvez ◽

Ricardo Sanmartín ◽

José Manuel García-Fernández

Keyword(s):

Personality Traits ◽

Big Five ◽

Statistical Significance ◽

Effect Sizes ◽

Big Five Personality ◽

Primary School Students ◽

School Students ◽

Socially Prescribed Perfectionism ◽

The Mean ◽

The Relationship

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The Relationship Between Intraabdominal Hypertension and Preeclampsia

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2016.628 ◽

2016 ◽

pp. 5

Author(s):

Mesut A. Ünsal ◽

Ülkü İnce ◽

Sevil Cengiz ◽

S. Caner Karahan ◽

Turhan Aran

Keyword(s):

Statistical Significance ◽

Intraabdominal Pressure ◽

Control Group ◽

Abdominal Pressure ◽

Study Group ◽

Abdominal Hypertension ◽

Intraabdominal Hypertension ◽

The Mean ◽

And Control ◽

The Relationship

OBJECTIVE: We aimed to measure abdominal pressure and placental levels of malondialdehyde in patients with preeclampsia and investigate the relationship between intraabdominal pressure and clinical features of preeclampsia. STUDY DESIGN: Study was conducted at a tertiary referral clinic. Study group consisted of patients with preeclampsia and control group consisted of normotensive pregnant women. Both placental malondialdehyde and intraabdominal pressure levels were studied in all patients. Intraabdominal pressure was assessed indirectly via a Foley bladder catheter both antepartum and postpartum period. Statistical comparisons among groups were made using the Mann-Whitney U test, independent T test and Chi-square test. Statistical significance was set as p<0.05. RESULTS: Study and control group consisted of 35 pregnant patients. The mean patients’ age, gravidity, parity, weight and BMI were not different between study and control groups. In the study group, Caesarean, preterm delivery and abdominal hypertension rate were significantly higher whereas the mean neonatal birth weight was lower. The mean antepartum and postpartum intraabdominal pressure levels were significantly higher in study group. The mean intraabdominal pressure was highest in patients with oliguria (19.8±1.8 cmH2O). Abdominal hypertension was detected in 30 (86%) patients in study group and in 3 (9%) patients in control group. The mean placental malondialdehyde level was significantly higher in patients with intraabdominal hypertension. CONCLUSION: Abdominal hypertension rate is very high in patients with preeclampsia. Abdominal hypertension may have an additional role in preeclampsia.

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Relationship between atopic manifestations, family history of atopic disease and cord blood IgE levels in children

Paediatrica Indonesiana ◽

10.14238/pi47.6.2007.278-82 ◽

2007 ◽

Vol 47 (6) ◽

pp. 278

Author(s):

Tisnasari Hafsah ◽

Myrna Soepriadi ◽

Budi Setiabudiawan ◽

Herry Garna

Keyword(s):

Family History ◽

Cord Blood ◽

Atopic Disease ◽

Mean Value ◽

Inclusion Criteria ◽

Chi Square ◽

The Past ◽

History Of ◽

The Mean ◽

The Relationship

Background The incidence of atopic disease tends to increaseover the past few decades and its morbidity interferes with thequality of life and health. Prediction of the disease is importantfor early prevention.Objective To evaluate the relationship between atopicmanifestations, family history (FH) of atopic disease and cordblood IgE (CB-IgE) levels.Methods We conducted an analytic observational study withcohort retrospective design on children with an average age of 3years whose CB-IgE had been measured at delivery inKiaracondong Primary Health Care during October–December2004. Manifestations of atopic disease were recorded using ISAACquestionaire for allergy. Chi-square, Mann-Whitney test, andlogistic regression analysis were used for analysis.Results Cord blood IgE was measured on 124 children after birth.Only 94 children (76%) fulfilled the inclusion criteria. Atopicdisease was found in 17 children (18%), consisting of 8 childrenwith atopic dermatitis, 4 with allergic rhinitis, and 5 suffered fromboth. There were significant differences in the mean value of CB-IgE (Z M-W =4.60; P<0.001) and FH (x 2 =19.059; P<0.001)between atopic and non atopic children. Cut off point of the CB-IgE concentration was 1.4 IU/mL (77.7%). The highest probabilityfor atopic manifestations was found in children who had highCB-IgE and positive FH (P=45%). Relative risk of children withhigh CB-IgE level in positive FH group was 3.636 (95% CI0.943;14.016).Conclusion CB-IgE level and family history of atopic disease arerisk factors for the development of atopic manifestation.

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Crises and Schlesinger's Cycles of American History (1789–1986)

Psychological Reports ◽

10.2466/pr0.1994.74.2.642 ◽

1994 ◽

Vol 74 (2) ◽

pp. 642-642 ◽

Cited By ~ 3

Author(s):

Stewart J. H. McCann

Keyword(s):

United States ◽

American History ◽

The United States ◽

Public Purpose ◽

History Of ◽

Entire History ◽

The Mean ◽

The Difference ◽

The Relationship ◽

Crisis Index

The relationship between Schlesinger's American history cycles and a crisis index was examined. The difference between the mean crisis value for private interest phases and public purpose phases approached significance, but adjustments for easily explained anomalies produced complete correspondence between cycle fluctuations and crises for the entire history of the United States.

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Evaluation of Serum CA 125 Levels in Patients with Pelvic Pain Related to Endometriosis

The International Journal of Biological Markers ◽

10.1177/172460080702200306 ◽

2007 ◽

Vol 22 (3) ◽

pp. 200-202 ◽

Cited By ~ 21

Author(s):

A. Maiorana ◽

C. Cicerone ◽

M. Niceta ◽

L. Alio

Keyword(s):

Pelvic Pain ◽

Statistical Significance ◽

Stage Iv ◽

Serum Levels ◽

Ca 125 ◽

Control Group ◽

Clinical Value ◽

Operative Laparoscopy ◽

Patient Series ◽

The Mean

The aim of the study was to investigate the clinical value of the serum CA 125 level for diagnosing and determining the severity of endometriosis and pelvic pain associated with endometriosis. Eighty-six women who underwent operative laparoscopy were enrolled. Sixty-nine women with endometriosis and 17 without endometriosis participated in this study. In all of the patients, endometriosis was diagnosed and classified into stages according to the Revised American Fertility Society (R-AFS) classification. The mean serum CA 125 levels were determined in each patient. We also investigated the relationship between serum CA 125 concentration and the intensity of dysmenorrhea and dyspareunia in the study group. The mean serum CA 125 levels of women with endometriosis were higher than those of the control group (p<0.050). However, the mean serum CA 125 levels were higher in stage IV than in other stages of endometriosis according to the R-AFS classification. On the other hand, the percentage of patients with serum CA 125 levels >35 U/mL was elevated in the subgroups with severe dyspareunia and severe dysmenorrhea versus the asymptomatic subgroup but the differences had no statistical significance. In conclusion, CA 125 serum levels were related to endometriosis and R-AFS score in the evaluated patient series. No correlation was found between serum levels of CA 125 and pelvic pain in patients with endometriosis.

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The Relationship Between Serum Vitamin D Level and Severity of Bronchiolitis in Infants Being Referred to in Bandar Abbas Children’s Hospital, Iran

International Electronic Journal of Medicine ◽

10.34172/iejm.2020.17 ◽

2020 ◽

Vol 9 (3) ◽

pp. 96-100

Author(s):

Mohammad Bagher Rahmati ◽

Mehran Ahmadi ◽

Seyed Alireza Sobhani ◽

Morteza Bakhshi ◽

Hosein Hamadiyan ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Serum Levels ◽

Children's Hospital ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Children’S Hospital ◽

The Mean ◽

Bandar Abbas ◽

The Relationship

Background: The present study aimed to investigate the relationship between the serum vitamin D level and the severity of bronchiolitis in infants. Materials and Methods: The population of this descriptive-analytical study included all infants within the age range of 1 month to 24 months old with bronchiolitis hospitalized in Bandar Abbas children’s hospital in 2018-2019. According to the exclusion and inclusion criteria, patients were entered in the study and diagnosed with bronchiolitis by a pediatric infectious disease specialist. Then, their serum levels of vitamin D were measured as well. Results: Of the 85 patients, 62.4% and 37.6% were males and females, respectively. The mean serum level of vitamin D was 29.74±13.44 ng/mL. In addition, the mean age in groups with mild-, moderate-, and severe-intensity was 9.27±4.52 months, 5.12±3.95 months, and 3.16±1.16 months (P<0.001), respectively. Further, the Spearman’s correlation between age and serum vitamin D levels was r = 0.05 (P<0.001). Based on the results, there was a statistically significant difference between the mean age in the two study groups (P<0.001). Finally, a statistically significant association was found between the severity of bronchiolitis and vitamin D status (P=0.007). Conclusion: According to the results of the present study, more than half of the infants admitted to the diagnosis of bronchiolitis had insufficient serum levels of vitamin D. There was also a significant association between the severity of bronchiolitis and serum vitamin D levels.

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