scholarly journals Relationship between atopic manifestations, family history of atopic disease and cord blood IgE levels in children

2007 ◽  
Vol 47 (6) ◽  
pp. 278
Author(s):  
Tisnasari Hafsah ◽  
Myrna Soepriadi ◽  
Budi Setiabudiawan ◽  
Herry Garna
Keyword(s):  
Family History ◽  
Cord Blood ◽  
Atopic Disease ◽  
Mean Value ◽  
Inclusion Criteria ◽  
Chi Square ◽  
The Past ◽  
History Of ◽  
The Mean ◽  
The Relationship

Background The incidence of atopic disease tends to increaseover the past few decades and its morbidity interferes with thequality of life and health. Prediction of the disease is importantfor early prevention.Objective To evaluate the relationship between atopicmanifestations, family history (FH) of atopic disease and cordblood IgE (CB-IgE) levels.Methods We conducted an analytic observational study withcohort retrospective design on children with an average age of 3years whose CB-IgE had been measured at delivery inKiaracondong Primary Health Care during October–December2004. Manifestations of atopic disease were recorded using ISAACquestionaire for allergy. Chi-square, Mann-Whitney test, andlogistic regression analysis were used for analysis.Results Cord blood IgE was measured on 124 children after birth.Only 94 children (76%) fulfilled the inclusion criteria. Atopicdisease was found in 17 children (18%), consisting of 8 childrenwith atopic dermatitis, 4 with allergic rhinitis, and 5 suffered fromboth. There were significant differences in the mean value of CB-IgE (Z M-W =4.60; P<0.001) and FH (x 2 =19.059; P<0.001)between atopic and non atopic children. Cut off point of the CB-IgE concentration was 1.4 IU/mL (77.7%). The highest probabilityfor atopic manifestations was found in children who had highCB-IgE and positive FH (P=45%). Relative risk of children withhigh CB-IgE level in positive FH group was 3.636 (95% CI0.943;14.016).Conclusion CB-IgE level and family history of atopic disease arerisk factors for the development of atopic manifestation.

scholarly journals Interleukin-4 and immunoglobulin E levels in newborns at risk of atopic diseases

2011 ◽  
Vol 51 (1) ◽  
pp. 12
Author(s):  
Frengky Sutanto ◽  
Rocky Wilar ◽  
Diana Devi Sondakh
Keyword(s):  
At Risk ◽  
Family History ◽  
Cord Blood ◽  
Immunoglobulin E ◽  
Atopic Disease ◽  
Interleukin 4 ◽  
Type I ◽  
Atopic Diseases ◽  
History Of ◽  
The Mean

Background The clinical syndrome of atopy is associated v.ith the production of immunoglobulin E (lgE) in response to antigenic stimulation as part of a type I hypersensitivity reaction. Since early prevention is regarded as an important cornerstone in the management of atopic diseases, the identification of reliable markers such as IgE and interleukin 4 (IL-4) in detecting individuals at risk are of major interest.Objective To determine whether cord blood IgE and IL-4 levels can be used as an predictor of atopy in newborns with a family history of atopic diseases.Methods We conducted a cross-sectional study on healthy-term newborns in the neonatal ward at R.D. Kandou Hospital from June to August 2010. A total of 50 healthy newborns in atopic and non-atopic groups were examined for cord blood IgE and IIA levels.Result The mean cord blood ILA levels in the atopic and non-atopic groups were 0.1 μg/mL (SD 0.08) and 0.1 μg/mL (SD 0.16) (P=0.359), respectively. The mean cord blood IgE levels in the atopic and non-atopic groups were 2.2 IU/mL (SD 1.98) and 0.5 IU/mL (SD 0.29) (P<0.00l), respectively. A point-biserial correlation coefficient analysis showed no significant correlation between ILA levels and family history of atopic disease (rpb=0.098), and a weak correlation between IgE levels and family history of atopic disease (rpb=0.54).Conclusions Cord blood IgE and IL-4 levels should not be used to distinguish newborns with a family history of atopic diseases from those without.

632 Family History of Children Diagnosed with Obstructive Sleep Apnea

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A248-A248
Author(s):  
Kristi Porterfield-Pruss ◽  
Denise Willis ◽  
Beverly Spray ◽  
Supriya Jambhekar
Keyword(s):  
Family History ◽  
Family Members ◽  
Biological Father ◽  
Medical Problems ◽  
Obstructive Sleep ◽  
Familial Association ◽  
History Of ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship

Abstract Introduction Limited evidence suggests a familial association of OSA. It is not known how often children who require positive airway pressure (PAP) devices have a family member with OSA or that requires PAP. It is felt that PAP adherence in children is affected by PAP adherence in parents. We wanted to explore the relationship of OSA in children requiring PAP to OSA in immediate family members as well as the association of obesity and adherence between children and family members. Methods Caregivers of children who utilize PAP devices at home were invited to complete an electronic questionnaire regarding family history of OSA. Descriptive statistics were utilized to summarize results. Results The study was completed by 75 participants. The majority of children were male (64%, 48/75), black (47%, 35/75) and non-Hispanic (88%, 66/75). The mean age was 11.8 years (median 13) and mean BMI was 32.8 (median 29.8). The mean AHI on the diagnostic polysomnogram was 28.4 events per hour (median 15.3). Mean adherence to PAP &gt; 4 hours per night was 56.5 (Median 68.2). Most, 87% (65/75), have other underlying medical problems. Twenty-four percent (18/75) have a biological father with OSA of whom 61% (11/18) are considered moderately/extremely obese. Of mothers, 13% (10/75) have OSA and 70% (7/10) are obese. Overall, 29% (22/75) had either a paternal (11%, 8/75) or maternal (19%, 14/75) grandfather with OSA of which 36% (8/22) are obese. For grandmothers, 31% (23/75) have OSA and 22% (5/23) are obese with more being paternal (19%, 14/75) compared to maternal (12%, 9/75). Of the 73 total family members reported to have OSA, 86% (63/73) use PAP and most (65%, 41/63) use it for &gt; 4 hours every night. Few participants had siblings with OSA. Conclusion There were more fathers with OSA than mothers, but mothers were reported to be obese more often. Grandparents were reported to have OSA but were reported to be obese less often than parents. Maternal grandparents with OSA were reported to be obese more than paternal grandparents. The majority of family members with OSA who use CPAP report nightly use. Support (if any):

scholarly journals Association between cord blood IgE levels in newborns and family history of atopic diseases

2016 ◽  
Vol 46 (5) ◽  
pp. 199
Author(s):  
Andhika T. Hutapea ◽  
Budi Setiabudiawan ◽  
Myrna Soepriadi ◽  
Diet Sadiah Rustama
Keyword(s):  
Family History ◽  
Cord Blood ◽  
Cross Sectional Study ◽  
T Test ◽  
Specific Marker ◽  
Atopic Diseases ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
The Mean

Background Cord blood-IgE (CB-IgE) levels have been usedwidely as a specific marker of atopic diseases. In some previousstudies, CB-IgE levels in subjects with and without a family historyof atopic diseases have been controversial.Objective To determine the CB-IgE level in newborns and to iden-tify the association between CB-IgE and family history of atopicdiseases.Methods A cross-sectional study was done to compare the CB-IgElevels in neonates with or without a family history of atopic diseasesin mother, father, or siblings. Subjects of this study were 124 new-borns who consecutively born in Puskesmas Kiaracondong,Bandung, during the period of March 2001 to July 2002. Subjectswere divided into 2 groups based on history of atopic diseases.Measurements of CB-IgE levels were done by sandwich ELISAmethods. Data were analyzed by c 2 statistics, t test, ANOVA, andDunkan’s test.Results The mean CB-IgE levels in the group with and without afamily history of atopic diseases were 3.2±2.5 IU/ml and 0.5±0.5IU/ml (P<0.001), respectively. The mean CB-IgE levels in maleand female infants with a family history of atopic diseases were3.3±2.7 IU/ml and 3.03±2.2 IU/ml (P>0.05), respectively. Basedon the cut-off point (1.3 IU/ml), CB-IgE levels had significant posi-tive association with a family history of atopic diseases (OR 156,95%CI 29.61;1104.24). CB-IgE levels in neonates with 1, 2, and 3atopic family members were 1.67±0.78 IU/ml, 3.76±2.11 IU/ml, and6.6±2.7 IU/ml, respectively (F=32.603; P<0.001).Conclusion Most newborns with a family history of atopic dis-eases showed high levels of CB-IgE, but there were no correlationwith gender. The probability of having atopic diseases increase inconcord with the number of family with atopic diseases

scholarly journals Relationship of Cord Blood Immunoglobulin E and Maternal Immunoglobulin E with Birth Order and Maternal History of Allergy in Albanian Mother/Neonate Pairs

2017 ◽  
Vol 5 (6) ◽  
pp. 751-756
Author(s):  
Hatixhe Latifi-Pupovci ◽  
Violeta Lokaj-Berisha ◽  
Besa Lumezi
Keyword(s):  
Cord Blood ◽  
Birth Order ◽  
Immunoglobulin E ◽  
Blood Levels ◽  
Significant Difference ◽  
History Of ◽  
Study Population ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship

BACKGROUND: Previous studies reported that familial factors such as birth order and mothers atopy might influence cord blood levels and development of allergies.AIM: The aim of the study was to evaluate the relationship of cord blood IgE and maternal IgE with birth order and mothers history of allergy in Albanian mother/neonate pairs.MATERIAL AND METHODS: Study population represented 291 mother-infant pairs. Mothers were interviewed with a questionnaire for personal history of allergy and pregnancy history whereas serum IgE levels were determined using sandwich IRMA assay.RESULTS: The mean level of cIgE in neonates with detectable levels was 1.59 (n = 78). No significant difference in means of cIgE was found between first born and later born neonates (p = 0.232) and between neonates of mothers with a negative and positive history of allergy (p = 0.125). Also, no significant difference was found between means of mIgE by birth order, whereas there was a significant difference of mIgE between mothers with and without a history of allergy (p = 0.01). In a group of neonates with detectable cIgE levels, maternal IgE levels were moderately correlated with cIgE levels.CONCLUSION: Cord blood IgE is not affected by birth order and mothers history of allergy, whereas mothers IgE are affected by the history of allergy but not by birth order.

scholarly journals Association between immunization coverage and atopy in children with or without family history of atopic disease

2016 ◽  
Vol 48 (6) ◽  
pp. 358
Author(s):  
Isabella Riandani ◽  
Budi Setiabudiawan ◽  
Cissy B. Kartasasmita
Keyword(s):  
Family History ◽  
Environmental Factors ◽  
Immunization Coverage ◽  
Atopic Disease ◽  
Total Serum ◽  
Atopic Diseases ◽  
Chi Square ◽  
Prick Test ◽  
History Of ◽  
Genetic And Environmental Factors

Background Atopic diseases are determined by the interactionbetween genetic and environmental factors. The possible effectsof immunization, as one of environmental factors, on atopy remaina matter of controversy.Objective We conducted an observational clinical epidemiologyto find out the protective effect of high vaccination coverage toatopy in children.Methods During January through March 2006, 150 of749 childrenat Garuda, Padasuka, and Babakan Sari Primary Health Care inBandung were randomized from group with and without familyhistory of atopic disease. Atopy derived from skin prick test andtotal serum lgE was evaluated. Atopy was defined as a positiveskin test to any of the eight allergens tested. The immunizationswere recorded from Kartu Menuju Sehat (KMS). Statistical analysesincluded Chi square to compare prevalence, independent T-testand Mann-Whitney to compare mean.Results Atopy was found in 28.2% of284 subjects, of which 32.4%with and 23.9% without a family history of atopic disease. Themedian of total serum lgE level was higher in children with familyhistory of atopic disease and in atopy children. Children weregrouped according to total dose of basic immunizations (0-17 and2: 18) based on Program Pengembangan Imunisasi (PPI). There wasnonsignificant association between total doses of immunizationand atopy. Even though no statistically significant, the cumulativeimmunization doses were inversely related to the median of totalserum IgE level.Conclusions The immunization coverage has not decreased atopyrisk.

scholarly journals Relation Between Hypertension Incidences with Family History of Hypertension to Summarecon Mall Serpong Visitors. Jurnal Kesehatan SCIENTIA Vol. 1 No.1, Juli 2020.

2020 ◽  
Author(s):  
Dwi Ayu Lestari ◽  
Ichsan Trisutrino ◽  
Kustia Anggereni ◽  
Resita Nurbayani
Keyword(s):  
Family History ◽  
Communicable Disease ◽  
Blood Pressure Measurement ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
History Of ◽  
Family History Of Hypertension ◽  
The Relationship ◽  
Non Communicable Disease

Hypertension is a non-communicable disease which causes death in the world, including in Indonesia. Increased prevalence of hypertension can be caused by lifestyle, stress and others. The purpose of this study was to determine the relationship between the incidence of hypertension and family history of suffering from hypertension. This study used an analytical survey with aCross-Sectional Study design conducted in August 2019. The research instrument was a questionnaire and blood pressure measurement. A total of 177 Summarecon Mall Serpong visitors were respondents in the study taken by accidental sampling. Data analysis using Chi Square test. The results of this study indicate that respondents who suffer from hypertension with a family history of hypertension by 60% and respondents who do not suffer from hypertension 17.5%, the incidence of hypertension with a family history of hypertension namely (OR = 7.05; 95%; CI 3.54 -14.05; p-value = 0,000). People who have a family history of suffering from hypertension 7x more at risk of developing hypertension. The conclusion of this study is that there is a relationship between the incidence of hypertension with a family history of hypertension in Summarecon Mall Serpong Visitors

scholarly journals Correlation between obesity with atopy and family history of atopy in children

2011 ◽  
Vol 51 (4) ◽  
pp. 227
Author(s):  
Putria Rayani Apandi ◽  
Budi Setiabudiawan ◽  
Abdurachman Sukadi
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Atopic Disease ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Chi Square ◽  
Cross Sectional ◽  
Prick Test ◽  
Chi Square Test ◽  
History Of

Background The prevalence of childhood obesity and atopy has increased in recent decades. Research on links between obesity and atopy has shown varied results. Few previous studies have reported on the significance of family history of atopic disease in children.Objective To determine correlation between obesity with atopy and family history of atopic disease in children.Methods This cross-sectional study was conducted from April to September 2010 in the Pediatric Allergy-Immunology subdivision, Hasan Sadikin Hospital. Children aged 6−11 years were divided into four groups of 40 each: obese subjects with and without family history of atopic disease, and normal weight subjects with and without family history of atopic disease. Skin prick test was performed to determine which subjects had atopy. Chi-square test was used to analyze mutual independence, and partial Chi-square test was used to analyze correlation of obesity to atopy and family history of atopic disease in children. Environmental factors, type of childbirth, and pregnancy history were also analyzed as risk factors for atopy.Results Of 80 obese children with and without family history of atopic disease, 40 (100%) and 38 (95%), respectively, were atopic. Of 80 normal weight children with and without family history of atopic disease, 39 (98%) and 9 (23%), respectively, were atopic. Thus atopy was observed in 126 subjects, while the remaining 34 subjects were non-atopic. Partial test showed a correlation between obesity with atopy and family history of atopic disease (P < 0.001). There were no significant differences in risk factors for atopy by group.Conclusion Obesity correlates with atopy and family history of atopic disease in children.

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