scholarly journals An Introduction to Fuzzy Testing of Multialternative Hypotheses for Group of Samples with the Single Parameter: Through the Fuzzy Confidence Interval of Region of Acceptance

2015 ◽  
Vol 2015 ◽  
pp. 1-8
Author(s):  
Manikandan Harikrishnan ◽  
Jeyabharathi Sundarrajan ◽  
Muthuraj Rengasamy

Classical statistics and many data mining methods rely on “statistical significance” as a sole criterion for evaluating alternative hypotheses. It is very useful to find out the significant difference existing between the samples as well as the population or between two samples. But in this paper, the researchers try to apply the concepts of fuzzy group testing of hypothesis problem between multi group of samples of same size or different, through comparing the parameters like mean, standard deviation, and so forth. Hence we can compare multigroups such that they have the significant difference in their mean or standard deviation or other parameters through the fuzzy group testing of multihypotheses. The authors introduced and investigated the concepts very first time through fuzzy analysis that can decide which group(s) or samples can be taken for further investigation and eitherH0is rejected or accepted and hence the next discussion provides the properties of group of samples which may result in the optimized solution for the problem.

Drug Research ◽  
2018 ◽  
Vol 68 (10) ◽  
pp. 596-600 ◽  
Author(s):  
Nasir Idkaidek ◽  
Salim Hamadi ◽  
Manal El-Assi ◽  
Ahmad Al-Shalalfeh ◽  
Ahmad Al-Ghazawi

AbstractThe objective is using saliva instead of plasma for pregabalin therapeutic drug monitoring (TDM) since saliva reflects the free non–protein bound drug concentration, simple and noninvasive sampling, cheaper and does not require the expertise of drawing blood. Forty four patients participated in this study, two samples of saliva and another two of blood were taken from each patient; first sample of both saliva and blood is the trough sample and was taken just before the first dose of the day and second sample is the peak sample and was taken 1 h after taking the first dose of the day. Descriptive statistics and t-testing after log transformation were done using Excel, p-value=0.05 was adopted for significant difference. Optimized effective intestinal permeability of pregabalin was estimated by PK-Sim program version 7. This study for the first time revealed that pregabalin is excreted in saliva and classified as class 1 based on Salivary Excretion Classification System (SECS). A good correlation of 0.71-0.83 between Cmin and Cmax of plasma and saliva pregabalin was observed respectively which indicate that saliva sampling is a good alternative matrix for pregabalin TDM. C/D-ratios were calculated to demonstrate pharmacokinetic variability of Pregabalin; the results showed that C/D-ratio was higher in women, elderly and in those patients who had Scr.≥0.9 mg/dl. Proposed pregabalin therapeutic ranges are 0.7 to 1.84 µg/ml in plasma and 0.055 to 0.145 µg/ml in saliva, for neuropathic pain, diabetic neuropathy and disc prolapse patients.


2011 ◽  
Vol 139 (1-2) ◽  
pp. 76-80
Author(s):  
Milutin Nenadovic ◽  
Rosa Sapic

Introduction. Polytoxicomanic proportions in subpopulations of youth have been growing steadily in recent decades, and this trend is pan-continental. Psychoticism is a psychological construct that assumes special basic dimensions of personality disintegration and cognitive functions. Psychoticism may, in general, be the basis of pathological functioning of youth and influence the patterns of thought, feelings and actions that cause dysfunction. Objective. The aim of this study was to determine the distribution of basic dimensions of psychoticism for commitment of youth to abuse psychoactive substances (PAS) in order to reduce disturbing intrapsychic experiences or manifestation of psychotic symptoms. Methods. For the purpose of this study, two groups of respondents were formed, balanced by age, gender and family structure of origin (at least one parent alive). The study applied a DELTA-9 instrument for assessment of cognitive disintegration in function of establishing psychoticism and its operationalization. The obtained results were statistically analyzed. From the parameters of descriptive statistics, the arithmetic mean was calculated with measures of dispersion. A cross-tabular analysis of variables tested was performed, as well as statistical significance with Pearson?s ?2-test, and analysis of variance. Results. Age structure and gender are approximately represented in the group of polytoximaniacs and the control group. Testing did not confirm the statistically significant difference (p>0.5). Statistical methodology established that they significantly differed in most variables of psychoticism, polytoxicomaniacs compared with a control group of respondents. Testing confirmed a high statistical significance of differences of variables of psychoticism in the group of respondents for p<0.001 to p<0.01. Conclusion. A statistically significant representation of the dimension of psychoticism in the polytoxicomaniac group was established. The presence of factors concerning common executive dysfunction was emphasized.


2021 ◽  
Author(s):  
◽  
Geraldine McDonald

<p>Using an analysis developed by the linguist Manfred Bierwisch of the semantic components of the set of spatial adjectives, big, little, long, short, high, low, wide, narrow, deep, shallow, far, near, thick, thin, fat, thin, tall and short, four series of tests were constructed in order to determine whether differences existed in the meaning systems of Maori and of Pakeha four-year-old children with respect to these words, and whether Maori and Pakeha performances were similar across all four series. The series were: (a) A word recognition series testing for components of meaning in which pairs of components were placed in binary opposition. (b) An implication series testing for understanding of the concepts referred to by the words of the set. (c) An anomaly series, designed to elicit words of the set and to explore the children's understanding of the use of words. (d) A feature series which explored the children's implicit understanding of normativity and proportion. In addition the children were asked to do a drawing of something big and something little. Their mothers were also interviewed in order to collect information about a number of background variables such as mother's education, father's occupation and the language background of the child. Maori and Pakeha samples were established by asking the mothers to give the ethnic identity of the child. The main findings were that the Pakeha performed better than the Maori sample on recognition of the set of target words but this difference did not reach a level of statistical significance. Two words of the set, low and wide were recognised significantly more often by Pakeha than by Maori. With regard to the range of the words of the set elicited the Pakeha children produced a greater variety of words but, again, this difference was not statistically significant. The two samples performed about equally with regard to comprehension of the concepts signified by the words of the set. Nor was any important difference detected in the feature series or the drawings. An analysis of choice patterns showed no significant difference between the two samples. These results were interpreted to mean that the four-year-old Maori children in the sample did not exhibit cognitive deficit relative to the Pakehas even though they showed differences in word recognition and word use. Nor were they hampered in their access to the meaning of the words in the study by acquaintance with the Maori language. In order to assess the possible effects of various background factors, measures of word recognition, concepts, and strategies (choice patterns) were correlated with the background variables. The age of the child was significantly associated with the concept scores and with number of words elicited. Father's occupation was associated significantly with words recognised in the Pakeha sample but not in the Maori sample. In addition to exploring possible Maori-Pakeha differences in interpretation of words and concepts, the semantic feature acquisition hypothesis was examined and found to be inadequate as an explanation of the acquisition of words and meaning. An alternative multi-level model based on a hierarchy of preferred interpretations was developed to suggest the way in which the words of the set and their meanings are acquired by the young child.</p>


2021 ◽  
Author(s):  
◽  
Geraldine McDonald

<p>Using an analysis developed by the linguist Manfred Bierwisch of the semantic components of the set of spatial adjectives, big, little, long, short, high, low, wide, narrow, deep, shallow, far, near, thick, thin, fat, thin, tall and short, four series of tests were constructed in order to determine whether differences existed in the meaning systems of Maori and of Pakeha four-year-old children with respect to these words, and whether Maori and Pakeha performances were similar across all four series. The series were: (a) A word recognition series testing for components of meaning in which pairs of components were placed in binary opposition. (b) An implication series testing for understanding of the concepts referred to by the words of the set. (c) An anomaly series, designed to elicit words of the set and to explore the children's understanding of the use of words. (d) A feature series which explored the children's implicit understanding of normativity and proportion. In addition the children were asked to do a drawing of something big and something little. Their mothers were also interviewed in order to collect information about a number of background variables such as mother's education, father's occupation and the language background of the child. Maori and Pakeha samples were established by asking the mothers to give the ethnic identity of the child. The main findings were that the Pakeha performed better than the Maori sample on recognition of the set of target words but this difference did not reach a level of statistical significance. Two words of the set, low and wide were recognised significantly more often by Pakeha than by Maori. With regard to the range of the words of the set elicited the Pakeha children produced a greater variety of words but, again, this difference was not statistically significant. The two samples performed about equally with regard to comprehension of the concepts signified by the words of the set. Nor was any important difference detected in the feature series or the drawings. An analysis of choice patterns showed no significant difference between the two samples. These results were interpreted to mean that the four-year-old Maori children in the sample did not exhibit cognitive deficit relative to the Pakehas even though they showed differences in word recognition and word use. Nor were they hampered in their access to the meaning of the words in the study by acquaintance with the Maori language. In order to assess the possible effects of various background factors, measures of word recognition, concepts, and strategies (choice patterns) were correlated with the background variables. The age of the child was significantly associated with the concept scores and with number of words elicited. Father's occupation was associated significantly with words recognised in the Pakeha sample but not in the Maori sample. In addition to exploring possible Maori-Pakeha differences in interpretation of words and concepts, the semantic feature acquisition hypothesis was examined and found to be inadequate as an explanation of the acquisition of words and meaning. An alternative multi-level model based on a hierarchy of preferred interpretations was developed to suggest the way in which the words of the set and their meanings are acquired by the young child.</p>


PEDIATRICS ◽  
1961 ◽  
Vol 27 (4) ◽  
pp. 597-602
Author(s):  
John B. Joseph ◽  
William H. Bergstrom

The mean concentration of sodium in serum of a group of normal children in Syracuse, N.Y., in midsummer was 146 meq/l. The total standard deviation for within-individual variation was 4 meq/l, comprising a laboratory error of ±2.5 meq/l and a "true" within-individual variability of ±3.2 meq/l. No significant difference between individuals was demonstrated. Within 90% confidence limits, the maximum chance difference between two successive concentrations of sodium in the serum, whose mean falls within the normal range for means of two samples was found to be 11 meq/l. Within 95% confidence limits, the maximum chance difference between any two values, duplicate or successive, due to laboratory error was 6.9 meq/l. The implications of these findings for the interpretation of sodium levels in serum of patients are discussed.


2020 ◽  
Vol 66 (1) ◽  
pp. 19-22
Author(s):  
Melania Macarie ◽  
Simona Maria Bataga ◽  
Monica Pantea ◽  
Razvan Opaschi ◽  
Simona Mocan ◽  
...  

AbstractObjective: This study aims to determine the correlation between risk factors and erosive esophagitis development.Methods: We conducted a retrospective observational study on a consecutive series of 19.672 patients who underwent upper gastrointestinal endoscopy between 01.01.2011-31.12.2017. A total of 3005 patients, diagnosed with erosive esophagitis, were included in the present study and stratified according to Los Angeles classification.Results: During the studied period we found 3005 patients with erosive esophagitis, sex ratio male to female was 1.3/1, the most common forms of esophagitis being grade A and B: 74.54% patients with esophagitis grade A, 14.80% patients with grade B; 5.29% patients were with grade C and 5.35% patients with esophagitis grade D. In severe esophagitis the male predominance was more prevalent (249 males, 71 female), with a sex ratio 3.50/1. The correlation of male gender with severe esophagitis was highly statistically significant (p < 0.0001, OR 2.97; 95% CI 2.25-3.91). Hiatal hernia was diagnosed in 1171 patients, the presence of large hiatal hernias, being an important predictor, with statistical significance (p < 0.0001, OR 3.41; 95% CI 2.22-5.21), for severe esophagitis development. Incidence of Helicobacter pylori infection was 11.51%, in the entire study group, with no statistical significant difference between patients with mild or severe esophagitis (12.02% vs 7.18%).Conclusion: Erosive esophagitis is a frequent disease, the most common forms being grade A and B. Male gender and the presence of hiatal hernia are the most important risk factors for erosive esophagitis development, in our study group.


2020 ◽  
Vol 41 (6) ◽  
pp. 436-441 ◽  
Author(s):  
Daniel A. Rosloff ◽  
Kunal Patel ◽  
Paul J. Feustel ◽  
Jocelyn Celestin

Background: Undifferentiated somatoform (US) idiopathic anaphylaxis (IA) is considered a psychogenic disorder characterized by a lack of observable physical findings and poor response to treatment. Although failure to diagnose true anaphylaxis can have disastrous consequences, identification of US-IA is crucial to limit unnecessary expenses and use of health care resources. Objective: To better define the presentation and understand the potential relationship between US-IA and underlying psychiatric comorbidities. Methods: We retrospectively reviewed 110 visits by 107 patients to our institution for evaluation and management of anaphylaxis over a 1-year period. The patients were classified as having either criteria positive (CP) or criteria negative (CN) anaphylaxis based on whether they met Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium criteria for the clinical diagnosis of anaphylaxis. Patient characteristics, including objective and subjective signs and symptoms, and the presence of psychiatric diagnoses were collected and analyzed. Statistical significance was assessed by using the Fisher exact test. A literature review of US-IA and other psychogenic forms of anaphylaxis was performed. Results: Patients with CP anaphylaxis were more likely to present with hypotension, wheezing, urticaria, and vomiting than were patients with CN anaphylaxis. The patients with CN anaphylaxis were more likely to present with subjective symptoms of sensory throat tightness or swelling compared with patients with CP anaphylaxis. No significant difference was detected in the prevalence of psychiatric conditions between the two groups. Conclusion: Patients who met previously established diagnostic criteria for anaphylaxis were more likely to present with objective physical findings than those who did not meet criteria for true anaphylaxis. CN patients who presented for treatment of anaphylaxis were more likely to present with subjective symptoms. Formal diagnostic criteria should be used by clinicians when evaluating patients with suspected anaphylaxis.


2008 ◽  
Vol 2 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Jorge Iván Sánchez-Botero ◽  
Danielle Sequeira Garcez ◽  
Wesllen Chaves Cortezão

This study evaluates the total length of tambaqui (Colossoma macropomum ) captured in the middle Solimões river and traded during seven years (1993, 1997 and 2000 to 2005) in the Tefé market, Amazon, Brazil. The Mamirauá Institute of Sustainable Development obtained measurements of the total lengths from 42207 individuals. The length average was 45.23 ± 6.29 cm (minim um of 13 cm and maximum of 105.5 cm ) and the mode was 45 cm . From the total tambaquis, 92.86% were smaller than 55 cm and 7.14% measured 58.24 ± 5.41 cm on average. Medium and standard deviation of the lengths recorded in all years showed sizes below the established by the environmental federal agency. The Kruskal Wallis test showed that there is no significant difference between the abundances and medium sizes of the captures during all months of the year. The historical data of the tambaqui fisheries for the middle Solimões region indicate that individuals of this species have been constantly captured at sizes below the minim um length of reproduction. Nine recommendations for tambaquis fisheries management in the region related to more efficient mechanisms of inspection, auto-ecology studies of the species, environmental protection, reduction of fishery pressure, diffusion and educational cam paigns that aim to correct exploitation of this resource are presented in this manuscript.


2015 ◽  
pp. 71-75
Author(s):  
Van Nam Phan ◽  
Ba Ken Tran

Purpose: Study clinical feature of phacomorphic glaucoma. To evaluate the result of treatment phacomorphic glaucoma. Method: The retrospective, interventional study on 36 cases with phacomorphic glaucoma who underwent treated at Hue Central Hospital from 6/2010 to 6/2011. Standard of research: visual, IOP, before and after surgery, accompanying lesions and post-operative complications. The surgery is considered successful when postoperative IOP less than 21 mmHg. Results: Age 50-59 presented 30.5 percent, ≥ 60 presented 91.7 percent. There was a slight female preponderance (66.7%) compared to the male population (33.3%) which implies a statistically marginally significant difference. However there was no statistical significance difference when compared by the two subgroups. Patient in country presented 61,1% and city presented 38,9%. The duration between the onset of pain and surgery from 0 to < 5 days (77.8%), from 6 to 10 (16.7%) and >10 days presented 5.5%. The preoperative intraocular pressure 35 to 45mmHg (47.2%), 46-55 (30.6%), 56-65 (13.9%) and more than 65 presented 8.3%. The visual acuity preoperation less than 1metre count finger (94.5%), less than 3 metre count finger presented 5.5%. Close anterior chamber angle presented 80.6% and shallow was presented 19.4%. Corneal edema presented 100%, iritis presented 94.4%, dilated pupil larger 5mm presented 83.3%, Synchynea iris and cataract presented 72.2%. ECCE, implantation IOL combined trabeculectomy presented 11.1%, Phaco, implantation IOL combined trabeculectomy presented 69,5%, ECCE implantation IOL presented 5.6%, Phaco, implantation IOL presented 13.8%. Postoperative visual acuity from 1/10 to 5/10 presented 72.2%, no case have VA larger than 5/10. Postoperative 3 months VA 1/10 to 5/10 presented 72.2%, larger VA 5/10 presented 8.3%. Postoperative 3 months intraocular pressure ≤ 21mmHg presented 91.7%, 22 to 24mmHg presented 8.3%, no case have IOP ≥25mmHg. Postoperative edema presented 58.3%, iritis presented 58.3%. Key words: phacomorphic Glaucoma


2020 ◽  
Vol 1 (2) ◽  
pp. 56-66
Author(s):  
Irma Linda

Background: Early marriages are at high risk of marital failure, poor family quality, young pregnancies at risk of maternal death, and the risk of being mentally ill to foster marriage and be responsible parents. Objective: To determine the effect of reproductive health education on peer groups (peers) on the knowledge and perceptions of adolescents about marriage age maturity. Method: This research uses the Quasi experimental method with One group pre and post test design, conducted from May to September 2018. The statistical analysis used in this study is a paired T test with a confidence level of 95% (α = 0, 05). Results: There is an average difference in the mean value of adolescent knowledge between the first and second measurements is 0.50 with a standard deviation of 1.922. The mean difference in mean scores of adolescent perceptions between the first and second measurements was 4.42 with a standard deviation of 9.611. Conclusion: There is a significant difference between adolescent knowledge on the pretest and posttest measurements with a value of P = 0.002, and there is a significant difference between adolescent perceptions on the pretest and posttest measurements with a value of p = 0.001. Increasing the number of facilities and facilities related to reproductive health education by peer groups (peers) in adolescents is carried out on an ongoing basis at school, in collaboration with local health workers as prevention of risky pregnancy.


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