scholarly journals The Impact ofLEPG-2548A andLEPRGln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a Mexican Mestizo Population

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Efraín Chavarria-Avila ◽  
Mónica Vázquez-Del Mercado ◽  
Eduardo Gomez-Bañuelos ◽  
Sandra-Luz Ruiz-Quezada ◽  
Jorge Castro-Albarran ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Leptin Receptor ◽  
Serum Levels ◽  
Normal Weight ◽  
Body Fat Mass ◽  
Western Mexico ◽  
Pcr Rflp ◽  
Obese Subjects ◽  
The Impact

The polymorphisms in leptin (LEPG-2548A) and leptin-receptor (LEPRGln223Arg) seem to influence obesity and lipid metabolism among others. The aim of this study was to investigate the effect of these polymorphisms on adiposity, leptin (sLeptin), and leptin-receptor (sLeptin-receptor) serum concentrations as well as inflammation markers. We included 382 adults originally from Western Mexico. They were genotyped by PCR-RFLP. Obese individuals showed higher sLeptin (58.2±31.35 ng/mL) but lower sLeptin-receptor (12.6±3.74 ng/mL) levels than normal weight ones (17.6±14.62 ng/mL,17.4±4.62 ng/mL, resp.),P<0.001. Obese subjects carriers of Arg/Arg genotype had more (P=0.016) sLeptin-receptor (14.7±4.96 ng/mL) and less (P=0.004) sLeptin (44.0±28.12 ng/mL) levels than Gln/Gln genotype (11.0±2.92 ng/mL,80.3±33.24 ng/mL, resp.). Body fat mass was lower (Pfrom 0.003 to 0.045) for A/A (36.5%±6.80) or Arg/Arg (36.8%±6.82) genotypes with respect to G/G (41.3%±5.52) and G/A (41.6%±5.61) or Gln/Gln (43.7%±4.74) and Gln/Arg (41.0%±5.52) genotypes carriers. Our results suggest thatLEP-2548A andLEPR223Arg could be genetic markers of less body fat mass accumulation in obese subjects from Western Mexico.

scholarly journals An investigation into the effect of body mass index on the agreement between whole-body fat mass determined by MRI and air-displacement plethysmography

2019 ◽  
Vol 92 (1103) ◽  
pp. 20190300
Author(s):  
Andrew D. Weedall ◽  
Adrian J. Wilson ◽  
Sarah C. Wayte
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Whole Body ◽  
Body Fat Mass ◽  
Fat Percentage ◽  
Air Displacement Plethysmography ◽  
Obese Subjects ◽  
Test Objects

Objective: To validate MRI fat measurement protocols using purpose built test objects and by comparison with air-displacement plethysmography (ADP) whole-body fat measurements in non-obese subjects. Methods: Test objects of known fat concentration were used to quantify the accuracy of the MRI measurements. 10 participants with a body mass index in the range 18–30 underwent whole-body MRI using two different Dixon-based sequences (LAVA Flex and IDEAL IQ) to obtain an estimate of their whole-body fat mass. The MRI determined fat mass was compared to the fat mass determined by ADP. Results: MRI test object measurements showed a high correlation to expected fat percentage (r > 0.98). The participant MRI and ADP results were highly correlated (r = 0.99) but on average (mean ± standard deviation) MRI determined a higher fat mass than ADP (3.8 ± 3.1 kg for LAVA Flex and 1.9 ± 3.2 kg for IDEAL IQ). There was no trend in the difference between MRI and ADP with total fat mass. Conclusion: The good agreement between MRI and ADP shows that Dixon-based MRI can be used effectively as a tool in physiological research for non-obese adults. Advances in knowledge: This work found that for ten non-obese subjects body mass index had no effect on the MRI determination of whole-body fat mass.

scholarly journals Body composition analysis in female ballet dancers

2003 ◽  
Vol 56 (11-12) ◽  
pp. 579-583 ◽  
Author(s):  
Bojan Mihajlovic ◽  
Sasa Mijatov ◽  
Biljana Srdic ◽  
Edita Stokic
Keyword(s):  
Body Composition ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Normal Weight ◽  
Control Group ◽  
Composition Analysis ◽  
Study Group ◽  
Body Fat Mass ◽  
Ballet Dancers

Introduction The aim of this study was to evaluate and compare the nutritional status and body composition in female ballet dancers and a group of non-athletic female controls. Materials and methods The study group consisted of 30 female ballet dancers, aged 17.4?2.01, whereas the control group included 30 non-athletic female examinees, aged 18.00 years on average. Height and weight were measured and body mass index (BMI) was calculated in all subjects. Body composition was estimated using the bioelectrical impedance method. Results Body composition analysis of ballet dancers revealed significantly lower values of body fat mass compared to the control group (18.85?4.50% vs. 23.41?4.34). Most examinees in both groups were of normal weight. 50% of ballet dancers and 23.33% of examinees in the control group were underweight, while overweight subjects were registered only in the control group. Most underweight ballet dancers had lower body fat mass, whereas majority of underweight examinees in the control group presented with normal body fat mass. Normal-weight obesity was established in 40.91% candidates in the control and 6.67% in the study group. Conclusion Ballet dancers had significantly lower values of body mass and BMI, compared to the study group. In order to prevent very serious complications caused by changes in size and proportion of some body compartments, it is necessary to carry out assessment of body composition more often in high-risk groups, such as the study group of ballet dancers.

scholarly journals Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women

2002 ◽  
pp. 173-180 ◽  
Author(s):  
M Matsubara ◽  
S Maruoka ◽  
S Katayose
Keyword(s):  
Gene Product ◽  
Body Fat ◽  
Fat Mass ◽  
Normal Weight ◽  
Body Fat Mass ◽  
Obese Women ◽  
Serum Leptin ◽  
Plasma Adiponectin ◽  
Significant Independent Variable ◽  
Independent Variable

BACKGROUND: Adiponectin, a novel adipocyte-derived collagen-like protein, is the gene product of the adipose most-abundant gene transcript 1 (apM1), which has been considered to have anti-inflammatory and anti-atherogenic effects. OBJECTIVE: To characterize the relationship between adiponectin and leptin, the ob gene product, in normal-weight and obese women. DESIGN AND METHODS: In this cross-sectional study, we measured fasting plasma adiponectin by ELISA, leptin concentrations by RIA, and related parameters such as blood pressure, body mass index (BMI), body fat mass, lipids, fasting blood glucose and insulin in 353 non-diabetic adult women with a wide range of BMI values. RESULTS: Plasma adiponectin concentrations in women with the highest tertile of BMI (at least 25.0 kg/m(2)) were decreased compared with those in the middle (22.0-25.0 kg/m(2)) or lowest (<or=22.0 kg/m(2)) tertile of BMI (means+/-s.e.m.: 6.7+/-0.3 microg/ml compared with 8.6+/-0.4 microg/ml and 9.2+/-0.3 microg/ml; both P<0.0001). Serum leptin concentrations in women with the highest tertile of BMI were increased compared with those in women in the middle or lowest tertile of BMI (13.2+/-0.4 ng/ml compared with 8.1+/-0.2 ng/ml and 5.2+/-0.2 ng/ml; both P<0.0001). These relationships were similar after adjustment for BMI or body fat mass. Adiponectin was negatively correlated with serum leptin concentration, fasting immunoreactive insulin, calculated insulin resistance (homeostasis model assessment), BMI and body fat mass. These negative relationships became stronger after adjustment for BMI or body fat mass. In stepwise regression analyses, leptin was the significant independent variable for adiponectin, and adiponectin was also the significant independent variable for leptin before and after adjustment for BMI or body fat mass. CONCLUSIONS: In this study, we found an inverse correlation between adiponectin and leptin in vivo.

scholarly journals No acute response of leptin to an oral fat load in obese patients and during circadian rhythm in healthy controls

2000 ◽  
pp. 649-655 ◽  
Author(s):  
B Guerci ◽  
S Hadjadj ◽  
D Quilliot ◽  
O Ziegler ◽  
P Drouin
Keyword(s):  
Circadian Rhythm ◽  
Body Fat ◽  
Fat Mass ◽  
The Body ◽  
Body Fat Mass ◽  
Healthy Controls ◽  
Obese Patients ◽  
Obese Subjects ◽  
Insulin Responses ◽  
Oral Fat Load

This study was done to elucidate the relationship between postprandial leptin and obesity, and the possible influence of the circadian rhythm on the dynamic leptin response to an oral fat load (OFLT). In experiment 1, we measured the leptin and insulin responses to an oral fat load in 16 non-diabetic obese subjects and in 16 healthy controls, matched for age and gender. In experiment 2, we measured the leptin and insulin responses to an OFLT according to the time of fat load ingestion: 0700 h (diurnal (D) test) or 2200 h (nocturnal (N) test) in nine normal-weight healthy males. Baseline leptin concentration was correlated with the body mass index, body fat mass and percentage of body fat mass in both experiments. The leptin concentrations were higher in women than in men (P<0.001). In experiment 1, the leptin concentrations were higher in obese subjects than in controls, but did not change over time in either group. The plasma insulin concentrations at baseline and during the postprandial state, as well as the area under the curve (AUC) of insulin, were higher in obese subjects than in controls (P<0.05-0. 0001). There was no correlation between postprandial insulin responses and postprandial leptin responses in either obese or control groups. In experiment 2, leptin (D vs N, 2.9+/-1.4 vs 2. 9+/-1.0 ng/ml) and insulin (D vs N, 41+/-18 vs 25+/-9 pmol/l) concentrations were similar at the beginning of the D and N tests after a 10 h fast. The leptin concentrations did not change after D or N tests and were not statistically different for D and N tests. Our results indicate that the leptin concentration in healthy controls and in obese patients is not acutely influenced by a high fat load.

scholarly journals Tryptophan Metabolism Is Associated with BMI and Adipose Tissue Mass and Linked to Metabolic Disease in Pediatric Obesity

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 286
Author(s):  
Julia Lischka ◽  
Andrea Schanzer ◽  
Margot Baumgartner ◽  
Charlotte de Gier ◽  
Susanne Greber-Platzer ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Body Fat ◽  
Fat Mass ◽  
Pediatric Obesity ◽  
Severe Obesity ◽  
Metabolic Diseases ◽  
Tryptophan Metabolism ◽  
Body Fat Mass ◽  
Tissue Mass ◽  
The Impact

The obesity epidemic has contributed to an escalating prevalence of metabolic diseases in children. Overnutrition leads to increased tryptophan uptake and availability. An association between the induction of the tryptophan catabolic pathway via indoleamine 2,3-dioxygenase (IDO) activity and obesity-related inflammation has been observed. This study aimed to investigate the impact of pediatric obesity on tryptophan metabolism and the potential relationship with metabolic disease. In this prospective cohort study, plasma kynurenine, tryptophan, and serotonin levels were measured by ELISA, and IDO activity was estimated by calculating the kynurenine/tryptophan ratio in a clinically characterized population with severe obesity (BMI ≥ 97th percentile) aged 9 to 19 (n = 125). IDO activity and its product kynurenine correlated with BMI z-score and body fat mass, whereas concentrations of serotonin, the alternative tryptophan metabolite, negatively correlated with these measures of adiposity. Kynurenine and tryptophan, but not serotonin levels, were associated with disturbed glucose metabolism. Tryptophan concentrations negatively correlated with adiponectin and were significantly higher in prediabetes and metabolically unhealthy obesity. In conclusion, BMI and body fat mass were associated with increased tryptophan catabolism via the kynurenine pathway and decreased serotonin production in children and adolescents with severe obesity. The resulting elevated kynurenine levels may contribute to metabolic disease in obesity.

scholarly journals Association between serum levels of vitamin D with body fat mass, fasting glucose and lipid profile in patients with osteogenesis imperfecta

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Barbara Santarosa Emo Peters ◽  
Marise Lazaretti‐Castro ◽  
Lilian F. Hayashi ◽  
Aline Vasques Costa ◽  
Lígia Araújo Martini
Keyword(s):  
Vitamin D ◽  
Osteogenesis Imperfecta ◽  
Lipid Profile ◽  
Body Fat ◽  
Fat Mass ◽  
Fasting Glucose ◽  
Serum Levels ◽  
Body Fat Mass

Correlation between postprandial bile acids and body fat mass in healthy normal-weight subjects

2014 ◽  
Vol 47 (12) ◽  
pp. 1128-1131 ◽  
Author(s):  
Tatsuya Suzuki ◽  
Junya Aoyama ◽  
Masao Hashimoto ◽  
Makoto Ohara ◽  
Shoko Futami-Suda ◽  
...  
Keyword(s):  
Bile Acids ◽  
Body Fat ◽  
Fat Mass ◽  
Normal Weight ◽  
Body Fat Mass

scholarly journals In vivo evidence for unidentified leptin-induced circulating factors that control white fat mass

2015 ◽  
Vol 309 (12) ◽  
pp. R1499-R1511 ◽  
Author(s):  
Ruth B. S. Harris
Keyword(s):  
Cell Size ◽  
Body Fat ◽  
Fat Mass ◽  
Leptin Receptor ◽  
Recipient Mouse ◽  
Body Fat Mass ◽  
Energy Status ◽  
Wild Type ◽  
Cell Size Distribution ◽  
Leptin Receptors

Fat transplants increase body fat mass without changing the energy status of an animal and provide a tool for investigating control of total body fat. Early transplant studies found that small pieces of transplanted fat took on the morphology of the transplant recipient. Experiments described here tested whether this response was dependent upon expression of leptin receptors in either transplanted fat or the recipient mouse. Fat from leptin receptor deficient db/db mice or wild-type mice was placed subcutaneously in db/db mice. After 12 wk, cell size distribution in the transplant was the same as in endogenous fat of the recipient. Thus, wild-type fat cells, which express leptin receptors, were enlarged in a hyperleptinemic environment, indicating that leptin does not directly control adipocyte size. By contrast, db/db or wild-type fat transplanted into wild-type mice decreased in size, suggesting that a functional leptin system in the recipient is required for body fat mass to be controlled. In the final experiment, wild-type fat was transplanted into a db/db mouse parabiosed to either another db/db mouse to an ob/ob mouse or in control pairs in which both parabionts were ob/ob mice. Transplants increased in size in db/db–db/db pairs, decreased in db/db–ob/ob pairs and did not change in ob/ob-ob/ob pairs. We propose that leptin from db/db parabionts activated leptin receptors in their ob/ob partners. This, in turn, stimulated release of unidentified circulating factors, which travelled back to the db/db partner and acted on the transplant to reduce fat cell size.

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