Polymorphisms inC-Reactive ProteinandGlypican-5Are Associated with Lung Cancer Risk andGartrokine-1Influences Cisplatin-Based Chemotherapy Response in a Chinese Han Population
The role of genetics in progression of cancer is an established fact, and susceptibility risk and difference in outcome to chemotherapy may be caused by the variation in low-penetrance alleles of risk genes. We selected seven genes (CRP, GPC5, ACTA2, AGPHD1, SEC14L5, RBMS3, andGKN1) that previously reported link to lung cancer (LC) and genotyped single nucleotide polymorphisms (SNPs) of these genes in a case-control study. A protective allele “C” was found in rs2808630 of the C-reactive protein (CRP). Model association analysis found genotypes “T/C” and “C/C” in the dominant model and genotype “T/C” in the overdominant model of rs2808630 associated with reduced LC risk. Gender-specific analysis in each model showed that genotypes “T/T” and “C/C” in rs2352028 of theGlypican 5(GPC5) were associated with increased LC risk in males. Logistic regression analysis showed “C/T” genotype carriers of rs4254535 in theGastrokine 1(GKN1) had less likelihood to have chemotherapy response. Our results suggest a potential association betweenCRPandGPC5variants with LC risk; variation inGKN1is associated with chemotherapy response in the Chinese Han population.