scholarly journals Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammad Hashemi ◽  
Javad Yousefi ◽  
Seyed Mehdi Hashemi ◽  
Shadi Amininia ◽  
Mahboubeh Ebrahimi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Case Control Study ◽  
Iranian Population ◽  
Interacting Protein ◽  
Apoptosis Pathway ◽  
Protein Insertion ◽  
The Relationship ◽  
Control Study

It has been suggested that genetic factors contribute to patients’ vulnerability to breast cancer (BC). The programmed cell death 6 interacting protein (PDCD6IP) encodes for a protein that is known to bind to the products of the PDCD6 gene, which is involved in the apoptosis pathway. The aim of this case-control study is to investigate the relationship between thePDCD6IP15 bp insertion/deletion (I/D) polymorphism (rs28381975) and BC risk in an Iranian population. A total of 491 females, including 266 BC patients and 225 control subjects without cancer, were enrolled into the study. Our findings revealed that thePDCD6IP15 bp I/D polymorphism decreased the risk of BC in codominant (OR=0.44, 95%CI=0.31–0.65,p<0.0001, I/D versus DD;OR=0.39, 95%CI=0.17–0.88,p=0.030, I/I versus DD) and dominant (OR=0.44, 95%CI=0.30–0.63,p<0.0001, D/I + I/I versus D/D) tested inheritance models. Also, thePDCD6IPI allele significantly decreased the risk of BC (OR=0.59, 95%CI=0.45–0.78,p<0.001) compared to the D allele.

scholarly journals The Relationship between Pre-miR-3131 3-bp Insertion/Deletion Polymorphism and Susceptibility and Clinicopathological Characteristics of Patients with Breast Cancer

MicroRNA ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 216-223
Author(s):  
Mahsa Azizi ◽  
Nahid Rahimi ◽  
Gholamreza Bahari ◽  
Seyed Mehdi Hashemi ◽  
Mohammad Hashemi
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Late Onset ◽  
Meta Analysis ◽  
Clinicopathological Characteristics ◽  
Increased Risk ◽  
Pcr Rflp ◽  
Risk Of Cancer ◽  
The Relationship ◽  
Control Study

Aims: This study aimed at examining the effect of 3-bp pre-miR-3131 insertion/deletion (ins/del) polymorphism on Breast Cancer (BC) risk. Objectives: Totally 403 women including 199 BC patients and 204 women who have no cancer were included in this case-control study. Genotyping of miR-3131 3-bp ins/del polymorphism was performed by mismatch PCR-RFLP method. Methods: The findings expressed that the pre-miR-3131 3-bp ins/del variant was not related to the risk of BC in all genetic tested models. While, the ins/del genotype was related to late onset BC (OR=2.53, 95%CI=1.27-4.84, p=0.008). Results: Pooled results from the meta-analysis indicated to that the pre-miR-3131 ins/del is related to with an increased risk of cancer in heterozygous (OR=1.26, 95%CI=1.06-1.51, p=0.01), dominant (OR=1.33, 95%CI=1.14-1.54, p=0.0002), and allele (OR=1.24, 95%CI=1.06-1.45, p=0.006) genetics models. Conclusion: It is concluded that, our findings did not support a relationship between pre-miR-3131 ins/del polymorphism and the risk of BC. While, this variant was significantly related to late onset BC. Combined results of this study with previous studies indicated that this polymorphism increased the risk of cancer. More studies in a study with larger population with variety of ethnicities are required to verify our findings.

A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population

2020 ◽  
Author(s):  
Zeinab TAVAKKOL AFSHARI ◽  
Zahra GHOLIZADEH ◽  
Amin Reza NIKPOOR ◽  
Jalil TAVAKKOL AFSHARI ◽  
Rashin GANJALI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Iranian Population ◽  
Control Group ◽  
Case Group ◽  
Medical Sciences ◽  
Control Groups ◽  
And Control ◽  
Control Study

Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population. Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer. Results: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group. Conclusion: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population.  

scholarly journals Correlation of FGFR2 rs2981582 polymorphisms with susceptibility to breast cancer: a case-control study in a Chinese population

2019 ◽  
Vol 47 (10) ◽  
pp. 4753-4763
Author(s):  
Jin Shu ◽  
Xuelian Hui ◽  
Xin Zheng ◽  
Juan Zhao ◽  
Zhaochen Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Estrogen Receptor Status ◽  
Meta Analysis ◽  
Case Control ◽  
Plasma Dna ◽  
Study Results ◽  
Significant Difference ◽  
The Relationship ◽  
Control Study

Objective Breast cancer (BC) is a common malignancy among women worldwide. Fibroblast growth factor receptor 2 (FGFR2) rs2981582 is reported to play a vital role in BC development. However, the relationship between them remains unclear. Methods Ninety-five patients and 140 healthy controls were enrolled in the study. Plasma DNA was genotyped by the MassARRAY method. A meta-analysis was conducted to clarify the effect of FGFR2 polymorphism on BC risk. Results Our case-control study results revealed a significant difference in CC, TC, and TT genotypes between patients and controls. Logistic regression analysis showed that TT and TC genotype and the dominant mode were significantly correlated with BC development [odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.050–2.27; OR = 1.81, 95% CI: 1.24–2.73; OR = 2.15, 95% CI: 1.25–5.31, respectively], even after adjusting for age, body weight, drinking, smoking, and estrogen receptor status. A meta-analysis of 15 studies showed significant differences among the dominant, recessive, heterozygote, and homozygote models between patients and controls. Conclusions Our results showed an association of FGFR2 rs2981582 polymorphism with BC in an Asian population. However, a more comprehensive study of the relationship between the polymorphism and BC is still needed.

scholarly journals Dietary patterns, nutrition, and risk of breast cancer: a case-control study in the west of Iran

2019 ◽  
Vol 41 ◽  
pp. e2019003 ◽  
Author(s):  
Behjat Marzbani ◽  
Javad Nazari ◽  
Farid Najafi ◽  
Behnaz Marzbani ◽  
Sara Shahabadi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Dietary Patterns ◽  
Case Control Study ◽  
Control Group ◽  
The West ◽  
Healthy Diets ◽  
Fried Foods ◽  
The Relationship ◽  
Control Study

OBJECTIVES: Unhealthy dietary patterns are the most important changeable risk factors for breast cancer. The aim of this study was to assess the relationship between dietary patterns and the risk of breast cancer among under-50 year women in the west of Iran.METHODS: All women under 50 years old with pathologically confirmed breast cancer between 2013 and 2015 who were referred to oncology clinics in the west of Iran, and 408 under-50 women referred to other outpatient clinics who were without breast or other cancers at the time of the study and 2 years later were selected as the control group. The data were collected using the middle-aged periodical care form of the Iranian Ministry of Health and analyzed using univariate and multivariate logistic regression in Stata.RESULTS: The most powerful risk factor for breast cancer was fried foods; the odds ratio of consuming fried foods more than once a month for breast cancer was 4.5 (95% confidence interval, 2.1 to 9.4). A dose-response model indicated that increasing vegetable and fruit consumption up to 90 servings per month decreased the odds of breast cancer, but consuming more than 90 servings per month increased the risk.CONCLUSIONS: Inadequate consumption of vegetables and consumption of soft drinks, industrially produced juices, fried foods, and sweets were identified as risk factors for breast cancer. In response to these findings, it is necessary to raise awareness and to provide education about healthy diets and the need to change unhealthy dietary patterns.

Association of caspase 8 promoter variants and haplotypes with the risk of breast cancer and its molecular profile in an Iranian population: A case‐control study

2019 ◽  
Vol 120 (10) ◽  
pp. 16435-16444 ◽  
Author(s):  
Matineh Barati Bagherabad ◽  
Fahimeh Afzaljavan ◽  
Elham Vahednia ◽  
Mahdi Rivandi ◽  
Fatemeh Vakili ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Iranian Population ◽  
Molecular Profile ◽  
Caspase 8 ◽  
Control Study

scholarly journals The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158984 ◽  
Author(s):  
Leila Dorling ◽  
Siddhartha Kar ◽  
Kyriaki Michailidou ◽  
Louise Hiller ◽  
Anne-Laure Vallier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Markers ◽  
Case Control Study ◽  
Case Control ◽  
The Relationship ◽  
Control Study

scholarly journals Dietary-Related Preventative Factors for Breast Cancer: A Case-Control Study from the Mecca Region

2021 ◽  
Author(s):  
Deena M. Hasanain ◽  
Alaa H. Qadhi ◽  
Khloud J. Ghafouri ◽  
Wedad F. Azhar ◽  
Mazen M. Ghaith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dairy Products ◽  
Fruits And Vegetables ◽  
Case Control Study ◽  
Dietary Habits ◽  
Cultural Beliefs ◽  
Black Tea ◽  
Case Control ◽  
The Relationship ◽  
Control Study

Abstract Background: Breast cancer is one of the leading causes of death worldwide, it affects both males and females. In Saudi Arabia, breast cancer has been the most prevalent type of cancer for the past few years in females. Dietary habits and cultural beliefs vary according to region, and further studies are required to demonstrate the relationship between these dietary habits and cultural beliefs and the risk of developing breast cancer. This study aims to discover the relationship between preventative dietary factors and rates of breast cancer among postmenopausal females in the Mecca region. Methods: A case-control study was conducted at King Abdulla Medical City hospital in Mecca and included 432 Saudi female participants: 218 in a control group and 214 breast cancer patients. All participants were postmenopausal, around the same age, and all were ethnically Arab Saudis. Data was obtained using a self-administered validated questionnaire. Results: Study results showed that a diet including 1-2 servings of legumes weekly, 1-5 servings of fish weekly, 1-5 servings of dairy products daily, 3-5 servings of fruits and vegetables daily, and more than one cup of black tea and coffee per day significantly (p<0.05) reduced the risk of breast cancer.Conclusion: This study supports the effect of a healthy diet incorporating dairy products, legumes, fish, fruits and vegetables, black tea, and coffee as a preventative factor against breast cancer in females from the Mecca region.

Sign in / Sign up

Export Citation Format

Share Document