Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis

Purpose.Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed.Methods.12 prepubertal and 7 early pubertal boys with active VKC and 6 male patients with VKC in remission phase at late pubertal age and 48 healthy age and sex-matched subjects were included. Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated.Results.Serum levels of Estrone were significantly increased in all groups of patients with VKC when compared to healthy controls (P<0.001). Prepubertal and early pubertal VKC showed a significant decrease in DHT (P=0.007andP=0.028, resp.) and SHBG (P=0.01andP=0.002, resp.) when compared to controls and serum levels of SHBG were increased in late pubertal VKC in remission phase (P=0.007).Conclusions and Relevance.VKC patients have different circulating sex hormone levels in different phases of the disease and when compared to nonallergic subjects. These findings suggest a role played by sex hormones in the pathogenesis and/or activity of VKC.

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How COVID-19 Infection can Alter the Sex Hormones in Hospitalized Patients? A Longitudinal Study in Iran

10.21203/rs.3.rs-1035005/v1 ◽

2021 ◽

Author(s):

Poorandokht Afshari ◽

Mehrnoosh Zakerkish ◽

Parvin Abedi ◽

Maryam Beheshtinasab ◽

Elham Maraghi ◽

...

Keyword(s):

Sex Hormones ◽

Severe Disease ◽

Free Testosterone ◽

Serum Levels ◽

Total Testosterone ◽

Demographic Questionnaire ◽

Moderate Disease ◽

Male Patients ◽

Primary Assessment

Abstract Background: There is some evidence about alteration of sex hormones in patients with COVID-19 infection. This study aimed to evaluate the levels of sex hormones in female and male patients with COVID-19 during hospitalization and one month after discharge. Methods: The levels of sex hormones including estradiol, progesterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone, and free testosterone were measured in 162 female and male patients with COVID-19 infection during hospitalization and one month after discharge. A demographic questionnaire and a checklist were used to collect the data. The ANCOVA test was used to compare the level of hormones in patients with severe and moderate disease. Results: In the primary assessment, 162 patients were assessed for serum levels of sex hormones, while a month after discharge, only 69 patients provided consent for assessment, and nine had passed away. During hospitalization, female patients with severe disease had an elevated level of estradiol (407.70±623.37 pg/mL) in comparison to those with a moderate disease (213.78±407.17 pg/mL). The levels of progesterone and LH were high during hospitalization, but there was a decrease in these levels after discharge. The reduction in the level of FSH in patients with severe disease was greater than in patients with moderate disease, which increased after discharge. While the level of testosterone decreased during hospitalization, the alteration of free testosterone was negligible in male patients.Conclusion: In this study, we observed alteration in sex hormones (increased level of estrogen, progesterone, LH and reduction in the level of FSH and total testosterone) in female and male patients, with the alteration being greater in the latter. Due to the attrition of patients in follow-up period, more studies are needed to confirm these results.

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Abstract TP323: Does Serum Level Of Sex Hormones Before Rehabilitation Predict Functional Recovery In Elderly Post-stroke Patients?

Stroke ◽

10.1161/str.44.suppl_1.atp323 ◽

2013 ◽

Vol 44 (suppl_1) ◽

Author(s):

Ryo Momosaki ◽

Masahiro Abo ◽

Wataru Kakuda

Keyword(s):

Serum Level ◽

Sex Hormones ◽

Functional Recovery ◽

Testosterone Level ◽

Free Testosterone ◽

Serum Levels ◽

Stroke Patients ◽

Post Stroke ◽

Male Patients ◽

Free Testosterone Level

Background: Sex hormone is recognized as a critical factor affecting physical function in the elderly. However, the influence of these hormones on functional recovery after stroke has not been studied in elderly patients. The objective of the study was to examine whether serum level of sex hormones before rehabilitation can predict clinical outcome in elderly post-stroke patients. Subjects and Methods: Seventy-on post-stroke hemiparetic patients who were hospitalized to our rehabilitation ward in their subacute-chronic phase, were subjected (age: 78 ± 6 years, period between onset and admission: 47 ± 31 days). On their admission, serum levels of dehydroepiandrosterone sulfate (DHEA-S) and free testosterone (only in male patients) were measured after an overnight fast. As functional measures, NIHSS and functional Independence Measure (FIM) were evaluated at their admission and discharge. We assessed the correlation between changes in serum levels of measured hormones and functional changes during hospitalization. Results: Neither DHEA-S nor free testosterone levels at admission correlated with the severity of stroke at admission. In male patients, significant positive correlation was found between free testosterone level at admission and FIM at discharge (r=0.31, p<0.05), although there was not significant correlation between DHEA-S level at admission and FIM change. Furthermore, the results of multivariate analysis showed that free testosterone level at admission significantly predicted the rate of FIM change during hospitalization in male patients. Conclusions: Serum level of free testosterone at the admission to rehabilitation ward can be a predictor of functional recovery in elderly male patients after stroke.

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The Role of Free Testosterone Comparative with Total Testosterone in Male Patients with Erectile Dysfunction

Medical Connections ◽

10.33311/medcon.2012.24.4.7 ◽

2012 ◽

Vol 24 (4/2012) ◽

Keyword(s):

Erectile Dysfunction ◽

Free Testosterone ◽

Total Testosterone ◽

Male Patients

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Male sex hormones response after a month-long Himalayas trek in relation to hemoglobin oxygen saturation

Kinesiology ◽

10.26582/k.50.2.18 ◽

2018 ◽

Vol 50 (2) ◽

pp. 157-164

Author(s):

Lana Ružić ◽

Maja Cigrovski Berković ◽

Hrvoje Starčević ◽

Dražen Lovrić ◽

Branka R. Matković

Keyword(s):

Sex Hormones ◽

Physical Exertion ◽

Free Testosterone ◽

Dehydroepiandrosterone Sulfate ◽

Sex Hormone Binding Globulin ◽

Total Testosterone ◽

Hemoglobin Oxygen Saturation ◽

Subsequent Decrease ◽

Male Sex ◽

Potential Impact

High-altitude tourism is becoming increasingly popular among non-athletic population, but its potential impact on health is often neglected. This study investigated the changes in male sex hormones after the trek at altitudes between 1400 m and 6476 m. Seventeen recreational lowland men (age 48±11 years) participated in a 26-day Himalayan trek, with the highest point reached being Mera Peak. The initial measurements were performed 10 days before departure and included blood tests (total testosterone, sex hormone-binding globulin – SHBG, dehydroepiandrosterone sulfate – DHEA-S, follicle stimulating hormone – FSH, and luteinizing hormone – LH) and ergometry on a treadmill. The final measurements were done 24 h after the return to 122 m (four days after reaching the altitude of 4300 m, and eight days after the altitude of 6476 m). During the tour, SpO2 and heart rate were measured 21 times. An increase in SHBG (42.6±10.6 to 50.7±12.0 nmol·L-1; p=.011), and subsequent decrease in calculated free testosterone (1.8±0.3 to 1.6±0.3%; p=.003) were observed. There was a significant correlation between the relative testosterone decrease and SHBG with mean SpO2 (Spearman R=-0.64 and 0.41, respectively). LH and FSH increased significantly (FSH Median/ IQR before=3.9/3.1-5.4 and after 4.6/4.0-7.1 IU·L-1; p=.001 and LH Median/IQR before=4.8/3.1-5.2 and after 5.9/4.9-9.3 IU·L-1; p=.008). The changes in LH and FSH did not correlate with SpO2, whereas the physical fitness levels (expressed in MET) did. The pituitary-adrenal-gonadal axis was affected by the altitude trek (involving physical exertion and hypoxia in combination), but the origin, duration and impact of changes in various aspects of men’s health should be further investigated.

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Prevalence of and Risk Factors for Low Free Testosterone Levels in Japanese Men with Well-controlled Human Immunodeficiency Virus Infection

Current HIV Research ◽

10.2174/1570162x18666200720000344 ◽

2020 ◽

Vol 18 (5) ◽

pp. 381-386

Author(s):

Yusuke Yoshino ◽

Ichiro Koga ◽

Yoshitaka Wakabayashi ◽

Takatoshi Kitazawa ◽

Yasuo Ota

Keyword(s):

Risk Factors ◽

Human Immunodeficiency Virus ◽

Standard Deviation ◽

Hiv Infection ◽

Free Testosterone ◽

Serum Levels ◽

University Hospital ◽

Rapid Decline ◽

Total Testosterone ◽

Immunodeficiency Virus

Background: The change in the prevalence of hypogonadism with age in men with human immunodeficiency virus (HIV) infection is subject to debate. Objective: To address this issue, we diagnosed hypogonadism based on serum levels of free testosterone (fTST) rather than total testosterone which is thought to be an inaccurate indicator. We also determined the relationship between age and fTST levels and identified risk factors for hypogonadism in men with HIV infection. Method: We retrospectively reviewed fTST levels and associated clinical factors in 71 wellcontrolled HIV-infected men who were treated at Teikyo University Hospital between April 2015 and March 2016 and who had data available on serum fTST levels, measured >6 months after starting antiretroviral therapy. fTST was measured using radioimmunoassay on blood samples collected in the morning. Risk factors for hypogonadism were identified using Welch’s t-test and multiple regression analysis. Results: The men had a mean (± standard deviation) age of 47.4 ± 13.6 years, and mean (± standard deviation) serum fTST level of 13.0 ± 6.1 pg/mL. Fifteen (21.1%) men had hypogonadism based on a fTST <8.5 pg/mL. Serum fTST levels significantly decreased with age (−0.216 pg/mL/year). Older age and low hemoglobin levels were identified as risk factors for hypogonadism. Conclusion: The men in the study experienced a more rapid decline in fTST levels with age than men in the general population (−0.161 pg/mL/year). Serum fTST levels in men with HIV infection should be monitored, especially in older men and those with low hemoglobin levels.

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Serum YKL-40 Levels in Patients with Gastric Cancer

Biomarkers in Cancer ◽

10.4137/bic.s7154 ◽

2011 ◽

Vol 3 ◽

pp. BIC.S7154 ◽

Cited By ~ 7

Author(s):

Veyis Itik ◽

Ozgur Kemik ◽

Ahu Kemik ◽

A. Cumhur Dulger ◽

Aziz Sümer ◽

...

Keyword(s):

Gastric Cancer ◽

Serum Levels ◽

Enzyme Linked Immunosorbent Assay ◽

Colorectal Cancers ◽

Healthy Population ◽

Serum Samples ◽

Future Studies ◽

Male Patients

Aims and background YKL-40 is secreted by several types of tumors. Increased serum YKL-40 levels have been reported in prostate, glioblastoma, breast and colorectal cancers. Determination of YKL-40 levels may serve as a valuable biomarker for the diagnosis and treatment of gastric cancer. The purpose of this study was to determine the serum YKL-40 levels expressed in gastric carcinomas. Methods Between 2009 and 2011, we retrospectively reviewed 100 patients with gastric cancer and compared their serum samples to 75 healthy volunteers. YKL-40 levels were determined by an enzyme-linked immunosorbent assay (ELISA). Results We found significantly higher serum levels of YKL-40 in patients with gastric cancer compared to the healthy population ( P < 0.0001). We also found significant differences in serum YKL-40 levels between female and male patients with gastric cancer ( P < 0.01). Conclusions YKL-40 is over-expressed in gastric cancer, suggesting a more aggressive phenotype. YKL-40 may be a useful serum biomarker for gastric cancer identification, and future studies should focus on the role of YKL-40 in the tumorigenesis of gastric cancer and responsiveness toward treatment.

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Evaluation of the Relationship between the Level of DHEA-S and Sex Hormones in Some Infertile Iraqi Men

International Journal for Research in Applied Sciences and Biotechnology ◽

10.31033/ijrasb.8.5.18 ◽

2021 ◽

Vol 8 (5) ◽

pp. 130-136

Author(s):

Khaled S. Abd ◽

Adnan F. AL-Azzawie

Keyword(s):

Sex Hormones ◽

Seminal Fluid ◽

Age Groups ◽

Serum Levels ◽

Dehydroepiandrosterone Sulfate ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Infertile Men ◽

The Relationship

This study aims to evaluate serum levels of the Dehydroepiandrosterone sulfate (DHEA-S) and its relationship with some sex hormones such as Follicle stimulating hormone (FSH), Luteinizing hormone (LH), prolactin and testosterone hormone and the infertility type in some infertile Iraqi men. Blood and seminal fluid samples from (60) idiopathic male infertile and (60) healthful individuals as a control group aged (18 to 60 year) were collected from private clinics. Serum hormones (DHEA-S, FSH, LH, prolactin and testosterone) were measurement using Enzyme Linked Immunosorbent Assay (ELISA). The levels of DHEA-S, FSH, LH and prolactin are significantly higher (P≤0.01) expect of the testosterone level was significantly decreased (P≤ 0.01) in the infertile men as compared with control group. High significant differences (P≤0.01) were recorded when comparing the hormonal levels (DHEA-S, FSH, LH, prolactin and testosterone) according to the age groups. There are significant differences (P≤ 0.01) in levels of (DHEA-S, FSH, LH, prolactin and testosterone) in the infertility period. Smoker infertile men have high levels (P≤ 0.05) in the DHEA-S and LH while have low levels in the prolactin hormones compared with control. Patients with family history have shown significant differences (P≤0.05) in the levels of DHEA-S, FSH, LH and prolactin. In conclusion, this study revealed significantly increase in the DHEA-S levels in the infertile men and negative correlation between DHEA-S and FSH. Therefore, DHEA-S has important role in the diagnosis and follow up of the male infertility.

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Clinical Impact of Estradiol/Testosterone Ratio in Patients with Acute Ischemic Stroke

10.21203/rs.3.rs-33503/v3 ◽

2020 ◽

Author(s):

Jung-Won Choi ◽

In Woo Ryoo ◽

Jun Yeong Hong ◽

Kyung-Yul Lee ◽

Hyo Suk Nam ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Sex Hormones ◽

Control Group ◽

Control Groups ◽

Sexual Hormones ◽

Stroke Group ◽

Male Patients ◽

And Control

Abstract Background: Sex hormones may be associated with a higher incidence of ischemic stroke or stroke-related events. In observational studies, lower testosterone concentrations are associated with infirmity, vascular disease, and adverse cardiovascular risk factors. Currently, female sexual hormones are considered neuroprotective agents. The purpose of this study was to assess the role of sex hormones and the ratio of estradiol/testosterone (E/T) in patients with acute ischemic stroke (AIS).Methods: Between January 2011 and December 2016, 146 male patients with AIS and 152 age- and sex-matched control subjects were included in this study. Sex hormones, including estradiol, progesterone, and testosterone, were evaluated in the AIS patient and control groups. We analyzed the clinical and physiological levels of sex hormones and hormone ratios in these patients.Results: The E/T ratio was significantly elevated among patients in the stroke group compared to those in the control group (P = 0.001). Categorization of data into tertiles revealed that patients with the highest E/T ratio were more likely to have AIS [odds ratio (OR) 3.084; 95% Confidence interval (CI): 1.616-5.886; P < 0.001) compared with those in the first tertile. The E/T ratio was also an independent unfavorable outcome predictor with an adjusted OR of 1.167 (95% CI: 1.053-1.294; P = 0.003).Conclusions: These findings support the hypothesis that increased estradiol and reduced testosterone levels are associated with AIS in men.

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