Early Vascular Damage in Young Women with DM-1 and Its Relation to Anti-Müllerian Hormone: A Cross-Sectional Study

Vascular function is suggested to be associated with ovarian reserve, but the relationship with microvascular function has never been studied. In this cross-sectional pilot study, the relationship of microvascular damage markers with AMH was studied in premenopausal women. Twenty-two regularly cycling women with type 1 diabetes (DM-1) and a reference group of 20 healthy regularly cycling women were included, from whom blood was drawn in the early follicular phase of the menstrual cycle. The main outcome was the correlation between circulating progenitor cells (CPCs), markers for early vascular damage, and AMH, a marker for ovarian reserve. Secondary endpoints for early vascular impairment were circulating angiogenic cells and additional biomarkers. Median AMH levels were 2.2 µg/L [1.2–3.5] in the DM-1 group and 2.1 µg/L [0.85–3.8] in the reference group. CPCs were significantly decreased in women with DM-1;1204±537CD34+/CD45dim cells were counted in the DM-1 group, compared to2264±1124in the reference group. CPCs and other markers of early vascular damage were not correlated with AMH levels in a multivariable analysis. These results underscore previous findings of early vascular damage in DM-1 and suggest that there may not be a relationship between vascular function and ovarian reserve.Trial Registration. This trial is registered with Clinicaltrials.govNCT01665716.

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Assessment of FMO3 SNPs in Relation to TMAO in Generally Healthy United States Adults

Current Developments in Nutrition ◽

10.1093/cdn/nzab050_007 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 940-940

Author(s):

Kristen James ◽

Erik Gertz ◽

Catherine Kirschke ◽

Liping Huang ◽

Charles Stephensen ◽

...

Keyword(s):

Postmenopausal Women ◽

Cystatin C ◽

A Priori ◽

Menopausal Status ◽

Premenopausal Women ◽

Cross Sectional Study ◽

Full Cohort ◽

Cross Sectional ◽

Relationship Of ◽

The Relationship

Abstract Objectives The hepatic enzyme flavin monooxygenase 3 (FMO3) oxidizes many metabolites including trimethylamine to the atherogenic molecule trimethylamine n-oxide (TMAO). Variants in the open reading frame of the FMO3 gene alter the enzyme's activity; therefore, we genotyped two a priori missense FMO3 SNPs in a cohort of unmedicated healthy adults. We hypothesized that the SNPs might affect the activity of the encoded enzyme leading to reductions in circulating TMAO. FMO3 expression is upregulated by estrogen, thus we also assessed the relationship of the SNPs and TMAO in pre- and postmenopausal women. Methods DNA was extracted from whole blood from 349 subjects (182 women) who were enrolled in a cross-sectional study at the USDA/ARS WHNRC. SNPs rs2266782 (G > A, p.Glu158Lys) and rs2266780 (A > G, p.Glu308Gly) were genotyped using TaqMan SNP genotyping kits and PCR. TMAO was purified from fasted plasma and quantified using high resolution LC-MS. Regression models were built to assess the relationship of the SNPs to TMAO in the full cohort and by self-reported menopausal status in women. Models assessing the full cohort were adjusted for plasma cystatin C and a sex*age interaction, whereas the menopausal analysis was adjusted for cystatin C. Results The cohort's minor allele frequencies were 36.5% and 17.5% for SNPs rs2266782 and rs2266780, respectively, which were consistent with the genome aggregation exome reports. For both SNPs, median TMAO concentrations increased in individuals carrying the risk alleles, however the differences by genotypes were not significant. In women, the AA genotype at rs2266780 was associated with reduced TMAO levels in pre-, but not postmenopausal women (P = 0.01). This effect was not identified in females with AG or GG genotypes, regardless of their menopausal state. Conclusions Effects of the evaluated FMO3 SNPs on TMAO levels were not identified in the full cohort. However, the SNP rs2266780 was associated with reduced TMAO in premenopausal women with the AA genotype but not women with the AG or GG genotypes, nor those who were postmenopausal. This finding reinforces previous observations that risks for cardiovascular diseases increase after menopause in women. Funding Sources The Beef Checkoff, R01HL128572; USDA-ARS 2032–53,000–001–00-D, 2032–51,530–022–00-D, and 2032–51,000-004–00D; NCATS NIH UL1 TR001860.

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Plasma n-3 fatty acids and psychological distress in aboriginal Cree Indians (Canada)

Public Health Nutrition ◽

10.1017/s1368980009004935 ◽

2009 ◽

Vol 12 (12) ◽

pp. 2343-2351 ◽

Cited By ~ 6

Author(s):

Michel Lucas ◽

Éric Dewailly ◽

Carole Blanchet ◽

Suzanne Gingras ◽

Bruce J Holub

Keyword(s):

Fatty Acids ◽

Psychological Distress ◽

Reference Group ◽

Docosapentaenoic Acid ◽

Population Based ◽

Cross Sectional Study ◽

Cross Sectional ◽

James Bay Cree ◽

High Level ◽

The Relationship

AbstractObjectiveTo examine the relationship between psychological distress (PD) and plasma n-3 long-chain (LC) PUFA, i.e. EPA, docosapentaenoic acid (DPAn-3) and DHA.DesignPopulation-based, cross-sectional Santé-Québec Health Survey (1991). Participants were categorized as high-level PD if they scored over the 80th percentile of the PD Index in the Santé-Québec Survey; non-distressed subjects were those who scored less than this cut-off. Associations between tertiles of n-3 fatty acids (FA) and the risk of high-level PD were expressed as odds ratios, with the lowest tertile as the reference group.SettingQuébec, Canada.SubjectsData were analysed from a representative sample of 852 James Bay Cree Indian adults aged 18 years and over.ResultsProportions of n-3 FA were statistically significantly lower in the PD than in the non-distressed group. After adjustment for confounders, EPA was the only individual n-3 FA significantly associated with the risk of high-level PD. Combinations of EPA + DHA or EPA + DPAn-3 + DHA or the sum of n-3 were also associated with the risk of high-level PD. Compared with the lowest tertile of EPA + DHA, the OR for high-level PD was 0·89 (95 % CI 0·59, 1·36) for the second and 0·56 (95 % CI 0·32, 0·98) for the third tertile, after controlling for confounders.ConclusionsIn the present retrospective, cross-sectional study, we found that proportions of n-3 LC PUFA in plasma phospholipids, markers of n-3 LC PUFA consumption from fish, were inversely associated with PD.

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Stunting dan perkembangan anak usia 12-60 bulan di Kalasan

Berita Kedokteran Masyarakat ◽

10.22146/bkm.26550 ◽

2017 ◽

Vol 33 (11) ◽

pp. 559 ◽

Cited By ~ 1

Author(s):

Hardiana Probosiwi ◽

Emy Huriyati ◽

Djauhar Ismail

Keyword(s):

Child Development ◽

Energy Intake ◽

Maternal Education ◽

Multivariable Analysis ◽

Cross Sectional Study ◽

Chi Square ◽

Cross Sectional ◽

Significance Level ◽

Chi Square Test ◽

The Relationship

PurposeThis study determine the relationship between stunting incidence with development in children aged 12-60 months.MethodsThe type of research used was observational with cross sectional study design. This research will be conducted in the working area of Puskesmas Kalasan Sleman regency Yogyakarta with subject children aged 12 to 60 months as many as 106 children. Data analysis with univariable, bivariable with chi-square test with significance level of p <0,05 and CI 95% and multivariable by using statistical test of logistic regression.ResultsBivariable analysis between stunting status and child development showed significant relationship (p <0,05) and OR 3,9 (95% CI; 1,8-8,9). The result of the multivariable analysis is the relationship between stunting status and the development of children aged 12-60 months who consider the energy intake.ConclusionsThere is a relationship between stunting and the development of children aged 12-60 months but between maternal education, infectious diseases, parenting, energy intake, long-term birth, and parental income, energy intake most closely related to child development when jointly considered.

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Conflict of interest disclosure slides at the European Society of Cardiology Congress 2016 in Rome: are they displayed long enough to assess their content? A cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2018-023534 ◽

2018 ◽

Vol 8 (11) ◽

pp. e023534 ◽

Cited By ~ 2

Author(s):

Christianne T van Lieshout ◽

Joeri K Tijdink ◽

Yvo M Smulders

Keyword(s):

Conflict Of Interest ◽

European Society ◽

Western Europe ◽

Reference Group ◽

Multivariable Analysis ◽

Cross Sectional Study ◽

Display Duration ◽

Cross Sectional ◽

European Society Of Cardiology ◽

Oral Presentations

ObjectivesTo assess the duration of display of conflict of interest (COI) disclosure slides of presentations at the European Society of Cardiology (ESC) Congress 2016, and to identify factors associated with the duration of display of the disclosure slide.DesignCross-sectional observational study.Outcome measuresDisplay duration of the COI disclosure slide and display duration per disclosure.ResultsAnalysis of official video recordings of all oral presentations, viewed on the ESC website. 1673 oral presentations were analysed. In 706 presentations (42.2%), COIs were present on the disclosure slide. The median display duration of the disclosure slide was 2.49 s (minimum value: 0.16 s; IQR 1.47–4.08). In multivariable analysis, time spent on COI disclosures was positively related to the number of COIs (+0.11 s per extra COI), older estimated age of the speaker (+3.92 s for 75–85 years compared with <25 years), verbally commenting on disclosures (up to +8.25 s) and disclosures being of a non-commercial nature (+2.83 s). In addition, speakers from Eastern, Southern and Western Europe, Africa+East Asia and Asia showed their disclosures significantly shorter than the reference group (Northern Europe).ConclusionCOI disclosure slides are often displayed too briefly to reasonably assess their content. Several factors appear to influence the duration of display of the COI disclosure slides, but none do so to the degree that the display duration becomes sufficiently long.

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Serum Testosterone Levels Are Positively Associated With Serum Anti-mullerian Hormone Levels in Infertile Women

10.21203/rs.3.rs-187757/v1 ◽

2021 ◽

Author(s):

Li-Te Lin ◽

Chia-Jung Li ◽

Kuan-Hao Tsui

Keyword(s):

Ovarian Reserve ◽

Binary Logistic Regression ◽

Serum Testosterone ◽

Cross Sectional Study ◽

Regression Analyses ◽

Sectional Study ◽

Androgen Excess ◽

Cross Sectional ◽

Infertile Women ◽

The Relationship

Abstract Anti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, the relationship between serum T and AMH levels is poorly understood. This study aimed to investigate the association between serum T and AMH levels in infertile women. A total of 1,935 infertile women aged 20 to 46 years were included in the cross-sectional study and divided into four quartile groups (Q1 to Q4) based on serum T levels. Compared to the subjects in the highest T quartile (Q4), those in the lowest T quartile (Q1) showed significantly lower AMH levels. After adjustment for age, body weight, body mass index and FSH, increasing T quartile categories were associated with higher AMH levels. Binary logistic regression analyses revealed that the odds for the risk of diminished ovarian reserve (DOR) were 11.44-fold higher in Q1 than in Q4 and the odds for the risk of excess ovarian reserve (EOR) were 10.41-fold higher in Q4 than in Q1. Our data show that serum T levels are positively associated with serum AMH levels and suggest that androgen insufficiency may be a potential risk factor for DOR; androgen excess may lead to EOR in infertile women.

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Pola asuh ibu dan peran teman sebaya pada perilaku pacaran remaja

Berita Kedokteran Masyarakat ◽

10.22146/bkm.11627 ◽

2017 ◽

Vol 33 (4) ◽

pp. 161

Author(s):

Novi Berliana ◽

Sumarni Sumarni ◽

Idei Khurnia Swasti

Keyword(s):

Courtship Behavior ◽

Multivariable Analysis ◽

Cross Sectional Study ◽

Chi Square ◽

Cross Sectional ◽

Male Adolescents ◽

Bivariable Analysis ◽

Relationship Of ◽

The Relationship

Maternal pattern and the role of peers in high school youth dating behavior in JambiPurposeThe purpose of this paper was to determine the relationship between parental parenting and the role of peers with youth dating behavior in Jambi. MethodA cross-sectional study was conducted involving 281 students of SMAN 4 and SMAN 11 in Jambi who were or have been dating. Data were analyzed using univariate, bivariate with chi square tests, and multivariate with logistic regression tests.Results281 respondents, 113 (72.44%) of the majority of male adolescents behaved in risky courtship. Bivariable analysis found that there was a significant correlation between the role of peers and teenage dating behavior, while the relationship of mother pattern with teenage dating behavior was found to be insignificant. Multivariable analysis, obtained the result that the role of peers is the dominant variable associated with youth dating behavior with OR 2.74 times (95%, CI = 1.61-4.67). ConclusionThis study contributes to the knowledge that a poor peer role for adolescents has a risk to behave in risky dating and mother's parenting does not have a meaningful relationship with youth courtship behavior.

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Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women

Scientific Reports ◽

10.1038/s41598-021-85915-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Li-Te Lin ◽

Chia-Jung Li ◽

Kuan-Hao Tsui

Keyword(s):

Ovarian Reserve ◽

Binary Logistic Regression ◽

Serum Testosterone ◽

Cross Sectional Study ◽

Regression Analyses ◽

Sectional Study ◽

Androgen Excess ◽

Cross Sectional ◽

Infertile Women ◽

The Relationship

AbstractAnti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, the relationship between serum T and AMH levels is poorly understood. This study aimed to investigate the association between serum T and AMH levels in infertile women. A total of 1935 infertile women aged 20–46 years were included in the cross-sectional study and divided into four quartile groups (Q1 to Q4) based on serum T levels. Compared to the subjects in the highest T quartile (Q4), those in the lowest T quartile (Q1) showed significantly lower AMH levels. After adjustment for age, body weight, body mass index and FSH, increasing T quartile categories were associated with higher AMH levels. Binary logistic regression analyses revealed that the odds for the risk of diminished ovarian reserve (DOR) were 11.44-fold higher in Q1 than in Q4 and the odds for the risk of excess ovarian reserve (EOR) were 10.41-fold higher in Q4 than in Q1. Our data show that serum T levels are positively associated with serum AMH levels and suggest that androgen insufficiency may be a potential risk factor for DOR; androgen excess may lead to EOR in infertile women.

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Coping Style as a Mediator of the Relationship Between Depressive Symptoms and Deliberate Self-Harm

Crisis ◽

10.1027/0227-5910/a000083 ◽

2011 ◽

Vol 32 (5) ◽

pp. 272-279 ◽

Cited By ~ 9

Author(s):

Allison S. Christian ◽

Kristen M. McCabe

Keyword(s):

Depressive Symptoms ◽

Undergraduate Students ◽

Cross Sectional Study ◽

Self Report ◽

Hierarchical Regression ◽

Cross Sectional ◽

Deliberate Self Harm ◽

Self Blame ◽

Self Harm ◽

The Relationship

Background: Deliberate self-harm (DSH) occurs with high frequency among clinical and nonclinical youth populations. Although depression has been consistently linked with the behavior, not all depressed individuals engage in DSH. Aims: The current study examined maladaptive coping strategies (i.e., self-blame, distancing, and self-isolation) as mediators between depression and DSH among undergraduate students. Methods: 202 students from undergraduate psychology courses at a private university in Southern California (77.7% women) completed anonymous self-report measures. Results: A hierarchical regression model found no differences in DSH history across demographic variables. Among coping variables, self-isolation alone was significantly related to DSH. A full meditational model was supported: Depressive symptoms were significantly related to DSH, but adding self-isolation to the model rendered the relationship nonsignificant. Limitations: The cross-sectional study design prevents determination of whether a casual relation exists between self-isolation and DSH, and obscures the direction of that relationship. Conclusions: Results suggest targeting self-isolation as a means of DSH prevention and intervention among nonclinical, youth populations.

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IDENTIFIKASI SERTA HUBUNGAN KONSTRUKSI SUMUR GALI TERHADAP KANDUNGAN COLIFORM PADA AIR SUMUR GALI DI DUSUN JIKEN KABUPATEN LOMBOK TIMUR

Bioscientist : Jurnal Ilmiah Biologi ◽

10.33394/bjib.v7i2.2371 ◽

2019 ◽

Vol 7 (2) ◽

pp. 115

Author(s):

Dini Yuliansari

Keyword(s):

Cross Sectional Study ◽

Coliform Bacteria ◽

Well Water ◽

Chi Square ◽

Cross Sectional ◽

Content Variable ◽

Chi Square Test ◽

Dug Wells ◽

Dug Well ◽

The Relationship

The well is one of the source water used for bathing, washing, and drinking by the citizens in Jiken Hamlet, Rarang Village, Terara Sub-District. Poor dug well construction conditions can affect the amount of coliform bacteria contained in the dug well water. The purpose of this study is to identify the construction of dug wells and the content of coliform bacteria in dug well water and determine the relationship between dug well construction and the content of coliform bacteria. This research is analytic with a cross sectional study design. The results were obtained from 11 samples of dug wells which were observed in construction and the coliform content was known that all samples did not requirements as good dug well construction. Coliform content test results showed that as many as 5 dug well water samples did not pass the clean water quality standards. The results of data analysis with the chi-square test variable construction of dug wells with coliform content variable showed 0,172 > 0,05, then the concluded is the dug well not suitable to use by people in that area as a source of water for daily needs.

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