scholarly journals Porcine Pancreatic Lipase Inhibitory Agent Isolated from Medicinal Herb and Inhibition Kinetics of Extracts from Eleusine indica (L.) Gaertner

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Siew Ling Ong ◽  
Siau Hui Mah ◽  
How Yee Lai
Keyword(s):  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
Hexane Fraction ◽  
Inhibition Mechanism ◽  
Porcine Pancreatic Lipase ◽  
Active Components ◽  
Reference Drug ◽  
Spectral Techniques ◽  
Eleusine Indica ◽  
Kinetics Of

Eleusine indica (Linnaeus) Gaertner is a traditional herb known to be depurative, febrifuge, and diuretic and has been reported with the highest inhibitory activity against porcine pancreatic lipase (PPL) among thirty two plants screened in an earlier study. This study aims to isolate and identify the active components that may possess high potential as an antiobesity agent. Of the screened solvent fractions of E. indica, hexane fraction showed the highest inhibitory activity of 27.01±5.68% at 100 μg/mL. Bioactivity-guided isolation afforded three compounds from the hexane fraction of E. indica, namely, β-sitosterol, stigmasterol, and lutein. The structures of these compounds were elucidated using spectral techniques. Lutein showed an outstanding inhibitory activity against PPL (55.98±1.04%), with activity 60% higher than that of the reference drug Orlistat. The other compounds isolated and identified were β-sitosterol (2.99±0.80%) and stigmasterol (2.68±0.38%). The enzyme kinetics of E. indica crude methanolic extract on PPL showed mixed inhibition mechanism.

scholarly journals A Pancreatic Lipase Inhibitory Activity by Mango (Mangifera indica) Leaf Methanolic Extract

2016 ◽  
Vol 5 (2) ◽  
pp. 72 ◽  
Author(s):  
Kimihisa Itoh ◽  
Kazuya Murata ◽  
Yuta Nakagaki ◽  
Ayaka Shimizu ◽  
Yusuke Takata ◽  
...  
Keyword(s):  
Natural Resource ◽  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
Leaf Extract ◽  
Methanolic Extract ◽  
Mangifera Indica ◽  
Porcine Pancreatic Lipase ◽  
Active Ingredients ◽  
Mango Leaves ◽  
Dark Green

<p>The objective of this study was to identify pancreatic lipase inhibitory active ingredients of mango leaves, and to examine a relationship between leaves maturation and pancreatic lipase inhibitory activity. A methanolic extract of old dark green mango leaves (OML-ext) showed a porcine pancreatic lipase inhibitory activity. The pancreatic lipase inhibitory activity of OML-ext was attributable to 3-C-<em>β</em>-D-glucosyl-2,4,4’,6-tetrahydroxybenzophenone (<strong>2</strong>) and mangiferin (<strong>1</strong>). The pancreatic lipase inhibitory activity of young mango leaf extract was superior to that of old leaf extract. It was suggested that the activity is correlated with the content of <strong>2</strong> in these extract. Considering the amounts of leaves obtained from pruning, old dark green leaves may be a reasonable natural resource for the preparation of ingredients with lipase inhibitory activity.</p>

scholarly journals Pancreatic Lipase Inhibitory Activity of Citrus unshiu Leaf Extract

2019 ◽  
Vol 14 (9) ◽  
pp. 1934578X1987343
Author(s):  
Kimihisa Itoh ◽  
Tetsuya Matsukawa ◽  
Kazuya Murata ◽  
Ryota Nishitani ◽  
Momona Yamagami ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Citrus Fruit ◽  
Late Winter ◽  
Citrus Unshiu ◽  
Porcine Pancreatic Lipase ◽  
Utility Value ◽  
Flower Buds

In the cultivation of Citrus fruit, pruning in late winter after harvest is important to obtain excellent flower buds in the next spring and a rich harvest of superior fruit in the following winter; a large number of pruned leaves are usually discarded. The purpose of this study was to determine the utility value of pruned leaves of Citrus unshiu. A methanol extract of pruned C. unshiu leaves showed a porcine pancreatic lipase inhibitory activity. Fractionation of C. unshiu leaf extract (CUL-ext) followed by bibliographic and chromatographic analyses revealed that a part of the pancreatic lipase inhibitory activity of CUL-ext was attributable to nobiletin (1), rutin (2), and hesperidin (3). Thus, pruned C. unshiu leaves may be a reasonable natural resource for the preparation of ingredients with lipase inhibitory activity.

scholarly journals α-Glucosidase and Pancreatic Lipase Inhibitory Activities of Diterpenes from Indian Mango Ginger (Curcuma amada Roxb.) and Its Derivatives

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4071 ◽  
Author(s):  
Yuri Yoshioka ◽  
Naori Yoshimura ◽  
Shinichi Matsumura ◽  
Hiroto Wada ◽  
Maya Hoshino ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
Parent Compound ◽  
Molecular Size ◽  
Porcine Pancreatic Lipase ◽  
Mango Ginger ◽  
Curcuma Amada ◽  
Structure Activity ◽  
Inhibitory Activities ◽  
Derivatives Of

Enzymatic inhibitions of crude extracts and their constituents from Zingiberaceae against both rat intestinal α-glucosidase and porcine pancreatic lipase were investigated. Structure–activity relationships using their derivatives were also investigated. The rhizomes extract of mango ginger, Curcuma amada showed remarkable inhibitory activity in the screening test. Two natural labdane diterpenes 1 and 2 and a drimane sesquiterpene 3 were major constituents isolated from this hexane extract. Among them, (E)-labda-8(17),12-diene-15,16-dial (1) was the most prominent compound and showed inhibitory activity against both α-glucosidase and lipase. Derivatives 4–10 from compound 1 were prepared and evaluated using inhibitory assays with these enzymes. The reduced derivative 4 maintained α-glucosidase inhibitory activity, but had decreased pancreatic lipase inhibitory activity compared with parent compound 1. Other tested derivatives of compound 1, including acetates 5–7 and oxidative derivatives 8–10, had very weak α-glucosidase inhibitory activity. Most of these compounds showed moderate pancreatic lipase inhibitory activity. However, only sesquiterpene albicanal (3) showed drastically decreased pancreatic lipase activity compared with 1. These findings suggested that molecular size was essential for enzymatic inhibitory activities of these compounds. These results demonstrated that mango ginger may be useful for the prevention of obesity and being overweight.

Modelling of impregnation of γ-alumina with cobalt and molybdenum salts. CoCl2-(NH4)2MoO4-γ-Al2O3 (aluminate type) system

1987 ◽  
Vol 52 (3) ◽  
pp. 663-671 ◽  
Author(s):  
Jiří Hanika ◽  
Vladimír Janoušek ◽  
Karel Sporka
Keyword(s):  
Effective Diffusion ◽  
Type System ◽  
Catalyst Particle ◽  
Ammonium Molybdate ◽  
Active Components ◽  
Model Set ◽  
Cobalt Dichloride ◽  
Set Up ◽  
Electron Microanalysis ◽  
Kinetics Of

Adsorption data for the impregnation of alumina with an aqueous solution of cobalt dichloride and ammonium molybdate were treated in terms of the Langmuir adsorption isotherm and compared with a mathematical model set up to describe the kinetics of simultaneous impregnation of a support by two components. The effective diffusion coefficients of the two components at 25 °C in a cylindrical particle of alumina were obtained. The validity of the model used was verified qualitatively by comparing the numerical results with the experimental time dependent concentration profiles of the active components in a catalyst particle, measured by electron microanalysis technique.

Hollow structure engineering of FeCo alloy nanoparticles electrospun in nitrogen-doped carbon enables high performance flexible all-solid-state zinc–air batteries

2020 ◽  
Vol 4 (4) ◽  
pp. 1747-1753 ◽  
Author(s):  
Yuanyuan Ma ◽  
Wenjie Zang ◽  
Afriyanti Sumboja ◽  
Lu Mao ◽  
Ximeng Liu ◽  
...  
Keyword(s):  
Active Sites ◽  
High Performance ◽  
Hollow Structure ◽  
Active Surface ◽  
Oxygen Electrode ◽  
Active Surface Area ◽  
Active Components ◽  
Nitrogen Doped Carbon ◽  
Structure Engineering ◽  
Kinetics Of

Hollow structuring of active components is an effective strategy to improve the kinetics of oxygen electrode catalysts, arising from the increased the active surface area, the defects on the exposed surface, and the accessible active sites.

Porcine pancreatic lipase partition in potassium phosphate–polyethylene glycol aqueous two-phase systems

2007 ◽  
Vol 859 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Georgina Bassani ◽  
Beatriz Farruggia ◽  
Bibiana Nerli ◽  
Diana Romanini ◽  
Guillermo Picó
Keyword(s):  
Polyethylene Glycol ◽  
Pancreatic Lipase ◽  
Potassium Phosphate ◽  
Porcine Pancreatic Lipase ◽  
Two Phase ◽  
Aqueous Two Phase Systems ◽  
Phase Systems
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