scholarly journals Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Yan-juan Zhu ◽  
Hai-bo Zhang ◽  
Li-rong Liu ◽  
Yi-hong Liu ◽  
Fu-li Zhang ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Logistic Regression ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Syndrome Type ◽  
Multivariate Logistic Regression ◽  
Group A ◽  
Gene Status ◽  
Group B ◽  
Nsclc Patients

Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCM Yin-cold (YC) or Yang-heat (YH) syndrome types and the EGFR gene status, we prospectively studied 310 NSCLC patients. TCM YH or YC was diagnosed by three TCM experts. TCM symptoms and signs were entered into a binary cluster analysis. The relationships between the EGFR gene status, YH or YC syndrome types, and classification by cluster analysis were analyzed using the chi-square test and multivariate logistic regression. In the 299 patients who had their EGFR gene tested, 45.24% YC (76/168) and 25.95% YH (34/131) patients had EGFR mutations (p=0.001). Among the 292 patients entered into the cluster analysis, 132 were classified into group A, with signs and symptoms similar to YC, whereas 160 group B patients were similar to YH. In the 281 patients with EGFR tested, 45.67% group A (58/127) and 28.57% group B patients (44/154) had EGFR mutations (p=0.003). The EGFR status was independently correlated with TCM syndrome type and classification by cluster analysis on multivariate logistic regression. NSCLC patients with YC were more likely to have EGFR gene mutations.

scholarly journals Treatment of knee osteoarthritis with traditional Chinese medicine sloughingClinical efficacy study

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Liang Wen
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Knee Osteoarthritis ◽  
Western Medicine ◽  
Clinical Effect ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Group A ◽  
Group B

Objective: To explore the clinical effect of the treatment of knee osteoarthritis with traditional Chinese medicine.Methods: 152 patients with knee osteoarthritis who were treated in our hospital from July 2018 to April 2020 were divided into two groups. Group A (control group) was treated with conventional western medicine, i.e. celecoxib 200 mg capsule +Glucosamine hydrochloride capsule 0.75g, group B (observation group): the treatment of traditional Chinese medicine sloughing using our experience formula, and further comparative evaluation of the treatment effect of the two groups. Results: the effective rate was 75% in the control group and 92% in the observation group. Conclusion: in the treatment of knee osteoarthritis, traditional Chinese medicine is more effective than western medicine.

scholarly journals Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Are Correlated with Complicated Diverticulitis and Hinchey Classification: A Simple Tool to Assess Disease Severity in the Emergency Department

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Amir Mari ◽  
Tawfik Khoury ◽  
Ahmad Lubany ◽  
Mohammad Safadi ◽  
Moaad Farraj ◽  
...  
Keyword(s):  
Emergency Department ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Univariate Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Complicated Diverticulitis ◽  
Multivariate Logistic Regression ◽  
Hinchey Classification ◽  
Group A ◽  
Group B

Background and Aim. Rapid identification of patients with complications related to acute diverticulitis who require urgent intervention in the emergency department (ED) is essential. The aim of our study was to determine the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting severity of diverticulitis as assessed by Hinchey classification. Patients and Methods. We performed a single retrospective study in EMMS Nazareth Hospital from 4/2014 to 4/2018. Patients were categorized into two groups: group A with mild to moderate complicated diverticulitis (Hinchey 1-2) and group B with severe complicated diverticulitis (Hinchey 3-4). Results. Two hundred twenty-five patients were included. Two hundred seven patients were in group A, and 18 patients were in group B. On univariate analysis, age, NLR, and PLR correlated with advanced Hinchey classification and disease severity (stages 3-4) (OR 1.038, 95% CI 1.001–1.076, P=0.0416; OR 1.192, 95% CI 1.093–1.300, P<0.0001; and OR 1.011, 95% CI 1.005–1.017, P=0.0005, respectively). On multivariate logistic regression analysis, the NLR and PLR remain significantly correlated with Hinchey 3-4 (OR 1.174, 95% CI 1.071–1.286, P=0.0006, and OR 1.008, 95% CI 1.001–1.015, P=0.0209, respectively). The area under the curve (AUC) for the NLR and PLR on univariate analysis was 0.7526 and 0.6748, respectively, and 0.7760 and 0.7391 on multivariate logistic regression analysis, respectively, and receiver-operating characteristic (ROC) curves were drawn. Conclusion. The NLR and PLR independently associated with diverticulitis severity and positively correlated with advanced Hinchey classification. This simple available laboratory tool can be implemented into clinical practice to optimize patient management.

scholarly journals A Comparison of Two Operation Methods Revealed the Risk Factors and the Necessity of LN-prRLN Dissection in Papillary Thyroid Carcinoma: A Retrospective Cohort Study in FUSCC

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yunjun Wang ◽  
Dezhi Wang ◽  
Lili Chen ◽  
Kai Guo ◽  
Tuanqi Sun
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Recurrent Laryngeal Nerve ◽  
Laryngeal Nerve ◽  
Papillary Thyroid ◽  
Multivariate Logistic Regression ◽  
Group A ◽  
Central Lymph ◽  
Group B ◽  
The Right

Background. Although the American Thyroid Association (ATA) guidelines indicate that central lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) should be routinely dissected, pr-RLN dissection is often neglected due to the high risk of injury to the recurrent laryngeal nerve (RLN). The purpose of this study was to investigate the risk factors associated with LN-prRLN metastasis in patients with papillary thyroid carcinoma (PTC) by preoperative examination and the indications for LN-prRLN dissection. Methods. A total of 1487 consecutive patients with PTC who underwent total thyroidectomy or right lobectomy plus isthmic resection with central LN dissection (CLND) were divided into two groups: patients with LN-prRLN dissection (group A) and patients without LN-prRLN dissection (group B). Clinicopathologic data were reviewed of the patients who were operated on by the same thyroid surgery team in the Department of Head Neck Surgery, Fudan University Shanghai Cancer Center (FUSCC) between August 2011 and May 2019. The relationships of LN-prRLN metastasis with clinicopathologic characteristics were analyzed by univariate and multivariate logistic regression. Results. The incidence of LN-prRLN metastasis was 34.1% (129/378). Univariate analysis showed that sex (P≤0.001), tumor size (P≤0.001), extrathyroidal extension (P=0.002), concurrent Hashimoto’s thyroiditis (P=0.009), cLNMa (central lymph nodes anterior to the right recurrent laryngeal nerve) (P≤0.001), cLNMa number (P≤0.001), and lateral LN metastasis (LLNM) (P≤0.001) were significantly associated with LN-prRLN metastasis in PTC. Multivariate logistic regression analysis revealed that tumor size (P=0.039), cLNMa (P=0.001), and LLNM (P=0.025) were independent risk factors for LN-prRLN metastasis in patients with PTC. Although there was no significant difference between the two groups in recurrence, we found that 4 cases relapsed in the LN-prRLN compartment in group B, while none relapsed in group A. Conclusion. LN-prRLN metastasis is often identified in patients with PTC. Patients with large tumor sizes, cLNMa and LLNM are at a high risk of LN-prRLN metastasis and should be recommended for careful LN-prRLN dissection.

scholarly journals Association between Non-Alcoholic Fatty Liver Disease and Intracerebral Hemorrhage

2019 ◽  
Vol 28 (8) ◽  
pp. 1033-1038 ◽  
Author(s):  
Sheng Tu ◽  
Ruihong Zhao ◽  
Hong Fang ◽  
Li Wang ◽  
Anwen Shao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Protective Factor ◽  
Multivariate Logistic Regression ◽  
Alcoholic Fatty Liver ◽  
Group A ◽  
Group B ◽  
Alcoholic Fatty Liver Disease

To determine whether non-alcoholic fatty liver disease (NAFLD) and intracerebral hemorrhage (ICH) are connected, and assess the role played by NAFLD in ICH development. A retrospective study evaluated inpatients treated at the First Affiliated Hospital of Zhejiang University. We divided the patients into Group A (ICH with NAFLD) and Group B (ICH alone). Moreover, univariate and multivariate logistic regression analyses were performed to identify the risk factors for unfavorable outcomes. A total of 128 patients were included: 34 ICH with NAFLD (group A) and 94 ICH (group B). Sixteen patients exhibited an unfavorable outcome. There was no significant difference among the two groups on the underlying diseases hypertension and heart disease. Group A had more diabetes mellitus cases (35.29% vs 12.76%, p = 0.004). Levels of alanine aminotransferase and triglyceride were higher in group A than in group B (all p < 0.05), while differences in other blood biochemistry tests were statistically insignificant (all p > 0.05). There was a similarity in bleeding sites except for brainstem hemorrhage, which was higher in group B patients ( p = 0.036). Multivariate logistic regression analysis revealed that low-density lipoprotein (OR, 0.278; 95% CI (0.107–0.702), p = 0.008) was a protective factor for ICH patients with NAFLD. The National Institute of Health Stroke Scale (NIHSS) score at discharge (OR, 3.152; 95% CI (1.532–6.486), p = 0.002) was independent of risk factors for unfavorable outcomes. Serum levels of LDL was a protective factor. NAFLD did not increase the unfavorable outcome of ICH patients in our study.

scholarly journals Effect of Perineum Block Anesthesia Combined with Unprotected Perineal Delivery on the Perineal Integrity Rate and Maternal-Infant Outcomes in Primiparas Taking Health Products Containing Traditional Chinese Medicine

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xu Liu ◽  
Jianyun Ge ◽  
Jiejie Zhang ◽  
Boxiang Du
Keyword(s):  
Quality Of Life ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Infant Outcomes ◽  
Labor Duration ◽  
Health Products ◽  
Group A ◽  
General Data ◽  
Group B

Objective. The purpose of the study was to investigate the effect of perineum block anaesthesia combined with unprotected perineal delivery on the perineal integrity rate and maternal-infant outcomes in primiparas taking health products containing traditional Chinese medicine (TCM). Methods. A total of 120 puerperae admitted to our hospital from July 2019 to July 2020 were selected as study subjects and divided into group A (n = 60) and group B (n = 60), according to the number table method. Both groups took health products containing TCM, and the puerperae in group A received perineum block anaesthesia combined with unprotected perineal delivery, while those in group B were treated with routine delivery combined with routine protected perineal delivery. After that, the effect of different delivery modes on the perineal integrity rate and maternal-infant outcomes in puerperae was analyzed by the comparison of delivery condition, perineal condition, and postpartum quality of life between the two groups. Results. There were no significant differences in average age and other general data between the two groups ( P > 0.05 ); the duration in first, second, and third stages of labor in group A was significantly lower than that in group B ( P < 0.001 ); the Apgar score in group A was significantly higher than that in group B ( P < 0.001 ); the number of puerperae with integrated perineum in group A was significantly higher than that in group B ( P < 0.05 ), while the number of puerperae receiving episiotomy in group A was significantly lower than that in group B ( P < 0.05 ); the quality of life score in group A was significantly higher than that in group B ( P < 0.001 ); the incidence of maternal postpartum complications in group A was significantly lower than that in group B ( P < 0.05 ). Conclusion. Perineum block anaesthesia combined with unprotected perineal delivery can effectively shorten maternal labor duration, improve perineal integrity rate, and reduce laceration of perineum, with a significant therapeutic effect, which is worthy of application and promotion.

P–520 Live birth rate with a euploid embryo is the same irrespective of the number of oocyte retrievals undertaken to produce a euploid embryo

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
E Theodorou ◽  
D Cardena. Armas ◽  
B P Jones ◽  
P Serhal ◽  
J Ben-Nagi
Keyword(s):  
Logistic Regression ◽  
Live Birth ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Multivariate Logistic Regression ◽  
Group A ◽  
Group B ◽  
Euploid Embryo

Abstract Study question Does a euploid embryo from one ovarian stimulation lead to the same live birth rate as a euploid embryo arising from multiple ovarian stimulations? Summary answer The live birth rate of a euploid embryo transferred is comparable irrespective of the number of ovarian stimulations required. What is known already Embryo transfer of a euploid embryo leads to a high live birth rate. Women with low ovarian reserve or poor responders may not have a euploid embryo from one cycle of ovarian stimulation and can be discouraged from undergoing preimplantation genetic testing for aneuploidy (PGT-A). Embryo batching from multiple cycles offers such patients a potential solution to increase their chance of achieving a euploid embryo. Study design, size, duration A retrospective analysis of 506 cycles of single euploid frozen embryo transfers (FET) from January 2015 to March 2020 was carried out. The indication for PGT-A was advanced maternal age, recurrent miscarriages or repetitive IVF failures. Only the first single euploid FETs per patient were included. Participants/materials, setting, methods Group A (N = 323) included women who had a normal ovarian reserve and only one cycle of ovarian stimulation before the FET, whilst Group B (N = 183) had low ovarian reserve or previous poor ovarian response requiring 2 or more cycles of ovarian stimulation. All embryos were biopsied at the blastocyst stage and subjected to a-CGH or NGS. Univariate statistical analysis with Chi-square or Wilcox Man U as required and multivariate logistic regression was performed with SPSS. Main results and the role of chance Group A and Group B were comparable in terms of BMI (average 22.3 vs 22.6), sperm origin, number of blastocysts biopsied (median N = 6, range 4–8), day 5 vs day 6 biopsy (day 5, 81.1% vs 75.4%, p = 0.130) and whether only one euploid embryo was available (42% vs 34%; p = 0.103). There was a significant difference in the number of eggs retrieved per cycle between the two groups (median 15 vs 9, p &lt; 0.001), the total number of eggs retrieved (median 15 vs 20, p &lt; 0.001) and whether a top-quality embryo was transferred (38% vs 25%, p = 0.026). Pregnancy rate, live birth rate and pregnancy loss was equivalent for both groups: 69.3% (224/323) vs 63.9% (178/183) (p = 0.212), 57.6% (186/323) vs 57.4% (105/183) (p = 0.096) and 17.0% (38/224) vs 10.3% (12/117) (p = 0.964), respectively. Multivariate logistic regression was performed to ascertain the effect of the treatment variables on the live birth rate. The number of oocyte collections was not a significant predictive factor (OR 1.19, 95% CI 0.72 - 1.96, p = 0.491), whilst an embryo biopsy performed on day 5 vs day 6, increased significantly the live birth rate (OR 2.58, 95% CI 1.61 - 4.13, p &lt; 0.001). Limitations, reasons for caution The main limitation of this study is that it is retrospective, single centre and therefore vulnerable to confounding factors and bias. Wider implications of the findings: These results can be used to counsel and reassure women with poor response embarking on embryo batching and PGT-A that should a euploid embryo become available, their chance of success is unaffected by the number of cycles they undertake albeit the physical, emotional and financial burden of multiple ovarian stimulations Trial registration number Not applicable

Detection of biodiversity local centers and gradients of change of Dolichopodidae (Diptera) in East Asia

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
IGOR GRICHANOV ◽  
MARIYA CHURSINA ◽  
MENGQING WANG
Keyword(s):  
Cluster Analysis ◽  
East Asia ◽  
Mathematical Analysis ◽  
East Asian ◽  
Species Number ◽  
Russian Regions ◽  
Biodiversity Indices ◽  
Group A ◽  
Group B ◽  
Total Species

The dolichopodid fauna of continental Chinese and Russian regions belonging to the East Palaearctic have been selected for a comparative diversity investigation. We gathered information about 654 species of long-legged flies in the studied areas. Regarding the total species number, Primorsky Kray and Republic of Sakha in Russia, Henan and Shaanxi in China, as well as Mongolia are the top five regions, each with more than 100 species known. Cluster analysis of the dolichopodid genera composition allows us to divide all studied territories into two groups: Group A is mixed, since it includes both the Russian regions and the Chinese provinces; Group B includes only Russian regions. Generally, the mathematical analysis of the dolichopodid species supports the uniqueness of Primorsky Kray as the biodiversity center in East Asian Palaearctic. A decrease in the number of known species and biodiversity indices is observed northward, southward and westward of Primorsky Kray. One more possible center is located closely to the Oriental provinces of China (Henan and Shaanxi provinces).

scholarly journals Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Huizi Ouyang ◽  
Jiayuan Shen ◽  
Xuhua Huang ◽  
Wenjuan Ma ◽  
Qi Jia ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Drug Treatment ◽  
Drug Interactions ◽  
Rat Plasma ◽  
Therapeutic Failure ◽  
Metoprolol Tartrate ◽  
Conventional Drug ◽  
Group A ◽  
Group B ◽  
Opposite Tendency

Naoxintong capsule (NXT), a prescribed Chinese medicine, has been used clinically for more than 20 years and is widely received by patients. We determined five probe drugs, namely, omeprazole (CYP2C19), midazolam (CYP3A4), phenacetin (CYP1A2), tolbutamide (CYP2C9), and dextromethorphan (CYP2D6) to study the potential influences of NXT on the activities of CYP enzymes and assessed the pharmacokinetics effect of NXT on metoprolol tartrate in rat plasma. The study showed that AUC(0–24) and AUC(0–∞) of midazolam (CYP3A4) in NXT coadministration group (283.7 ± 65.2 h·ng·mL−1 and 292.0 ± 75.1 h·ng·mL−1 in group B; 295.7 ± 62.7 h·ng·mL−1 and 299.5 ± 60.0 h·ng·mL−1 in group C) were significantly decreased as compared to another group (416.8 ± 82.3 h·ng·mL−1 and 424.9 ± 77.9 h·ng·mL−1 in group A), while that of dextromethorphan (CYP2D6) showed an opposite tendency (540.7 ± 119.7 h·ng·mL−1 and 595.3 ± 122.2 h·ng·mL−1 in group A, 760.6 ± 184.9 h·ng·mL−1 and 788.7 ± 211.0 h·ng·mL−1 in group B, and 734.3 ± 118.5 h·ng·mL−1 and 757.2 ± 105.4 h·ng·mL−1 in group C). Moreover, NXT preadministration can enhance the metabolism of metoprolol tartrate and reduce the metabolism of O-demethylmetoprolol. The results indicated that NXT had potential effects in inducing CYP3A4 and inhibiting CYP2D6 in the metabolism of metoprolol tartrate. It suggests that patients who coadministered NXT and metoprolol tartrate should be advised of potential herb-drug interactions (HDIs) to reduce therapeutic failure or accelerated toxicity of conventional drug treatment.

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