Recent Advances in Hydrogel-Based Drug Delivery for Melanoma Cancer Therapy: A Mini Review

The purpose of this study is to describe some of the latest advances in using hydrogels for cancer melanoma therapy. Hydrogel formulations of polymeric material from natural or synthetic sources combined with therapeutic agents have gained great attention in the recent years for treating various maladies. These formulations can be categorized according to the strategies that induce cancer cell death in melanoma. First of all, we should note that these formulations can only play a supporting role that releases bioactive agents against cancer cells rather than the main role. This strategy involves delivering the drug via transdermal pathways, resulting in the death of cancerous cells. Another strategy utilizes magnetic gel composites to combat melanoma via hyperthermia therapy. This review discusses both transdermal and hyperthermia therapies and the recent advances that have occurred in the field.

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The Efficacy of Cholesterol-Based Carriers in Drug Delivery

Molecules ◽

10.3390/molecules25184330 ◽

2020 ◽

Vol 25 (18) ◽

pp. 4330

Author(s):

Ngonidzashe Ruwizhi ◽

Blessing Atim Aderibigbe

Keyword(s):

Drug Delivery ◽

Biological Activity ◽

Wide Distribution ◽

Therapeutic Agents ◽

The Body ◽

In Vivo Studies ◽

Routes Of Administration ◽

Bioactive Agents

Several researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety of therapeutic agents such as anticancer, antimalarials and antivirals. These cholesterol-based carriers were designed as micelles, nanoparticles, copolymers, liposomes, etc. and their routes of administration include oral, intravenous and transdermal. The biocompatibility, good bioavailability and biological activity of cholesterol-based carriers make them potent prodrugs. Several in vitro and in vivo studies revealed cholesterol-based carriers potentials in delivering bioactive agents. In this manuscript, a critical review of the efficacy of cholesterol-based carriers is reported.

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Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: Recent advances, current obstacles, and challenges for clinical translation

Seminars in Cancer Biology ◽

10.1016/j.semcancer.2020.08.007 ◽

2020 ◽

Cited By ~ 1

Author(s):

Marco Pirisinu ◽

Tin Chanh Pham ◽

Daniel Xin Zhang ◽

Tran Nguyen Hong ◽

Lap Thi Nguyen ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Extracellular Vesicles ◽

Drug Delivery Systems ◽

Therapeutic Agents ◽

Delivery Systems ◽

Clinical Translation ◽

Recent Advances

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Plantago Ovata and Locust Bean Gum as a Natural Polymer in Hydrodynamically Balanced Systems: A Review

Journal of Biomedical and Allied Research ◽

10.37191/mapsci-2582-4937-2(1)-015 ◽

2020 ◽

Author(s):

Ghildiyal s

Keyword(s):

Drug Delivery ◽

Locust Bean Gum ◽

Main Role ◽

Natural Polymer ◽

Release Formulation ◽

Sustained Drug Delivery ◽

Modern Drug ◽

Buccal Drug Delivery ◽

Locust Bean ◽

Ceratonia Siliqua L

Hydrodynamically Balanced systems have wide development as they have achieved the parameters of modern drug delivery system, it is a type of system which owes very tremendous and curative benefits for the delivery of oral controlled release dosage forms and have wide properties in many aspects such as its main role is to maintain the effective concentration in the system for longer period of time. To reduce the gastric mucosal irritation due to the presence of synthetic polymers, being a natural polymer incorporation of Plantago ovate (Psyllium Husk) could ease out the mucosal irritation in the gastric region. Due to its properties such as a rate-controlling polymer possessing a very good quality of swelling and good gelling nature, and also incorporated as a matrix-forming agent basically in the modified release formulation. Locust bean gum can be used as sustained-release carriers and release modifiers for the delivery of drugs. It is a neutral plant galactomannan extracted from the seeds (kernels) of the carob tree Ceratonia siliqua L fabaceae. Nowadays it is focussing polymer and a lot of researchers are focussing on exploring the potential in topical drug delivery, colonic drug delivery, oral sustained drug delivery, ocular drug delivery, buccal drug delivery.

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Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00303 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1014

Author(s):

Xiao-Hong HAO ◽

Cui-Miao ZHANG ◽

Xiao-Long LIU ◽

Xing-Jie LIANG ◽

Guang JIA ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Recent Advances ◽

Nano Drug Delivery

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Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants

Current Medicinal Chemistry ◽

10.2174/0929867326666190726123229 ◽

2020 ◽

Vol 27 (6) ◽

pp. 854-902 ◽

Cited By ~ 5

Author(s):

Raluca Ion ◽

Madalina Georgiana Necula ◽

Anca Mazare ◽

Valentina Mitran ◽

Patricia Neacsu ◽

...

Keyword(s):

Drug Delivery ◽

Tio2 Nanotubes ◽

Therapeutic Agent ◽

Bone Defects ◽

Delivery Systems ◽

Antimicrobial Compounds ◽

Bone Implant ◽

Bioactive Agents ◽

Localized Drug Delivery ◽

Regeneration Of Bone

TiO2 nanotubes (TNTs) are attractive nanostructures for localized drug delivery. Owing to their excellent biocompatibility and physicochemical properties, numerous functionalizations of TNTs have been attempted for their use as therapeutic agent delivery platforms. In this review, we discuss the current advances in the applications of TNT-based delivery systems with an emphasis on the various functionalizations of TNTs for enhancing osteogenesis at the bone-implant interface and for preventing implant-related infection. Innovation of therapies for enhancing osteogenesis still represents a critical challenge in regeneration of bone defects. The overall concept focuses on the use of osteoconductive materials in combination with the use of osteoinductive or osteopromotive factors. In this context, we highlight the strategies for improving the functionality of TNTs, using five classes of bioactive agents: growth factors (GFs), statins, plant derived molecules, inorganic therapeutic ions/nanoparticles (NPs) and antimicrobial compounds.

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Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190904145355 ◽

2020 ◽

Vol 20 (11) ◽

pp. 1001-1016

Author(s):

Sandra Ramírez-Rave ◽

María Josefa Bernad-Bernad ◽

Jesús Gracia-Mora ◽

Anatoly K. Yatsimirsky

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery Systems ◽

Mesoporous Silica Nanoparticles ◽

High Surface ◽

Delivery Systems ◽

Surface Reactivity ◽

External Stimulus ◽

Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System

Current Drug Delivery ◽

10.2174/1567201817666200717090623 ◽

2020 ◽

Vol 17 (10) ◽

pp. 911-924

Author(s):

Rohitas Deshmukh

Keyword(s):

Drug Delivery ◽

Colon Cancer ◽

Targeted Drug Delivery ◽

Targeted Delivery ◽

Therapeutic Agent ◽

Therapeutic Agents ◽

Delivery Systems ◽

Target Tissue ◽

Polymer Carriers

Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective drug delivery system. The delivery systems employing the use of polymers, such as chitosan and pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an increased amount of the drug to reach the target tissue or cells. In this systematic review of published literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the use of chitosan and pectin in colon targeted drug delivery systems.

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Heat Stress and Pulsed Unfocused Ultrasound: The Viability of these Physical Approaches for Drug Delivery into Testicular Seminiferous Tubules

Current Drug Delivery ◽

10.2174/1567201817666200514080811 ◽

2020 ◽

Vol 17 (5) ◽

pp. 438-446 ◽

Cited By ~ 1

Author(s):

Yuanyuan Li ◽

Mohammad Ishraq Zafar ◽

Xiaotong Wang ◽

Xiaofang Ding ◽

Honggang Li

Keyword(s):

Drug Delivery ◽

Heat Stress ◽

Targeted Drug Delivery ◽

Therapeutic Agents ◽

Seminiferous Tubules ◽

Adult Mice ◽

Targeted Drug ◽

To Receive ◽

Unfocused Ultrasound ◽

Blood Testis Barrier

Aim: To investigate the application of Scrotal Heat Stress (SHS) and Pulsed Unfocused Ultrasound (PuFUS) to explore Blood-Testis Barrier (BTB) permeability in adult mice. Background: The BTB provides a stable microenvironment and a unique immune barrier for spermatogenesis. Meanwhile, it blocks macromolecular substances access, including therapeutic agents and antibodies, thereby it decreases the therapeutic or immunocontraception effects. Objectives: To determine the viability of these physical approaches in delivering macromolecular substances into seminiferous tubules. Material & Methods: Mice were subjected to receive single SHS intervention at 39°C, 41°C, or 43°C for 30 min. Whereas, mice received the PuFUS intervention at 1.75w/cm2, 1.25w/cm2, and 2.5w/cm2 for 2 min, 5 min, and 10 min, respectively. The Biotin and macromolecular substances (IgG, IgM, and exosomes) were separately injected into the testicular interstitium at different times following SHS or PuFUS interventions, to observe their penetration through BTB into seminiferous tubules. Results: As detected by Biotin tracer, the BTB opening started from day-2 following the SHS and lasted for more than three days, whereas the BTB opening started from 1.5h following PuFUS and lasted up to 24h. Apparent penetration of IgG, IgM, and exosomes into seminiferous tubules was observed after five days of the SHS at 43°C, but none at 39°C, or any conditions tested with PuFUS. Conclusion: The current results indicate that SHS at 43°C comparatively has the potential for delivering macromolecular substances into seminiferous tubules, whereas the PuFUS could be a novel, quick, and mild approach to open the BTB. These strategies might be useful for targeted drug delivery into testicular seminiferous tubules. However, further studies are warranted to validate our findings.

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