scholarly journals Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances

2018 ◽  
Vol 2018 ◽  
pp. 1-19 ◽  
Author(s):  
Shreya Kaul ◽  
Neha Gulati ◽  
Deepali Verma ◽  
Siddhartha Mukherjee ◽  
Upendra Nagaich
Keyword(s):  
Entrapment Efficiency ◽  
Skin Penetration ◽  
Nanostructured Lipid Carrier ◽  
Sustained Drug Release ◽  
Care Industry ◽  
Specific Targeting ◽  
Innovative Solutions ◽  
High Entrapment Efficiency ◽  
The Impact

Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have come into widespread use. Novel nanocarriers like liposomes, niosomes, nanoemulsions, microemulsion, solid lipid nanoparticles, nanostructured lipid carrier, and nanospheres have replaced the usage of conventional delivery system. These novel nanocarriers have advantages of enhanced skin penetration, controlled and sustained drug release, higher stability, site specific targeting, and high entrapment efficiency. However, nanotoxicological researches have indicated concern regarding the impact of increased use of nanoparticles in cosmeceuticals as there are possibilities of nanoparticles to penetrate through skin and cause health hazards. This review on nanotechnology used in cosmeceuticals highlights the various novel carriers used for the delivery of cosmeceuticals, their positive and negative aspects, marketed formulations, toxicity, and regulations of nanocosmeceuticals.

Nanotechnology Based Cosmeceuticals

2021 ◽  
pp. 94-106
Author(s):  
Ranajit Nath ◽  
Rajarshi Chakraborty ◽  
Ratna Roy ◽  
Debleena Mukherjee ◽  
Srijita Nag ◽  
...  
Keyword(s):  
Entrapment Efficiency ◽  
Skin Penetration ◽  
Nanostructured Lipid Carrier ◽  
Sustained Drug Release ◽  
Private Care ◽  
Care Industry ◽  
Specific Targeting ◽  
Innovative Solutions ◽  
High Entrapment Efficiency ◽  
The Impact

Nanotechnology manifests the progression within stage of research and development, by increasing the efficacy of the merchandise through delivery of innovative solutions. to beat certain drawbacks associated with the traditional products, application of nanotechnology is escalating within the world of cosmeceuticals. In private care industry, cosmeceuticals are considered the fastest growing segment and thus the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have inherit widespread use. Novel nanocarriers like nano emulsions, liposomes, microemulsions, niosomes, solid lipid nanoparticles, nanospheres and nanostructured lipid carrier have replaced the usage of conventional delivery system. These novel nanocarriers have advantages of controlled and sustained drug release, enhanced skin penetration, higher stability, high entrapment efficiency and site-specific targeting. However, nanotoxicological researches have indicated concern regarding the impact of increased use of nanoparticles in cosmeceuticals as there are possibilities of nanoparticles to penetrate through skin and cause health hazards. This review on nanotechnology utilized in cosmeceuticals highlights the various novel carriers used for the delivery of cosmeceuticals, marketed formulations, their positive and negative aspects, toxicity, and regulations of nanocosmeceuticals.

scholarly journals Agricultural Cooperatives and COVID-19 in Southeast Africa. The Role of Managerial Capital for Rural Resilience

2021 ◽  
Vol 13 (3) ◽  
pp. 1046
Author(s):  
Nicola Francesconi ◽  
Fleur Wouterse ◽  
Dorothy Birungi Namuyiga
Keyword(s):  
Health Impact ◽  
Value Chains ◽  
Agricultural Cooperatives ◽  
African Countries ◽  
Elite Capture ◽  
Innovative Solutions ◽  
Reduced Mobility ◽  
The Impact ◽  
Food Value

While the health impact of COVID-19 in most African countries appears modest, the impact of social distancing measures, closing of markets and reduced mobility is felt across the board. Domestic, labor-intensive and traditional food value chains and the smallholders they serve appear to be particularly affected. During a systemic shock where idiosyncratic risk coping strategies fail, collective or organizational resilience becomes of the essence to protect the livelihoods of smallholders. In this study, we have used pre- and during-shock data on agricultural cooperatives from Southeast Africa to understand how resilient these smallholder-owned organizations are. We find that many organizations could not countervail market-disruptions and fell into a state of dormancy during the pandemic. One reason for this is that collective decision-making was heavily affected by the banning of gatherings. Only a few organizations devised innovative solutions to maintain the market linkages of rural smallholders. The lack of resilience demonstrated by most cooperatives appears to be associated with organizational immaturity, large membership size, elite capture and limited business-orientation, which underscore a general lack of managerial capital.

scholarly journals Formulation And Evaluation Of Floating Microspheres Of Cefdinir

2021 ◽  
Vol 23 (11) ◽  
pp. 906-929
Author(s):  
Jeslin. D ◽  
◽  
Nithya Kalyani.K ◽  
Padmaja. V ◽  
Suresh Kumar.P ◽  
...  
Keyword(s):  
Drug Release ◽  
Residence Time ◽  
Entrapment Efficiency ◽  
Sustained Drug Release ◽  
Magnetic Systems ◽  
Gastric Residence Time ◽  
Gum Karaya ◽  
High Entrapment Efficiency ◽  
Full Factorial ◽  
Good Flow

Various approaches have been used to retain the dosage form in the stomach as a way ofincreasing the gastric residence time (GRT), including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extendible, or swellable systems; andsuperporous hydrogel systems. The aim of this study was to prepare and evaluate floatingmicrospheres of cefdinir for the prolongation of gastric residence time. Themicrospheres were prepared byCapillary Extrusion method.A full factorial design was applied to optimize the formulation. The optimum batch of microsphere exhibited smooth surfaces with good flow and packing properties, prolonged sustained drug release, remained buoyant for more than 12 hrs, high entrapment efficiency upto68%.Scanning electron microscopy confirmed the hollown structure with particle size in the order of190 μm. The studies revealed that increase in concentration of gum Karaya increased the drug release from the floating microspheres.

scholarly journals Preparation and Evaluation of Intraperitoneal Long-Acting Oxaliplatin-Loaded Multi-Vesicular Liposomal Depot for Colorectal Cancer Treatment

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 736
Author(s):  
Sharif Md Abuzar ◽  
Eun Jung Park ◽  
Yeji Seo ◽  
Juseung Lee ◽  
Seung Hyuk Baik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Release ◽  
Entrapment Efficiency ◽  
Lag Phase ◽  
Burst Release ◽  
Sustained Drug Release ◽  
Long Acting ◽  
High Entrapment Efficiency

Colorectal cancer with peritoneal metastasis has a poor prognosis because of inadequate responses to systemic chemotherapy. Cytoreductive surgery followed by intraperitoneal (IP) chemotherapy using oxaliplatin has attracted attention; however, the short half-life of oxaliplatin and its rapid clearance from the peritoneal cavity limit its clinical application. Here, a multivesicular liposomal (MVL) depot of oxaliplatin was prepared for IP administration, with an expected prolonged effect. After optimization, a combination of phospholipids, cholesterol, and triolein was used based on its ability to produce MVL depots of monomodal size distribution (1–20 µm; span 1.99) with high entrapment efficiency (EE) (92.16% ± 2.17%). An initial burst release followed by a long lag phase of drug release was observed for the MVL depots system in vitro. An in vivo pharmacokinetic study mimicking the early postoperative IP chemotherapy regimen in rats showed significantly improved bioavailability, and the mean residence time of oxaliplatin after IP administration revealed that slow and continuous erosion of the MVL particles yielded a sustained drug release. Thus, oxaliplatin-loaded MVL depots presented in this study have potential for use in the treatment of colorectal cancer.

NANOMATERIALS IN COSMETIC PREPARATIONS

2021 ◽  
pp. 48-50
Author(s):  
Bandaru Hemanth Kumar ◽  
Shaik Farooq Ahmed ◽  
Prasanthi D
Keyword(s):  
Skin Penetration ◽  
Health Hazards ◽  
Nano Particles ◽  
Nanosized Materials ◽  
Care Industry ◽  
Solid Lipid ◽  
The Past ◽  
Nanosized Material ◽  
The Impact ◽  
Active Substances

This review determines various nanomaterial based cosmeceuticals. And glance on the properties, types, techniques used for preparation of nanomaterials, their advantages & disadvantages and various marketed products. Cosmeceuticals are fastest growing segment in the personal care industry and their use has increased drastically over the past years. The nanocosmeceuticals are mainly used in the application of cosmetics in managing conditions of wrinkling, dehydrated & inelastic skin associated with aging and dispersed hyperpigmentation, with the use of nanosized materials. The nanosized materials are nano emulsions, liposomes, nanosomes, dendrimers, nanocapsules and solid lipid nano particles. These nanosized materials have an advantage in increasing skin penetration and they release the active substances in a controlled and sustained manner. They have a higher stability; can be site specic targeting and high entrapment efcacy. Researchers have indicated concern regarding the impact of increased use of nanosized materials in cosmeceuticals and there are some possibilities of nanosized material can penetrate into the skin and cause health hazards.

scholarly journals Targeted Nanostructured Lipid Carrier for Brain Delivery of Artemisinin: Design, Preparation, Characterization, Optimization and Cell Toxicity

2018 ◽  
Vol 21 (1s) ◽  
pp. 225s-241s ◽  
Author(s):  
Jaber Emami ◽  
Hessam Yousefian ◽  
Hojjat Sadeghi
Keyword(s):  
Cancer Cell Line ◽  
Entrapment Efficiency ◽  
Tween 80 ◽  
In Vitro Cytotoxicity ◽  
Release Time ◽  
Nanostructured Lipid Carrier ◽  
Brain Delivery ◽  
Solvent Evaporation Method ◽  
The Impact

In the present study, a transferrin-conjugated nanostructured lipid carrier (TF-NLCs) for brain delivery of artemisinin (ART) was developed. ART-loaded NLCs (ART-NLCs) were prepared using solvent evaporation method and the impact of various formulation or process variables on the responses were assessed using a Taguchi design. Optimized ART-NLC was then coupled with transferrin as targeting ligand and its in vitro cytotoxicity was investigated against U-87MG brain cancer cell line. As a result, the following values are suggested by the software to prepare the optimized formulation: 20 mg Compritol®, 0.25% Tween 80, 5 mg oleic acid, 2.5 mL dichloromethane and 4 min sonication. Mean particle size (PS), zeta potential (ZP), polydispersity index (PDI), entrapment efficiency (EE), mean release time (MRT) of adopted formulation were confirmed to be 145 ± 12.5 nm, 24.3 ± 1.5 mV, 0.513 ± 0.021, 82.3 ± 7.3 % and 24.0 ± 1.1 h, respectively. Following conjugation of optimized ART-NLCs with TF, PS and MRT were increased, while ZP, and EE were decreased significantly. TF-ART-NLCs showed higher cytotoxic activity compared to non-targeted NLCs and free drug. These results indicated that the TF-ART-NLCs could potentially be exploited as a delivery system for anticancer and antimalarial drug ART in brain tumors and malaria.

scholarly journals FABRICATION, CHARACTERIZATION, AND IN VITRO EVALUATION OF PEGYLATED GLYCERIDE LABRASOL® NANOSTRUCTURED LIPID CARRIER COMPOSITES OF METHOTREXATE: THE PATHWAY TO EFFECTIVE CANCER THERAPY

2019 ◽  
pp. 229-237 ◽  
Author(s):  
RADHARANI PANDA ◽  
KETOUSETUO KUOTSU
Keyword(s):  
Sustained Release ◽  
Drug Loading ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Nanostructured Lipid Carrier ◽  
Transmission Electron Microscopy Analysis ◽  
Transmission Electron ◽  
Electron Microscopy Analysis ◽  
High Entrapment Efficiency

Objective: The objective of the current study is to optimize and evaluate the potential of polyethylene glycolylated (PEG) glyceride Labrasol® nanostructured lipid carrier (NLC) composites of methotrexate (MTX) to achieve enhanced sustained release delivery in cancer treatment. Materials and Methods: MTX-NLC was successfully prepared by hot melt emulsification and probe sonication method for spatial and controlled release of this therapeutic agent. Results: The solubility screening of MTX and lipids resulted in the selection of Monostearin as solid lipid, PEGylated glyceride Labrasol® and olive oil as liquid lipids for the formulation of MTX-loaded NLC composites. Particle size, zeta potential, and polydispersity index of both the composites were confirmed using dynamic light scattering, whereby Labrasol® MTX-NLC showed high entrapment efficiency and drug loading. A spherical particle shape with smooth surface of all the composites was confirmed from the scanning electron microscope and transmission electron microscopy analysis. Labrasol® MTX-NLC showed remarkably increased cytotoxic response, augmented cellular uptake, and low half maximal inhibitory concentration value in MCF-7 cells. In vitro release study confirmed that encapsulation of MTX in PEGylated glyceride Labrasol® MTX-NLC resulted in enhanced sustained release of MTX for a period of 48 h. Conclusion: The present study establishes that PEGylated glyceride Labrasol® MTX-NLC can be considered as a promising anticancer delivery system, thereby improving antitumor efficacy of the drug.

scholarly journals Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Sanjay Dey ◽  
Soumen Pramanik ◽  
Ananya Malgope
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Entrapment Efficiency ◽  
Sustained Drug Release ◽  
Independent Variables ◽  
Optimum Formulation ◽  
Dependent Variables ◽  
High Entrapment Efficiency ◽  
Full Factorial

The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio () and stirring speed (), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release. The best batch exhibited a high entrapment efficiency of 70% and mean particle size 290 μm. The drug release was also sustained for more than 12 hours. The study helped in finding the optimum formulation with excellent sustained drug release.

scholarly journals The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

Nanomaterials ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 622 ◽  
Author(s):  
In Ki Hong ◽  
Ji Hoon Ha ◽  
Sangkeun Han ◽  
Hakhee Kang ◽  
Soo Nam Park
Keyword(s):  
Human Skin ◽  
Alkyl Chain ◽  
Skin Permeation ◽  
Entrapment Efficiency ◽  
Skin Penetration ◽  
Skin Permeability ◽  
Non Invasive ◽  
Edge Activator

Non-invasive skin penetration of a drug is increased by an edge activator, which enhances the nanoliposome deformability. The objective of this study was to investigate the role of the alkyl chain number of sucrose surfactants as an edge activator in elastic nanoliposomes. In addition, the physicochemical properties of the elastic nanoliposomes were characterized and an in vitro human skin permeation study was performed. Elastic nanoliposomes that were composed of sucrose monostearate (MELQ), sucrose distearate (DELQ), and sucrose tristearte (TELQ) were prepared using a thin-film hydration method. Particle size and entrapment efficiency of elastic nanoliposomes increased proportionally with an increase in the amounts and the numbers of the stearate in sucrose surfactant. Deformability of elastic nanoliposomes was indicated as DELQ > MELQ > TELQ and the same pattern was revealed through the in vitro human skin permeability tests. These results suggest that the number of alkyl chains of sucrose surfactant as edge activator affects the physicochemical property, stability, and skin permeability in elastic nanoliposome. Our findings give a valuable platform for the development of elastic nanoliposomes as skin drug delivery systems.

scholarly journals Formulation and Optimization of Nanospanlastics for Improving the Bioavailability of Green Tea Epigallocatechin Gallate

2021 ◽  
Vol 14 (1) ◽  
pp. 68
Author(s):  
Eman A. Mazyed ◽  
Doaa A. Helal ◽  
Mahmoud M. Elkhoudary ◽  
Ahmed G. Abd Elhameed ◽  
Mohamed Yasser
Keyword(s):  
Drug Release ◽  
Pharmacokinetic Study ◽  
Ex Vivo ◽  
Epigallocatechin Gallate ◽  
Entrapment Efficiency ◽  
Sustained Drug Release ◽  
Ethanol Injection ◽  
23 Factorial Design ◽  
The Impact

The present study aimed to investigate the potential of nanospanlastics for boosting the bioavailability of epigallocatechin gallate (EGCG). EGCG has valuable effects like anti-inflammation, anti-oxidation, and anti-tumorigenesis. Unfortunately, it has a low oral bioavailability due to its limited permeation and poor stability. To overcome these pitfalls, EGCG was fabricated as a nanospanlastic. Nanospanlastics are flexible nanovesicles that are composed of surfactants and edge activators (EAs). EAs improve the deformability of spanlastics by acting as a destabilizing factor of their vesicular membranes. EGCG-loaded spanlastics were prepared by an ethanol injection method, according to 23 factorial design, to explore the impact of different independent variables on entrapment efficiency (EE%), % drug released after 12 h (Q12h), and particle size (PS). In vitro characterization, ex vivo intestinal permeation test, and pharmacokinetic study of the optimized formula were performed. A newly developed RP-HPLC technique was adopted for the estimation of EGCG. The optimized formula (F4) demonstrated more prolonged drug release and a significant improvement in the EE%, permeability, deformability and stability than the corresponding niosomes. The pharmacokinetic study investigated that F4 had a more sustained drug release and a higher bioavailability than the conventional niosomes and free drugs. Nanospanlastics could be a promising approach for improving the bioavailability of EGCG.

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