scholarly journals Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Stéphane Zingue ◽  
Harquin Simplice Foyet ◽  
Sefirin Djiogue ◽  
Yannick Ezo’o Ezo’o ◽  
Hervé Hervé Ngatanko Abaïssou ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Aqueous Extract ◽  
Memory Impairment ◽  
Wistar Rats ◽  
Reference Memory ◽  
Ovariectomized Rats ◽  
Estradiol Valerate ◽  
Memory Errors ◽  
Neuroprotective Effects ◽  
Before And After

The present work was undertaken to evaluate the ability of F. umbellata aqueous extract and its major component 7-methoxycoumarin (MC) to improve scopolamine-induced spatial memory impairment in ovariectomized Wistar rats. For this to be done, 10 sham-operated and 30 postmenopausal-like rats were randomly distributed in eight groups (n=5) and treated with distilled water (2 mL/250 g), estradiol valerate (1 mg/kg BW), piracetam (1.5 mg/kg BW), F. umbellata aqueous extract (50 and 200 mg/kg BW), or MC (1 mg/kg BW) for 21 consecutive days. Before and after the memory impairment with scopolamine (2 mg/kg BW), animals underwent behavioral evaluations on Y- and radial mazes. As results, age and ovariectomy did not induce significant changes in the reference memory errors. While age decreased working memory errors, ovariectomy increased it. The MC as well as F. umbellata extract significantly increased (p<0.01) the percentage of spontaneous alternation and decreased (p<0.001) working and spatial reference memory errors and anxiety parameters (rearing and grooming) in ovariectomized rats. MC significantly reduced (p<0.05) the MDA level, but resulted in an increase in GSH level in brain homogenates. These results suggest that MC is endowed with neuroprotective effects and could account for the neuroprotective effects of F. umbellata in rats.

Neuroprotective Effects of the Anthocleista Schweinfurthii Gilg. (Loganiaceae) Stem Bark Extract in Postmenopause-Like Model of Ovariectomized Wistar Rats

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Ngoungoure Madeleine Chantal ◽  
Dzeufiet Djomeni Paul Désiré ◽  
Bilanda Danielle Caude ◽  
Mengue Ngandena Yolande Sandrine ◽  
Mbolang Nguegang Lohik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Plant Extract ◽  
Total Protein ◽  
Wistar Rats ◽  
Stem Bark ◽  
Bark Extract ◽  
Estradiol Valerate ◽  
Neuroprotective Effects ◽  
Protein Levels ◽  
Stem Bark Extract

Abstract Background Estrogen deficiency in postmenopausal period causes severe neuroendocrine changes in brain which influences memory and other nervous functions. Anthocleista schweinfurthii is used traditionally to treat female infertility and menopause related symptoms. This study was performed to investigate the potential neuroprotective effects of aqueous extract of Anthocleista schweinfurthii on brain in a postmenopause-like model of ovariectomized Wistar rats. Methods Thirty animals were sham-operated or ovariectomized (Ovx) 84 days after surgery, six groups of five rats each were daily treated orally during 28 days with: distilled water for groups 1 (sham-operated) and 2 (Ovx), estradiol valerate (group 3) and the three doses of extracts {groups 4, 5 and 6 (Ovx)}. Biochemical and histological evaluations focused on brain. Results Compared to sham-operated control, ovariectomy decreased total protein levels in brain (p<0.01) which was increased by plant extract at the dose of 300 mg/kg (p<0.05), underlying its anabolic properties. Ovariectomy significantly decreased magnesium levels in brain (p<0.001). Anthocleista schweinfurthii increased significantly magnesium levels (p<0.01), showing its capacity to act on synaptic conduction. Ovariectomy induced oxidative stress by increasing malondialdehyde levels (p<0.05) and decreasing reduced glutathione levels (p<0.05) in brain. The plant extract exhibited antioxidative activity by reducing malondialdehyde levels and increasing glutathione levels in brain. Damage in brain structure which was caused by ovariectomy disappeared following the treatment. Conclusions Results suggest that Anthocleista schweinfurthii may have neuroprotective effects in Ovx Wistar rats by increasing total protein, magnesium levels and reducing oxidative stress in brain.

scholarly journals The Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibits Cell Proliferation Induced by Estradiol on the Uterus and Vagina of Ovariectomized Female Wistar Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Marius Trésor Wego Kamgaing ◽  
Marie Alfrede Mvondo ◽  
Sylviane Laure Poualeu Kamani ◽  
Stéphane Minko Essono ◽  
Sylvie Lea Wansi Ngnokam
Keyword(s):  
Cell Proliferation ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Estradiol Valerate ◽  
Control Groups ◽  
Natural Substances ◽  
Ovx Rats ◽  
Female Wistar Rats ◽  
Potential Alternative ◽  
Dacryodes Edulis

Proliferation is a cellular process strongly linked to the genesis of cancer. Natural substances with antiproliferative activities are currently potential alternatives in the treatment of cancers. Dacryodes edulis, for instance, is a medicinal plant traditionally used in the treatment of cancer. Scientific studies have reported the antioxidant activity of this plant. In addition, the presence of prostate cancer chemopreventive polyphenols was reported in D. edulis extracts. Therefore, this study was aimed to evaluate the effects of the aqueous extract of D. edulis leaves on cell proliferation induced by estradiol in ovariectomized female Wistar rats. In this regard, ovariectomized (OVX) rats were cotreated with estradiol valerate (E2V) (0.75 mg/kg) and the aqueous extract of D. edulis leaves. Control groups received either the vehicle (sham-operated animals and the OVX control), E2V (0.75 mg/kg) only, or E2V (0.75 mg/kg) and tamoxifen (10 mg/kg). Treatments were administered orally for 3 consecutive days, and animals were sacrificed thereafter. Epithelial heights of the uterus and vagina were assessed. Uterine levels of total cholesterol and estradiol were determined as well. Results showed that the aqueous extract of D. edulis leaves reversed the effects of estradiol as it reduced uterine weight ( p < 0.05 ), uterine ( p < 0.05 ), and vaginal ( p < 0.001 ) epithelium heights. This antiproliferative effect of D. edulis was associated with reduced tissue (uterine) levels of estradiol ( p < 0.001 ). These results suggest that the aqueous extract of D. edulis leaves could be a potential alternative treatment for proliferation-related diseases.

scholarly journals Reduction of Phosphorylated Synapsin I (Ser-553) Leads to Spatial Memory Impairment by Attenuating GABA Release after Microwave Exposure in Wistar Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95503 ◽  
Author(s):  
Simo Qiao ◽  
Ruiyun Peng ◽  
Haitao Yan ◽  
Yabing Gao ◽  
Changzhen Wang ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Impairment ◽  
Wistar Rats ◽  
Gaba Release ◽  
Synapsin I ◽  
Microwave Exposure

scholarly journals Effect of Achillea millefolium aqueous extract on memory deficit and anxiety caused by stroke in ovariectomized rats

2019 ◽  
Vol 8 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Gila Pirzad Jahromi ◽  
Esmail Imani ◽  
Mohammad Nasehi ◽  
Alireza Shahriari
Keyword(s):  
Cerebral Ischemia ◽  
Aqueous Extract ◽  
Memory Impairment ◽  
Develop Breast Cancer ◽  
Ovariectomized Rats ◽  
Menopausal Woman ◽  
Artery Ligation ◽  
Plus Maze ◽  
Female Wistar Rats ◽  
Restoration Effect

Introduction: Some studies indicated that the decrease of estrogen level in menopausal woman results in increasing the risk of stroke. Although estrogen is a neuroprotective factor, high consumption of this compound may develop breast cancer and endometriosis. The present study investigated the effect of Achilles millefolium extract, containing estrogenlike compounds, on memory impairment and anxiogenic-like behaviors caused by cerebral ischemia in ovariectomized rats. Methods: Permanent middle cerebral artery ligation was performed, as a model for studying postmenopausal condition, in 48 female Wistar rats weighing 200-250 g. The aqueous extract of A. millefolium was prepared and gavaged for 4 weeks after inducing cerebral ischemia. Memory and anxiety-like behavior assessments were evaluated by step-through and elevated plus maze apparatus, respectively. Result: According to the results, cerebral ischemia in ovariectomized rats induced amnesia and anxiogenic-like behaviors which were restored by 7 mg/kg of A. millefolium aqueous extract. Furthermore, inactivation of estrogen receptors (ERs) by tamoxifen (100 µg/kg, intraperitoneally) blocked the restoration effect of A. millefolium on behaviors induced by cerebral ischemia. Conclusion: It could be concluded that, oral administration of A. millefolium extract is able to restore memory impairment and anxiogenic-like behaviors induced by ischemia via ERs in ovariectomized rat.

Mammillary body alterations and spatial memory impairment in Wistar rats with thioacetamide-induced cirrhosis

2008 ◽  
Vol 1233 ◽  
pp. 185-195 ◽  
Author(s):  
Marta Méndez ◽  
Magdalena Méndez-López ◽  
Laudino Lopez ◽  
María A. Aller ◽  
Jaime Arias ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Impairment ◽  
Wistar Rats ◽  
Mammillary Body

scholarly journals Spatial Memory Impairment Is Associated with Hippocampal Insulin Signals in Ovariectomized Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104450 ◽  
Author(s):  
Fang Wang ◽  
Yan-Feng Song ◽  
Jie Yin ◽  
Zi-Hua Liu ◽  
Xiao-Dan Mo ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Impairment ◽  
Ovariectomized Rats

scholarly journals HISTOLOGICAL VARIANCES OF MORINGA OLIFERA ON THE KIDNEY OF ADULT WISTAR RATS

2021 ◽  
pp. 36-38
Author(s):  
ADETUNJI OPEYEMI ADEBOLA ◽  
OYEWO OLUWATOYIN ◽  
ADETUNJI IYABODE TOYIN ◽  
NWOBI NNENA LINDA
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
The Body ◽  
Damage Effect ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
The One ◽  
Convoluted Tubules ◽  
Crude Aqueous Extract

Aim and Objectives: Demonstrating the exact quantity of Moringa oleifera (MO) that will cure any hepatocyte diseases and the one that can harm the hepatocytes of the Adult Wistar rats. Methods: Twenty (20) adult Wistar rats (both sex) were used for the study (caged based on same sex to avoid mating and pregnancy) and were randomly assigned into four groups (n=5); A-Control, B-250 mg/body weight (BW) of MO, C-500 mg/BW of MO, and D-750 mg/BW of MO orally. Result: The crude aqueous extract of MO Lam, shows insignificant increased in BW at the 1st week of administration which latter dropped little by little doing the weeks of the administration in groups (B, C, and D) rats, by comparing (p<0.05) to the control group after MO administration, the organ (Kidneys) shows a significant difference between the kidneys (left and right kidneys) in relation to the control group rats. MO increases the weight of the animals morphologically by comparing the weight of the animals before and after administration. Histological sections shows a normal Glomerulli, Peri-Glomerular Space, Convoluted Tubules, and Interstitium, after administration of the Crude Aqueous Extract of MO lame in terms with the control group rats. Conclusion: MO is a good herb that has no damage effect on the body and hepatocytes but of more beneficial.

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

2020 ◽  
Author(s):  
Heresh Moridi ◽  
Abdolrahman Sarihi ◽  
Elahe Habibitabar ◽  
Hossein Shateri ◽  
Iraj Salehi ◽  
...  
Keyword(s):  
Spatial Memory ◽  
High Fat Diet ◽  
Memory Impairment ◽  
Metabotropic Glutamate Receptors ◽  
Reference Memory ◽  
Memory Deficit ◽  
Male Rats ◽  
High Fat ◽  
Target Zone ◽  
Spatial Memory Deficit

Abstract Background High-fat diets (HFDs) adversely influence glutamate metabolism and neurotransmission. The precise role of the group II metabotropic glutamate receptors (mGluR2/3) antagonist on spatial memory deficit following consumption of HFD has not yet been clarified. Therefore, in this study, we examined the effects of post-training administration of mGluR2/3 antagonism; LY341495 on spatial memory in rats fed with HFD by using Morris Water Maze (MWM) task. Intraperitoneal injection (i.p) injection of LY341495 was done 30 minutes before retention test. Results Our results showed that HFD did not have any effect on memory acquisition. There were not significant differences in escape latency and swimming distance between experimental groups (P>0.05, Two-way ANOVA). Our finding showed that consumption of an HFD leads to spatial memory impairment. There were significant differences in time spent in target zone between experimental groups [F (3, 20) = 7.031, P=0.0021, one-way ANOVA]. Also, LY341495 improved HFD-induced reference memory impairment. HFD animals treated with LY341495 spent more time in the target zone in compare with HFD animals (P= 0.0449). Conclusions Our results suggested that prolonged consumption of high-fat diet has no effects on the acquisition of spatial learning, but can impair memory retention of the adult male rats and post-training administration of LY341495 can improve HFD-induced reference memory impairment.

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