scholarly journals Investigation of Magnetic Nanoparticle Motion under a Gradient Magnetic Field by an Electromagnet

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Weizhong Wei ◽  
Zhen Wang
Keyword(s):  
Magnetic Field ◽  
Finite Element ◽  
Electromagnetic Field ◽  
Magnetic Nanoparticles ◽  
Particle Motion ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Magnetic Particles ◽  
Magnetic Force ◽  
Gradient Magnetic Field

Finite element numerical simulations were carried out in 2D geometry to calculate the magnetic force on magnetic nanoparticles under a specially fabricated electromagnet. The particle motion was modeled by a system of ordinary differential equations. The snapshots of trajectories of 4000 MNPs with and without magnetic field were analyzed and qualitatively found to be in agreement with camera visualizations of MNP movement in a container. The results of the analysis could be helpful for the design of electromagnetic field and motion analysis of magnetic particles for the delivery of magnetic materials in biomedical applications.

scholarly journals Importance of Basset History Force for the Description of Magnetically Driven Motion of Magnetic Particles in Air

2020 ◽  
Vol 20 (2) ◽  
pp. 50-58 ◽  
Author(s):  
Andrej Krafcik ◽  
Peter Babinec ◽  
Melania Babincova ◽  
Ivan Frollo
Keyword(s):  
Magnetic Field ◽  
Magnetic Particles ◽  
Magnetic Force ◽  
Magnetic Particle ◽  
Homogeneous Magnetic Field ◽  
Gradient Magnetic Field ◽  
Driven Systems ◽  
Long Time ◽  
History Force ◽  
Stokes Force

AbstractLungs are used as an attractive possibility for administration of different therapeutic substances for a long time. An innovative method of such administration widely studied nowadays is the application of aerosolized magnetic particles as the carriers to the lungs in the external non-homogeneous magnetic field. For these reasons we have studied dynamics of such a system on a level of particle trajectory in air in the presence of magnetic force as a driving force exerted on micrometric magnetic particle. On two typical examples of magnetically driven systems—motion of magnetic particle in a gradient magnetic field and cyclotron-like motion of a charged particle in homogeneous magnetic field in microscale, where the external accelerating forces are very large and the relevant time scale is of the order from fraction of milliseconds to seconds, we have examined the importance of these forces. As has been shown, for particles with high initial acceleration, not only the commonly used Stokes force but also the Basset history force should be used for correct description of the motion.

Simulated Clustering Dynamics of Colloidal Magnetic Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Frederik Laust Durhuus ◽  
Lau Halkier Wandall ◽  
Mathias Hoeg Boisen ◽  
Mathias Kure ◽  
Marco Beleggia ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Bottom Up ◽  
Novel Materials ◽  
Nanoparticle Clusters ◽  
Clustering Dynamics

Magnetically guided self-assembly of nanoparticles is a promising bottom-up method to fabricate novel materials and superstructures, such as, for example, magnetic nanoparticle clusters for biomedical applications. The existence of assembled...

THE ROTATIONAL EFFECT OF MAGNETIC PARTICLES ON CELLULAR APOPTOSIS BASED ON FOUR ELECTROMAGNET FEEDBACK CONTROL SYSTEM

2021 ◽  
pp. 2150045
Author(s):  
Jia Ji Lee ◽  
Chang Hong Pua ◽  
Misni Misran ◽  
Poh Foong Lee
Keyword(s):  
Magnetic Field ◽  
Electromagnetic Field ◽  
Control System ◽  
Feedback Control ◽  
Cell Apoptosis ◽  
Magnetic Particles ◽  
Drug Carriers ◽  
Feedback Control System ◽  
Rotational Effect ◽  
Dynamic Magnetic Field

Objectives: Magnetic drug targeting offers the latest popular alternative option to deliver magnetic drug carriers into targeting region body parts through manipulation of an external magnetic field. However, the effectiveness of using an electromagnetic field to manipulate and directing magnetic particles is yet to be established. Methods: In this paper, a homemade cost-effective electromagnet system was built for the purpose of studying the control and directing the magnetic drug carriers. The electromagnet system was built with four electromagnetic sources and tested the capability in directing the particles’ movement in different geometry patterns. Besides that, the creation of the self-rotation of individual magnetic particle clusters was achieved by using fast switching between magnetic fields. This self-rotation allows the possibility of cell apoptosis study to carry out. The system was constructed with four electromagnets integrated with a feedback control system and built to manipulate a droplet of commercially available iron (II, III) oxide nanoparticles to steer the magnetic droplet along different arbitrary trajectories (square, circle, triangle, slanted line) in 2-dimensional. Results: A dynamic magnetic field of 25 Hz was induced for magnetic nanoparticles rotational effect to observe the cell apoptosis. A profound outcome shows that the declining cell viability of the cell lines by 40% and the morphology of shrinking cells after the exposure of the dynamic magnetic field. Conclusion: The outcome from the pilot study gives an idea on the laboratory setup serves as a fundamental model for studying the electromagnetic field strength in applying mechanical force to target and to rotate for apoptosis on cancer cell line study.

scholarly journals Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

2018 ◽  
Author(s):  
Mahendran Subramanian ◽  
Arkadiusz Miaskowski ◽  
Stuart Iain Jenkins ◽  
Jenson Lim ◽  
Jon Dobson
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Field Gradient ◽  
Biomedical Applications ◽  
Magnetic Field Gradient ◽  
Field Source ◽  
Remote Manipulation ◽  
Cancer Cell Death ◽  
The Magnetic Field

AbstractThe manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been demonstrated to be useful in various biomedical applications. Some techniques have evolved utilizing this non-invasive external stimulus but the scientific community widely adopts few, and there is an excellent potential for more novel methods. The primary focus of this study is on understanding the manipulation of MNPs by a time-varying static magnetic field and how this can be used, at different frequencies and displacement, to manipulate cellular function. Here we explore, using numerical modeling, the physical mechanism which underlies this kind of manipulation, and we discuss potential improvements which would enhance such manipulation with its use in biomedical applications, i.e., increasing the MNP response by improving the field parameters. From our observations and other related studies, we infer that such manipulation depends mostly on the magnetic field gradient, the magnetic susceptibility and size of the MNPs, the magnet array oscillating frequency, the viscosity of the medium surrounding MNPs, and the distance between the magnetic field source and the MNPs. Additionally, we demonstrate cytotoxicity in neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells in vitro. This was induced by incubation with MNPs, followed by exposure to a magnetic field gradient, physically oscillating at various frequencies and displacement amplitudes. Even though this technique reliably produces MNP endocytosis and/or cytotoxicity, a better biophysical understanding is required to develop the mechanism used for this precision manipulation of MNPs, in vitro.

Sinusoidal magnetic field stimulates magnetosome formation and affects mamA, mms13, mms6, and magA expression in Magnetospirillum magneticum AMB-1

2008 ◽  
Vol 54 (12) ◽  
pp. 1016-1022 ◽  
Author(s):  
Xiaoke Wang ◽  
Likun Liang ◽  
Tao Song ◽  
Longfei Wu
Keyword(s):  
Magnetic Field ◽  
Geomagnetic Field ◽  
Biomedical Applications ◽  
Magnetic Particles ◽  
Industrial Sector ◽  
Magnetic Pole ◽  
Variable Intensity ◽  
New Approach ◽  
Sinusoidal Magnetic Field ◽  
Magnetospirillum Magneticum

Magnetic particles are currently one of the most important materials in the industrial sector, where they have been widely used for biotechnological and biomedical applications. To investigate the effects of the imposed magnetic field on biomineralization in Magnetospirillum magneticum AMB-1 and to suggest a new approach that enhances formation of magnetosomes, cultures inoculated with either magnetic or nonmagnetic precultures were incubated under a sinusoidal magnetic field or geomagnetic field. The results showed that the sinusoidal magnetic field up-regulated mms6 expression in the cultures inoculated with magnetic cells, and magA, mms6, and mamA expression in the cultures inoculated with nonmagnetic cells. The applied sinusoidal magnetic field could block cell division, which could contribute to a decrease in the OD600 values and an increase in the coefficient of magnetism values of the cultures, which could mean that the percentage of mature magnetosome-containing bacteria was increased. The linearity of magnetosome chains was affected, but the number of magnetic particles in cells was increased when a sinusoidal magnetic field was applied to the cultures. The results imply that the variable intensity and orientation of the sinusoidal magnetic field resulted in magnetic pole conversion in the newly forming magnetic particles, which could affect the formation of magnetic crystals and the arrangement of the adjacent magnetosome.

scholarly journals Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16470-16480 ◽  
Author(s):  
Hyun-Chul Kim ◽  
Eunjoo Kim ◽  
Sang Won Jeong ◽  
Tae-Lin Ha ◽  
Sang-Im Park ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Magnetic Nanoparticle ◽  
Polymeric Micelles ◽  
Alternating Magnetic Field ◽  
Rapid Release

The cytotoxicity of magnetic nanoparticles-conjugated polymeric micelles encapsulated with an anticancer drug on cancer cells was enhanced by the synergistic effect of heat and the rapid release of the drug under an alternating magnetic field.

Simulation research on low frequency sound absorption of monostable metamaterials

2021 ◽  
Vol 263 (6) ◽  
pp. 648-652
Author(s):  
Tuo Xing ◽  
Xianhui Li ◽  
Xiaoling Gai ◽  
Zenong Cai ◽  
Xiwen Guan
Keyword(s):  
Magnetic Field ◽  
Finite Element ◽  
Theoretical Model ◽  
Finite Element Simulation ◽  
Sound Absorption ◽  
Magnetic Force ◽  
Low Frequency ◽  
Low Frequencies ◽  
Element Simulation ◽  
Simulation Results

The monostable acoustic metamaterial is realized by placing a flexible panel with a magnetic proof mass in a symmetric magnetic field. The theoretical model of monostable metamaterials has been proposed. The method of finite element simulation is used to verify the theoretical model. The magnetic force of the symmetrical magnetic field is simplified as the relationship between force and displacement, acting on the mass. The simulation results show that as the external magnetic force increases, the peak sound absorption shifts to low frequencies. The theoretical and finite element simulation results are in good agreement.

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