scholarly journals Simultaneous Determination of Night Effective Constituents and Correlation Analysis of Multiconstituents and Antiplatelet Aggregation Bioactivity In Vitro in Chuanxiong Rhizoma Subjected to Different Decoction Times

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Peihua Zhang ◽  
Linming Chen ◽  
Xiaoxiao Wang ◽  
Jinpei Chen ◽  
Shungui Xu ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Ferulic Acid ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Mutual Transformation ◽  
Antiplatelet Aggregation ◽  
Effective Components ◽  
Senkyunolide I

Several effective constituents, such as vanillin, ferulic acid, senkyunolide I, senkyunolide H, coniferyl ferulate, Z-ligustilide, butylphthalide, senkyunolide A, and levistilide A, are unstable and possess mutual transformation relationships in Chuanxiong Rhizoma (CR). Traditional Chinese medicine mainly involves decoction, and the content of effective constituents and antiplatelet aggregation bioactivity (AAB) in CR may vary with different decoction time (10 min, 20 min, 30 min, 40 min, 50 min, and 60 min). Here, we showed that coniferyl ferulate and levistilide A were detected in CR material, but not in the decoction. The effective components possessed transformation and degradation in CR decoction of different times. The effective components and the strength of AAB at 10 and 20 minutes were the strongest, followed by 30–50 minutes, and 60 minutes were the weakest by analysis of SIMCA-PLS in CR decoction of different times. In the Pearson correlation analysis, there were correlations (P<0.05) between effective components, which were ferulic acid and senkyunolide I (coefficient was 0.976), ferulic acid and senkyunolide H (coefficient was 0.972), senkyunolide I and senkyunolide H (coefficient was 0.982), senkyunolide A and butylphthalide (coefficient was 0.974), senkyunolide A and Z-ligustilide (coefficient was 0.947), and butylphthalide and Z-ligustilide (coefficient was 0.993). Effective components (ferulic acid, senkyunolide I, and senkyunolide H) and AAB were correlated and the Pearson correlation coefficients were respectively 0.965, 0.973, and 0.999. In the stepwise regression analysis, senkyunolide H and senkyunolide I were correlated with AAB (P<0.05). Senkyunolide H (H) was positively correlated with AAB, senkyunolide I (I) was negatively correlated with AAB, and its expression was AAB = 1.187 ∗ H − 0.199 ∗ I − 0.422. These findings indicate that there are some correlations between effective components and AAB in CR.

scholarly journals Influence of Macrotexture and Microtexture on the Skid Resistance of Aggregates

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Bowen Guan ◽  
Jiayu Wu ◽  
Chao Xie ◽  
Jianhong Fang ◽  
Haile Zheng ◽  
...  
Keyword(s):  
Fractal Dimension ◽  
Correlation Analysis ◽  
Surface Treatment ◽  
Critical Point ◽  
Friction Surface ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Skid Resistance ◽  
Mean Square

This article intends to study the influence of macrotexture and microtexture on the skid resistance of four types of aggregates. For this purpose, fractal dimension (D), root mean square height (Rq), and Polished Stone Value (PSV) were tested. The Pearson correlation coefficients between PSV and D or Rq in the interval of different polishing cycles were calculated and analyzed with correlation analysis. The relationships between PSV and Rq were also established. The results showed that the PSV development was approximately divided into 3 stages including accelerated attenuation stage, decelerated attenuation stage, and stabilization stage. There is a critical point of the entire polishing cycles. When the number of the polishing cycles exceeds this critical point, microtexture replaces macrotexture to play a major role in the skid resistance of aggregates. In the accelerated attenuation stage, macrotexture plays a major role in the skid resistance of aggregates. In the decelerated attenuation stage and stabilization stage, microtexture gradually plays a major role in the skid resistance of aggregates. Because of roughest microtexture in the stabilization stage, bauxite can provide the highest levels of skid resistance for high friction surface treatment over the long-term period.

scholarly journals Prediction of crude protein digestibility of animal by-product meals for dogs by the protein solubility in pepsin method

2014 ◽  
Vol 3 ◽  
Author(s):  
Iris M. Kawauchi ◽  
Nilva K. Sakomura ◽  
Cristiana F. F. Pontieri ◽  
Aline Rebelato ◽  
Thaila C. Putarov ◽  
...  
Keyword(s):  
Crude Protein ◽  
Pearson Correlation ◽  
Protein Solubility ◽  
Correlation Coefficients ◽  
Basal Diet ◽  
Protein Digestibility ◽  
Large Variability ◽  
The Relationship

AbstractAnimal by-product meals have large variability in crude protein (CP) content and digestibility. In vivo digestibility procedures are precise but laborious, and in vitro methods could be an alternative to evaluate and classify these ingredients. The present study reports prediction equations to estimate the CP digestibility of meat and bone meal (MBM) and poultry by-product meal (PM) using the protein solubility in pepsin method (PSP). Total tract CP digestibility of eight MBM and eight PM samples was determined in dogs by the substitution method. A basal diet was formulated for dog maintenance, and sixteen diets were produced by mixing 70 % of the basal diet and 30 % of each tested meal. Six dogs per diet were used to determine ingredient digestibility. In addition, PSP of the MBM and PM samples was determined using three pepsin concentrations: 0·02, 0·002 and 0·0002 %. The CP content of MBM and PM ranged from 39 to 46 % and 57 to 69 %, respectively, and their mean CP digestibility by dogs was 76 (2·4) and 85 (2·6) %, respectively. The pepsin concentration with higher Pearson correlation coefficients with the in vivo results were 0·0002 % for MBM (r 0·380; P = 0·008) and 0·02 % for PM (r 0·482; P = 0·005). The relationship between the in vivo and in vitro results was better explained by the following equations: CP digestibility of MBM = 61·7 + 0·2644 × PSP at 0·0002 % (P = 0·008; R2 0·126); and CP digestibility of PM = 54·1 + 0·3833 × PSP at 0·02 % (P = 0·005; R2 0·216). Although significant, the coefficients of determination were low, indicating that the models were weak and need to be used with caution.

Determination of Neutral Urinary 17-Oxosteroids with Hydroxide of Hyamine 1O-X in the Zimmermann Reaction

1967 ◽  
Vol 13 (9) ◽  
pp. 717-733 ◽  
Author(s):  
Solveig Bjerre ◽  
Rose Kita
Keyword(s):  
Incubation Temperature ◽  
Potassium Hydroxide Solution ◽  
Correlation Coefficients ◽  
Ethylene Dichloride ◽  
Laboratory Personnel ◽  
Hydroxide Solution ◽  
Modified Method ◽  
Color Development

Abstract A modified method for 17-oxosteroid determination is described. The organic base, hydroxide of Hyamine lO-X,° which is stable in methanol, has replaced the unstable ethanolic potassium hydroxide solution in the Zimmermann reaction. Maximal color development was studied by varying incubation temperature, time, m-dinitrobenzene, and concentration of hydroxide of Hyamine 10-X. An incubation temperature of 37° for 30 min., with 1% m-dinitrobenzene in 1 M Hyamine 10-X hydroxide solution, gave close to maximal color. The major urinary 17-oxosteroids, dehydroepiandrosterone, androsterone, and etiocholanolone, gave similar chromogenic values. However, C3 and C20 oxosteroids produced some color in the Zimmermann reaction, and thus if present in large amounts, interfere. The interference in vitro of 35 drugs was tested, and several drugs were found to interfere. An essentially pigment-free urinary extract was obtained during the washing step, by addition of water to the ethylene dichloride extract containing sodium hydroxide pellets. Comparative 17-oxosteroid studies of urine specimens from laboratory personnel and from patients were performed, based on absorbance at a single wavelength (520 mµ) and at three wavelengths (Allen correction). Correlation coefficients for the laboratory personnel were .983 for females and .996 for males; for the patients, .974 and .975, respectively.

scholarly journals Design, Synthesis, andIn VitroAntiplatelet Aggregation Activities of Ferulic Acid Derivatives

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Peng-Xuan Zhang ◽  
Hang Lin ◽  
Cheng Qu ◽  
Yu-Ping Tang ◽  
Nian-Guang Li ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Target Compound ◽  
Design Synthesis ◽  
Antiplatelet Aggregation ◽  
Aggregation Activity ◽  
New Compounds

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. Thein vitroantiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound7fhad potent antiplatelet aggregation activity with its IC5027.6 μmol/L, and7fcan be regarded as a novel potent antiplatelet aggregation candidate.

scholarly journals Co-culture with leukemia cells decreases proliferation and increases chemoprotective capacity of normal mesenchymal stromal cells

2020 ◽  
Author(s):  
Ruixia Hou ◽  
Wanfang Yang ◽  
Yaofang Zhang ◽  
Xiuhua Chen ◽  
Fanggang Ren ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Healthy Donor ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Cell Types ◽  
Leukemia Cells ◽  
Cell Counts ◽  
Functional Components

Abstract Background Bone marrow mesenchymal stromal cells (BM-MSCs) are essential structural and functional components of the BM microenvironment and play an important role in acute myeloid leukemia (AML) pathogenesis. BM-MSCs isolated from AML patients (AML-MSCs) show distinct signatures from normal BM-MSCs. However, the exact abnormalities of AML-MSCs and the origin of these abnormalities are still unknown.Methods In this study, we evaluated the proliferative activity of AML-MSCs, and the influence of leukemia cells (LCs) on BM-MSCs. These two cell types were co-cultured using an in vitro co-culture system, and the biological functions of AML-MSCs, healthy donor derived MSCs (HD-MSCs), and LC-treated HD-MSCs (LCtrHD-MSCs) were compared by flow cytometry, and CCK-8 and chemotaxis assays. Student t-test (between two groups) and one-way ANOVA (more than 2 groups) were used to compare differences. Pearson correlation coefficients were used to assess correlations between two factors.Results AML-MSCs display a significant proliferative deficiency, which correlates with primary leukemic blast cell counts but not with patients’ age. Inhibition of BM-MSC proliferation could be induced by leukemia cells through direct contact. Co-cultured leukemia cells also increase expression of several inflammatory cytokines, and chemokines in BM-MSCs. Furthermore, LCtrHD-MSCs reduced apoptosis, and increased migration and chemoresistance in co-cultured AML cells, comparable with AML-MSCs.Conclusions Our results showed that leukemia cells can induce healthy donor derived BM-MSCs to exhibit AML-MSC-like characteristics and indicated that AML-MSC abnormalities may be partly induced by leukemia cells.

scholarly journals Influence of Different Enamel Shades and Thickness on Chroma and Value of Dentin Vita Shade: An in vitro Comparative Assessment Study

2015 ◽  
Vol 16 (4) ◽  
pp. 304-309 ◽  
Author(s):  
N Meena ◽  
Deepak Mehta ◽  
Noor Saira Wajid Najma Hajira ◽  
P Ashwini ◽  
HL Usha
Keyword(s):  
Composite Resin ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Comparative Assessment ◽  
Optimum Thickness ◽  
Assessment Study ◽  
Natural Teeth ◽  
Post Hoc ◽  
One Way Anova

ABSTRACT Background The aim of the present study is to determine the influence of different enamel shades of various thickness on chroma and value of vita shade of dentin. Materials and methods Three enamel composite resin shades (Enamel white, grey and neutral) and one dentin shade (A2) from Amelogen Plus (Ultradent) was used. Ninety Enamel disk specimens of 0.5, 0.75 and 1 mm thickness and 10 mm in diameter for each shade and 90 dentin disk specimens of 2 mm in thickness and 10 mm in diameter was used for the study. The spectrophotometric values of the dentin shade with and without enamel specimens were recorded and the values were converted to CIE L*a*b values. Results Statistical analysis was done using Pearson correlation coefficients to verify the effect of thickness on Chroma and value, and the significance was evaluated by one-way ANOVA and Tukey post hoc test. Two way ANOVA and Tukey post hoc was done to verify the variation within the groups. Results revealed a significant positive correlation between thickness and chroma and a negative correlation between thickness and value. There was a statistically significant variation in between the groups. Conclusion All groups produced a significant increase in chroma with increase in thickness of enamel shade upto a thickness of 0.75 mm after which the behavior of each shade was erratic. Hence, the optimum thickness would be 0.75 mm. All groups produced a significant decrease in value with increase in thickness of enamel shade. Enamel white produced the greatest reduction in value, enamel neutral the least and enamel grey demonstrated an intermediate result. Clinical significance There is a need to have a knowledge of the effect on chroma and value when dentin is layered with different enamel shades, it is also important to understand the effect of these enamel shades at different thicknesses to better control the color and reproduce esthetic simulating natural teeth. How to cite this article Hajira NSWN, Mehta D, Ashwini P, Meena N, Usha HL. Influence of Different Enamel Shades and Thickness on Chroma and Value of Dentin Vita Shade: An in vitro Comparative Assessment Study. J Contemp Dent Pract 2015;16(4):304-309.

A Separation Method of 3D Engineering Surface with Correlation Analysis of NSCT Sub-Bands

2012 ◽  
Vol 248 ◽  
pp. 443-449
Author(s):  
Ming Wei Chui ◽  
You Qian Feng ◽  
Wei Wang ◽  
Xiao Dong Xu ◽  
Zheng Chao Li
Keyword(s):  
Correlation Analysis ◽  
Surface Topography ◽  
Pearson Correlation ◽  
Correlation Method ◽  
Correlation Coefficients ◽  
Separation Method ◽  
Real Surface ◽  
Nonsubsampled Contourlet Transform ◽  
Filtering Method ◽  
Frequency Components

The 3D engineering surfaces are comprised of a range of spatial frequency components, such as form, waviness and roughness. Filtering techniques are commonly adopted to separate the different components. To overcoming the shortcomings of traditional filtering method, a new separation method is proposed with the correlation analysis of sub-bands in nonsubsampled contourlet transform (NSCT) domain. The 3D engineering surface topography is decomposed into different sub-bands by NSCT, and the correlation coefficients of NSCT sub-bands with its parent and children sub-bands are calculated by Pearson correlation method. Then the roughness, waviness and form of 3D real surface topography are restructured respectively by the inverse NSCT based on the NSCT sub-bands which belong to different components. Finally, a group of 3D engineering surfaces are separated into different components, and the result shown that the proposed method can separate 3D engineering surface effectively.

Heritability of in vitro characteristics and correlation with field performance in Pinusradiata

1995 ◽  
Vol 25 (12) ◽  
pp. 1944-1952 ◽  
Author(s):  
Ben A. Bergmann ◽  
Anne-Marie Stomp ◽  
Sue D. Carson
Keyword(s):  
Tissue Culture ◽  
Seed Size ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Field Performance ◽  
Adventitious Shoot ◽  
Field Trials ◽  
Shoot Production ◽  
Almost All

Twenty-nine full-sib crosses were used in an in vitro adventitious shoot production trial with Pinusradiata D. Don. Analyses with four pairs of reciprocal crosses showed that seed-size effects are significant for seed weight prior to tissue culture and embryo weight after 6 days in vitro. However, no significant influence of initial seed size was found on any other interim tissue-culture trait or on final shoot production. Narrow-sense heritabilities, calculated using nine half-sib families each comprising two full-sib crosses, were high for most tissue culture traits. For number of shoots per embryo they were 0.53 ± 0.22 based on individuals and 0.94 based on family means. Subsets of the families used in the tissue-culture study were represented in two field trials. One included parents of 11 of the control-pollinated families, and one included offspring from 13 of the control-pollinated families. Nine families were common to both field trials. Pearson correlation coefficients were determined between each of 13 in vitro traits and six field characteristics measured in one trial and seven traits in the other trial (five traits in common between the two field trials). Almost all correlations were nonsignificant. The significant correlations found were fewer than the number to be expected by chance alone when calculating such a large number of correlations. Thus, this study provides no evidence for significant associations between the in vitro traits measured, including frequency of highly proliferative embryos and shoot production per embryo, and the field characteristics assessed, including diameter, straightness, malformation, branch habit, needle retention, percent acceptable stems, Dothistroma resistance, and pilodyn rating.

scholarly journals Provider–patient communication and hospital ratings: perceived gaps and forward thinking about the effects of COVID-19

2020 ◽  
Author(s):  
Alan T Belasen ◽  
Jane Oppenlander ◽  
Ariel R Belasen ◽  
Attila J Hertelendy
Keyword(s):  
Correlation Analysis ◽  
Psychiatric Patients ◽  
Pearson Correlation ◽  
Descriptive Analysis ◽  
Healthcare Providers ◽  
Correlation Coefficients ◽  
Composite Measures ◽  
The Usa ◽  
Willingness To Recommend ◽  
Operational Issues

Abstract Objectives To highlight clinical and operational issues, identify factors that shape patient responses in Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) and test the correlations between composite measures and overall hospital ratings. Design Responses to HCAHPS surveys were used in a partial correlation analysis to ascertain those HCAHPS composite measures that most relate to overall hospital ratings. The linear mean scores for the composite measures and individual and global items were analyzed with descriptive analysis and correlation analysis via JMP and SPSS statistical software. Setting HCAHPS is a patient satisfaction survey required by the Centers for Medicare and Medicaid Services for hospitals in the USA. The survey is for adult inpatients, excluding psychiatric patients. Participants 3382 US hospitals. Intervention None. Main Outcome Measure Pearson correlation coefficients for the six composite measures and overall hospital rating. Results The partial correlations for overall hospital rating and three composite measures are positive and moderately strong for care transition (0.445) and nurse communication (0.369) and weak for doctor communication (0.066). Conclusions From a health policy standpoint, it is imperative that hospital administrators stress open and clear communication between providers and patients to avoid problems ranging from misdiagnosis to incorrect treatment. Additional research is needed to determine how the coronavirus of 2019 pandemic influences patients’ perceptions of quality and willingness to recommend hospitals at a time when nurses and physicians show symptoms of burnout due to heavy workloads and inadequate personal protective equipment.

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