scholarly journals Release Behavior of Folic Acid Grafted Hollow Hydroxyapatite as Drug Carrier

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Qing Liu ◽  
Wenjing Guo ◽  
Mei Yang ◽  
Kejie Wang ◽  
Weijun Liu ◽  
...  

Based on the formation of carbodiimide compounds between carboxyl and primary amines, hollow microspheres arising from the folic acid (folate-FA) grafted onto the surface of the modified hydroxyapatite were successfully prepared. The hollow morphology and composition of the FA-grafted hydroxyapatite microspheres were confirmed by scanning electron microscopy (SEM) and other characterizations. Brunauer-Emmett-Teller (BET) assay revealed the specific surface area and average pore size of the microspheres were 34.58m2/g and 17.80 nm, respectively. As a drug carrier, the kinetic investigation of doxorubicin (DOX) loaded shows that the adsorbed behavior of drug on the adsorbent is more suitable to be described with pseudo-first-order model. Furthermore, the release rate can reach 83% at pH 5.7, which is greater than the release of 39% at pH 7.4, indicating an excellent performance of controlled drug release for response pH. The release mechanism of DOX coincides with Fickian diffusion as a result of Korsmeyer-Peppas model analysis and the release phenomena can be well explained by Fickian diffusion second law.

Author(s):  
DHARMENDER PALLERLA ◽  
SUMAN BANOTH ◽  
SUNKARI JYOTHI

Objective: The objective of this study was to formulate and evaluate the Curcumin (CUR) encapsulated sodium alginate (SA)/badam gum (BG)/kaolin (KA) microbeads for controlled drug release studies. Methods: The fabricated microbeads were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), and scanning electron microscopy (SEM). Dynamic swelling studies and in vitro release kinetics were performed in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 °C. Results: FTIR confirms the formation of microbeads. DSC studies confirm the polymorphism of CUR in drug loaded microbeads which indicate the molecular level dispersion of the drug in the microbeads. SEM studies confirmed the microbeads are spherical in shape with wrinkled and rough surfaces. XRD studies reveal the molecular dispersion of CUR and the presence of KA in the developed microbeads. In vitro release studies and swelling studies depend on the pH of test media, which might be suitable for intestinal drug delivery. The % of drug release values fit into the Korsmeyer-Peppas equation and n values are obtained in the range of 0.577-0.664, which indicates that the developed microbeads follow the non-Fickian diffusion drug release mechanism. Conclusion: The results concluded that the CUR encapsulated microbeads are potentially good carriers for controlled drug release studies.


Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 179 ◽  
Author(s):  
Shiao-Wen Tsai ◽  
Wen-Xin Yu ◽  
Pai-An Hwang ◽  
Sheng-Siang Huang ◽  
Hsiu-Mei Lin ◽  
...  

Hydroxyapatite (HAp) is the main inorganic component and an essential part of hard bone and teeth. Due to its excellent biocompatibility, bioactivity, and osteoconductivity, synthetic HAp has been widely used as a bone substitute, cell carrier, and therapeutic gene or drug carrier. Recently, numerous studies have demonstrated that strontium-substituted hydroxyapatite (SrHAp) not only enhances osteogenesis but also inhibits adipogenesis in mesenchymal stem cells. Mesoporous SrHAp has been successfully synthesized via a traditional template-based process and has been found to possess better drug loading and release efficiencies than SrHAp. In this study, strontium-substituted hydroxyapatite-CaO-CaCO3 nanofibers with a mesoporous structure (mSrHANFs) were fabricated using a sol–gel method followed by electrospinning. X-ray diffraction analysis revealed that the contents of CaO and CaCO3 in the mSrHANFs decreased as the doping amount of Sr increased. Scanning electron microscopy (SEM) images showed that the average diameter of the mSrHANFs was approximately 200~300 nm. The N2 adsorption–desorption isotherms demonstrated that the mSrHANFs possessed a mesoporous structure and that the average pore size was approximately 20~25 nm. Moreover, the mSrHANFs had excellent drug- loading efficiency and could retard the burst release of tetracycline (TC) to maintain antibacterial activity for over 3 weeks. Hence, mSrHANFs have the potential to be used as drug carriers in bone tissue engineering.


RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 102853-102868 ◽  
Author(s):  
Ayan Manna ◽  
Sumit Pramanik ◽  
Ashis Tripathy ◽  
Ali Moradi ◽  
Zamri Radzi ◽  
...  

A model of a controlled drug release mechanism of a dielectric core–shell composite carrier.


INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (05) ◽  
pp. 19-25
Author(s):  
B. Venkateswara Reddy ◽  
◽  
K. Navaneetha

Cyclobenzaprine Hydrochloride is a centrally acting muscle relaxant which is mostly available in the form of tablets and capsules. The present aim of the study was to develop a sustained release formulation of cyclobenzaprine Hydrochloride pellets using powder layering technique. Nine different formulations of pellets were prepared by using different concentrations of Ethyl Cellulose-50, Hypromellose (HPMC), and PEG 6000 of all formulations, F8 formulation was the optimized formulation. The kinetic studies of F8 formulation was best fitted in the First order model as it had the highest value (R2 = 0.981) and it follows non- fickian diffusion. Among all the formulations F8 gave better drug release 85.7% when compared to innovator, F8 was selected as optimized formulation. The optimized formulation was kept for stability studies for 3 months at 40°C /75% RH and 25°C /60% RH and the results indicated that there was no much variation in their physiochemical characteristics and the formulation was found to be stable.


Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 593
Author(s):  
Zhuo Wang ◽  
Su Bin Kang ◽  
Sung Wook Won

This study reports the recovery of Pd(II) from acid solution by a polyethylenimine (PEI)-crosslinked chitin (PEI-chitin) biosorbent. FE-SEM analysis demonstrated that there are many slot-like pores on PEI-chitin. The N2 adsorption–desorption experiment revealed that the average pore size was 47.12 nm. Elemental analysis verified the successful crosslinking of PEI with raw chitin. The Langmuir model better explained the isotherm experimental data and the theoretical maximum Pd(II) uptake was 57.1 mg/g. The adsorption kinetic data were better described by the pseudo-second-order model and the adsorption equilibrium was achieved within 30 min for all initial Pd(II) concentrations of 50–200 mg/L. In the fixed-bed column, the adsorption of Pd(II) on PEI-chitin showed a slow breakthrough and a fast saturation performance. The desorption experiments achieved a concentration factor of 8.4 ± 0.4; in addition, the adsorption–desorption cycles in the fixed-bed column were performed up to three times, consequently confirming the good reusability of PEI-chitin for Pd(II) recovery. Therefore, the PEI-chitin can be used as a promising biosorbent for the recovery of Pd(II) in practical applications.


2021 ◽  
Author(s):  
Imane Toumi ◽  
Halima Djelad ◽  
Faiza Chouli ◽  
Benyoucef Abdelghani

Abstract In this research, a simple oxidation chemical process was applied for the synthesis of novel PANI@ZnO nanocomposite. The prepared nanocomposites were characterized by XPS, XRD, FTIR, SEM, TGA and N2 adsorption-desorption isotherms. Thereby, PANI@ZnO highest SBET values (about 40.84 m2.g− 1), total mesoporous volume (about 3.214 cm3.g− 1) and average pore size (about 46.12 nm). Afterwards, the prepared nanomaterial was applied as novel nanoadsorbent for the adsorption of Congo Red (CR) and Methylene Blue (MB) dyes from aqueous solutions at 298 K and pH 5.0. Besides, the pseudo-second-order model was obtained the best for the adsorption of both dyes. In the case of isotherm models, the Freundlich model showed the best fit. After removal, the spent adsorbent was regenerated. With the regeneration repeated five cycles, the PANI@ZnO regeneration efficiency remained at a very adequate level.


2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Long Li ◽  
Yuanwei Li ◽  
Zhiying Wu ◽  
Jinhui Chen ◽  
Jia Chen

This study is aimed at using spray drying method to codisperse it with the commonly used drug carrier lactose in different solvents and then pass it through a spray dryer to obtain different samples. The results showed that the dissolution rate and solubility of the samples obtained by dispersion in hot water and 25% ethanol were significantly higher. The water of crystallization peaks of the raw material disappeared at 105-125°C and 130-150°C (DSC). The excipient lactose had a small upward exothermic peak at 177°C and a significant heat absorption peak at 209°C before untreated (XRD). α-Lactose peaks were observed at 12.5°, 19.1°, 19.6°, and 19.9° at 2θ in both samples, and β-lactose peaks were found at 10.5° at 2θ in sample A, but not in sample B (FTIR). The complex sharp peaks of lactose at 1100 cm-1 and quercetin at 1700-1000 cm-1 became moderated (SEM). The sample obtained by spray drying has a slit-type mesoporous structure with an average pore size of about 9.3 nm.


Author(s):  
Robert J. Thomas ◽  
Rebecca L. Vincelette ◽  
Gavin D. Buffington ◽  
Amber D. Strunk ◽  
Michael A. Edwards ◽  
...  

2017 ◽  
Vol 54 (3) ◽  
pp. 181-201
Author(s):  
Rebecca Johnson ◽  
Mark Longman ◽  
Brian Ruskin

The Three Forks Formation, which is about 230 ft thick along the southern Nesson Anticline (McKenzie County, ND), has four “benches” with distinct petrographic and petrophysical characteristics that impact reservoir quality. These relatively clean benches are separated by slightly more illitic (higher gamma-ray) intervals that range in thickness from 10 to 20 ft. Here we compare pore sizes observed in scanning electron microscope (SEM) images of the benches to the total porosity calculated from binned precession decay times from a suite of 13 nuclear magnetic resonance (NMR) logs in the study area as well as the logarithmic mean of the relaxation decay time (T2 Log Mean) from these NMR logs. The results show that the NMR log is a valid tool for quantifying pore sizes and pore size distributions in the Three Forks Formation and that the T2 Log Mean can be correlated to a range of pore sizes within each bench of the Three Forks Formation. The first (shallowest) bench of the Three Forks is about 35 ft thick and consists of tan to green silty and shaly laminated dolomite mudstones. It has good reservoir characteristics in part because it was affected by organic acids and received the highest oil charge from the overlying lower Bakken black shale source rocks. The 13 NMR logs from the study area show that it has an average of 7.5% total porosity (compared to 8% measured core porosity), and ranges from 5% to 10%. SEM study shows that both intercrystalline pores and secondary moldic pores formed by selective partial dissolution of some grains are present. The intercrystalline pores are typically triangular and occur between euhedral dolomite rhombs that range in size from 10 to 20 microns. The dolomite crystals have distinct iron-rich (ferroan) rims. Many of the intercrystalline pores are partly filled with fibrous authigenic illite, but overall pore size typically ranges from 1 to 5 microns. As expected, the first bench has the highest oil saturations in the Three Forks Formation, averaging 50% with a range from 30% to 70%. The second bench is also about 35 ft thick and consists of silty and shaly dolomite mudstones and rip-up clast breccias with euhedral dolomite crystals that range in size from 10 to 25 microns. Its color is quite variable, ranging from green to tan to red. The reservoir quality of the second bench data set appears to change based on proximity to the Nesson anticline. In the wells off the southeast flank of the Nesson anticline, the water saturation averages 75%, ranging from 64% to 91%. On the crest of the Nesson anticline, the water saturation averages 55%, ranging from 40% to 70%. NMR porosity is consistent across the entire area of interest - averaging 7.3% and ranging from 5% to 9%. Porosity observed from samples collected on the southeast flank of the Nesson Anticline is mainly as intercrystalline pores that have been extensively filled with chlorite clay platelets. In the water saturated southeastern Nesson Anticline, this bench contains few or no secondary pores and the iron-rich rims on the dolomite crystals are less developed than those in the first bench. The chlorite platelets in the intercrystalline pores reduce average pore size to 500 to 800 nanometers. The third bench is about 55 ft thick and is the most calcareous of the Three Forks benches with 20 to 40% calcite and a proportionate reduction in dolomite content near its top. It is also quite silty and shaly with a distinct reddish color. Its dolomite crystals are 20 to 50 microns in size and partly abraded and dissolved. Ferroan dolomite rims are absent. This interval averages 7.1% porosity and ranges from 5% to 9%, but the pores average just 200 nanometers in size and occur mainly as microinterparticle pores between illite flakes in intracrystalline pores in the dolomite crystals. This interval has little or no oil saturation on the southern Nesson Anticline. Unlike other porosity tools, the NMR tool is a lithology independent measurement. The alignment of hydrogen nuclei to the applied magnetic field and the subsequent return to incoherence are described by two decay time constants, longitudinal relaxation time (T1) and transverse relaxation time (T2). T2 is essentially the rate at which hydrogen nuclei lose alignment to the external magnetic field. The logarithmic mean of T2 (T2 Log Mean) has been correlated to pore-size distribution. In this study, we show that the assumption that T2 Log Mean can be used as a proxy for pore-size distribution changes is valid in the Three Forks Formation. While the NMR total porosity from T2 remains relatively consistent in the three benches of the Three Forks, there are significant changes in the T2 Log Mean from bench to bench. There is a positive correlation between changes in T2 Log Mean and average pore size measured on SEM samples. Study of a “type” well, QEP’s Ernie 7-2-11 BHD (Sec. 11, T149N, R95W, McKenzie County), shows that the 1- to 5-micron pores in the first bench have a T2 Log Mean relaxation time of 10.2 msec, whereas the 500- to 800-nanometer pores in the chlorite-filled intercrystalline pores in the second bench have a T2 Log Mean of 4.96 msec. This compares with a T2 Log Mean of 2.86 msec in 3rd bench where pores average just 200 nanometers in size. These data suggest that the NMR log is a useful tool for quantifying average pore size in the various benches of the Three Forks Formation.


2019 ◽  
Vol 26 (14) ◽  
pp. 2502-2513 ◽  
Author(s):  
Md. Iqbal Hassan Khan ◽  
Xingye An ◽  
Lei Dai ◽  
Hailong Li ◽  
Avik Khan ◽  
...  

The development of innovative drug delivery systems, versatile to different drug characteristics with better effectiveness and safety, has always been in high demand. Chitosan, an aminopolysaccharide, derived from natural chitin biomass, has received much attention as one of the emerging pharmaceutical excipients and drug delivery entities. Chitosan and its derivatives can be used for direct compression tablets, as disintegrant for controlled release or for improving dissolution. Chitosan has been reported for use in drug delivery system to produce drugs with enhanced muco-adhesiveness, permeation, absorption and bioavailability. Due to filmogenic and ionic properties of chitosan and its derivative(s), drug release mechanism using microsphere technology in hydrogel formulation is particularly relevant to pharmaceutical product development. This review highlights the suitability and future of chitosan in drug delivery with special attention to drug loading and release from chitosan based hydrogels. Extensive studies on the favorable non-toxicity, biocompatibility, biodegradability, solubility and molecular weight variation have made this polymer an attractive candidate for developing novel drug delivery systems including various advanced therapeutic applications such as gene delivery, DNA based drugs, organ specific drug carrier, cancer drug carrier, etc.


Sign in / Sign up

Export Citation Format

Share Document