scholarly journals Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Jianan Zhang ◽  
Jing Li ◽  
Shi Chen ◽  
Linglin Gao ◽  
Xiaoluan Yan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Platelet Count ◽  
Cross Sectional Survey ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Serum Homocysteine ◽  
Low Platelet Count ◽  
High Platelet Count ◽  
Interaction Term

Background. Platelet consumption followed by homocysteine-induced endothelial injury suggests a crosstalk between platelet activation and homocysteine on hypertension. Platelet count has been found to modify the effect of folic acid on vascular health. However, whether platelet count could modify the contribution of homocysteine to blood pressure (BP) remains unclear. Methods. Leveraging a community-based cross-sectional survey in 30,369 Chinese hypertensive patients (mean age 62 years, 52% female), we examined the moderation of platelet count on the association between serum homocysteine and BP by constructing hierarchical multiple regression models, adjusting for conventional risk factors. If adding the interaction term of homocysteine and platelet count could explain more variance in BP and the interaction is significant, then we believe that moderation is occurring. Results. The association between serum homocysteine and diastolic BP was significantly stronger (β = 0.092 vs. 0.035, P=0.004) in participants with low platelet count (<210 × 109/L) than in those with high platelet count (≥210 × 109/L). Adding the interaction term of homocysteine and platelet count additionally explained 0.05% of the variance in diastolic BP (P=0.0001), and the interaction was significant (β = −0.021, P<0.001). Excluding participants receiving antihypertensive medications did not change our results. Conclusions. The association between homocysteine and BP was significantly stronger in participants with low vs. high platelet count and was partially moderated by platelet count. These results indicate that platelet count may be useful in the identification of individuals who are most beneficial to reducing-homocysteine treatments but this usefullness still needs further investigation.

scholarly journals A comparative study on the adherence to anti-hypertensive medications in urban and rural areas of Hubballi

2019 ◽  
Vol 6 (4) ◽  
pp. 1701 ◽  
Author(s):  
Pratibha Rao Katapadi ◽  
Dattatreya D. Bant
Keyword(s):  
Blood Pressure ◽  
Rural Areas ◽  
Rural Population ◽  
Antihypertensive Drugs ◽  
Cross Sectional Study ◽  
Uncontrolled Hypertension ◽  
Public Health Issue ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Hypertensive Patients

Background: Hypertension is a significant public health issue worldwide and can have deleterious effects on the health when it is not under control. Adherence to antihypertensive medications is thus necessary for better control of blood pressure and to reduce the risk of complications. There are various factors which support or hinder the patient’s adherence to anti- hypertensive treatment. Thus this study was done to reflect the factors influencing the adherence to antihypertensive drugs among urban and rural population.Methods: A community based cross sectional study was conducted in urban and rural field practice areas of Karnataka Institute of Medical Sciences, Hubballi. A semi-structured questionnaire was used for data collection among the known hypertensive patients. The data was entered in Microsoft Excel and analysed using SPSS software.Results: Most of the hypertensive patients were aged 45 and above (89.5%). A total of 73.5% of the participants were adherent to antihypertensive medications and adherence was more among urban (76%) as compared to rural population (71%). Knowledge regarding complications of uncontrolled hypertension was the major factor for adherence in both the areas. The mean systolic and diastolic blood pressure was controlled in patients who were adherent.Conclusions: There is a higher level of adherence to antihypertensive medications in urban population as compared to rural population of Hubballi. The findings suggest patient factors, clinical factors and socio-demographic factors play an important role in determining the adherence to the medication.

scholarly journals Overcoming Barriers in the Management of Hypertension: The Experience of the Cardiovascular Health Program in Chilean Primary Health Care Centers

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Daniela Sandoval ◽  
Miguel Bravo ◽  
Elard Koch ◽  
Sebastián Gatica ◽  
Ivonne Ahlers ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Primary Care ◽  
Health Program ◽  
Cardiovascular Health ◽  
Pressure Control ◽  
Diabetic Patients ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Primary Health Care Centers

Objective. To assess the blood pressure control and cardiovascular risk factors (CVRFs) in a population of hypertensive patients with access to care under a government-financed program, the Cardiovascular Health Program (CHP).Design. A cross-sectional and multicenter study.Setting. 52 primary care centers, metropolitan area of Santiago, Chile.Participants. 1,194 patients were selected by a systematic random sampling from a universe of 316,654 hypertensive patients.Key Measurements. Demographic information, blood pressure (BP) measurements, and CVRF were extracted from medical records of patients followed for a 12-month period.Results. 59.7% of patients reached target BP<140/90 mmHg. More women were captured in the sampling (2.1 : 1), achieving better BP control than men. Diabetic patients (26.4%) had worse BP control than nondiabetics. Antihypertensive medications were used in 91.5%, with multidrug therapy more frequent in patients with higher BP and more difficult control.Conclusions. The success in improving the BP control to values <140/90 mmHg from 45.3% to 59.7% underscores the contribution of this program in the Chilean primary care cardiovascular preventive strategies. However, fewer hypertensive men than women were captured by this program, and it is of concern the underperforming of BP control observed in diabetics.

scholarly journals Characterizing Patients with Uncontrolled Blood Pressure at an Urban Hospital in Hanoi, Vietnam

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hoang Thanh Nguyen ◽  
Nam Hoang Thi Phuong ◽  
Ngoc Tran Nguyen ◽  
Tuan Nguyen Anh ◽  
Vung Nguyen Dang
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Self Care ◽  
Uncontrolled Hypertension ◽  
Urban Hospital ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Uncontrolled Blood Pressure ◽  
Hypertensive Patients

Great efforts to advance the diagnosis and treatment of hypertension for controlling hypertension have been made; however, the rates of uncontrolled blood pressure are still high. This study explored the rate of uncontrolled hypertension in patients with hypertension managed in an urban hospital of Vietnam and identified associated factors. A cross-sectional survey was performed from August to October 2019 among hypertensive patients at an urban hospital in Hanoi, Vietnam. Blood pressure was evaluated at the time of medical examination. Demographic, clinical, and behavioral characteristics were also collected. Multivariate logistic regression was used to identify the factors related to uncontrolled hypertension. Among 220 patients, the rate of uncontrolled hypertension was 40.5%. Females had a lower likelihood of having uncontrolled hypertension compared to males (adjusted OR = 0.33; 95% CI = 0.11–0.98). Higher duration of diseases (adjusted OR = 1.07; 95% CI = 1.01–1.14) and higher body mass index (adjusted OR = 1.23; 95% CI = 1.05–1.45) were positively associated with uncontrolled hypertension. Patients who carried supplies needed for self-care, cut down on stress, exercised regularly, and stopped/cut down on smoking were also less likely to develop uncontrolled hypertension. This study reveals that uncontrolled hypertension was common among hypertensive patients in Vietnam. Improving self-care capacity and encouraging healthy behaviors are critically important to control blood pressure, particularly among patients who were males and had high disease duration and body mass index.

scholarly journals May Measurement Month 2019: an analysis of blood pressure screening results from Korea

2021 ◽  
Vol 23 (Supplement_B) ◽  
pp. B89-B91
Author(s):  
Hae-Young Lee ◽  
Gyu Chul Oh ◽  
Il Suk Sohn ◽  
Sungha Park ◽  
Jinho Shin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Treatment Rate ◽  
Cross Sectional Survey ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Screening Programs ◽  
Increased Risk ◽  
Temporary Solution ◽  
Artery Disease ◽  
Global Initiative

Abstract Hypertension is the biggest contributing risk factor to cerebrovascular disease and is associated with increased risk of coronary artery disease. The May Measurement Month (MMM) campaign is a global initiative aimed at raising awareness of hypertension and acting as a temporary solution to the lack of screening programs worldwide. An opportunistic cross-sectional survey of participants aged ≥18 was carried out during May 2019 in Korea. Over 10 000 participants were recruited in the MMM campaign in Korea, with a slogan of ‘A simple measure to save lives—#checkyourpressure’. A total of 9975 participants with valid clinical and blood pressure (BP) data were used for analysis. All participants were Korean in ethnicity, mean age was 57.2 (SD ± 21.2) years, 57.7% were females, and the mean body mass index was 23.4 kg/m2 (SD ± 3.3). In total, 37.7% of the participants reported a previous diagnosis of hypertension, and 91.3% of those diagnosed were on antihypertensive medications. For other comorbidities, 11.6% reported having diabetes mellitus, 2.0% had previous stroke, and 1.0% had previous myocardial infarction. Mean BP was 130.0/81.0 mmHg in the overall population. After multiple imputation, 47.6% of participants were classified as hypertensive (systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg or on treatment for raised BP). Among all hypertensive participants, the awareness rate, the treatment rate, and the control rate (systolic BP &lt;140 mmHg and diastolic BP &lt;90 mmHg) were 76.2%, 74.0%, and 50.5%, respectively. Of those on antihypertensive medication, the control rate was 68.2%. While awareness and treatment rates were relatively high in the MMM19 campaign, the BP control rate of the total hypertensive population was still only ∼50%, which demands more emphasis on strict BP control.

scholarly journals Prevalence of Hypertension and Diabetes Mellitus among Haemodialysis Patients at Elobied Haemodialysis Unit –West Sudan

2019 ◽  
pp. 1-5
Author(s):  
Abdelsalam Mohamed Hamed Elfaki ◽  
Samia Tarig Abdalla Mohamed
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Insulin Therapy ◽  
Blood Pressure Measurement ◽  
Diabetic Patients ◽  
Chronic Haemodialysis ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Female Ratio ◽  
Hypertensive Patients

Background and Objectives: Hypertension and diabetes mellitus are major risk factors of end – stage renal disease (ESRD). This study aimed to determine the prevalence of hypertension and diabetes mellitus among haemodialysis patients at Elobeid haemodialysis unit. Patients and Methods: The study was a single – centre cross - sectional study including 130 patients on chronic haemodialysis in Elobeid hospital haemodialysis unit. Each patient was personally interviewed by the co-author in the haemodialysis unit using a structured questionnaire prepared by the investigators. Data collected include: socioeconomic data (gender, age, residence, and occupation), history of hypertension, diabetes mellitus, treatment of hypertension, treatment of diabetes mellitus, duration of hypertension, duration of diabetes mellitus and duration of dialysis. Hypertension was defined as blood pressure ≥ 140/90 or the use of antihypertensive medications. Diabetes mellitus is defined by use of insulin therapy. In this study both hypertension and diabetes mellitus were already diagnosed and on regular medications. Statistic package for social sciences (SPSS) version 20 was used for data analysis. Results: One hundred and thirty patients were recruited. More than two thirds of patients were males with male to female ratio of 2.2: 1. Patient’s age ranged from 12 years to 90 years. The mean age was 46.3 ± 17.8 years. Forty (32%) patients were above 56 years of age. Ninety eight (75%) patients were hypertensive, the majority of hypertensive patients were males (90%). Eighty six hypertensive patients were on calcium channel blocker (88%). Amlodipine was the commonly used antihypertensive used. Twenty five (19%) patients were diabetics and all of them were males. All diabetic patients were also hypertensive. Fourteen diabetic patients (56%) were on insulin therapy, while 11 patients were using metformin. Conclusion: The prevalence of hypertension among haemodialysis patients was high while the prevalence of diabetes is less than that reported globally. The blood pressure should be tidily controlled specially in diabetic patients and patients with impaired renal function. For early detection of chronic kidney disease and elevated blood pressure as a sequel, routine blood pressure measurement is highly recommended in adult patients attend the clinic for any reason.

scholarly journals Adherence to drug therapy among hypertensive patients attending two district hospitals in Ghana

2020 ◽  
Vol 20 (3) ◽  
pp. 1355-1367
Author(s):  
Emmanuel Sarkodie ◽  
Daniel Kwame Afriyie ◽  
Araba Hutton-Nyameaye ◽  
Seth Kwabena Amponsah
Keyword(s):  
Blood Pressure ◽  
Antihypertensive Drugs ◽  
Patient Adherence ◽  
Antihypertensive Medications ◽  
Major Drawback ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Medical Practitioners ◽  
District Hospitals ◽  
Predictors Of Adherence

Background: A major drawback to the management of hypertension among patients is poor adherence to pharmacother- apy. Factors that influence non-adherence to antihypertensive drugs could vary, depending on the prevailing condition of patient and setting. Knowledge of adherence patterns and behavior of hypertensive patients to pharmacotherapy could improve health-directed policies towards hypertension management. Objective: The objective of this study was to determine factors that influence adherence to oral antihypertensive drugs among patients attending two district hospitals in the Volta Region of Ghana. Methods: The study was cross-sectional. Respondents were hypertensive patients attending Krachi West District (n=187) and Hohoe Municipal (n=183) hospitals between March 2016 to May 2016. Data was collected using a structured question- naire and Morisky 8 Item Measurement of adherence scale. Results: Adherence to oral antihypertensive drugs was 89.2%. However, more than half of these respondents appeared to have uncontrolled blood pressure; and this may be due to self-response bias, blood pressure being measured only on the day of the interview or use of fake drugs (which was not assessed in this study). The strongest predictors of adherence were; knowledge on hypertension, perception of severity of condition and the amount of alcohol consumed in a day by respondents. Conclusion: Good adherence to oral antihypertensive drugs was observed in this population despite uncontrolled hyper- tension in a number of the respondents. The three independent predictors of adherence to antihypertensive medications in this study were respondent’s knowledge about hypertension, perception of severity of their condition and the amount of alcohol consumed in a day. Regular patient education and counseling by medical practitioners should be encouraged in these settings to improve patient adherence. Keywords: Adherence; antihypertensive drug; hypertension; Ghana.

scholarly journals May Measurement Month 2019: an analysis of blood pressure screening results from Lebanon

2021 ◽  
Vol 23 (Supplement_B) ◽  
pp. B92-B94
Author(s):  
Robert N Najem ◽  
Ahmad Halawi ◽  
Bassem Tanios ◽  
Rasha Ambriss ◽  
Rana El Bikai ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Health Concern ◽  
Cross Sectional Survey ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Raising Awareness ◽  
High Prevalence ◽  
Lebanese Population ◽  
Treatment Of Hypertension ◽  
The Mean

Abstract Hypertension is an important public health concern of high prevalence among adults. It is associated with an increased mortality rate. The prevalence of hypertension in Lebanon has increased during the last decades, affecting around one-third of the Lebanese population. Since diagnosis and treatment of hypertension is associated with a better prognosis, annual screening and raising awareness about this ‘silent killer’ disease is of extreme value. We conducted a cross-sectional survey in various Lebanese cities in 2019. We recruited adults (≥18 years old) from different sites, through an opportunistic sampling method. For each participant, three blood pressure (BP) readings were recorded and the average of the last two was analysed. In addition, data on lifestyle factors and comorbidities were collected. Participants were considered hypertensive if they had at least one of the following: systolic or diastolic BP ≥140 and/or ≥90 mmHg, respectively, or taking antihypertensive medication. Blood pressure was measured in 7019 participants. The mean age was 46.0 (SD 16.6) years. In total, 2572 participants (36.6%) had hypertension among whom only 64.1% were aware of their disease and 62.3% were on treatment. Blood pressure was controlled in 62.6% of participants taking antihypertensive medications. This study is the largest on hypertension prevalence in Lebanon. The results demonstrated that around one-third of the hypertensive population were not aware of their disease, and that a high percentage was not being treated. These results suggest the need for rapid interventions aimed at raising awareness regarding hypertension in the Lebanese population.

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