Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Guinea’s reference ranges for biological parameters rely on those of Caucasian values. Variability in reference ranges according to the context is well-documented. We conducted this study for the purpose of future malaria clinical trials that assess the efficacy and safety of malaria drugs. A repeated cross-sectional study was carried out, in an apparently healthy cohort population. Surveys took place in Maferinyah rural community, which is located at 75 km from the capital. The 2.5th and 97.5th percentiles were determined nonparametrically and stood for reference intervals. Reference values were determined separately for males and females according to ranges of age (6-10 years of age; 11-15 years of age; 16-45 years of age). Differences between genders were tested using the Mann-Whitney test, while the Friedman test was performed to test differences within each gender group according to the seasons. A total of 450 volunteers were enrolled. The median age was 13. Males 16-45 years of age had significantly higher hematologic and biochemical values compared to a female of the same age (for hematological parameters: Mean Cell Hemoglobin Concentration MCHC p≤0.001, Platelets p≤0.001, monocytes p=0.0305, eosinophils p=0.0225; for biochemical parameters: Aspartate aminotransferase AST p≤0.001, Alanine Aminotransferase ALT p≤0.001, creatinine p≤0.001). We noticed significant seasonal variations for all the biochemical parameters and some hematologic parameters (Mean Corpuscular Hemoglobin MCH, MCHC, Mean Cell volume). This is the first study establishing hematologic and biochemical parameters in Guinea. These findings provide a useful guide for the clinical researchers and care providers. Studies on large scale and in different settings would be also desirable.

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Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces)

Pan African Medical Journal ◽

10.11604/pamj.2018.29.205.13043 ◽

2018 ◽

Vol 29 ◽

Cited By ~ 2

Author(s):

Saad Bakrim ◽

Youssef Motiaa ◽

Ali Ouarour ◽

Azlarab Masrar

Keyword(s):

Pregnant Women ◽

Reference Values ◽

Blood Count ◽

Complete Blood Count ◽

Hematological Parameters ◽

Control Group ◽

Mean Corpuscular Hemoglobin ◽

Healthy Population ◽

Corpuscular Hemoglobin ◽

Significant Difference

Introduction: numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature. Methods: blood samples were taken voluntarily from 3898 healthy pregnant women from 18 to 46 years old who presented themselves at the center of health Kalaa and at the service of gynecology obstetrics of the Provincial Hospital Center of M'diq (Morocco), for prenatal care. To establish the reference intervals of the CBC for non-pregnant women, a control group was constituted by 7035 healthy women from 18 to 50 years old selected according to the Moroccan law of blood donation. The CBC was measured on a Sysmex KX21N® analyzer. For each sample a systematic blood smear was done to determine the leukocyte differential. Results: a statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. So, the comparison of the averages established between the first, second and third trimester of pregnancy showed the existence of a significant variation with regard to all the parameters of the CBC test looked for (p < 0.001). Conclusion: the present study provides additional baseline data for basic hematological parameters in healthy pregnant Moroccan women and concluded that pregnancy in women has the tendency to alter some hematological indices. For these reasons, there is an interest to take these modifications into account for optimal maternal and fetal medical care.

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Normal Reference Values of Complete Blood Count in Healthy Adult Population of Pakistan; A Multicentre Study

10.53350/pjmhs2115113040 ◽

2021 ◽

Vol 15 (11) ◽

pp. 3040-3042

Author(s):

Neelam Mazhar ◽

Sarah Rafi ◽

Saima Farhan ◽

Shazia Yaseen ◽

Nisar Ahmed

Keyword(s):

Reference Values ◽

Blood Count ◽

Blood Donors ◽

Complete Blood Count ◽

Hematological Parameters ◽

Adult Population ◽

Armed Forces ◽

Reference Ranges ◽

Medical College ◽

Normal Reference

Aim: To establish the reference values of hematological parameters in blood donors of all the four provinces of Pakistan as a general population. Methods: This was a multicenter cross-sectional study conducted from Jan 2017-Oct 2017 in the blood bank and the Dept. of Haematology, The CH&ICH, Lahore, Fatimid Foundation, Karachi, Bolan medical college, Quetta, Armed Forces Institute of Transfusion, Rawalpindi & Ayub medical college, Abbottabad, KPK. Blood samples of 1060 male and female blood donors were collected from the blood banks of all the centers mentioned above. CBC and differential were performed using an automated hematology analyzer in the respective departments. Results: The mean and 95% reference values (2.5th-97.5th) for males WBC 7.752+4.506×109 cells/L, RBC 4.958 +1.331, HB 14.258 +3.423 g/dl, HCT 41.967 +16.345, MCV 84.584 +15.933, PLT 219.485 +197.331, LYM 3.346 +10.112, NEUT 6.843+23.557, MONO 0.811 +3.601, EO 0.327 +0.995. For females WBC 7.174+3.037, RBC4.567 +1.086, HB 12.972 +2.752, HCT39.647 +48.186, PLT 264.07+175.079, LYM 2.537+5.005, NEUT 4.769+11.314, MONO 0.460 +0.909, EO 0.188+0.39 Conclusion: The hematological profile of the population in all four provinces of Pakistan differed from the reports of other countries and the standard reference ranges described in the textbook. So, our own hematological parameters must be followed. More studies must be carried out on other age groups and even on adults to strengthen our results. Keywords: Normal reference values, Complete blood count, Healthy adults of Pakistan

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Variation in blood count parameters of children aged 5 to 11 years in Abidjan, Côte d'Ivoire

Iranian Journal of Pediatric Hematology & Oncology ◽

10.18502/ijpho.v11i3.6562 ◽

2021 ◽

Author(s):

Kokore Angoua Baudouin ◽

Kamagate Soualio ◽

Ouattara Howélé ◽

Bleyere Nahounou Mathieu ◽

Yapo Paul

Keyword(s):

Reference Values ◽

Cote D'ivoire ◽

Mean Corpuscular Volume ◽

Blood Count ◽

Côte D’Ivoire ◽

Hematological Parameters ◽

Mean Corpuscular Hemoglobin ◽

Corpuscular Hemoglobin ◽

Cote D’Ivoire ◽

Côte D'ivoire

Background: In Côte d’Ivoire, as in most developing countries, the reference values of hematological indices currently in use come from data collected from populations living in industrialized countries. The aim of this study was to determine variations in the child's blood count in Cote d'Ivoire. Materials and Methods: This descriptive cross-sectional study has focused on 310 children (172 girls and 138 boys) aged 5 to 11 years selected from three municipalities of Abidjan. Blood samples were taken from each child in order to assess the parameters of the blood count. Results: The results revealed that the means of the different hematological parameters (red blood cells, hemoglobin, hematocrit, white blood cells, neutrophils, eosinophils, monocyte, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration) were in accordance with the normal physiological reference values from the literature apart lymphocyte. The rate of lymphocytes (51.3 ± 0.5) was higher overall. All the parameters did not indicate significant differences between girls and boys (p > 0.05) except mean corpuscular volume, and mean corpuscular hemoglobin that were statistically different by sex (p < 0.05). The percentage of having a rate of haemoglobin lower than 11.5 decreased significantly (p˂0.005) when the age increased. In addition, the rate of hemoglobin and hematocrit increased slightly starting from the age of 8 years. There is a significant difference (p < 0.05) in hemoglobin level between girls and boys in the age group of 9 years. Leukopenia is observed in a minority of children in the age groups of 5, 6, 7, 8, and 10 years. Conclusion: Some hematological parameters were different from other data published in the literature, which suggested a local development of reference values for children.

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Blood Donation in Nigeria: Standard of the Donated Blood

Journal of Laboratory Physicians ◽

10.4103/0974-2727.105589 ◽

2012 ◽

Vol 4 (02) ◽

pp. 094-097 ◽

Cited By ~ 4

Author(s):

Nwogoh Benedict ◽

Awodu Omolade Augustina ◽

Bazuaye Godwin Nosakhare

Keyword(s):

Blood Donation ◽

Hematological Parameters ◽

Hemoglobin Concentration ◽

Mean Corpuscular Hemoglobin ◽

Corpuscular Hemoglobin ◽

Mean Cell Volume ◽

Benin City ◽

Cell Counts ◽

Significant Difference ◽

The Mean

ABSTRACT Objective: The objective was to determine the basic hematological parameters of remunerated blood donors in Benin City and to compare them with those of voluntary donors. Materials and Methods: This is a prospective study conducted in a tertiary health facility in Benin City. Pretransfusion samples were obtained from blood bags after gentle mixing and analyzed for hematological parameters. Samples were analyzed using the hematology autoanalyzer MODEL SYSMEX KN21. Result: A total of 215 samples were obtained comprising 160 remunerated (paid) and 55 voluntary donor samples. In the paid donors, the mean hemoglobin concentration (Hb) and hematocrit (HCT) 7.7±2.9 and 28.8±8.5 respectively. This was significantly lower than those of voluntary donors who had 13.9±1.2 and 42.2±3.3 with P < 0.001. The mean values of the red cell counts (RBC), white cell counts (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in paid donors as P-values were <0.001. MCV was significantly low but not compared to the other parameters as P=0.04. There was no significant difference in the platelet count. Conclusion: Paid donors in Benin City have significantly lower hematological parameters than controls.

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Hematology of Wild Caught Dubois’s Tree FrogPolypedates teraiensis, Dubois, 1986 (Anura: Rhacophoridae)

The Scientific World JOURNAL ◽

10.1155/2014/491415 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Madhusmita Das ◽

Pravati Kumari Mahapatra

Keyword(s):

Blood Cell ◽

Blood Serum ◽

Blood Cells ◽

Hematological Parameters ◽

Hemoglobin Concentration ◽

Mean Corpuscular Hemoglobin ◽

Reference Ranges ◽

Corpuscular Hemoglobin ◽

Differential Leukocyte Count ◽

Rbc Count

Blood was analyzed from eighty (forty males and forty females) adult individuals ofPolypedates teraiensisto establish reference ranges for its hematological and serum biochemical parameters. The peripheral blood cells were differentiated as erythrocytes, lymphocytes, eosinophils, neutrophils, monocytes, basophils, and thrombocytes, with similar morphology to other anurans. Morphology of blood cells did not vary according to sex. The hematological investigations included morphology and morphometry of erythrocytes, morphometry of leucocytes, packed cell volume (PCV), hemoglobin content (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), erythrocyte or red blood cell (RBC) count, leukocyte or white blood cell (WBC) count, differential leukocyte count, and neutrophil to lymphocyte (N/L) ratio. Besides, protein, cholesterol, glucose, urea, uric acid, and creatinine content of blood serum were assayed. Hematological parameters that differed significantly between sexes were RBC count, length and breadth of RBC, neutrophil %, N/L ratio, area occupied by basophils, and diameter of large lymphocyte and eosinophils. The level of glucose, urea, and creatinine in blood serum also significantly differed between sexes.

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Length and Weight (LW) Related Variations on Haematological Parameters of Hetropneustes Fossilis (Bloch.)

10.21203/rs.3.rs-996037/v1 ◽

2021 ◽

Author(s):

Induja Mishra ◽

Namita Joshi ◽

Pashupati Nath ◽

B. D. Joshi

Keyword(s):

Significant Positive Correlation ◽

Hematological Parameters ◽

Blood Parameters ◽

Mean Corpuscular Hemoglobin ◽

Corpuscular Hemoglobin ◽

Mean Cell Volume ◽

Positive Correlation ◽

Erythrocyte Sedimentation ◽

Positive Correlations ◽

Living Creature

Abstract The paper mainly described the haematological values of a fresh water catfish Hetropneustes fossilis (Bloch.) in relation to its length and weight which are the prime basic factor of the differences in blood parameters of any living creature including fishes. The hematological parameters showed significant differences with increase in length and weight of the fishes. Differential leucocytes count did not showed any significant differences except macrophages and differential erythrocytes count showed significant differences only in macrocytes. All three groups (Length and weight) of fishes showed significant positive correlations for total erythrocytes count, hemoglobin, mean corpuscular hemoglobin and erythrocyte sedimentation rate while negative correlation was noted for mean corpuscular hemoglobin; mean cell volume. Among differential leukocytes count only neutrophil showed positive correlation, while other parameters did not show any significant correlation. In differential erythrocyte count only microcytes showed significant positive correlation.

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Reference Values and Correlations for Multiple Physical Performance Measures: A Cross-Sectional Study among Independently Mobile Older Men in Japan

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17072305 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2305

Author(s):

Yoshinori Ishii ◽

Hideo Noguchi ◽

Junko Sato ◽

Hana Ishii ◽

Ryo Ishii ◽

...

Keyword(s):

Life Expectancy ◽

Physical Performance ◽

Performance Measures ◽

Reference Values ◽

Older Men ◽

Reference Ranges ◽

Care Providers ◽

Total Life Expectancy ◽

Functional Reach Test ◽

Balance Ability

Purpose: Japan is one of few countries with a male life expectancy over 80 years. The gap between the healthy life span and the total life expectancy is large, highlighting the importance of maintaining physical performance. The present study aims to establish reference values for multiple physical performance measures among high-functioning oldest-old Japanese men and to investigate the correlations among these measurements to understand how these variables are related. Methods: This study was conducted with 120 Japanese males aged 80 years or older who were able to walk independently. Seven measures of physical performance were assessed: handgrip strength, quadriceps strength, static balance ability (one-legged stance), dynamic balance ability (Functional Reach Test; FRT), walking ability (5-m walking time test), combined movement ability (Timed Up & Go test), and bone quality. Cognitive function was also measured (Mini-Mental State Examination; MMSE). Results: Specific reference values are reported for each physical performance measurement explored in this study. Only six participants were classified as cognitively impaired, and 16 had mild cognitive impairment. There were significant correlations of varying levels among all of the measures of physical performance. Age was significantly correlated with all performance measures except FRT, and there was no correlation between age and MMSE. MMSE was weakly correlated with FRT and unrelated to the other performance measures. Conclusions: The reference ranges can be used by older men who have not yet reached 80 years and their health care providers as physical performance targets to facilitate the maintenance of independent mobility in later life.

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Abstract 15230: Sex and Racial Differences in Normative Reference Ranges and Healthy Aging on Diastolic Function in Ethnic Asians: 2016 Ase Guideline Revisited

Circulation ◽

10.1161/circ.142.suppl_3.15230 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Sheng Nan Chang ◽

Kuo-Tzu Sung ◽

Wen-Hung Huang ◽

Jou-Wei Lin ◽

Shih-Chieh Chien ◽

...

Keyword(s):

Diastolic Dysfunction ◽

Racial Differences ◽

Reference Values ◽

Healthy Aging ◽

Population Based ◽

Advanced Age ◽

Healthy Population ◽

Reference Ranges ◽

Using Data ◽

Age And Sex

Introduction: However, the reference ranges for echocardiography might be varying due to ethnicity, gender and age. Therefore, the normal reference ranges obtained from the healthy Asians are important for clinical utility of echocardiography in Asia. Methods: Population-based echocardiography dataset from 6,023 healthy ethnic Asians (47.1±10.9 years, 61.3% men) were divided into 6 age decades: ≤29, 30-39, 40-49, 50-59, 60-69 and ≥70 years. We explored age- and sex-related structural/functional alterations according to 2016 American Society of Echocardiography (ASE) diastolic dysfunction (DD) criteria and their correlates with clinical N-terminal pro-brain natriuretic peptide (NT-proBNP) cut-off for heart failure (HF). Racial comparisons were made using data from London Life Sciences Prospective Population (LOLIPOP) study. Results: Age- and sex-based normative reference ranges (including mean, median, 10% and 90% lower and upper reference values) were extracted from our large healthy population. In fully adjusted models, advanced age (treated as linear) was independently associated with cardiac structural remodeling and worsened diastolic parameters: larger indexed LA volume (LAVi), lower e’, higher E/e’, and higher TR velocity; all p <0.001), and were broadly more prominent in women (P interaction : <0.05). in general, markedly lower e’, higher E/e’ and smaller LAVi were observed in ethnic Asians compared to Whites. DD defined by 2016 ASE criteria, despite at low prevalence (0.42%) in current healthy population, increased drastically with advanced age and performed perfectly in excluding abnormal NT-proBNP (≥125 pg/ml) (Specificity: 99.8%, NPV: 97.6%). Conclusions: This is to date the largest cohort exploring the normative reference values using guideline-centered diastolic parameters from healthy Asians, with senescence process played as central role in diastolic dysfunction. Observed sex and ethnic differences in defining healthy diastolic cut-offs likely impact future clinical definition for DD.

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Hematological profile of captive bearded capuchin monkeys (Sapajus libidinosus) from Northeastern Brazil

Ciência Rural ◽

10.1590/0103-8478cr20180065 ◽

2018 ◽

Vol 48 (10) ◽

Author(s):

Adriano Fernandes Ferreira ◽

Felisbina Luísa Queiroga ◽

Rinaldo Aparecido Mota ◽

Eneida Willcox Rêgo ◽

Stéphanie Machado Mota ◽

...

Keyword(s):

Reference Values ◽

Hematological Parameters ◽

Age Factors ◽

Erythrocyte Count ◽

Northeastern Brazil ◽

Capuchin Monkeys ◽

Mean Corpuscular Hemoglobin ◽

Corpuscular Hemoglobin ◽

Hematological Profile ◽

In Captivity

ABSTRACT: Bearded Capuchin or Black-striped Capuchin monkeys (Sapajus lidibinosus) are New World robust capuchin monkeys widely used in medical research. Few data are available concerning hematological reference values for these species, with no studies available from the Northeast region in Brazil. The aim of this study was to determine the hematological reference values for healthy bearded capuchin monkeys and to analyze the influence of sex and age factors. Blood samples were collected from 50 healthy bearded capuchin monkeys housed in captivity. These were analysed for total erythrocyte, hemoglobin, leukocyte and platelet count, packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). When considering the age factor, significant differences were reported for total erythrocyte count, PCV, hemoglobin, total leucocytes, band neutrophils, eosinophils and lymphocytes (higher in juveniles). Significant sex-associated differences were noted for total erythrocyte count, PCV, hemoglobin (higher in males) and number of lymphocytes (higher in females).We have reported for the first time the hematological profile of bearded capuchin monkeys in captivity in the state of Paraíba, Brazil. These results can contribute for a better understanding of the normal physiology of capuchin monkeys, while demonstrating that factors such as sex and age influence hematological parameters should be taken into consideration in the hematological evaluation of this species.

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Tunisian Newborn's Cord Blood: Reference Values of Complete Blood Count and Hemoglobin Fractions

American Journal of Perinatology ◽

10.1055/s-0040-1722199 ◽

2020 ◽

Author(s):

Sana Zitouni ◽

Emna Bouatrous ◽

Ons Laabidi ◽

Imen Boudrigua ◽

Dorra Chaouachi ◽

...

Keyword(s):

Blood Cell ◽

Cord Blood ◽

Reference Values ◽

Blood Count ◽

Complete Blood Count ◽

Hematological Parameters ◽

Reference Ranges ◽

Hematological Indices ◽

Umbilical Blood ◽

Vaginal Deliveries

Objective This study was aimed to establish local reference values for hematological indices and hemoglobin (Hb) fractions in umbilical cord blood (UCB) for the northern population of Tunisia. Study Design Our study included full-term newborns by vaginal deliveries. Hematological parameters were collected using an automated blood cell counter. The amounts of Hb fractions were measured by capillary electrophoresis of Hb. Statistical analysis was performed using R software. Results A total of 328 cord blood samples were analyzed. Among them, 154 (male: 44.8%, female: 55.2%) were used to establish reference values. The normal reference values of complete blood count (CBC) and Hb fractions were calculated. Mean neonatal Hb was 14.75 ± 2.26 g/dL. Gestational age affects the expression of CBC values as red blood cell (RBC), Hb, hematocrit (Hct), mean corpuscular volume (MCV), white blood cell (WBC), and the Hb profile. Umbilical blood hemogram parameters and Hb profile are affected by the environment; higher in newborns from urban regions but not affected by gender ratio. Conclusion Reference ranges of normal CBC indices and Hb fractions have been successfully established in Tunisian neonates' UCB. Our data suggest reference values that could be useful for neonatal patients' laboratory results and clinical interpretation. Key Points

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