A Systematic Review of the Potential Chemoprotective Effects of Resveratrol on Doxorubicin-Induced Cardiotoxicity: Focus on the Antioxidant, Antiapoptotic, and Anti-Inflammatory Activities

Purpose. Although doxorubicin chemotherapeutic drug is commonly used to treat various solid and hematological tumors, its clinical use is restricted because of its adverse effects on the normal cells/tissues, especially cardiotoxicity. The use of resveratrol may mitigate the doxorubicin-induced cardiotoxic effects. For this aim, we systematically reviewed the potential chemoprotective effects of resveratrol against the doxorubicin-induced cardiotoxicity. Methods. In the current study, a systematic search was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline for the identification of all relevant studies on “the role of resveratrol on doxorubicin-induced cardiotoxicity” in the electronic databases of Web of Science, PubMed, and Scopus up to March 2021 using search terms in their titles and abstracts. Two hundred and eighteen articles were screened in accordance with a predefined set of inclusion and exclusion criteria. Finally, 33 eligible articles were included in this systematic review. Results. The in vitro and in vivo findings demonstrated a decreased cell survival, increased mortality, decreased heart weight, and increased ascites in the doxorubicin-treated groups compared to the control groups. The combined treatment of resveratrol and doxorubicin showed an opposite pattern than the doxorubicin-treated groups alone. Furthermore, this chemotherapeutic agent induced the biochemical and histopathological changes on the cardiac cells/tissue; however, the results (for most of the cases) revealed that these alterations induced by doxorubicin were reversed near to normal levels (control groups) by resveratrol coadministration. Conclusion. The results of this systematic review stated that coadministration of resveratrol alleviates the doxorubicin-induced cardiotoxicity. Resveratrol exerts these chemoprotective effects through several main mechanisms of antioxidant, antiapoptosis, and anti-inflammatory.

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Zirconia Biocompatibility in Animal Studies - A Systematic Review

Defect and Diffusion Forum ◽

10.4028/www.scientific.net/ddf.376.12 ◽

2017 ◽

Vol 376 ◽

pp. 12-28 ◽

Cited By ~ 2

Author(s):

Sanda Mihaela Popescu ◽

Horia Octavian Manolea ◽

Oana Andreea Diaconu ◽

Veronica Mercuţ ◽

Monica Scrieciu ◽

...

Keyword(s):

Systematic Review ◽

Dental Implants ◽

Animal Studies ◽

Case Reports ◽

Powder Injection ◽

Mesh Terms ◽

Meta Analyses ◽

Abstract Screening

Zirconia is a metal used in dental implantology. Its biocompatibility was studied in vitro and in vivo, results of the studies being analyzed in reviews and meta analyses. The aim of this systematic review was to evaluate biocompatibility of zirconia in animal studies in vivo expressed as results of histomorphometric tests. Databases were searched from 1980 until February 2016, with different combination of the following MeSH terms: zirconium, biocompatibility, dental implants, in vivo, animal studies. Letters to the editors, case reports, commentaries, review articles and articles published in other languages then English were excluded. The search of PubMed, ScienceDirect and Google Scholar databases yielded 690 titles. After abstract screening and duplicate discarding 50 articles were identified and finally, 40 were included in the review. Most of the studies compared zirconia with titanium, a well established material for dental implants. In majority of the studies zirconia showed a similar osseointegration with titanium. Surface implant treatments, like sandblasted and etched zirconia (ZrO2-SLA), alumina toughed zirconia (ATZ), and powder injection molding (PIM) were used to improve osseointegration of zirconia with good results. In the light of histomorphometric test, zirconia, no matter physical and structural forms tested, is a biocompatible material.

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Use of DIAGNOdent and VistaProof in diagnostic of Pre-Cavitated Caries Lesions—A Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm9010020 ◽

2019 ◽

Vol 9 (1) ◽

pp. 20 ◽

Cited By ~ 2

Author(s):

José Enrique Iranzo-Cortés ◽

José María Montiel-Company ◽

Teresa Almerich-Torres ◽

Carlos Bellot-Arcís ◽

José Manuel Almerich-Silla

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

A Value ◽

Published Evidence ◽

Meta Analyses ◽

Fail Safe ◽

Cavitated Lesions

Objective: To analyse the published evidence of the validity of DIAGNDOdent and VistaProof in diagnosing carious depths in pre-cavitated lesions. Material and methods: A systematic review was carried out after identifying a total of 184 articles, including 27 concerning the qualitative review and a subsequent meta-analysis. The quality of the studies was evaluated by using the QUADAS-2 tool. Results: For DIAGNOdent, the sensitivity value was 0.77, the specificity value was 0.75 and AUC was 0.81 for the global meta-analyses. In relation to subgroups, the values estimated 0.85, 0.76 and 0.86, respectively, for the in vivo group and 0.71, 0.75 and 0.83 for the in vitro group. For VistaProof, sensitivity was 0.81, specificity 0.75 and AUC had a value of 0.80 in the global meta-analysis. For the subgroups, these were considered at 0.75, 0.81 and 0.89, respectively, for the in vivo group and 0.91, 0.74 and 0.76 for the in vitro group. Neither case presented publication bias when analysing the funnel plot, the classic fail-safe number and Egger’s intercept. Conclusion: Both VistaProof and DIAGNOdent are valid as they offer a moderate to high diagnostic effectiveness for dentine depth in pre-cavitated lesions.

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Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.00029.2015 ◽

2015 ◽

Vol 309 (6) ◽

pp. L593-L604 ◽

Cited By ~ 22

Author(s):

Yanli Hou ◽

Min Liu ◽

Cristiana Husted ◽

Chihhsin Chen ◽

Kavitha Thiagarajan ◽

...

Keyword(s):

Cell Proliferation ◽

Combined Treatment ◽

Nuclear Factor Κb ◽

Inflammatory Stress ◽

Inflammatory Protein ◽

Inflammatory Stimuli ◽

Anti Inflammatory ◽

Macrophage Inflammatory Protein

A significant portion of lung development is completed postnatally during alveolarization, rendering the immature lung vulnerable to inflammatory stimuli that can disrupt lung structure and function. Although the NF-κB pathway has well-recognized pro-inflammatory functions, novel anti-inflammatory and developmental roles for NF-κB have recently been described. Thus, to determine how NF-κB modulates alveolarization during inflammation, we exposed postnatal day 6 mice to vehicle (PBS), systemic lipopolysaccharide (LPS), or the combination of LPS and the global NF-κB pathway inhibitor BAY 11-7082 (LPS + BAY). LPS impaired alveolarization, decreased lung cell proliferation, and reduced epithelial growth factor expression. BAY exaggerated these detrimental effects of LPS, further suppressing proliferation and disrupting pulmonary angiogenesis, an essential component of alveolarization. The more severe pathology induced by LPS + BAY was associated with marked increases in lung and plasma levels of macrophage inflammatory protein-2 (MIP-2). Experiments using primary neonatal pulmonary endothelial cells (PEC) demonstrated that MIP-2 directly impaired neonatal PEC migration in vitro; and neutralization of MIP-2 in vivo preserved lung cell proliferation and pulmonary angiogenesis and prevented the more severe alveolar disruption induced by the combined treatment of LPS + BAY. Taken together, these studies demonstrate a key anti-inflammatory function of the NF-κB pathway in the early alveolar lung that functions to mitigate the detrimental effects of inflammation on pulmonary angiogenesis and alveolarization. Furthermore, these data suggest that neutralization of MIP-2 may represent a novel therapeutic target that could be beneficial in preserving lung growth in premature infants exposed to inflammatory stress.

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BIOACTIVITIES OF GUETTARDA SPECIOSA L. EXTRACTS

Acta Scientifica Malaysia ◽

10.26480/asm.01.2021.20.22 ◽

2020 ◽

Vol 5 (1) ◽

pp. 20-22

Author(s):

Saravanan Vivekanandarajah Sathasivampillai ◽

Moon Jain ◽

Pholtan Rajeev Sebastian Rajamanoharan

Keyword(s):

Systematic Review ◽

Plant Species ◽

Web Of Science ◽

Antioxidant Activities ◽

Bioactive Compound ◽

Scientific Data ◽

Anti Inflammatory

Guettarda speciosa L. is a tree of the Rubiaceae family. G. specious has been used to treat diarrhea, abscesses, wounds, epilepsy, and malaria in ethnomedicinal systems. So far, there is no systematic review for the bioactivities of G. speciosa. Therefore, the purpose of this minireview is to analyze, summarize and document the reported bioactivities of G. speciosa. Major electronic databases (Web of Science, Scopus, ScienceDirect, PubMed, and Semantic Scholar) were used to identify related studies from 1900 to January 2021. So far, in vivo and in vitro scientific data are available for the bioactivities of this plant species. Studies have reported that G. speciosa contains antidiarrheal, antiepileptic, anti-inflammatory, anti-ulcer, antimalarial, antineurodegenerative, and antioxidant activities. Furthermore, no bioactive compound of G. speciosa has been isolated. This work will be useful for researchers interested in bioactivity and phytochemical researches.

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Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review

International Journal of Molecular Sciences ◽

10.3390/ijms22157937 ◽

2021 ◽

Vol 22 (15) ◽

pp. 7937

Author(s):

Juan Antonio Giménez-Bastida ◽

Antonio González-Sarrías ◽

José Moisés Laparra-Llopis ◽

Claus Schneider ◽

Juan Carlos Espín

Keyword(s):

Systematic Review ◽

Nordihydroguaiaretic Acid ◽

Current Evidence ◽

Inflammatory Mechanism ◽

Tnf Α ◽

Beneficial Impact ◽

Cox 2 ◽

Anti Inflammatory

5-Lipoxygenase (5-LOX) plays a key role in inflammation through the biosynthesis of leukotrienes and other lipid mediators. Current evidence suggests that dietary (poly)phenols exert a beneficial impact on human health through anti-inflammatory activities. Their mechanisms of action have mostly been associated with the modulation of pro-inflammatory cytokines (TNF-α, IL-1β), prostaglandins (PGE2), and the interaction with NF-κB and cyclooxygenase 2 (COX-2) pathways. Much less is known about the 5-lipoxygenase (5-LOX) pathway as a target of dietary (poly)phenols. This systematic review aimed to summarize how dietary (poly)phenols target the 5-LOX pathway in preclinical and human studies. The number of studies identified is low (5, 24, and 127 human, animal, and cellular studies, respectively) compared to the thousands of studies focusing on the COX-2 pathway. Some (poly)phenolics such as caffeic acid, hydroxytyrosol, resveratrol, curcumin, nordihydroguaiaretic acid (NDGA), and quercetin have been reported to reduce the formation of 5-LOX eicosanoids in vitro. However, the in vivo evidence is inconclusive because of the low number of studies and the difficulty of attributing effects to (poly)phenols. Therefore, increasing the number of studies targeting the 5-LOX pathway would largely expand our knowledge on the anti-inflammatory mechanisms of (poly)phenols.

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New Knowledge About Old Drugs: The Anti-Inflammatory Properties of Cardiac Glycosides

Planta Medica ◽

10.1055/s-0043-105390 ◽

2017 ◽

Vol 83 (12/13) ◽

pp. 977-984 ◽

Cited By ~ 9

Author(s):

Robert Fürst ◽

Ilse Zündorf ◽

Theo Dingermann

Keyword(s):

Cardiac Glycosides ◽

Research Field ◽

Safety Issues ◽

Anti Inflammatory ◽

Underlying Mechanisms ◽

The 1960S ◽

Meta Analyses ◽

The 19Th Century

AbstractIn the 19th century, cardio-active steroid glycosides, shortly cardiac glycosides, were scientifically established as drugs against heart failure. Their in vivo, cellular, and molecular actions as well as their predominant target, Na+-K+-ATPase, have been comprehensively investigated in the 20th century and the discovery of endogenous cardiac glycosides has fostered this research field. In the last years, however, results from clinical trials and meta-analyses have questioned their therapeutic value due to efficacy and safety issues. This has led to a considerable decline of their usage. Beyond the cardiovascular system, cardiac glycosides have been increasingly recognized as antitumor compounds and Na+-K+-ATPase has evolved into a promising drug target in oncology. A wealth of review articles exists that intensively discuss these topics. Surprisingly, the anti-inflammatory actions of cardiac glycosides, which were discovered in the 1960s, have so far hardly been perceived and have not yet been summarized. This review provides an overview of the in vivo and in vitro actions of cardiac glycosides on inflammatory processes and of the signaling mechanisms responsible for these effects: cardiac glycosides have been found to decrease inflammatory symptoms in different animal models of acute and chronic inflammation. Regarding the underlying mechanisms most research has focused on leukocytes. In these cells, cardiac glycosides primarily inhibit cell proliferation and the secretion of proinflammatory cytokines.

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Systematic Review—The Potential Implications of Different Platelet-Rich Plasma (PRP) Concentrations in Regenerative Medicine for Tissue Repair

International Journal of Molecular Sciences ◽

10.3390/ijms21165702 ◽

2020 ◽

Vol 21 (16) ◽

pp. 5702 ◽

Cited By ~ 2

Author(s):

Pietro Gentile ◽

Simone Garcovich

Keyword(s):

Systematic Review ◽

Tissue Regeneration ◽

Tissue Repair ◽

Platelet Rich Plasma ◽

Platelet Concentration ◽

Volume Group ◽

Scopus Database ◽

Meta Analyses

The number of studies evaluating platelet-rich plasma (PRP) concentration has substantially grown in the last fifteen years. A systematic review on this field has been realized by evaluating in the identified studies the in vitro PRP concentration—also analyzing the platelet amount—and the in vivo PRP effects in tissue regeneration compared to any control. The protocol has been developed in agreement with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols (PRISMA-P) guidelines. Multistep research of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database and Cochrane databases has permitted to identify articles on different concentrations of PRP in vitro and related in vivo impact for tissue repair. Of the 965 articles initially identified, 30 articles focusing on PRP concentration have been selected and, consequently, only 15 articles have been analyzed. In total, 40% (n = 6) of the studies were related to the fixed PRP Concentration Group used a fixed PRP concentration and altered the platelet concentration by adding the different volumes of the PRP (lysate) to the culture. This technique led to a substantial decrease in nutrition available at higher concentrations. Sixty percent (n = 9) of the studies were related to the fixed PRP Volume Group that used a fixed PRP-to-media ratio (Vol/Vol) throughout the experiment and altered the concentration within the PRP volume. For both groups, when the volume of medium (nutrition) decreases, a lower rate of cell proliferation is observed. A PRP concentration of 1.0 × 106 plt/μL, appears to be optimal thanks to the constant and plentiful capillary nutrition supply and rapid diffusion of growth factors that happen in vivo and it also respects the blood decree-law. The PRP/media ratio should provide a sufficient nutrition supply to prevent cellular starvation, that is, PRP ≤ 10% (Vol/Vol) and thus best mimic the conditions in vivo.

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