scholarly journals The Effectiveness of the Bacteria Derived Extremolyte Ectoine for the Treatment of Allergic Rhinitis

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Andreas Bilstein ◽  
Nina Werkhäuser ◽  
Anna Rybachuk ◽  
Ralph Mösges
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Nasal Spray ◽  
Inflammatory Diseases ◽  
Symptom Relief ◽  
Concomitant Treatment ◽  
Good Tolerability ◽  
Study Results ◽  
Patient Groups ◽  
Preclinical And Clinical Studies

Nonpharmacological therapies with a good tolerability and safety profile are of interest to many patients with allergic rhinitis, as a relevant proportion of them have reservations about guideline-concordant pharmacological therapies due to their local irritations and side effects. Ectoine is a bacterial-derived extremolyte with an ability to protect proteins and biological membranes against damage caused by extreme conditions of salinity, drought, irradiation, pH, and temperature. Evidence from preclinical and clinical studies attests its effectiveness in the treatment of several inflammatory diseases, including allergic rhinitis. In this review, we analyzed 14 recent clinical trials investigating ectoine nasal spray in patients with allergic rhinitis and/or conjunctivitis, including sensitive patient groups like children or pregnant women. Some studies investigated monotherapy with ectoine; others investigated combination therapy of ectoine and an antihistamine or a corticosteroid. Analysis of the study results demonstrated that patients with mild-to-moderate symptoms of allergic rhinitis can be successfully treated with ectoine-containing nasal spray. When applied as monotherapy, ectoine exerted noninferior effects compared to first-line therapies such as antihistamines and cromoglicic acid. Using ectoine as an add-on therapy to antihistamines or intranasal glucocorticosteroids accelerated symptom relief by days and improved the level of symptom relief. Importantly, concomitant treatment with ectoine was proven beneficial in a group of difficult-to-treat patients suffering from moderate-to-severe rhinitis symptoms. Taken together, the natural substance ectoine represents a viable alternative for allergic rhinitis and conjunctivitis patients who wish to avoid local reactions and side effects associated with pharmacological therapies.

scholarly journals Evaluating the Protective Properties of a Xyloglucan-Based Nasal Spray in a Mouse Model of Allergic Rhinitis

2021 ◽  
Vol 22 (19) ◽  
pp. 10472
Author(s):  
Marika Lanza ◽  
Giovanna Casili ◽  
Alessia Filippone ◽  
Michela Campolo ◽  
Irene Paterniti ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Nasal Spray ◽  
Standard Of Care ◽  
Similar Efficacy ◽  
Specific Ige ◽  
Ar Model ◽  
Concomitant Treatment ◽  
Junction Protein ◽  
Significant Efficacy

A breached nasal epithelial barrier plays an important role in driving allergic rhinitis (AR). Corticosteroids remain the standard of care (SoC) but come with side effects, thus alternative safe and effective treatments able to avoid inflammation and restore barrier integrity are needed. The aim of the present study is to evaluate the barrier-forming capacity of a xyloglucan-based nasal spray (XG) and compare its efficacy to several SoC treatments (corticosteroid spray, oral mast-cell stabilizer and oral antihistamine) in reducing allergic responses in addition to its effect when concomitantly administered with an antihistamine. An ovalbumin (OVA)-induced mouse AR model was used. XG shows a significant efficacy in reducing histological damage in AR mice; improves nasal rubbing and histamine-induced hyper-responsiveness. Total and OVA-specific IgE as well as pro-inflammatory cytokines are significantly reduced compared to OVA challenged-mice, with im-proved efficacy when used as an add-on treatment. However, XG reduces mucous secreting cells (PAS-positive) and mucin mRNA expression similar to the corticosteroid-treated mice. XG-spray maintains tight junction protein expression (ZO-1) and conversely decreases HDAC1 significantly; the latter being highly expressed in AR patients. Moreover, the concomitant treatment showed in all of the endpoints a similar efficacy to the corticosteroids. This innovative approach may represent a novel therapeutic strategy for nasal respiratory diseases like AR, reducing undesirable side effects and improving the quality of life in patients.

scholarly journals Ectoine in the Treatment of Irritations and Inflammations of the Eye Surface

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Andreas Bilstein ◽  
Anja Heinrich ◽  
Anna Rybachuk ◽  
Ralph Mösges
Keyword(s):  
Ocular Surface ◽  
Uv Light ◽  
Inflammatory Diseases ◽  
Symptom Relief ◽  
Stress Factors ◽  
Eye Drops ◽  
Ophthalmic Surgery ◽  
Ocular Symptoms ◽  
Preclinical And Clinical Studies ◽  
Standard Treatment Regimen

The ocular surface is facing various unspecific stress factors resulting in irritation and inflammation of the epithelia, causing discomfort to the patients. Ectoine is a bacteria-derived extremolyte with the ability to protect proteins and biological membranes from damage caused by extreme environmental conditions like heat, UV-light, high osmolarity, or dryness. Evidence from preclinical and clinical studies attest its effectiveness in treating several epithelium-associated inflammatory diseases, including the eye surface. In this review, we analysed 16 recent clinical trials investigating ectoine eye drops in patients with allergic conjunctivitis or with other unspecific ocular inflammations caused by e.g. ophthalmic surgery. Findings from these studies were reviewed in context with other published work on ectoine. In summary, patients with irritations and unspecific inflammations of the ocular surface have been treated successfully with ectoine-containing eye drops. In these patients, significant improvement was observed in ocular symptoms of allergic rhinoconjunctivitis, postoperative secondary dry eye syndrome, or ocular reepithelisation after surgery. Using ectoine as an add-on therapy to antihistamines, in allergy patients accelerated symptom relief by days, and its use as an add-on to antibiotics resulted in faster wound closure. Ectoine is a natural substance with an excellent tolerability and safety profile thus representing a helpful alternative for patients with inflammatory irritation of the ocular surface, who wish to avoid local reactions and side effects associated with pharmacological therapies or wish to increase the efficacy of standard treatment regimen.

scholarly journals TO ASSES THE EFFICACY OF MOMETASONE AND HYDROXYPROPYLMETHYLCELLULOSE NASAL SPRAY TO CONTROL SYMPTOMS OF ALLERGIC RHINITIS: A COMPARATIVE STUDY

2021 ◽  
pp. 14-16
Author(s):  
Arup Chakraborty ◽  
Biswajit Sukla ◽  
Prabir Kumar Saha ◽  
Bidhan Das
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Comparative Study ◽  
Nasal Spray ◽  
Daily Life ◽  
P Value ◽  
Complete Relief ◽  
Chi Square ◽  
Common Disorder

Allergic rhinitis is very common disorder. It significantly effects patient's daily life. So many drugs are in use for the control of symptoms of allergic rhinitis.Steroid nasal spray was the mainstay of topical medicine for long.Hpmc powder nasal sprayis not so old medication used now a days.In our study we try to find out the effictiveness of mometasone and HPMC powder nasal spray to control the symptoms of allergic rhinitis.In each group we had 60 nos of patient receiving the medication as stated. Evaluation was done at 14th days and 28th days of starting the drugs. At day 14th The chisquare statistic was 1.8682. The p value was 0.602. The result was not significant as p more than o.5. there was same response for both drugs at 14th day of starting treatment.At day 28h The chi-square statistic was 14.8428.The p value was 0.005039.The result was significant as p less than o.5.there was same response for both drugs at 28th day of starting treatment. There was more relief of major symptoms and complete relief of symptoms with HPMC powder nasal spray at 28th day of treatment.The value of z (two proportion test ) is -3.7158 .The value of p is 0.0001.There was minimal side effects for both drugs.only 7 nos of patients said that three times daily dosage of HPMC is not convenient

scholarly journals Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Nina Werkhäuser ◽  
Andreas Bilstein ◽  
Uwe Sonnemann
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Nasal Spray ◽  
Treatment Strategies ◽  
Common Disease ◽  
Eye Drops ◽  
Treatment Regimens ◽  
Ocular Symptoms ◽  
New Treatment ◽  
Design And Methods

Objectives. Allergic rhinitis is a common disease with increasing prevalence and high impact on economic burden and comorbidities. As treatment with pharmacological drugs is not always satisfactory due to side effects and incomplete efficacy, alternative treatment strategies are needed. Ectoine is an osmolyte with membrane stabilizing and inflammation reducing capacities. Nasal spray and eye drops containing ectoine are promising new treatment regimens for allergic rhinitis sufferers. Design and Methods. The current two noninterventional trials evaluated the efficacy and safety of ectoine containing nasal spray and eye drops for treating allergic rhinitis in comparison with either azelastine or cromoglycic acid containing products. Nasal and ocular symptom developments as well as judgment of tolerability and efficacy were assessed both by investigators and patients over a time period of one to two weeks. Results. Both trials confirmed that ectoine containing products reduced nasal and ocular symptoms in allergic rhinitis patients. Results clearly demonstrated good safety profiles of the ectoine products comparable to those of azelastine and even better to those of cromoglycate products. Conclusion. Ectoine containing nasal spray and eye drops are interesting new treatment strategies for sufferers of allergic rhinitis, combining both good efficacy and absence of side effects.

scholarly journals Observational study investigating Ectoin® Rhinitis Nasal Spray as natural treatment option of acute rhinosinusitis compared to treatment with Xylometazoline

2021 ◽  
Author(s):  
Nina Werkhäuser ◽  
Andreas Bilstein ◽  
Kathrin Mahlstedt ◽  
Uwe Sonnemann
Keyword(s):  
Side Effects ◽  
Observational Study ◽  
Nasal Spray ◽  
Nasal Mucosa ◽  
Treatment Option ◽  
Symptomatic Relief ◽  
Concomitant Treatment ◽  
Acute Rhinosinusitis ◽  
Nasal Decongestants ◽  
Natural Treatment

Abstract Introduction Symptomatic relief of acute rhinosinusitis is commonly achieved with nasal decongestants. The current observational study investigated the efficacy and safety of treatment of acute rhinosinusitis with Ectoin® Rhinitis Spray compared to or in combination with Xylometazoline-containing decongesting nasal spray. Methods Patients with acute rhinosinusitis applied either Ectoin® Rhinitis Spray, Xylometazoline nasal spray or a combination of both products. Rhinosinusitis symptoms were assessed, and nasal oedema and endonasal redness were determined by rhinoscopy. Patient diaries based on the validated SNOT (Sino Nasal Outcome Test) questionnaire evaluated rhinosinusitis parameters over time and influences of the disease on quality of life. Following treatment, investigators and patients judged the efficacy and tolerability. Results Ectoin® Rhinitis Spray diminished common rhinosinusitis symptoms such as nasal obstruction, nasal secretion, facial pain/headache, and smell/taste impairment. Upon treatment over 7 days, rhinosinusitis sum scores decreased statistically significantly (p < 0.001) by − 64.25%, which was comparable to that achieved with Xylometazoline-containing decongesting nasal spray (− 67.60%). No side effects were observed during treatment with Ectoin® Rhinitis Spray, whereas treatment with Xylometazoline-containing nasal spray resulted in nasal mucosa dryness. Concomitant treatment with both products diminished the development of nasal dryness and required fewer applications of Xylometazoline-containing nasal spray. Conclusion Ectoin® Rhinitis Spray is an effective, natural treatment option for acute rhinosinusitis, which may be used as monotherapy or as add-on treatment with a Xylometazoline-containing nasal spray. The concomitant use of Ectoin® Rhinitis Spray might reduce the needed dose of decongestant nasal spray and counteract bothersome side effects such as dry nasal mucosa. Trial registration The current study was registered in the ClinicalTrials.gov database under the identifier: NCT03693976 (date of registration: Oct 3, 2018).

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

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