scholarly journals TO ASSES THE EFFICACY OF MOMETASONE AND HYDROXYPROPYLMETHYLCELLULOSE NASAL SPRAY TO CONTROL SYMPTOMS OF ALLERGIC RHINITIS: A COMPARATIVE STUDY

2021 ◽  
pp. 14-16
Author(s):  
Arup Chakraborty ◽  
Biswajit Sukla ◽  
Prabir Kumar Saha ◽  
Bidhan Das
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Comparative Study ◽  
Nasal Spray ◽  
Daily Life ◽  
P Value ◽  
Complete Relief ◽  
Chi Square ◽  
Common Disorder

Allergic rhinitis is very common disorder. It significantly effects patient's daily life. So many drugs are in use for the control of symptoms of allergic rhinitis.Steroid nasal spray was the mainstay of topical medicine for long.Hpmc powder nasal sprayis not so old medication used now a days.In our study we try to find out the effictiveness of mometasone and HPMC powder nasal spray to control the symptoms of allergic rhinitis.In each group we had 60 nos of patient receiving the medication as stated. Evaluation was done at 14th days and 28th days of starting the drugs. At day 14th The chisquare statistic was 1.8682. The p value was 0.602. The result was not significant as p more than o.5. there was same response for both drugs at 14th day of starting treatment.At day 28h The chi-square statistic was 14.8428.The p value was 0.005039.The result was significant as p less than o.5.there was same response for both drugs at 28th day of starting treatment. There was more relief of major symptoms and complete relief of symptoms with HPMC powder nasal spray at 28th day of treatment.The value of z (two proportion test ) is -3.7158 .The value of p is 0.0001.There was minimal side effects for both drugs.only 7 nos of patients said that three times daily dosage of HPMC is not convenient

A Comparative Study between Ketamine and Lidocaine ro Decrease Propofol Injection Pain During Induction of Anesthesia

2021 ◽  
Vol 6 (1) ◽  
pp. 1304-1309
Author(s):  
Bikash Khadka ◽  
Nil Raj Sharma
Keyword(s):  
Comparative Study ◽  
Venous Occlusion ◽  
Verbal Response ◽  
Injection Pain ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Lidocaine Group ◽  
Mild Pain ◽  
Significant Difference

Introduction: Pain during the injection of anesthetic agents may be distressing and can reduce the acceptability of an otherwise useful agent such as propofol during daycare surgeries. Lidocaine and ketamine both are used as pre-treatment to decrease propofol induced pain. This study aims to compare the effectiveness of ketamine injection to decrease propofol-induced pain in comparison to lidocaine injection. Methodology: This is a prospective cross-sectional comparative study. Eighty-nine cases were divided into two groups where group K received ketamine 2 ml (0.2 mg/kg) whereas group L received lidocaine 2% 2ml (0.5 mg/kg) after venous occlusion with rubber tourniquet. One-fourth dose of propofol was injected 1 min after release of tourniquet and pain accessed at 0, 1, and 2 minutes of propofol injection with a verbal response and behavioral signs. Chi-square test and paired T-test were used and a p-value less than 0.05 was considered significant. Result: Regarding hemodynamic, oxygenation, and adverse effects there was no significant difference. Immediately after propofol injection, only 1 patient of the ketamine group had mild pain (2.22%) while 12 patients from the lignocaine group had mild pain (27.27%) with a p-value of 0.009. Also after 2 minutes of propofol injection, only 12 cases had mild pain i.e. 13.48% (1 from ketamine group i.e. 2.22% and 11 from lidocaine group i.e. 25%) with p-value of 0.002. Conclusion: Our study helps prove low-dose ketamine is more effective in reducing the incidence and severity of pain on injection of propofol in comparison to Lidocaine with better hemodynamic stability. 

A Comparative Study to verify the Efficacy of Preoperative Intravenous Tranexamic Acid in Control of Tonsillectomy Bleeding

2016 ◽  
Vol 8 (1) ◽  
pp. 22-25 ◽  
Author(s):  
KB Prashanth ◽  
S Abhilash
Keyword(s):  
Side Effects ◽  
Tranexamic Acid ◽  
Comparative Study ◽  
Intravenous Dose ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Not Given ◽  
Single Intravenous Dose ◽  
Group I

ABSTRACT Objectives This study was conducted to assess the efficacy of the drug tranexamic acid administered preoperatively in controlling the bleeding during tonsillectomy intraoperatively. Materials and methods A total of 50 patients who underwent tonsillectomy were randomized into two groups. Group I (study group): Intravenous tranexamic acid was given with dose of 10 mg/kg. Group II (control group): Tranexamic acid injection was not given. Intraoperative amount of bleeding was assessed in each case. Results The study group had significant reduction in bleeding and the p-value was <0.05, which was statistically significant, when compared to control group. There were no side effects of the drug observed. Conclusion Single intravenous dose of tranexamic acid at a dose of 10 mg/kg preoperatively is effective in control of tonsillectomy bleeding. How to cite this article Santosh UP, Prashanth KB, Abhilash S. A Comparative Study to verify the Efficacy of Preoperative Intravenous Tranexamic Acid in Control of Tonsillectomy Bleeding. Int J Otorhinolaryngol Clin 2016;8(1):22-25.

scholarly journals Evaluation of adverse effects with COVID-19 vaccination in Pakistan

2021 ◽  
Vol 37 (7) ◽  
Author(s):  
Dr Sana Abbas ◽  
Beenish Abbas ◽  
Sidra Amir ◽  
Mehreen Wajahat
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Post Vaccination ◽  
Gastrointestinal Disturbance ◽  
Creative Commons ◽  
Chi Square Test ◽  
Categorical Groups

Objectives: Vaccinations work with different mechanisms to offer protection against disease; however, process of immunity building can cause symptoms. Therefore, this study aimed to determine the immediate side effects of COVID–19 vaccination in the Pakistani Population. Methods: This cross-sectional analytical study was conducted at Foundation University College of Dentistry, Islamabad from February to April 2021. 0.5 mL per dose of the Covid-19 vaccine was administered to the candidates. These 205 candidates receiving vaccination were then interviewed investigating the adverse effects of the vaccine. Post-vaccination side effects were compared among categorical groups using the Chi-Square test, whereas post-vaccination side effects were compared with age using independent samples T-test. A p-value of ≤0.05 was statistically significant. Results: Among post-vaccination side effects, fever was reported by 69 participants, while 56 of 205 reported soreness, redness, and swelling at the injection site. It was reported by 42/205 participants to have felt chills and rigor, whereas gastrointestinal disturbance and flu-like symptoms were reported in 55/205 and 28/205 participants, respectively. Younger participants were more likely to develop gastrointestinal disturbance and flu-like symptoms following vaccination as compared to older participants. Conclusion: Malaise, headache, and fever were observed to be the most common side effects of the vaccine, moreover there was a linear relationship between manifestations of adverse effects and history of comorbidities. doi: https://doi.org/10.12669/pjms.37.7.4522 How to cite this:Abbas S, Abbas B, Amir S, Wajahat M. Evaluation of adverse effects with COVID-19 vaccination in Pakistan. Pak J Med Sci. 2021;37(7):---------.   doi: https://doi.org/10.12669/pjms.37.7.4522 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Knowledge and awareness of mercury disposal among health care providers

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 492-499
Author(s):  
Preethi Shankar ◽  
Kavitha S ◽  
Preetha S ◽  
Vishnupriya V ◽  
Gayathri R
Keyword(s):  
Side Effects ◽  
Health Care Providers ◽  
Healthcare Providers ◽  
Mercury Vapour ◽  
P Value ◽  
First Year ◽  
Care Providers ◽  
Chi Square ◽  
Spss Software ◽  
Second Year

Mercury is considered to be a powerful neurotoxin which leads to mercury poisoning. Mercury can harm us in many ways. Mercury vapour can harm the nervous system in newborn babies and can further lead to cough, tremor and irritability. Being a healthcare provider, it is necessary to know about mercury spill management. To assess the awareness and knowledge of mercury spill management among healthcare providers, an online based survey was created using google forms. The students were asked to answer 10 questions based on mercury spill management and its usefulness. 100 students actively participated in the survey. Correlation analysis was done by chi square test using SPSS software. The results were analysed by Spss software. From the correlation, only 18% of the students in first year, 6% of the students in second year, 2% of the students in third year, 4% of the students in fourth year and 5% of the students in final year were aware of the side effects of mercury with the p value of 0.879 which is statistically insignificant . Similarly, 26% of the first year students, 7% of the second year students, 4% of the third year students, 8% of the fourth year students and 7% of the final year students were aware that hypochlorite solution is used to wipe the mercury spill with p value of 0.323 which is statistically insignificant. On analysing the data it was found that healthcare providers had only little knowledge on mercury spill management. Many healthcare providers were aware of the side effects of mercury and some students were aware of its management. This survey in the current scenario is of utmost importance to reduce exposure of mercury among healthcare providers.

scholarly journals Prevalence of Allergic Rhinitis in Children with Adenotonsillar Hypertrophy Referred to Imam Khomeini Hospital of Ahvaz from 2019 to 2020

2021 ◽  
Vol 10 (2) ◽  
Author(s):  
Soheila Nikakhlagh ◽  
Shohreh Norouzi ◽  
Nader Saki ◽  
Mohammad Bagher Bakhshipour
Keyword(s):  
Allergic Rhinitis ◽  
Strong Association ◽  
Allergic Diseases ◽  
P Value ◽  
Chi Square ◽  
Exact Test ◽  
Adenotonsillar Hypertrophy ◽  
Chi Square Test ◽  
Main Components ◽  
Age Range

Background: Allergic diseases are among the most common chronic conditions in pediatrics. Objectives: This study aimed to evaluate the relative frequency of allergic rhinitis (AR) in children with adenotonsillar hypertrophy. Methods: In this descriptive study, 175 patients with adenotonsillar hypertrophy referred to the Imam Khomeini hospital of Ahvaz from March 2019 to March 2020 were enrolled. Allergic rhinitis was diagnosed based on the Score for AR (SFAR) questionnaire. The questionnaire, including the expert-designed SFAR, has eight main components that evaluate eight quantitative features of AR, and each was designated with a specific weighted score based on previous clinical studies. The total score could vary from 0 to 16. Frequency and percentage were used to describe the data. The chi-square test and Fisher's exact test were used to analyze the data. Results: One hundred seventy-five patients with adenotonsillar hypertrophy in the age range of 1 to 17 years were studied. Ninety-one patients (52%) were male, and 84 patients (48%) were female. Based on the score obtained from the questionnaire, 146 patients (83.4%) had a score of less than seven, indicating susceptibility to AR. Twenty-nine patients (16.6%) had a score equal to or higher than 7, confirming the diagnosis of AR. The Chi-square test showed that AR was significantly associated with all the components of the questionnaire, except for cigarette smoking (P-value < 0.001). Conclusions: This study showed the strong association of AR with some demographic factors. Allergic rhinitis could potentially increase the risk of adenotonsillar hypertrophy in children.

scholarly journals Hubungan Rinitis Alergi Dengan Otitis Media Akut Pada Anak Di RSUD Dr. H Abdul Moeloek Bandar Lampung Tahun

2021 ◽  
Vol 1 (3) ◽  
pp. 198-203
Author(s):  
Muslim Kasim ◽  
Arti Febriyani Hutasuhut ◽  
Tan’im Arief ◽  
Farah Ulya Suryadana
Keyword(s):  
Allergic Rhinitis ◽  
Data Analysis ◽  
Otitis Media ◽  
Research Design ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Sampling Technique ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional

ABSTRACT: RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND ACUTE OTITIS MEDIA IN CHILDREN IN RSUD DR. H ABDUL MOELOEK  BANDAR LAMPUNG  Introduction: Background : Acute Otitis Media (AOM) is an inflammation that happen in the middle ear and is very common, especially in children. Children are susceptible to acute otitis media (AOM) due to the shorter and horizontal anatomy of the eustachian tube. Allergic Rhinitis is one of the risk factos that caused acute otitis media in children.Purpose : The purpose of this study was to determine the correlation between Allergic Rhinitis and Acute Otitis Media in ChildrenMethod: This study used an observational analytic research with cross sectional research design. The sample in this study was 59 patients diagnosed with acute otitis media at RSUD Dr. H. Abdul Moeloek in 2019-2020. The sampling technique used total sampling. Data analysis using Chi-Square testResult: The results of this study indicated that there was a relationship between allergic rhinitis and acute otitis media in children with p value = 0,047(<0,05) with an OR = 0,146 (95%CI 0,17-1,232). Conclusion: There is a relationship between Allergic Rhinitis and Acute Otitis Media in children at Dr. H Abdul Moeloek Bandar Lampung in 2019-2020 Keyword : Allergic Rhinitis, Acute Otitis Media, Children  INTISARI: HUBUNGAN RINITIS ALERGI DENGAN OTITIS MEDIA AKUT PADA ANAK DI RSUD DR. H ABDUL MOELOEK BANDAR LAMPUNG  Latar belakang: Otitis Media Akut (OMA) merupakan peradangan yang terjadi pada telinga bagian tengah dan sangat sering terjadi terutama pada anak-anak. Anak-anak rentan terkena Otitis Media Akut (OMA) dikarenakan bentuk anatomi tuba eustachius yang lebih pendek dan horizontal. Rinitis Alergi merupakan salah satu faktor risiko yang menyebabkan Otitis Media Akut pada anak.Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan Rinitis Alergi dengan Otitis Media akut pada Anak.Metode: Penelitian analitik observasional dengan desain penelitian cross sectional. Sampel sebanyak 59 pasien dengan diagnosa otitis media akut anak di RSUD Dr. H. Abdul Moeloek tahun 2018. Teknik pengambilan sample menggunakan total sampling. Analisis data menggunakan uji Chi-SquareHasil : Hasil penelitian ini menunjukkan bahwa terdapat hubungan antara rinitis alergi dengan otitis media akut pada anak dengan p value = 0,047(<0,05) dengan nilai OR = 0,146 (95%CI 0,17-1,232).Kesimpulan : Terdapat hubungan antara Rinitis Alergi dengan Otitis Media Akut pada anak di RSUD Dr. H Abdul Moeloek Bandar Lampung tahun 2019-2020 Kata Kunci : Rinitis Alergi, Otitis Media Akut, Anak  

scholarly journals A Cross-Sectional Study of Antibiotic Self-Medication

Thrita ◽  
2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Fatemeh Mousavi ◽  
Parisa Shojaei ◽  
Azadeh Nazemi ◽  
Atefe Dadashi
Keyword(s):  
Logistic Regression ◽  
Side Effects ◽  
Cross Sectional Study ◽  
Study Data ◽  
P Value ◽  
Sectional Study ◽  
Self Medication ◽  
Chi Square ◽  
Cross Sectional ◽  
Significant Difference

Objectives: This research has been conducted to study antibiotic self-medication, prevalence, and reasons. Methods: A questionnaire containing 30 comprehensive questions in terms of the experience of antibiotic self-medication was prepared. In this cross-sectional study, data were analyzed using analytical statistics bases on chi-square and logistic regression. Results: The results showed that 61.3% of the participants were self-antibiotic users. There was a significant difference only between gender and self-medication such that self-medication in males was more than females (P value = 0.027). Conclusions: Self-medication of antibiotics is almost high and requires more information about the side effects of these drugs in order to promote rational and physically prescribed use.

scholarly journals The effect of intravenous ketamine and pethidine on postoperative shivering in surgical patients under general anesthesia in Tikur anbessa specialized hospital, Addis Ababa, Ethiopia: A prospective observational cohort study 

2021 ◽  
Author(s):  
Geresu Gebeyehu ◽  
Betelihem Girma
Keyword(s):  
Cohort Study ◽  
Side Effects ◽  
General Anesthesia ◽  
Low Dose ◽  
Elective Surgery ◽  
Addis Ababa ◽  
P Value ◽  
Chi Square ◽  
Pacu Stay ◽  
Intravenous Ketamine

Abstract Background: Postanesthesia shivering is one of the potential complications of anesthesia which may increase patient morbidity. Various methods have been employed to control postoperative shivering. This study assessed the effectiveness of prophylactic low-dose intravenous ketamine and pethidine for postoperative shivering after general anesthesia.Methods and materials: This prospective cohort study recruited 76 ASA I and II patients aged 18-65 years old and underwent elective surgery under general anesthesia. The patients were grouped based on either ketamine 0.5mg/kg or pethidine 0.5 mg/kg having been administered by the anaesthetist in charge as a prophylaxis for postoperative shivering 20 minutes before completion of the surgery. The incidence and severity of postoperative shivering were compared between the two groups every 10 minutes until one hour postoperatively. The side effects of the study drugs were also compared between the two groups in the recovery room. Categorical data were analyzed with the Chi-Square test. Parametric and nonparametric data between the groups were analyzed using independent samples t-test and Mann-Whitney U test, respectively. A p-value of <0.05 was considered statistically significant. Results: The incidence of shivering between the ketamine and pethidine groups was 11(28.2%) and 14(35.9%), respectively (p=0.467). The severity of shivering was not significantly different between the two groups (p=0.893). The occurrence of nausea and vomiting and sedation attributed to the drugs was significantly less in the ketamine group (p<0.05). PACU stay duration and occurrence of hallucinations among the groups were comparable. (p>0.05)Conclusion and Recommendation: This study revealed administering low-dose IV ketamine (0.5mg/kg) 20 minutes before completion of surgery reduced postoperative shivering as nearly equally as pethidine. The study also showed clinically better outcomes in favor of ketamine since it was associated with fewer side effects. Thus, we recommend low-dose IV ketamine 20 minutes before completion of surgery under general anesthesia to prevent postoperative shivering.

scholarly journals Evaluating the Protective Properties of a Xyloglucan-Based Nasal Spray in a Mouse Model of Allergic Rhinitis

2021 ◽  
Vol 22 (19) ◽  
pp. 10472
Author(s):  
Marika Lanza ◽  
Giovanna Casili ◽  
Alessia Filippone ◽  
Michela Campolo ◽  
Irene Paterniti ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Nasal Spray ◽  
Standard Of Care ◽  
Similar Efficacy ◽  
Specific Ige ◽  
Ar Model ◽  
Concomitant Treatment ◽  
Junction Protein ◽  
Significant Efficacy

A breached nasal epithelial barrier plays an important role in driving allergic rhinitis (AR). Corticosteroids remain the standard of care (SoC) but come with side effects, thus alternative safe and effective treatments able to avoid inflammation and restore barrier integrity are needed. The aim of the present study is to evaluate the barrier-forming capacity of a xyloglucan-based nasal spray (XG) and compare its efficacy to several SoC treatments (corticosteroid spray, oral mast-cell stabilizer and oral antihistamine) in reducing allergic responses in addition to its effect when concomitantly administered with an antihistamine. An ovalbumin (OVA)-induced mouse AR model was used. XG shows a significant efficacy in reducing histological damage in AR mice; improves nasal rubbing and histamine-induced hyper-responsiveness. Total and OVA-specific IgE as well as pro-inflammatory cytokines are significantly reduced compared to OVA challenged-mice, with im-proved efficacy when used as an add-on treatment. However, XG reduces mucous secreting cells (PAS-positive) and mucin mRNA expression similar to the corticosteroid-treated mice. XG-spray maintains tight junction protein expression (ZO-1) and conversely decreases HDAC1 significantly; the latter being highly expressed in AR patients. Moreover, the concomitant treatment showed in all of the endpoints a similar efficacy to the corticosteroids. This innovative approach may represent a novel therapeutic strategy for nasal respiratory diseases like AR, reducing undesirable side effects and improving the quality of life in patients.

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