scholarly journals Clinical Evaluation and Treatment of Patients with Postconcussion Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Vijay Renga
Keyword(s):  
Literature Review ◽  
Clinical Evaluation ◽  
Standard Treatment ◽  
Postconcussion Syndrome ◽  
Treatment Protocols ◽  
Cognitive Difficulties ◽  
Underlying Pathophysiology

Postconcussion syndrome (PCS) is a complex set of symptoms occurring in a small percentage of patients following concussion. The condition is characterized by headaches, dizziness, cognitive difficulties, somatosensory issues, and a variety of other symptoms with varying durations. There is a lack of objective markers and standard treatment protocols. With the complexity created by premorbid conditions, psychosomatic issues, secondary gains, and litigations, providers often find themselves in a tough situation in the care of these patients. This article combines literature review and clinical insights with a focus on the underlying pathophysiology of PCS to provide a roadmap for evaluating and treating this condition.

scholarly journals AN INSIGHT INTO AYURVEDIC VIEW OF SARS -COVID – 19

2020 ◽  
Vol 8 (7) ◽  
pp. 3925-3929
Author(s):  
Sreelakshmi S ◽  
Varghese Jibi ◽  
Manna Mathew ◽  
Priyanka Yadav
Keyword(s):  
Standard Treatment ◽  
Lifestyle Changes ◽  
Personal Hygiene ◽  
Treatment Modalities ◽  
Effective Management ◽  
Treatment Protocols ◽  
Health Crisis ◽  
Health Measures ◽  
Care Health ◽  
Insight Into

The Covid - 19 pandemic is defining the global health crisis of our time and occurs to be the greatest chal-lenge. The number of people getting affected and deaths are raising daily throughout the world. COVID-19 is the infectious disease caused by the most recently discovered Corona virus. The situation is much more than a health crisis with a potential to create devastating situations at social, economic, and political levels. Till date, no effective management to address this infection has been identified and attempts are being made to integrate a few traditional interventions along with standard treatment protocols of COVID-19. Ayurveda’s extensive knowledge is based on preventive care, health measures and boosting immunity. Contribution of Ayurveda in the management of various communicable and non-communicable diseases cannot be undermined. Through its wider concepts and treatment modalities, it has greater potential to ad-dress such situations. Awareness about the mode of spread of this disease is recommended highly to pre-vent oneself from falling prey to the disease. The large resource of time-tested traditional knowledge has to be used for the benefit of mankind. In addition to the personal hygiene and social distancing measures, it is of immense importance to improve individual’s natural defence system (immunity). Ayurveda can play a major role in mitigating the spread of COVID -19 by implementing some lifestyle changes along with sim-ple herbal medications and procedures by properly classifying and distinguishing the stage of the disease.

scholarly journals Enoxaparin in cardiovascular disease: how to improve effectiveness and safety?

2011 ◽  
Vol 10 (6) ◽  
pp. 112-123
Author(s):  
I. S. Yavelov
Keyword(s):  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Acute Coronary Syndrome ◽  
Body Weight ◽  
Standard Treatment ◽  
Decision Strategy ◽  
Elderly Age ◽  
Treatment Protocols ◽  
Coronary Syndrome ◽  
Optimal Balance

The review analyses the specifics of enoxaparin therapy in the most prevalent cardiovascular diseases, such as acute coronary syndrome, venous thromboembolism, and atrial fibrillation. The decision strategy is presented for difficult and non-standard clinical situations (renal dysfunction, elderly age, heparin medication change, or abnormal body weight), when the optimal balance between effectiveness and safety requires modifying the standard treatment protocols.

Calcaneal Osteomyelitis: Current Treatment Concepts

2019 ◽  
Vol 19 (3) ◽  
pp. 230-235 ◽  
Author(s):  
Michael J. McCann ◽  
Ashleigh Wells
Keyword(s):  
Prognostic Factors ◽  
Literature Review ◽  
Medical Management ◽  
Current Treatment ◽  
Proper Treatment ◽  
Treatment Protocols ◽  
Clinical Diagnostic ◽  
Treatment Concepts

Calcaneal osteomyelitis can be a debilitating disease if proper treatment protocols are not initiated. This literature review details the epidemiology, clinical, diagnostic, and prognostic factors, and medical management in those who developed this disease.

scholarly journals Successful treatment of thrombocytopenia with daratumumab after allogeneic transplant: a case report and literature review

2020 ◽  
Vol 4 (5) ◽  
pp. 815-818 ◽  
Author(s):  
Yazan Migdady ◽  
Asiri Ediriwickrema ◽  
Ryan Patrick Jackson ◽  
Wendy Kadi ◽  
Ridhi Gupta ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Successful Treatment ◽  
Standard Treatment ◽  
Treatment Options ◽  
Allogeneic Transplant ◽  
Novel Treatment ◽  
Short Course ◽  
Key Points ◽  
Lymphocyte Populations

Key Points A source of treatment refractoriness in immune cytopenias appears to be residual CD138/38-positive lymphocyte populations. A short course of daratumumab is a novel treatment of refractory thrombocytopenia after failure of standard treatment options.

Venous malformations: Coagulopathy control and treatment methods

2020 ◽  
pp. 026835552097291
Author(s):  
Eleanor J Budge ◽  
Muhammad AA Khalil Allam ◽  
Imogen Mechie ◽  
Marie Scully ◽  
Obi Agu ◽  
...  
Keyword(s):  
Literature Review ◽  
Treatment Options ◽  
Mammalian Target Of Rapamycin ◽  
Tyrosine Kinase Receptor ◽  
Venous Malformations ◽  
Phosphatidylinositol 3 Kinase ◽  
Treatment Protocols ◽  
Long Term Follow Up ◽  
Intravascular Coagulopathy ◽  
Phosphatidylinositol 3

Venous malformations (VMs) are ectatic channels which arise as a result of vascular dysmorphogenesis, commonly caused by activating mutations in the endothelial tyrosine kinase receptor (TIE2)/phosphatidylinositol 3-kinase (PI3Kinase) pathway. With a prevalence of 1% in the general population, and a diverse clinical presentation depending on site, size and tissue involvement, their treatment requires a personalised and multidisciplinary approach. Larger lesions are complicated by local intravascular coagulopathy (LIC) causing haemorrhagic and/or thrombotic complications which can progress to disseminated intravascular coagulopathy (DIC). Methods We performed a literature review using a PubMed® search and identified 15 articles to include. References of these texts were examined to further expand the literature review. Principle findings: Several treatment options have been explored, including compression, sclerotherapy, laser therapy, cryoablation and surgery in addition to the management of LIC with low-molecular-weight-heparin (LMWH) and other anticoagulants. Targeted molecular therapies acting on the phosphatidylinositol 3-kinase (PI3Kinase)/Protein Kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway are newly emerging. Conclusion Despite a wealth of literature, larger, multi-centric, randomised and prospective trails are required to offer further clarification on the therapeutic management of coagulopathy control and to provide symptomatic benefit to patients with VMs. There should be efforts to provide long term follow up and to use standardised risk stratification tools and quality of life (QOL) questionnaires to aid comparison of agents and treatment protocols.

scholarly journals Intravenous Tigecycline Facilitates Cure of Severe Clostridium difficile Infection (CDI) After Failure of Standard Therapy: A Case Report and Literature Review of Tigecycline Use in CDI

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Bhagyashri D. Navalkele ◽  
Stephen A. Lerner
Keyword(s):  
Septic Shock ◽  
Case Report ◽  
Clostridium Difficile ◽  
Literature Review ◽  
Clostridium Difficile Infection ◽  
Standard Treatment ◽  
Fecal Transplant ◽  
Oral Vancomycin ◽  
Standard Regimen ◽  
Severe Clostridium Difficile Infection

Abstract Standard treatment for severe Clostridium difficile infection (CDI) is oral vancomycin with metronidazole. After failure of this standard regimen, treatment becomes challenging. A young woman treated for septic shock developed CDI. Standard treatment failed and she was ineligible for fecal transplant. Addition of tigecycline to her regimen resulted in cure.

scholarly journals Clinical evaluation for chin augmentation: literature review and algorithm proposal

2016 ◽  
Vol 82 (5) ◽  
pp. 596-601 ◽  
Author(s):  
Helena Hotz Arroyo ◽  
Isabela Peixoto Olivetti ◽  
Leila Freire Rego Lima ◽  
José Roberto Parisi Jurado
Keyword(s):  
Literature Review ◽  
Clinical Evaluation ◽  
Chin Augmentation

scholarly journals Napping the Day Away

2019 ◽  
pp. 397-417
Author(s):  
Erin Golden ◽  
Maja Tippmann-Peikert
Keyword(s):  
Differential Diagnosis ◽  
Clinical Evaluation ◽  
Treatment Options ◽  
Evaluation Study ◽  
Disturbed Sleep ◽  
Study Results ◽  
Nonpharmacologic Treatment ◽  
Underlying Pathophysiology

This chapter describes a patient with narcolepsy type 1, a disorder of central hypersomnolence. His history, clinical evaluation, study results, treatment, and clinical course are detailed. The disorder is then reviewed, highlighting its classic clinical features—hypersomnia, cataplexy, sleep paralysis, hypnagogic and hypnopompic hallucinations, and disturbed sleep—and its underlying pathophysiology. The differential diagnosis is discussed, and recommendations for clinical evaluation are provided with official diagnostic criteria from the International Classification of Sleep Disorders, 3rd edition. Pharmacologic and nonpharmacologic treatment options are then addressed, along with their respective benefits and side-effect profiles.

scholarly journals Presence of the Human Cytomegalovirus in Glioblastomas—A Systematic Review

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5051
Author(s):  
Inti Peredo-Harvey ◽  
Afsar Rahbar ◽  
Cecilia Söderberg-Nauclér
Keyword(s):  
Human Cytomegalovirus ◽  
Standard Treatment ◽  
Clinical Samples ◽  
Treatment Protocols ◽  
Blood Samples ◽  
The Past ◽  
Dismal Prognosis ◽  
High Prevalence ◽  
New Treatment ◽  
Immunohistochemical Techniques

Glioblastoma is a malignant brain tumor with a dismal prognosis. The standard treatment has not changed in the past 15 years as clinical trials of new treatment protocols have failed. A high prevalence of the human cytomegalovirus (HCMV) in glioblastomas was first reported in 2002. The virus was found only in the tumor and not in the surrounding healthy brain tissue. Many groups have confirmed the presence of the HCMV in glioblastomas, but others could not. To resolve this discrepancy, we systematically reviewed 645 articles identified in different databases. Of these, 81 studies included results from 247 analyses of 9444 clinical samples (7024 tumor samples and 2420 blood samples) by different techniques, and 81 articles included 191 studies that identified the HCMV in 2529 tumor samples (36% of all tumor samples). HCMV proteins were often detected, whereas HCMV nucleic acids were not reliably detected by PCR methods. Optimized immunohistochemical techniques identified the virus in 1391 (84,2%) of 1653 samples. These data suggest that the HCMV is highly prevalent in glioblastomas and that optimized immunohistochemistry techniques are required to detect it.

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