scholarly journals Effects of “Bacuri” Seed Butter (Platonia insignis Mart.) on Metabolic Parameters in Hamsters with Diet-Induced Hypercholesterolemia

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Geovanni de Morais Lima ◽  
Ana Karolinne da Silva Brito ◽  
Luciana Melo de Farias ◽  
Lays Arnaud Rosal Lopes Rodrigues ◽  
Cristian Francisco de Carvalho Pereira ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Liver Function ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Risk Index ◽  
Atherogenic Index ◽  
Weight Growth

This study aimed to evaluate the effects of the treatment with bacuri seed butter (BB) on body weight, growth, body mass index, lipid profile, atherosclerotic indices, and liver function in dyslipidemic hamsters. Freshly weaned, male hamsters were divided into four groups: (1) normal group (NG)—maintained with standard chow (AIN-93G); (2) dyslipidemia group (DG)—maintained with hyperlipidemic chow (AIN-93G modified) throughout the follow-up period; (3) bacuri seed butter 25 mg/kg/day (BB-25); and (4) bacuri seed butter 50 mg/kg/day (BB-50). BB groups (25 and 50 mg/kg/day) were also maintained with hyperlipidemic chow throughout the follow-up period, and the treatment started after 21 days receiving a hyperlipidemic diet to induce hypercholesterolemia and maintained for 28 days. No significant differences in triglycerides and total cholesterol were observed for BB-25 and BB-50 groups when compared with NG and DG groups. On the contrary, BB-25 and BB-50 induced both increase of HDL-c (51.40 ± 1.69 and 51.00 ± 2.34, respectively) and decrease of LDL-c (103.80 ± 6.87 and 100.50 ± 3.95, respectively) when compared with DG (41.00 ± 2.94 and 132.70 ± 9.41, respectively). In addition, BB promoted a reduction in the risk of atherosclerotic disease by decreasing p < 0.05 the atherogenic index, coronary artery risk index, and LDL/CT ratio p < 0.05 and increasing HDL/CT ratio. On the contrary, no changes were observed in total cholesterol and triglyceride levels or in body weight, growth, body mass index, or liver function parameters. Thus, bacuri seed butter at doses of 25 and 50 mg/kg/day has positive repercussions on the lipid profile, more precisely on plasma HDL-c and LDL-c, and additionally promotes reduction in the risk of atherosclerosis in hamsters.

scholarly journals Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110110
Author(s):  
Wiraphol Phimarn ◽  
Bunleu Sungthong ◽  
Hiroyuki Itabe
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Body Mass ◽  
The Body ◽  
Current Evidence ◽  
Diabetic Patients ◽  
Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

P0708ASSOCIATION OF OBESITY WITH KIDNEY CYST GROWTH IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE; RESULTS FROM KNOW-CKD COHORT DATA

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Chang Seong Kim ◽  
Hong Sang Choi ◽  
Eun hui Bae ◽  
Seong Kwon Ma ◽  
Soo Wan Kim
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Body Mass ◽  
Autosomal Dominant ◽  
Obese Patients ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

Abstract Background and Aims Overweight or obese patients with autosomal dominant polycystic kidney disease (ADPKD) are associated with the decline of glomerular filtration rate. However, little is known about the annual rate of change in total kidney volume (TKV) in patients with ADPKD according to the body mass index (BMI) corrected by TKV and total liver volume (TLV). Method We analyzed 364 patients with ADPKD from the KoreaN Cohort Study for Outcomes in Patients with Chronic Kidney Disease. We compared the changes in TKV in less than 1-year, 2-years and 4-year follow-up from patients by dividing baseline body mass index (BMI) by 18.5 to 22.9 (normal), 23 to 24.9 (overweight), and &gt; 25 kg/m2 (obesity). Results During the 4-year follow-up period, TKV tended to increase statistically with increasing BMI (P = 0.032). Similarly, higher BMI group showed higher TKV than lower BMI group (P = 0.016). Conventional BMI is affected by TKV and TLV in advanced ADPKD patients. Therefore, we reclassified patients by corrected BMI using the adjusted body weight (body weight – TKV – TLV). Although the statistical significances between absolute value of TKV and corrected BMI groups were disappeared during the follow-up, TKV% change/year showed significantly higher in ADPKD patients with obesity among corrected BMI groups (normal; 20.2%, overweight; 17.6% and obesity; 30.6%, P for trend = 0.022) Conclusion Even after correcting the TKV and TVL, obese patients showed a high of TKV% change/year compared to non-obese patients with ADPKD.

scholarly journals The effects of three-week fasting diet on blood pressure, lipid profile and glucoregulation in extremely obese patients

2007 ◽  
Vol 135 (7-8) ◽  
pp. 440-446 ◽  
Author(s):  
Biljana Beleslin ◽  
Jasmina Ciric ◽  
Milos Zarkovic ◽  
Zorana Penezic ◽  
Svetlana Vujovic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Insulin Sensitivity ◽  
Lipid Profile ◽  
Body Mass ◽  
Glucose Intolerance ◽  
The Body ◽  
Obese Patients

Introduction Obesity is often accompanied by a number of complications including diabetes mellitus and cardiovascular diseases. Elevated blood pressure and lipids, as well as deterioration of glucoregulation are attributed, as the most significant factors, to development of diabetes mellitus and cardiovascular complications in obese patients. Objective The aim of our study was to evaluate the effects of a fasting diet on blood pressure, lipid profile and glucoregulatory parameters. Method We included 110 patients (33 male and 77 female; mean age 35?1 years, body weight 131.7?2.6 kg, body mass index 45.4?0.8 kg/m2) who were hospitalized for three weeks for the treatment of extreme obesity with the fasting diet. At the beginning, during, and at the end of this period, we evaluated changes in blood pressure, lipid profile, as well as parameters of glucoregulation including glycaemia, insulinaemia, and insulin sensitivity by HOMA. Oral glucose tolerance test (OGTT) was performed in all patients at the beginning and at the end of the fasting diet. Results During the fasting diet, the body weight decreased from 131.7?2.6 kg to 117.7?2.4 kg (p<0.001), the body mass index decreased from 45.4?0.8 kg/m2 to 40.8?0.8 kg/m2 (p<0.001), and both systolic and diastolic blood pressure significantly declined (143?2 vs. 132?2 mm Hg, p<0.001; 92?2 vs. 85?2 mm Hg, p<0.001). In addition, the fasting diet produced a significant decrease in total cholesterol, LDL cholesterol, triglycerides, as well as basal glycaemia and insulinaemia (p<0.001) Before the fasting diet, OGTT was normal in 76% of patients, whereas 21% of patients showed glucose intolerance, and 4% of patients diabetes mellitus. After the fasting diet, OGTT was normal in 88% of patients, whereas 12% of patients still had signs of glucose intolerance (p<0.05). In addition, insulin resistance significantly (p<0.05) increased from 54?6% to 89?13% after the fasting diet. Conclusion The three-week fasting diet in extremely obese patients produced a significant decrease and normalization of blood pressure, decrease in lipids, and improvement in glucoregulation including the increase in insulin sensitivity.

scholarly journals CLOCK 3111TT Genotype Is Associated with Increased Total Cholesterol and Low-Density Lipoprotein Levels in Menopausal Women with a Body Mass Index of at Least 25 kg/m2

2020 ◽  
Vol 28 (1) ◽  
pp. 1-9
Author(s):  
Natalya Semenova ◽  
Irina Madaeva ◽  
Sergey Kolesnikov ◽  
Lyubov Rychkova ◽  
Tatjana Bairova ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Gene Polymorphism ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Minor Allele ◽  
Low Density ◽  
Menopausal Women

Lipid profile comparative analysis was performed to reveal the interdependence of lipids with Circadian locomoter output cycles protein kaput (CLOCK) 3111T/C gene polymorphism in menopausal women with/without a body mass index (BMI) of ≥25 kg/m2. Methods: A total of 193 female volunteers aged 45 to 60 years were divided into two groups: Those with BMI < 25 kg/m2 (control) and those with BMI ≥ 25 kg/m2. Each group was then divided into two subgroups: Those with the CLOCK TT-genotype and those with the CLOCK TC-, CC-genotypes. Lipid metabolism parameters were determined by the enzymatic method. Single-nucleotide polymorphisms (SNPs) were detected via polymerase chain reaction–restriction fragment length polymorphism technology. Results: There were no differences in CLOCK 3111T/C genotypes or allele frequency between the control and main groups. In addition, there were no differences in lipid profile parameters between women of the control group and different CLOCK 3111T/C genotypes. The total cholesterol (p = 0.041) and low-density lipoprotein cholesterol (p = 0.036) levels were higher in the subgroup of women with a BMI ≥ 25 kg/m2 and CLOCK TT-genotype as compared to the subgroup with a BMI ≥ 25 kg/m2 and minor allele 3111C. Conclusions: SNP 3111T/C of the CLOCK gene is not associated with BMI however, data suggest that the minor allele of the CLOCK 3111T/C gene polymorphism may have a protective role in atherogenic lipid levels in women with a BMI greater than or equal to 25 kg/m2.

scholarly journals Body Weight and Body Mass Index Influence Bone Mineral Density in Late Adolescence in a Two‐Year Follow‐Up Study. The Tromsø Study: Fit Futures

JBMR Plus ◽  
2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Ole Andreas Nilsen ◽  
Luai Awad Ahmed ◽  
Anne Winther ◽  
Tore Christoffersen ◽  
Gyrd Thrane ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Bone Mineral ◽  
Late Adolescence ◽  
Mineral Density ◽  
Follow Up Study

scholarly journals ASSOCIATION OF LIPID PROFILE WITH BODY MASS INDEX IN GALL STONE DISEASE

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Pravin Shirke ◽  
Dr. Suryakant Nagtilak
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Gall Stone ◽  
Density Lipoprotein ◽  
College Teaching ◽  
Stone Disease ◽  
Gall Stones ◽  
Gall Stone Disease

Introduction: Gall stone disease is common in northern regions of India including Uttarakhand. It is traditionally seen in fat, fertile, female of fourty. Apart from this, age, obesity, hyperlipidemia, smoking & diabetes are other risk factors. Gall stones show more association with elevated levels of triglyceride and low high density lipoprotein (HDL-C) where less association with total cholesterol and low density lipoprotein (LDL-C). Increased prevalence of gall stone reported in overweight. This present study conducted with an aim to find out the co-relation of lipid profile, BMI (body mass index) and gall stones in Uttarakhand population attending Shridev Suman Subharti Medical College Teaching Hospital, Dehradun. Material & Methods: Total 120 patients (10 M, 110 F) were included in the study following confirmation of diagnosis of gall stones on ultrasound. Age, sex, dietary habits, occupation, medical history and drug history of each patient were recorded in predesigned, tested proforma. The BMI calculated as weight in Kg/height in meter square. BMI of 18 to 24.9 were regarded as normal, whereas, 25 to 29.9 as overweight, 30 to 39.9 as obese and above 40 as morbid obese. The serum cholesterol, LDL, HDL and Triglyceride were estimated on a fasting sample by keeping patient nil orally for 12hrs after their normal meal. Results: Out of total 120 patients, 110(91.67%) were female & 10(8.33%) were male, with female to male ratio 9:1. The age-group of 21 to 40 years was the most common, with 64(53.33%) patients belonging to this group. Triglyceride was raised in 35(29.17%) patients, total cholesterol was raised in 7(5.83%) patients and LDL was raised in 5(4.17%) patients. The cholesterol was lowered in 13(10.83%) patients, HDL was lowered in 8(6.66%) patients and triglyceride was lowered in 3(2.5%) patients. Triglyceride & LDL were raised in 4(3.3%) patients, cholesterol and triglyceride were raised in 3(2.5%) patients and cholesterol and HDL were lowered in 4 (3.33%) patients. Patients with BMI of 18.0-24.9 were 72(60.00%), BMI of 25-29.9 were 36(30.00%) and BMI of 30-39.9 were 9(7.50%) respectively. Conclusion: The present study on presence of Gall stones which are more commonly found in females aged 21 to 40 years. Raised levels of Triglyceride and lower levels of cholesterol are associated with gall stones. There is no association between Increased BMI & presence of gall stones. BMI is associated with higher level of   Triglyceride. Key Words: Gall stone, BMI, Triglyceride, Cholesterol, and HDL-C.

scholarly journals Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis

2020 ◽  
Author(s):  
Sung Soo Ahn ◽  
Lucy Eunju Lee ◽  
Jung Yoon Pyo ◽  
Jason Jungsik Song ◽  
Yong-Beom Park ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cerebrovascular Accident ◽  
Multivariable Analysis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Immunosuppressive Drug ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma ◽  
And Gender

Abstract Background: We investigated whether the atherogenic index of plasma (AIP) at diagnosis can predict cerebrovascular accident (CVA) and cardiovascular disease during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods: The medical records of 167 immunosuppressive drug-naïve AAV patients and those of 300 age- and gender-matched controls were retrospectively reviewed. AIP was calculated using the following equation: AIP = Log (triglyceride (mmol/L) / high-density-cholesterol (mmol/L)). AAV patients were divided into two groups according to their AIP, AAV patients with AIP < 0.11 (N=115) and AAV patients with AIP ≥ 0.11 (N=52). Results: The median age and body mass index of AAV patients were 59.0 years and 22.1 kg/m2, respectively. The median calculated AIP of patients was 0.01 and AAV patients with AIP < 0.11 exhibited a lower Birmingham vasculitis activity score than those with AIP ≥ 0.11 but it was not significant (P = 0.064). AAV patients had a significantly lower body mass index than controls, nevertheless, AAV patients had a significantly higher AIP than controls (0.01 vs. -0.12). Sixteen patients were diagnosed with CVA, and AAV patients with AIP ≥ 0.11 had a significantly lower CVA-free survival rate than those with AIP < 0.11. Multivariable analysis indicated that AIP ≥ 0.11 at diagnosis was significantly associated with CVA during follow-up. Conclusions: AIP was significantly higher in AAV patients than in controls. Furthermore, AIP at diagnosis could predict CVA occurrence during follow-up in AAV patients.

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