scholarly journals Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis

2020 ◽  
Author(s):  
Sung Soo Ahn ◽  
Lucy Eunju Lee ◽  
Jung Yoon Pyo ◽  
Jason Jungsik Song ◽  
Yong-Beom Park ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cerebrovascular Accident ◽  
Multivariable Analysis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Immunosuppressive Drug ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma ◽  
And Gender

Abstract Background: We investigated whether the atherogenic index of plasma (AIP) at diagnosis can predict cerebrovascular accident (CVA) and cardiovascular disease during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods: The medical records of 167 immunosuppressive drug-naïve AAV patients and those of 300 age- and gender-matched controls were retrospectively reviewed. AIP was calculated using the following equation: AIP = Log (triglyceride (mmol/L) / high-density-cholesterol (mmol/L)). AAV patients were divided into two groups according to their AIP, AAV patients with AIP < 0.11 (N=115) and AAV patients with AIP ≥ 0.11 (N=52). Results: The median age and body mass index of AAV patients were 59.0 years and 22.1 kg/m2, respectively. The median calculated AIP of patients was 0.01 and AAV patients with AIP < 0.11 exhibited a lower Birmingham vasculitis activity score than those with AIP ≥ 0.11 but it was not significant (P = 0.064). AAV patients had a significantly lower body mass index than controls, nevertheless, AAV patients had a significantly higher AIP than controls (0.01 vs. -0.12). Sixteen patients were diagnosed with CVA, and AAV patients with AIP ≥ 0.11 had a significantly lower CVA-free survival rate than those with AIP < 0.11. Multivariable analysis indicated that AIP ≥ 0.11 at diagnosis was significantly associated with CVA during follow-up. Conclusions: AIP was significantly higher in AAV patients than in controls. Furthermore, AIP at diagnosis could predict CVA occurrence during follow-up in AAV patients.

scholarly journals Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis

2020 ◽  
Author(s):  
Sung Soo Ahn ◽  
Lucy Eunju Lee ◽  
Jung Yoon Pyo ◽  
Jason Jungsik Song ◽  
Yong-Beom Park ◽  
...  
Keyword(s):  
Cerebrovascular Accident ◽  
Survival Rates ◽  
Density Lipoprotein ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Atherogenic Index ◽  
Healthy Controls ◽  
Atherogenic Index Of Plasma ◽  
Free Survival ◽  
Kaplan Meier

Abstract Background: To investigate whether atherogenic index of plasma (AIP) at diagnosis is associated with the occurrence of cerebrovascular accident (CVA) or coronary artery disease (CAD) in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods: The medical records of 167 AAV patients on initial diagnosis was reviewed, and 300 healthy controls were included. AIP was calculated using the following equation: AIP = Log (triglyceride [mg/dL] / high-density lipoprotein cholesterol [mg/dL]). AAV patients were divided into two groups according to the AIP cut-off of 0.11. The event of stroke, transient ischemic attack, and cerebral hemorrhage was recorded as CVA, and CAD events consisted of either myocardial infarction and angina pectoris. CVA- and CAD- free survival rate between those with AIP ≥ 0.11 and < 0.11 were compared by the Kaplan-Meier analysis, and Cox hazard analysis was conducted to identify predictors of CVA. Results: The median age of AAV patients were 59.0 years, and 54 (32.3%) patients were male. One-hundred and fifteen (68.9%) patients had AIP < 0.11 and 52 (31.1%) had AIP ≥ 0.11. The mean Birmingham vasculitis activity score in AAV patients with AIP < 0.11 was lower than that seen in patients with AIP ≥ 0.11 (12.0 vs. 14.0, P = 0.041). AAV patients had a significantly higher AIP compared to controls (mean -0.01 vs. -0.10, P < 0.001). During follow-up, the occurrence of CVA and CAD was observed in 16 (9.6%) and 14 (8.4%) patients, respectively. In Kaplan-Meier analysis, AAV patients with AIP ≥ 0.11 had significantly lower CVA-free survival rates than in those with AIP < 0.11 (P = 0.027), whereas there was no difference in CAD according to AIP (P = 0.390). Multivariable Cox analysis indicated that AIP ≥ 0.11 at diagnosis was the sole predictor of CVA (Hazard ratio 3.392, 95% confidence interval 1.076, 10.696, P = 0.037). Conclusions: AIP is significantly higher in AAV patients than in healthy controls, and AIP ≥ 0.11 at diagnosis is a significant predictor of CVA during follow-up. Stringent surveillance should be provided in AAV patients with AIP ≥ 0.11 regarding the occurrence of CVA.

scholarly journals Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis

2020 ◽  
Author(s):  
Sung Soo Ahn ◽  
Lucy Eunju Lee ◽  
Jung Yoon Pyo ◽  
Jason Jungsik Song ◽  
Yong-Beom Park ◽  
...  
Keyword(s):  
Cerebrovascular Accident ◽  
Survival Rates ◽  
Density Lipoprotein ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Atherogenic Index ◽  
Healthy Controls ◽  
Atherogenic Index Of Plasma ◽  
Free Survival ◽  
Kaplan Meier

Abstract Background: To investigate whether atherogenic index of plasma (AIP) at diagnosis is associated with the occurrence of cerebrovascular accident (CVA) or coronary artery disease (CAD) in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods: The medical records of 167 AAV patients on initial diagnosis was reviewed, and 300 healthy controls were included. AIP was calculated using the following equation: AIP = Log (triglyceride [mg/dL] / high-density lipoprotein cholesterol [mg/dL]). AAV patients were divided into two groups according to the AIP cut-off of 0.11. The event of stroke, transient ischemic attack, and cerebral hemorrhage was recorded as CVA, and CAD events consisted of either myocardial infarction and angina pectoris. CVA- and CAD- free survival rate between those with AIP ≥ 0.11 and < 0.11 were compared by the Kaplan-Meier analysis, and Cox hazard analysis was conducted to identify predictors of CVA.Results: The median age of AAV patients were 59.0 years, and 54 (32.3%) patients were male. One-hundred and fifteen (68.9%) patients had AIP < 0.11 and 52 (31.1%) had AIP ≥ 0.11. The mean Birmingham vasculitis activity score in AAV patients with AIP < 0.11 was lower than that seen in patients with AIP ≥ 0.11 (12.0 vs. 14.0, P = 0.041). AAV patients had a significantly higher AIP compared to controls (mean -0.01 vs. -0.10, P < 0.001). During follow-up, the occurrence of CVA and CAD was observed in 16 (9.6%) and 14 (8.4%) patients, respectively. In Kaplan-Meier analysis, AAV patients with AIP ≥ 0.11 had significantly lower CVA-free survival rates than in those with AIP < 0.11 (P = 0.027), whereas there was no difference in CAD according to AIP (P = 0.390). Multivariable Cox analysis indicated that AIP ≥ 0.11 at diagnosis was the sole predictor of CVA (Hazard ratio 3.392, 95% confidence interval 1.076, 10.696, P = 0.037). Conclusions: AIP is significantly higher in AAV patients than in healthy controls, and AIP ≥ 0.11 at diagnosis is a significant predictor of CVA during follow-up. Stringent surveillance should be provided in AAV patients with AIP ≥ 0.11 regarding the occurrence of CVA. Trial registration: Retrospectively registered.

scholarly journals Effect of individual- versus collective-based nutritional-lifestyle intervention on the atherogenic index of plasma in children with obesity: a randomized trial

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Elvira Verduci ◽  
Giuseppe Banderali ◽  
Elisabetta Di Profio ◽  
Sara Vizzuso ◽  
Gianvincenzo Zuccotti ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lifestyle Intervention ◽  
Body Mass ◽  
Univariate Analysis ◽  
Atherogenic Index ◽  
Z Score ◽  
Blood Profile ◽  
Atherogenic Index Of Plasma ◽  
Paediatric Obesity ◽  
The Individual

Abstract Background The Atherogenic Index of Plasma is a predictive biomarker of atherosclerosis in adults but there is a lack of studies in paediatric population aimed at evaluating the longitudinal changes of the AIP and of the cardiometabolic blood profile related to nutritional interventions. The aim of this study was to compare the effect of individual- versus collective-based nutritional-lifestyle intervention on the Atherogenic Index of Plasma in schoolchildren with obesity. Methods One-hundred sixty-four children aged 6–12 years with Body Mass Index z-score > 2 referred to the Paediatric Obesity Clinic, San Paolo Hospital, Milan, Italy, were consecutively enrolled and randomized to undergo to either an individual- (n = 82) or a collective- (n = 82) based intervention promoting a balanced normo-caloric diet and physical activity. In addition, the individual intervention included a tailored personalized nutritional advice and education based on the revised Coventry, Aberdeen, and London-Refined taxonomy. Both at baseline and after 12 months of intervention, dietary habits and anthropometric measures were assessed, a fasting blood sample were taken for biochemistry analysis. Results The participation rate at 12 months was 93.3% (n = 153 patients), 76 children in the individual-intervention and 77 children in the collective intervention. At univariate analysis, mean longitudinal change in Atherogenic Index of Plasma was greater in the individual than collective intervention (− 0.12 vs. − 0.05), as well as change in triglyceride-glucose index (− 0.22 vs. − 0.08) and Body Mass Index z-score (− 0.59 vs. − 0.37). At multiple analysis, only change in Body Mass Index z-score remained independently associated with intervention (odds ratio 3.37). Conclusion In children with obesity, an individual-based nutritional and lifestyle intervention, including techniques from the CALO-RE taxonomy, could have an additional beneficial effect over a collective-based intervention, although the actual size of the effect remains to be clarified. Trial Registration Clinical Trials NCT03728621

Changes regarding Age and Correlations between Serum Lipids and Body Mass Index in Humankind

2002 ◽  
Vol 41 (03) ◽  
pp. 202-208 ◽  
Author(s):  
I. Yamasawa ◽  
S. Kamohara ◽  
M. Shiota ◽  
T. Komori ◽  
Y. Watanabe ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Serum Lipids ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Health Examination ◽  
Age And Gender ◽  
Gender And Age ◽  
Specialized Care ◽  
And Gender

Summary Objectives: To improve insight into age and gender related distributions of serum lipids and their correlation with body mass index (BMI). Methods: Serum lipids embracing atherogenic index (AI) and BMI were analyzed from the results obtained in 19,823 men and 14,788 women undergoing a health examination between 1986 and 1996. Results: The changes in total cholesterol (TC), triglyceride (TG), AI and BMI differed regarding gender. Although high-density lipoprotein-cholesterol (HDL-C) showed a flat pattern for all ages in both genders, its level in women was higher than in men. The ratio of the number in the unsuitable range to those in the suitable range increased with age as to TC in both sexes, then more than half of the population have an unsuitable level in the sixth decade. As for the correlation between serum lipids and BMI: TC, TG and AI correlated positively, but HDL-C correlated negatively. There were significant gaps between both age and gender. Conclusions: We suggest that the normal range of values of serum lipids needs to be revised according to gender and age to evaluate the risk status for a cardio-cerebrovascular disease more precisely in the field of preventive medicine. Simpler guidelines are preferable in specialized care as well as in general practice, particularly since computer technology is not yet universally adapted. In the near future, when computed information technology will be as common as the electricity and the telephone are current on the whole earth, all guidelines will have to be computed on the spot and personally.

scholarly journals Effects of “Bacuri” Seed Butter (Platonia insignis Mart.) on Metabolic Parameters in Hamsters with Diet-Induced Hypercholesterolemia

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Geovanni de Morais Lima ◽  
Ana Karolinne da Silva Brito ◽  
Luciana Melo de Farias ◽  
Lays Arnaud Rosal Lopes Rodrigues ◽  
Cristian Francisco de Carvalho Pereira ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Liver Function ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Risk Index ◽  
Atherogenic Index ◽  
Weight Growth

This study aimed to evaluate the effects of the treatment with bacuri seed butter (BB) on body weight, growth, body mass index, lipid profile, atherosclerotic indices, and liver function in dyslipidemic hamsters. Freshly weaned, male hamsters were divided into four groups: (1) normal group (NG)—maintained with standard chow (AIN-93G); (2) dyslipidemia group (DG)—maintained with hyperlipidemic chow (AIN-93G modified) throughout the follow-up period; (3) bacuri seed butter 25 mg/kg/day (BB-25); and (4) bacuri seed butter 50 mg/kg/day (BB-50). BB groups (25 and 50 mg/kg/day) were also maintained with hyperlipidemic chow throughout the follow-up period, and the treatment started after 21 days receiving a hyperlipidemic diet to induce hypercholesterolemia and maintained for 28 days. No significant differences in triglycerides and total cholesterol were observed for BB-25 and BB-50 groups when compared with NG and DG groups. On the contrary, BB-25 and BB-50 induced both increase of HDL-c (51.40 ± 1.69 and 51.00 ± 2.34, respectively) and decrease of LDL-c (103.80 ± 6.87 and 100.50 ± 3.95, respectively) when compared with DG (41.00 ± 2.94 and 132.70 ± 9.41, respectively). In addition, BB promoted a reduction in the risk of atherosclerotic disease by decreasing p < 0.05 the atherogenic index, coronary artery risk index, and LDL/CT ratio p < 0.05 and increasing HDL/CT ratio. On the contrary, no changes were observed in total cholesterol and triglyceride levels or in body weight, growth, body mass index, or liver function parameters. Thus, bacuri seed butter at doses of 25 and 50 mg/kg/day has positive repercussions on the lipid profile, more precisely on plasma HDL-c and LDL-c, and additionally promotes reduction in the risk of atherosclerosis in hamsters.

scholarly journals The influence of sex and body mass index on the association between soluble neprilysin and risk of heart failure hospitalizations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julio Núñez ◽  
Eduardo Núñez ◽  
Elena Revuelta-López ◽  
Gema Miñana ◽  
Jaume Barallat ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Interaction Analysis ◽  
Multivariable Analysis ◽  
Incidence Rates ◽  
Overweight Women ◽  
Prognostic Effect ◽  
Increased Risk ◽  
Secondary Endpoints

AbstractA higher neprilysin activity has been suggested in women. In this retrospective analysis, we evaluated the association of sex and body mass index (BMI) with soluble neprilysin (sNEP) and recurrent admissions among 1021 consecutive HF outpatients. The primary and secondary endpoints were the number of HF hospitalizations and all-cause mortality, respectively. The association between sNEP with either endpoint was evaluated across sex and BMI categories (≥ 25 kg/m2 vs. < 25 kg/m2). Bivariate count regression (Poisson) was used, and risk estimates were expressed as incidence rates ratio (IRR). During a median follow-up of 6.65 years (percentile 25%-percentile 75%:2.83–10.25), 702 (68.76%) patients died, and 406 (40%) had at least 1 HF hospitalization. Median values of sNEP and BMI were 0.64 ng/mL (0.39–1.22), and 26.9 kg/m2 (24.3–30.4), respectively. Left ventricle ejection fraction was < 40% in 78.9% of patients, and 28% were women. In multivariable analysis, sNEP (main effect) was positively associated with HF hospitalizations (p = 0.001) but not with mortality (p = 0.241). The predictive value of sNEP for HF hospitalizations varied non-linearly across sex and BMI categories (p-value for interaction = 0.003), with significant and positive effect only on women with BMI ≥ 25 kg/m2 (p = 0.039). For instance, compared to men, women with sNEP of 1.22 ng/mL (percentile 75%) showed a significantly increased risk (IRRs: 1.26; 95% CI: 1.05–1.53). The interaction analysis for mortality did not support a differential prognostic effect for sNEP (p = 0.072). In conclusion, higher sNEP levels in overweight women better predicted an increased risk of HF hospitalization.

scholarly journals Age and gender aspects of the association of generalized obesity with development of fatal and nonfatal cardiovascular events (results of the prospective cohort study “Interepepid”)

2021 ◽  
Vol 6 (5) ◽  
pp. 245-252
Author(s):  
A. G. Polupanov ◽  
A. U. Mamatov ◽  
M. T. Duishenalieva ◽  
A. T. Аrykova ◽  
F. T. Rysmatova ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cardiovascular Events ◽  
Cardiovascular Complications ◽  
Survival Models ◽  
Kyrgyz Republic ◽  
Kaplan Meier ◽  
And Gender ◽  
Cox Proportional Hazard Regression

Background. Currently, obesity has become one of the most important medical and social problems in the world due to its high prevalence. Numerous literature data indicate that high BMI is associated with increased mortality from cardiovascular diseases.The aim: to study the relationship between overweight and generalized obesity with the development of fatal and non-fatal cardiovascular events among residents of the Chui region of the Kyrgyz Republic, taking into account gender and age.Material and methods. This study was carried out as part of the international crosssectional epidemiological study “Interepid”. The total follow-up period was 7 years. Life status at the end of the follow-up period was monitored in 1096 respondents out of 1341 initial cohorts (response – 82.1 %). The endpoints were cases of fatal and non-fatal cardiovascular events. The frequency of events was assessed using methods of analysis of survival (Cox proportional hazard regression model, parametric survival models, survival by the Kaplan – Meier method).Results. A total of 181 cases of fatal and non-fatal cardiovascular events (16.44 %) were recorded during the follow-up. In persons with normal body weight, the incidence of cardiovascular complications was 10 %. In overweight individuals, the value of this indicator increased and reached 17.99 % (p˂ 0.001), and in individuals with obesity – 24.5 % (p˂ 0.0001). The increase in the frequency of events with the increase in body mass index did not depend on the gender of the respondents but was typical only for people under 60 years of age. For elderly patients, there was no relationship between BMI and the development of cardiovascular complications. In contrast, the relative risk had an insignificant tendency to decrease by 2.6 % for every 1 kg/m2 increase in body mass index (RR – 0.974; 95% CI: 0.924–1.025).Conclusion. The increase of body mass index above 25 kg/m2 is an independent risk factor for the development of fatal and non-fatal cardiovascular events in the analyzed cohort of the Chui region residents, regardless of gender, but only in persons under 60 years of age. 

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