scholarly journals B7-H4 Expression in Precancerous Lesions of the Uterine Cervix

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Qianqian Zhang ◽  
Liju Zong ◽  
Hui Zhang ◽  
Wei Xie ◽  
Fan Yang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Uterine Cervix ◽  
Precancerous Lesions ◽  
Intraepithelial Neoplasia ◽  
Interferon Γ ◽  
Control Group ◽  
Low Grade ◽  
Chronic Cervicitis ◽  
Cervical Conization

Over 10% of patients diagnosed with cervical intraepithelial neoplasia (CIN) have no lesions detected in their cervical conization specimens. The purpose of this study was to determine the factors related to the absence of such lesions. We particularly sought to investigate whether the expression of B7-H4 in precancerous lesions and cancer of the uterine cervix plays a role in the presence or absence of residual lesions in conization specimens and whether this protein is associated with T cells (i.e., Foxp3+ regulatory T cells, CD4+, and CD8+) and interferon-γ production. Of the 807 patients with CIN treated by conization, 104 (12.9%) had no lesions in their conization specimens. Seventy-five of these patients were deemed the study group and were matched with 75 patients who did have CIN detected in their conization specimens (the control group). Immunohistochemistry and immunofluorescence staining were used to detect B7-H4, Foxp3, CD4, CD8, and interferon-γ in the 75 pairs of specimens obtained via biopsy; 20 samples were found to have chronic cervicitis, and another 20 had squamous cell carcinoma of the cervix. Menopause, the absence of human papillomavirus, low-grade histological findings, and a diagnosis of CIN1 and CIN2 on biopsy correlated with a low probability of lesions on conization specimens. B7-H4 expression was detected in 11.1% of CIN2, 46.6% of CIN3, and 70% of cervical cancer samples, but not in tissues representing chronic cervicitis or CIN1. B7-H4 expression was associated with the presence of lesions on conization specimens, increased regulatory T cells, decreased CD8+ T cells, and lower interferon-γ production. These data suggest that close follow-up and thorough reevaluation should be considered for patients diagnosed with CIN2 who are negative for B7-H4 expression on biopsy before proceeding with cervical conization.

scholarly journals Management of Precancerous Lesions of the Uterine Cervix according to Demographic Data

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Olga Modinou ◽  
Lykourgos Liaropoulos ◽  
Dafni Kaitelidou ◽  
kyriakos Kioulafas ◽  
Eleni-Maria Theodoraki
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Uterine Cervix ◽  
Precancerous Lesions ◽  
Demographic Data ◽  
Intraepithelial Neoplasia ◽  
Diagnostic Procedures ◽  
Educational Status ◽  
Pap Smears ◽  
Low Grade ◽  
Treatment Profile

Aims. Worldwide, cervical cancer is the fifth most deadly cancer in women, but screening prevents cancer by detecting precancerous lesions. The purpose of this study is to present the treatment profile for precancerous lesions of the uterine cervix, according to demographic data. Methods. An annual retrospective study was conducted in two public primary health care centres in Greece. The total number of Pap smears and colposcopies performed as well as the management of women with cervical intraepithelial neoplasia was collected and analysed. Results. Demographic characteristics and correlations with levels of Cervical Intraepithelial Neoplasia (CIN) and treatment path are presented. For each case, we noted the patients' age, the marital and educational status, and the professional and insurance type. From a total of 238 diagnostic procedures, 118 (49.5%) showed precancerous lesions, 83.3% of these were high grade while 16.7% were low grade. Conclusions. This study provides an estimate of the extensiveness of precancerous lesions of the uterine cervix. Management of CIN should be accounted for when balancing the benefits and unfavourable effects of this screening.

scholarly journals Multicentre Evaluation of Hepika Test Clinical Accuracy in Diagnosing HPV-Induced Cancer and Precancerous Lesions of the Uterine Cervix

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 619
Author(s):  
Daniela Gustinucci ◽  
Lucia Ciccocioppo ◽  
Luigi Coppola ◽  
Giovanni Negri ◽  
Gianfranco Zannoni ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Protein Complexes ◽  
Precancerous Lesions ◽  
Intraepithelial Neoplasia ◽  
Population Based ◽  
Enzyme Linked Immunosorbent Assay ◽  
Lower Sensitivity ◽  
Adenocarcinoma In Situ ◽  
Clinical Accuracy ◽  
Grade 3

Objective: To evaluate the clinical accuracy of Hepika test to identify cancer/precancerous lesions of the uterine cervix. Materials and Methods: A multicentre retrospective study was carried out in 2018 and included 330 liquid-based cytology samples from three Italian centres of women aged 25–64 who had been tested for the human papillomavirus (HPV) and whose histology or follow-up outcome was known. Hepika is an enzyme-linked immunosorbent assay (ELISA) targeting the protein complexes E6#p53 and E7#pRb. After excluding samples without sufficient residual material, the clinical accuracy of Hepika test was evaluated in 274 samples: adenocarcinoma (ADC) (4), squamous cell carcinoma (SCC) (7), adenocarcinoma in situ (AIS) (1), cervical intraepithelial neoplasia (CIN) grade 3 (60), CIN2 (51), CIN1 (34), and negative histology (117). Association, sensitivity, and specificity for carcinoma, CIN3+ and CIN2+ are reported. Results: Positive Hepika test was associated with a high probability of carcinoma (odds ratio (DOR) = 33.68, 95% confidence interval (CI) 7.0–163.1); sensitivity was 81.8%, specificity, 88.2%. A positive Hepika test showed a weaker association with CIN3+ lesions (DOR = 3.5; 95% CI 1.75–6.99) and lower sensitivity (27.8%). Conclusion: The Hepika test was found to be an accurate biomarker for HPV-induced cervical carcinoma. Population-based prospective studies are needed to confirm the clinical usefulness of the Hepika test in the differential diagnosis of HPV-induced invasive lesions.

scholarly journals Photodynamic Therapy for Low-grade Cervical Intraepithelial Neoplasia (CIN1): A Case Report

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yinyin Zhang ◽  
Hong Lin ◽  
Huizhen Fan
Keyword(s):  
Photodynamic Therapy ◽  
Cervical Intraepithelial Neoplasia ◽  
Persistent Infection ◽  
Precancerous Lesions ◽  
Irradiation Time ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Cervical Canal ◽  
Low Grade ◽  
Oxygen Inhalation

As a drug-mechanical combination technology, photodynamic (PDT) can achieve accurate and targeted therapy for malignant tumors and benign diseases through the production of reactive oxygen species, oxygen free radicals or singlet oxygen by photosensitizers at specific wavelengths. Compared with traditional surgery, it has the advantages of selective killing, repeatable treatment, preserving target organ function and so on. The purpose of this study was to explore the clinical value of photodynamic therapy in cervical precancerous lesions by taking the patients with low-grade cervical intraepithelial neoplasia (CIN1) with high-risk human papillomavirus (HR-HPV) persistent infection diagnosed by "three-step diagnosis and treatment procedure" as an example. Using HiPorfin as a photosensitizer, photodynamic therapy was performed 48 hours after intravenous drip. Set laser wavelength 630nm, light dose density 137.58J/cm2, transmission efficiency 1.42, output power 2w. 3cm columnar optical fiber was placed around the 2cm in the cervical canal to cover all the lesions, and the irradiation time was 900s (600s in the cervical canal and 300s outside the cervical canal). The patients were given oxygen inhalation for 6 hours after operation, and the patients were observed for itching and other discomfort, and paid attention to avoid light. Photodynamic therapy was performed again in the same way on the second day. After two months of treatment, pathological biopsy showed chronic cervicitis, indicating that the disease had been effectively controlled. Theoretically, although the patient is not the absolute indication of photodynamic therapy (that is, meeting CIN ? or CIN ?, having fertility requirements and not undergoing surgery), this therapy can remove not only the superficial lesions inside and outside the cervix, but also the potential lesions not found under colposcopy. It can also block the persistent infection of HPV by inhibiting the expression of HPV18, E6 and E7mRNA in Hela cells. In combination with Baofukang suppository, it can block HPV infection. Increase the negative conversion rate of cervical HPV and reduce the probability of recurrence after CIN1 cure. For young female patients with persistent HR-HPV infection and fertility requirements, photodynamic therapy is an effective choice for clinical treatment of CIN1.

scholarly journals Abnormal colposcopic images in patients with preinvasive cervical lesions

2013 ◽  
Vol 3 (2) ◽  
pp. 98-102
Author(s):  
Adnan Babović ◽  
Dženita Ljuca ◽  
Gordana Bogdanović ◽  
Lejla Muminhodžić
Keyword(s):  
Intraepithelial Neoplasia ◽  
Control Group ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Cytological Examination ◽  
Chi Square ◽  
Chi Square Test ◽  
Intraepithelial Lesion ◽  
Experimental Group

Introduction: The objective of the study was to determine frequency and to compare frequency of the abnormal colposcopic images in patients with low and high grade pre-invasive lesions of cervix.Methods: Study includes 259 patients, whom colposcopic and cytological examination of cervix was done. The experimental group of patients consisted of patents with pre-invasive low grade squamousintraepithelial lesion (LSIL) and high grade squamous intraepithelial lesion (HSIL), and the control group consisted of patients without cervical intraepithelial neoplasia (CIN).Results: In comparison to the total number of satisfactory fi ndings (N=259), pathological findings were registered in N=113 (43.6 %) and abnormal colposcopic fi ndings in N=128 (49.4%). The study did notinclude patients with unsatisfactory fi nding N=22 (8.5%). Abnormal colposcopic image is present most frequently in older patients but there are no statistically important difference between age categories(Pearson Chi-Square 0.47, df -3, p=0.923). Frequency of abnormal colposcopic fi ndings (N=128) is the biggest in pathological cytological (N=113) and HSIL 58 (45.3%), LSIL 36 (28.1%). There is statisticallysignifi cant difference in frequency of abnormal colposcopic images in patients with low-grade in comparison to patients with high-grade pre-invasive cervix lesions (Chi-Square test, Pearson Chi-Square 117.14,df-12 p<0.0001).Conclusion: Thanks to characteristic colposcopic images, abnormal epithelium is successfully recognized, but the severity grade of intraepithelial lesion cannot be determined.

scholarly journals Role of Regulatory B Cells in the Progression of Cervical Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Zhifang Chen ◽  
Yuejie Zhu ◽  
Rong Du ◽  
Nannan Pang ◽  
Fengbo Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
T Cells ◽  
Cancer Patients ◽  
Intraepithelial Neoplasia ◽  
Serum Levels ◽  
Hpv Infection ◽  
Control Group ◽  
Cell Percentage

This study is to investigate the role of regulatory B (Breg) cells in cervical cancer. In total, 70 cases of cervical cancer, 52 cases of cervical intraepithelial neoplasia (CIN), and 40 normal controls were enrolled. The percentage of Breg cells was detected by flow cytometry. Serum levels of IL-10 were measured by ELISA. The correlation between Breg cells and the clinical characterizations of cervical cancer was analyzed. The inhibition effect of Breg cells on CD8+ T cells was tested by blocking IL-10 in vitro. The percentage of CD19+CD5+CD1d+ Breg cells and the level of IL-10 of patients with cervical cancer or CIN were significantly higher than those in the control group (P<0.05). And the postoperative levels of Breg cells and IL-10 were significantly lower than the preoperative levels (P<0.05). Breg cells and the IL-10 level were positively correlated in cervical cancer patients (r=0.516). In addition, the Breg cell percentage was closely related to the FIGO stages, lymph node metastasis, tumor differentiation, HPV infection, and the tumor metastasis of cervical cancer (P<0.05). The Breg cell percentage was negatively correlated with CD8+ T cells of cervical cancer patients (r=‐0.669). The level of IL-10 in the culture supernatant of Bregs treated with CpG was significantly higher than that of non-Bregs (P<0.05). After coculture with Bregs, the quantity of CD8+ T cells to secrete perforin and Granzyme B was significantly decreased, and this effect was reversed after blocking IL-10 by a specific antibody. Breg cells are elevated in cervical cancer and associated with disease progression and metastasis. Moreover, they can inhibit the cytotoxicity of CD8+ T cells.

scholarly journals Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome

Blood ◽  
2010 ◽  
Vol 116 (19) ◽  
pp. 3818-3827 ◽  
Author(s):  
Lis R. V. Antonelli ◽  
Yolanda Mahnke ◽  
Jessica N. Hodge ◽  
Brian O. Porter ◽  
Daniel L. Barber ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Cd4 T Cells ◽  
Immune Reconstitution ◽  
Interferon Γ ◽  
Effector Memory ◽  
Hiv Patients ◽  
Inflammatory Syndrome

Abstract Immune reconstitution inflammatory syndrome (IRIS) is a considerable problem in the treatment of HIV-infected patients. To identify immunologic correlates of IRIS, we characterized T-cell phenotypic markers and serum cytokine levels in HIV patients with a range of different AIDS-defining illnesses, before and at regular time points after initiation of antiretroviral therapy. Patients developing IRIS episodes displayed higher frequencies of effector memory, PD-1+, HLA-DR+, and Ki67+ CD4+ T cells than patients without IRIS. Moreover, PD-1+ CD4+ T cells in IRIS patients expressed increased levels of LAG-3, CTLA-4, and ICOS and had a Th1/Th17 skewed cytokine profile upon polyclonal stimulation. Elevated PD-1 and Ki67 expression was also seen in regulatory T cells of IRIS patients. Furthermore, IRIS patients displayed higher serum interferon-γ, compared with non-IRIS patients, near the time of their IRIS events and higher serum interleukin-7 levels, suggesting that the T-cell populations are also exposed to augmented homeostatic signals. In conclusion, our findings indicate that IRIS appears to be a predominantly CD4-mediated phenomenon with reconstituting effector and regulatory T cells showing evidence of increased activation from antigenic exposure. These studies are registered online at http://clinicaltrials.gov as NCT00557570 and NCT00286767.

Identifying early cancer of the uterine cervix - a look at the precursor lesions: literature integrative review

2011 ◽  
Vol 5 (3) ◽  
pp. 812
Author(s):  
Rosana Oliveira Melo ◽  
Regina Mendonça Lopes ◽  
Rita Rocha Moreira
Keyword(s):  
Early Diagnosis ◽  
Uterine Cervix ◽  
Precancerous Lesions ◽  
Intraepithelial Neoplasia ◽  
Service Access ◽  
Precursor Lesions ◽  
Treatment Access ◽  
Calidad De Vida ◽  
Factores De Riesgo ◽  
Las Mujeres

ABSTRACTObjective: presenting a literature review reflects on the prevention of precursor lesions for cancer of the uterine cervix. Method: this is about a literature integrative study. Were used in this review: books (6), summaries of theses (5) and thesis (1) articles (7), as well as national and international publications in terms of health print and online. These materials were read and analyzed between April 2009 and July 2010. Results: upon reading and cataloging the data were organized into analytical categories: identification of risk factors, prevention, early diagnosis and appropriate treatment, access to services, recognition of the subjectivity of women with precancerous lesions of the cervix. Conclusion: this study allowed reflection on the diagnosis and treatment of precursor lesions demonstrating the importance of a closer look at prevention in order to improve service access, dialogue with health professionals, as well as the quality of life and longevity of women with these lesions. Descriptors: nursing; women's health; cervix neoplasms prevention; cervical intraepithelial neoplasia;  early diagnosis.  RESUMOObjetivo: apresentar revisão da literatura sobre a importância do diagnóstico precoce das lesões precursoras para prevenção do câncer do colo do útero. Método: utilizou- se a pesquisa bibliográfica. Foram utilizados nesta revisão: livros (6), resumos de dissertações (5) e tese (1), artigos (7), além de publicações nacionais e internacionais da saúde nas modalidades impressa e online. Estes materiais foram lidos e analisados entre abril de 2009 a julho de 2010. Resultados: após a catalogação e leitura, os dados encontrados foram organizados em eixos analíticos: identificação dos fatores de risco, a prevenção, diagnóstico precoce e tratamento adequado, acesso aos serviços, valorização da subjetividade das mulheres com lesões precursoras de câncer do colo do útero. Conclusão: este estudo permitiu reflexões sobre o diagnóstico e a terapêutica das lesões precursoras demonstrando a relevância de um olhar atento para a prevenção na perspectiva de melhorar o acesso ao serviço, o diálogo com os profissionais de saúde, bem como, a qualidade de vida e longevidade das mulheres portadoras destas lesões.      Descritores: enfermagem; saúde da mulher; prevenção de câncer de colo uterino; neoplasia intra-epitelial cervical; diagnóstico precoce. RESUMEN Objetivo: presentar una revisión de la literatura con el objetivo reflexionar sobre la prevención de las lesiones precursoras de cáncer de cuello uterino. Método: se utilizó la búsqueda bibliográfica. Se utilizaron en esta revisión: los libros (6), resúmenes de tesis (5) y la tesis (1) artículos (7), así como publicaciones nacionales e internacionales en materia de salud y de impresión en línea. Estos materiales fueron leídos y analizados entre abril de 2009 y julio de 2010. Resultados: Al momento de la lectura y la catalogación de los datos fueron organizados en    categorías de análisis: la identificación de factores de riesgo, prevención, diagnóstico precoz y un tratamiento adecuado, el acceso a los servicios, el reconocimiento de la subjetividad de las mujeres con lesiones precancerosas del cuello uterino. Conclusión: este estudio permitió la reflexión sobre el diagnóstico y tratamiento de lesiones precursoras que demuestra la importancia de una mirada más cercana a la prevención con el fin de mejorar el acceso de servicio, el diálogo con los profesionales de la salud, así como la calidad de vida y longevidad de las mujeres con estas lesiones. Descriptores: enfermería, salud de la mujer; prevención de cáncer de cuello uterino; neoplasia intraepitelial del cuello uterino;  diagnóstico precoz.  

High Percentage of Regulatory T Cells before and after Vitamin B12 Treatment in Patients with Pernicious Anemia

2014 ◽  
Vol 133 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Satoru Watanabe ◽  
Norifumi Ide ◽  
Hatsue Ogawara ◽  
Akihiko Yokohama ◽  
Takeki Mitsui ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Vitamin B12 Deficiency ◽  
T Cell Subsets ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
The Mean

Introduction: In some previous studies, vitamin B12 treatment showed immunomodulatory effects and restored the immunological abnormalities in patients with pernicious anemia (PA). In the present study, peripheral blood T cell subsets, including regulatory T cells (Tregs), were examined before and after vitamin B12 treatment in PA patients. Patients and Methods: The percentages of CD4, CD8, Th1, Th2 and Tregs were examined in 23 PA patients before vitamin B12 treatment, in 23 other PA patients after vitamin B12 treatment and in 28 healthy controls. Results: The mean percentage of CD8+ T cells was significantly higher in the control group (23.0%; 95% CI, 20.4-25.6%) than in the pre- (16.0%; 95% CI, 12.1-20.0%) and posttreatment groups (15.2%; 95% CI, 11.8-18.6%; p < 0.05). The CD4/CD8 ratio was significantly lower in the control group (2.01; 95% CI, 1.66-2.34) than in the pre- (3.45; 95% CI, 2.55-7.80) and posttreatment groups (2.97; 95% CI, 2.22-3.72; p < 0.05). There was no significant difference in the mean Th1/Th2 ratio among these groups. There were significant increases in the mean percentage of Tregs in the pre- (6.29%; 95% CI, 5.04-7.54%) and posttreatment groups (7.77%; 95% CI, 6.34-9.20%) compared with the control group (4.18%; 95% CI, 3.92-4.47%; p < 0.05). Conclusions: The percentage of Tregs was significantly higher in PA patients than in normal subjects, and this high Treg percentage was not different before and after vitamin B12 treatment. Other immunological alterations also did not recover after vitamin B12 treatment, so that these immunological changes appear to be the cause of PA and are not induced by vitamin B12 deficiency.

Anal colposcopy and the diagnosis of anal intraepithelial neoplasia in high-risk gynecologic patients

1994 ◽  
Vol 4 (2) ◽  
pp. 119-126 ◽  
Author(s):  
J. H. Scholefield ◽  
O. A. Ogunbiyi ◽  
J. H.F. Smith ◽  
K. Rogers ◽  
F. Sharp
Keyword(s):  
At Risk ◽  
Previous History ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Anal Intraepithelial Neoplasia ◽  
Control Group ◽  
Low Grade ◽  
Field Change ◽  
Histologic Diagnosis ◽  
Histopathologic Diagnosis

The objective of this study was to define the colposcopic features of the normal anal canal and of anal human papillomavirus (HPV)-associated lesions, including anal intraepithelial neoplasia (AIN), and to correlate the colposcopic impression with the final histopathologic diagnosis. A controled colposcopic screening study of women considered at risk for HPV-associated anal epithelial abnormalities was carried out. All colposcopic assessments included a biopsy with matching histopathologic diagnosis. The study group consisted of 213 women who were considered at risk of anal HPV infection and AIN. A further group of 50 women, who had no previous history of ano-genital HPV infection or AIN and whose recent cervical smear was negative were recruited as controls. Informed consent was obtained from all patients, and the study was approved by the local ethical committee. In the control group of 50 women no AIN was detected. Normal histology was obtained in 45/50 (90%) biopsies where normality had been predicted on colposcopy. Histologic diagnosis in the at-risk group was normal in 143 (67%), subclinical papillomarvirus infection (SPI) in 24 (11%), and AIN of all grades (including three cases of early invasive squamous cancer in a field change of AIN III) in 46 (22%) patients. Nineteen of 24 (79%) cases of SPI were incorrectly predicted as normal on colposcopy, and another one (4%) as AIN I–II. Only four (17%) cases of SPI were correctly predicted at colposcopy. Of the 46 cases of histologically proven AIN, 26 (56%) were AIN I–II, and 20 (44%) were AIN III. Some 50% of AIN I–II were incorrectly predicted as SPI on colposcopy. Of the 20 AIN III lesions, 15 (75%) were correctly predicted by colposcopy. Three (20%) of these lesions contained foci of early invasion, of which in only one case (33.3%) was invasive disease suspected at colposcopy. Some 25% (5/20) of AIN III lesions were incorrectly diagnosed as AIN I–II at colposcopy. As is the experience with colposcopic assessment of the cervix, anal colposcopy predictions correlated well with the final histologic diagnosis, at the normal and high-grade AIN ends of the spectrum. The colposcopic predictive distinction between SPI and low-grade AIN (I–II) was less accurate. It was difficult to distinguish early invasive lesions within a field change of AIN III, from pure AIN III. In these studies there were three cases of early anal squamous carcinoma arising in AIN III lesions, two of which were unsuspected clinically.

scholarly journals A Study on the Effect of Cervical Conization on the pregnancy and Cervical Length after Pregnancy of Patients with High-grade Cervical Intraepithelial Neoplasia

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Rui Cai
Keyword(s):  
Pregnancy Rate ◽  
Intraepithelial Neoplasia ◽  
Tube Length ◽  
Control Group ◽  
Cervical Canal ◽  
High Grade ◽  
Successful Pregnancy ◽  
Significant Difference ◽  
Experimental Group ◽  
Cervical Conization

Objective: To investigate the effect of cervical cone excision on cervical canal length in patients with high cervical intraepithelial neoplasia. Methods: 30 cases of patients with high-grade cervical intraepithelial neoplasia who admitted in our hospital and underwent cervical cone resection were selected as the experimental group and 30 cases of healthy pregnancy at the same period were selected as the control group. The experimental group was given cervical conization. The cervical canal length of patients in the experimental group, the cervical canal length of successful pregnancy patients, pregnancy and pregnancy outcome pregnancy of the two groups were detected after treatment. Results: Compared with the control group ,the cervical tube length level was significantly lower in the experimental group after treatment (P<0.05);the cervical tube length of successful pregnancy underwent cervical conization at 12 weeks , 20 weeks, 28 weeks after pregnancy showed no significant difference (P>0.05), the successful pregnancy rate of experimental group after surgery was lower(P<0.05), the incidence of pregnancy with preterm premature rupture of membranes, umbilical cord around the neck prematurity and cases of term delivery number between experimental and control groups showed no significant difference between two groups(P>0.05). Conclusion: The cervical canal length level of patients with high-grade cervical intraepithelial neoplasia was lower after cervical conization, the successful pregnancy rate was low, the pregnancy cervical tube length and the rate of preterm birth had no difference compared with normal pregnant women.

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