A Comparison of Dynamic and Static Hip-Knee-Ankle Angle during Gait in Knee Osteoarthritis Patients and Healthy Individuals

Malalignment of the lower limbs is the main biomechanical factor for knee osteoarthritis (KOA). The static hip-knee-ankle angle (S-HKAA) measured from radiograph is regarded as the “gold standard” of the malalignment. However, many evidences showed that the S-HKAA has no significant correlation with the knee dynamic-load distribution, unlike the dynamic HKAA (D-HKAA). The purpose of this study was to quantitatively analyze the D-HKAA and investigate the relationship between D-HKAA and S-HKAA for both KOA and healthy participants. In this paper, twenty-five healthy subjects and twenty-five medial compartment KOA (M-KOA) patients were recruited. Three-dimensional motion analysis and standing lower-limbs-full-length radiograph were utilized to obtain the D-HKAA and S-HKAA, respectively. The results showed that the mean D-HKAA was more varus than the S-HKAA ( p < 0.05 ). For the mean D-HKAA, larger varus angle was observed in swing phase than stance phase ( p < 0.05 ). Compared with healthy subjects, the M-KOA patients had remarkably smaller S-HKAA and D-HKAA during gait cycle ( p < 0.01 ). For the relationship between the S-HKAA and mean D-HKAA, no significant correlation was found for both healthy subjects and M-KOA patients ( r < 0.357 , n = 25 , p > 0.05 , Spearman correlation analysis). In conclusion, the S-HKAA was limited to predict the D-HKAA for both M-KOA patients and healthy subjects. The D-HKAA should be given more attention to the orthopedist and the designer of knee brace and orthotics.

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The Influence of Adipose-derived Stromal Vascular Fraction Cells on the Treatment of Knee Osteoarthritis

10.21203/rs.2.21422/v2 ◽

2020 ◽

Author(s):

Masanori Tsubosaka ◽

Tomoyuki Matsumoto ◽

Satoshi Sobajima ◽

Takehiko Matsushita ◽

Hideki Iwaguro ◽

...

Keyword(s):

Knee Osteoarthritis ◽

T2 Mapping ◽

Stromal Vascular Fraction ◽

Short Term ◽

Cell Injection ◽

Knee Oa ◽

Ankle Angle ◽

The Mean ◽

Hip Knee Ankle Angle ◽

Better Than

Abstract Background Adipose-derived stromal vascular fraction (SVF) cells are a mixed cell population that includes cells with multilineage potential, similar to bone marrow-derived mesenchymal stem cells. Our purpose is to investigate the influence of SVF cells in patients with knee osteoarthritis (OA) and the short-term treatment effects. Methods Fifty-seven patients were enrolled and treated with intra-articular injection of 5.0×10 7 SVF cells into the knee joint between September 2017 and March 2018. All patients were followed up for 12 months or longer. Mean age at treatment and follow-up period were 69.4±6.9 years and 13.7±2.0 months, respectively. The mean preoperative hip-knee-ankle angle was 6.7±3.6°. SVF cells were prepared using the Celution®800/CRS system from the patients’ abdominal or breech subcutaneous fat. The mean SVF cell viability was 90.6±2.7%. Clinical evaluations were performed for range of motion, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analog scale (VAS) for pain, and the Knee injury and Osteoarthritis Outcome Score (KOOS). Imaging evaluations, which included the hip-knee-ankle angle assessed via radiography, and T2 mapping value using a 3.0-T magnetic resonance imaging unit were also assessed. Both clinical and imaging evaluations were performed preoperatively, 1, 3, 6, and 12 months postoperatively, and compared among all timepoints (p<0.05). Results Knee extension angle at 6 and 12 months postoperatively was significantly better than the preoperative angle. Total WOMAC, VAS, and KOOS scores at 1, 3, 6 and 12 months postoperatively were significantly better than preoperative scores. There was no significant difference in hip-knee-ankle angle among the five time periods. T2 mapping values of lateral femur and tibia were significantly higher 12 months postoperatively than preoperatively. Conclusions The short-term clinical effects of intra-articular SVF cell injection on knee OA were excellent. Intra-articular SVF cell injection is a novel and innovative approach for treating patients with knee OA.

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Relationship between the Height of Fibular Head and the Incidence and Severity of Knee Osteoarthritis

10.21203/rs.3.rs-986056/v1 ◽

2021 ◽

Author(s):

Xinghui Xu ◽

Jun Li ◽

Deping Yao ◽

Pan Deng ◽

Boliang Chen ◽

...

Keyword(s):

Body Mass Index ◽

Knee Osteoarthritis ◽

Body Mass ◽

Three Dimensional ◽

Varus Deformity ◽

Fibular Head ◽

Varus Knee ◽

Ankle Angle ◽

Head Height ◽

Hip Knee Ankle Angle

Abstract Objective: To investigate the correlation between fibular head height and the incidence and severity of varus knee osteoarthritis based on three-dimensional reconstruction of the knee joint.Methods: The data of knee joint imaging in our hospital from June 2018 to June 2020 were collected. The degree of varus deformity of the knee was assessed at the superior hip-knee-ankle angle of the X-rays. Three-dimensional reconstruction of patient computed tomography(CT)data was performed by mimics software. The fibular head height, joint line convergence angle (JLCA) and medial proximal tibial angle (MPTA) were measured in a three-dimensional model. The patients were divided according to the Kellgren-Lawrence grade: group A: grade 0, group B: grade I, group C: grade II, group D: grade III, and group E: grade IV. The differences in age, gender, height, weight, body mass index(BMI), fibular head height, and degree of varus deformity (JLCA, MPTA, and coxa-knee-ankle angle) were compared. Ordinal multivariate logistic regression was used to analyze the correlation between fibular head height and Kellgren-Lawrence grade.Pearson correlation was used to analyze the correlation between fibular head height and Kellgren-Lawrence grade.Results: 232 patients (232 knees) were finally included in the study, with Kellgren-Lawrence grades of 28 in group A, 31 in group B, 49 in group C, 53 in group D, and 71 in group E. The differences in age, gender, height, body mass index, fibular head height, JLCA, MPTA, and hip-knee-ankle angle among the five groups were statistically significant (P < 0.05), and the differences in body weight were not statistically significant (P > 0.05). There were significant differences in fibular head height, JLCA, JLCA and hip-knee-ankle angle between different groups (P < 0.05). Furthermore, there were significant differences in JLCA and hip-knee-ankle angle (P < 0.05), and both JLCA and hip-knee-ankle angle increased with severe aggravation of Kellgren-Lawrence grade. Furthermore, both fibular head height and MPTA decreased as the Kellgren-Lawrence grade was severely aggravated. There was a significant negative correlation between Kellgren-Lawrence grade and fibular head height (r = -0.812, P < 0.001). Furthermore, there was a significant negative correlation between fibular head height and hip-knee-ankle angle (r = -0.7905, P < 0.001). When Kellgren-Lawrence grade III and IV knees were considered as disease, ROC curve analysis showed a cut-off value of 10.63 for fibular head height and an AUC of 0.872.Conclusion: The height of fibular head in patients with varus knee osteoarthritis is smaller than that in non-osteoarthritis patients. In addition to body mass index, fibular head height is a risk factor for the pathogenesis of varus knee osteoarthritis,the smaller the fibular head height, the more severe the severity of osteoarthritis and the more severe the degree of varus deformity.

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A Field Measurement Based Wind Characteristics Analysis of a Typhoon in Near-Ground Boundary Layer

Atmosphere ◽

10.3390/atmos12070873 ◽

2021 ◽

Vol 12 (7) ◽

pp. 873

Author(s):

Dandan Xia ◽

Liming Dai ◽

Li Lin ◽

Huaifeng Wang ◽

Haitao Hu

Keyword(s):

Turbulence Intensity ◽

Field Measurement ◽

Three Dimensional ◽

Wind Data ◽

Statistical Characteristics ◽

Gust Factor ◽

Characteristics Analysis ◽

Wind Characteristics ◽

The Mean ◽

The Relationship

The field measurement was conducted to observe the wind field data of West Pacific typhoon “Maria” in this research. With the application of ultrasonic anemometers installed in different heights (10 m, 80 m, 100 m) of the tower, the three dimensional wind speed data of typhoon “Maria” was acquired. In addition, vane-type anemometers were installed to validate the accuracy of the wind data from ultrasonic anemometers. Wind characteristics such as the mean wind profile, turbulence intensity, integral length scale, and wind spectrum are studied in detail using the collected wind data. The relationship between the gust factor and turbulence intensity was also studied and compared with the existing literature to demonstrate the characteristics of Maria. The statistical characteristics of the turbulence intensity and gust factor are presented. The corresponding conclusion remarks are expected to provide a useful reference for designing wind-resistant buildings and structures.

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Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

10.21203/rs.3.rs-59394/v1 ◽

2020 ◽

Author(s):

Yuan-jing Leng ◽

Hai-bin Zhou ◽

Jiang-ling Fu ◽

Wen-juan Wang

Keyword(s):

Healthy Subjects ◽

Characteristic Curve ◽

Urinary Stone ◽

Urinary Stones ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Healthy Control ◽

The Mean ◽

The Difference ◽

The Relationship

Abstract PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

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Increase in Tibial Internal Rotation Due to Weight-bearing is a Key Feature to Diagnose Early-stage Knee Osteoarthritis: A Study with Upright Computed Tomography

10.21203/rs.3.rs-957182/v1 ◽

2021 ◽

Author(s):

Kazuya Kaneda ◽

Kengo Harato ◽

Satoshi Oki ◽

Yoshitake Yamada ◽

Masaya Nakamura ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Internal Rotation ◽

Early Stage ◽

Weight Bearing ◽

Three Dimensional ◽

Surface Registration ◽

Lower Limbs ◽

Clinical Issue ◽

Osteoarthritic Change ◽

Tibial Internal Rotation

Abstract Background The classification of knee osteoarthritis is an essential clinical issue, particularly in terms of diagnosing early knee osteoarthritis. However, the evaluation of three-dimensional limb alignment on two-dimensional radiographs is limited. This study evaluated the three-dimensional changes induced by weight-bearing in the alignments of lower limbs at various stages of knee osteoarthritis.Methods 45 knees of 25 patients (69.9 ± 8.9 years) with knee OA were examined in the study. CT images of the entire leg were obtained in the supine and standing positions using conventional CT and 320 low-detector upright CT, respectively. Next, the differences in the three-dimensional alignment of the entire leg in the supine and standing positions were obtained using 3D-3D surface registration technique, and those were compared for each Kellgren–Lawrence grade. Results Increased flexion, adduction, and tibial internal rotation were observed in the standing position, as opposed to the supine position. Kellgren–Lawrence grades 1 and 4 showed significant differences in flexion, adduction, and tibial internal rotation between two postures. Grades 2 and 4 showed significant differences in adduction, while grades 1 and 2, and 1 and 3 showed significant differences in tibial internal rotation between standing and supine positions.Conclusions Weight-bearing increased the three-dimensional deformities in knees with osteoarthritis. Particularly, increased tibial internal rotation was observed in patients with grades 2 and 3 compared to those with grade 1. The increase in tibial internal rotation due to weight-bearing is a key pathologic feature to detect early osteoarthritic change in knees undergoing osteoarthritis.

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Three-dimensional analysis of acetabular cup orientation and an evaluation of the relationship with pelvic sagittal parameters

Journal of Orthopaedic Surgery ◽

10.1177/2309499019861225 ◽

2019 ◽

Vol 27 (2) ◽

pp. 230949901986122

Author(s):

Ali Sahin ◽

Mehmet Emin Simsek ◽

Safa Gursoy ◽

Mustafa Akkaya ◽

Cetin Isik ◽

...

Keyword(s):

Pelvic Tilt ◽

Three Dimensional ◽

Preoperative Assessment ◽

Statistical Correlation ◽

Acetabular Cup ◽

Pelvic Parameters ◽

Sagittal Parameters ◽

The Mean ◽

The Difference ◽

The Relationship

Background: This study aimed to evaluate the effect of total hip arthroplasty (THA) on sagittal pelvic parameters and to evaluate the effect of sagittal pelvic parameters on acetabular cup orientation. Methods: The study included 86 patients who underwent THA for a diagnosis of unilateral coxarthrosis between 2011 and 2015. Measurements were taken of the preoperative and postoperative acetabular cup inclination (ACI), anteversion, and sagittal pelvic parameters. The effect of THA on sagittal pelvic parameters and the effects of the sagittal pelvic parameters on acetabular cup orientation were investigated. Results: The sagittal pelvic tilt values calculated were mean 9.7° ± 6.3° (2°; 23°) preoperatively and 11.0° ± 6.1° (2°; 25°) postoperatively. The increase in postoperative pelvic incidence (PI) values was determined to be statistically significant ( p < 0.05). The preoperative PI values had no significant effect on ACI, but in cases with high preoperative PI values, a tendency to high anteversion values was determined. The mean inclination values were found to be 40.2° ± 11.0° in the low PI group, 41.7° ± 7.4° in the normal PI group, and 44.1° ± 8.3° in the high PI group. As no increase in inclination values was observed with an increase in PI values, no statistical correlation was determined ( p = 0.343). Average of anteversion values in the low PI group was 9.2° ± 13.7°, in the normal PI group 19.3° ± 10.5°, and in the high PI group 21.1° ± 12.5°. The difference between the groups was statistically significant ( p = 0.001). Conclusion: Evaluating the results of this study, it can be concluded that varying PI values do affect the acetabular cup anterversion in THA. So, preoperative assessment of PI values is important in preventing postoperative acetabular cup malposition.

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Correlations using the NREM-REM sleep cycle frequency support distinct regulation mechanisms for REM and NREM sleep

Journal of Applied Physiology ◽

10.1152/japplphysiol.00917.2001 ◽

2002 ◽

Vol 93 (1) ◽

pp. 141-146 ◽

Cited By ~ 21

Author(s):

O. Le Bon ◽

L. Staner ◽

S. K. Rivelli ◽

G. Hoffmann ◽

I. Pelc ◽

...

Keyword(s):

Rem Sleep ◽

Healthy Subjects ◽

Nrem Sleep ◽

Sleep Cycle ◽

Cycle Frequency ◽

Regulation Mechanisms ◽

The Mean ◽

Number Of Cycles ◽

The Relationship ◽

Sleep Cycles

Polysomnograms of most homeothermic species distinguish two states, rapid eye movement (REM) and non-REM (NREM) sleep. These alternate several times during the night for reasons and following rules that remain poorly understood. It is unknown whether each state has its own function and regulation or whether they represent two facets of the same process. The present study compared the mean REM/NREM sleep ratio and the mean number of NREM-REM sleep cycles across 3 consecutive nights. The rationale was that, if REM and NREM sleep are tightly associated, their ratio should be comparable whatever the cycle frequency in the night. Twenty-six healthy subjects of both sexes were recorded at their home for 4 consecutive nights. The correlation between the REM/NREM sleep ratio and the number of cycles was highly significant. Of the two sleep components, REM sleep was associated to the number of cycles, whereas NREM sleep was not. This suggests that the relationship between REM sleep and NREM sleep is rather weak within cycles, does not support the concept of NREM-REM sleep cycles as miniature units of the sleep process, and favors the concept of distinct mechanisms of regulation for the two components.

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Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2020.559603 ◽

2020 ◽

Vol 12 ◽

Author(s):

Wei Zhou ◽

Bo Shen ◽

Wei-qiang Shen ◽

Hao Chen ◽

Yi-feng Zheng ◽

...

Keyword(s):

Red Nucleus ◽

Normal Aging ◽

Iron Deposition ◽

Aging Brain ◽

Brain Iron ◽

Glymphatic System ◽

The Alps ◽

The Mean ◽

The Relationship ◽

Healthy Participants

Objective: The study aims to detect the potential relationship between iron deposition and the function of the glymphatic system in the normal aging brain.Methods: We recruited 213 healthy participants. We evaluated the function of the glymphatic system using the index for diffusivity along the perivascular space (ALPS-index), assessed iron deposition on quantitative susceptibility mapping (QSM), and analyzed their relationship.Results: The mean age of participants was 60.1 ± 7.3, and 107 (50.2%) were female. The mean ALPS-index was 1.4 ± 0.2. The QSM values of the caudate nucleus, putamen, globus pallidus, thalamus, red nucleus, substantia nigra, and dentate nucleus were all related to the ALPS-index (all P < 0.001).Conclusions: The main finding of the current study is that the regional brain iron deposition was related to the function of the glymphatic system.Advances in knowledge: We first evaluated the relationship between deposition of brain iron and the dysfunction of the glymphatic system.

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Relationship between Self-Focused Attention and Mindfulness in People with and without Hallucination Proneness

The Spanish Journal of Psychology ◽

10.1017/sjp.2014.23 ◽

2014 ◽

Vol 17 ◽

Cited By ~ 5

Author(s):

Salvador Perona-Garcelán ◽

José M. García-Montes ◽

Ana Mª López-Jiménez ◽

Juan Francisco Rodríguez-Testal ◽

Miguel Ruiz-Veguilla ◽

...

Keyword(s):

Standard Deviation ◽

Correlational Analysis ◽

Negative Association ◽

The Self ◽

Focused Attention ◽

Private And Public ◽

The Mean ◽

The Relationship ◽

Healthy Participants

AbstractThe purpose of this work was to study the relationship between self-focused attention and mindfulness in participants prone to hallucinations and others who were not. A sample of 318 healthy participants, students at the universities of Sevilla and Almería, was given the Launay-Slade Hallucinations Scale-revised (LSHS-R, Bentall & Slade, 1985). Based on this sample, two groups were formed: participants with high (n = 55) and low proneness (n = 28) to hallucinations. Participants with a score higher than a standard deviation from the mean in the LSHS-R were included in the high proneness group, participants with a score lower than a standard deviation from the mean in the LSHR-R were included in the second one. All participants were also given the Self-Absorption Scale (SAS, McKenzie & Hoyle, 2008) and the Southampton Mindfulness Questionnaire (SMQ, Chadwick et al., 2008). The results showed that participants with high hallucination proneness had significantly higher levels of public (t(80) = 6.81, p < .001) and private (t(77) = 7.39, p < .001) self-focused attention and lower levels of mindfulness (t(81) = -4.56, p < .001) than participants in the group with low hallucination proneness. A correlational analysis showed a negative association between self-focused attention (private and public) and mindfulness (r = -0.23, p < .001; r = -0.38, p < .001 respectively). Finally, mindfulness was found to partly mediate between self-focused attention and hallucination proneness. The importance of self-focused attention and mindfulness in understanding the etiology of hallucinations discussed and suggest some approaches to their treatment.

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The Effects of Uni- and Bilateral Fatigue on Postural and Power Tasks

Journal of Applied Biomechanics ◽

10.1123/jab.29.1.44 ◽

2013 ◽

Vol 29 (1) ◽

pp. 44-48 ◽

Cited By ~ 7

Author(s):

Paulo H. Marchetti ◽

Maria I.V. Orselli ◽

Marcos Duarte

Keyword(s):

Lower Limb ◽

Healthy Subjects ◽

Postural Sway ◽

Center Of Pressure ◽

Lower Limbs ◽

Quiet Standing ◽

Ground Reaction Forces ◽

Before And After ◽

Reaction Forces ◽

The Mean

The aim of this study was to investigate the effects of unilateral and bilateral fatigue on both postural and power bipedal tasks. Ten healthy subjects performed two tasks: bipedal quiet standing and a maximal bipedal counter-movement jumping before and after unilateral (with either the dominant or nondominant lower limb) and bilateral (with both lower limbs) fatigue. We employed two force plates (one under each lower limb) to measure the ground reaction forces and center of pressure produced by subjects during the tasks. To quantify the postural sway during quiet standing, we calculated the resultant center of pressure (COP) speed and COP area of sway, as well as the mean weight distribution between lower limbs. To quantify the performance during the countermovement jumping, we calculated the jump height and the peak force of each lower limb. We observed that both unilateral and bilateral fatigue affected the performance of maximal voluntary jumping and standing tasks and that the effects of unilateral and bilateral fatigue were stronger in the dominant limb than in the nondominant limb during bipedal tasks. We conclude that unilateral neuromuscular fatigue affects both postural and power tasks negatively.

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