scholarly journals Effect of Application of Different Exercise Intensities on Vitamin D and Parathormone in Children with Down’s Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Hatem H. Allam ◽  
Alaa Shafie ◽  
Amal F. Gharib ◽  
Ahmad El Askary ◽  
Mazen Almehmadi ◽  
...  
Keyword(s):  
Vitamin D ◽  
High Intensity ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Serum Levels ◽  
Repeated Measure ◽  
Moderate Intensity ◽  
Group I ◽  
Repeated Measure Manova ◽  
Nonsignificant Effect

Background. Children with Down’s syndrome are more liable to vitamin D deficiency. Treating this deficiency with supplements is associated with the risk of intoxication. Aim. The study is aimed at comparing the effect of two exercise intensities on the modulation of vitamin D and parathormone levels in children with DS. Methods. Forty-four DS male children aged from 8 to 12 years participated in the study. They were assigned randomly into two equal groups. Group I received high-intensity treadmill aerobic exercises, and group II received moderate-intensity T-AE, three times per week for three months. The blood samples were collected from both groups before the intervention, after one month of intervention, then after three months of intervention to assess serum 25(OH)D and PTH levels. Results. Repeated measure MANOVA revealed that the high-intensity T-AE induced a significant increase in 25(OH)D after one month and after three months while it significantly decreased PTH only after three months. Moderate-intensity T-AE had a nonsignificant effect on both hormones. Conclusion. The current study concluded that the high-intensity T-AE improved both vitamin D and parathormone serum levels after three months of intervention.

scholarly journals Effect of vitamin D and calcium supplementation on bone turnover in institutionalized adults with Down's Syndrome

2005 ◽  
Vol 60 (5) ◽  
pp. 605-609 ◽  
Author(s):  
P Zubillaga ◽  
A Garrido ◽  
I Mugica ◽  
J Ansa ◽  
R Zabalza ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Calcium Supplementation ◽  
Down's Syndrome ◽  
Down’S Syndrome

scholarly journals The effect of moderate versus high intensity exercise on heart rate variability in sedentary office workers

2021 ◽  
Vol 16 (1) ◽  
pp. 16-23
Author(s):  
Vibha Gangwar ◽  
Manish Kumar Verma ◽  
Ritesh Singh Gangwar ◽  
Nitin Ashok John ◽  
Rajani Bala Jasrotia
Keyword(s):  
Heart Rate ◽  
Exercise Training ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Office Workers ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Group I ◽  
Before And After ◽  
Group Ii

Background: Sedentary behavior is one of the leading modifiable risk factors for cardiovascular disease and all-cause mortality. Physical exercise exerts beneficial physiological effects on cardiovascular fitness. Different grades of physical exercise have different effects on cardiovascular health. Objective: To compare the effect of moderate and high intensity exercise training on heart rate variability (HRV) in sedentary office workers. Methods: This study was conducted on 40 healthy sedentary volunteers aged between 20-40 years of both the genders. Participants were distributed into two groups of 20 subjects each. Subjects of group I and group II performed moderate intensity and high intensity exercise respectively on bicycle ergometer for 12 weeks. Their 5- minute ECG recording was done by three channel physiograph, and frequency domain indices of HRV and heart rate (HR) were analyzed and compared before and after exercise training. Their blood pressure was also recorded and compared before and after exercise training. Independent sample t-test and paired sample ttest were used for statistical analysis. Results: HF, systolic and diastolic blood pressure reduced significantly after exercise in group II (p=0.015, 0.005, and 0.015 respectively) while HR and LF/HF ratio reduced in both group I and group II (p=0.000 for HR, and 0.034, 0.001 for LF/HF). The decrease in HR was greater after high intensity exercise than moderate intensity exercise (p= 0.025). Conclusion: Parasympathetic activity improves after moderate and high intensity exercise but improvement is more after high intensity exercise training. Therefore, high intensity exercise training is more beneficial than moderate intensity exercise training. J Bngladesh Soc Physiol 2021;16(1): 16-23

scholarly journals The Effects of Acute and Chronic Aerobic Activity on the Signaling Pathway of the Inflammasome NLRP3 Complex in Young Men

Medicina ◽  
2019 ◽  
Vol 55 (4) ◽  
pp. 105 ◽  
Author(s):  
Iman Khakroo Abkenar ◽  
Farhad Rahmani-nia ◽  
Giovanni Lombardi
Keyword(s):  
Heart Rate ◽  
Aerobic Exercise ◽  
Signaling Pathway ◽  
High Intensity ◽  
Serum Levels ◽  
Moderate Intensity ◽  
Chronic Exercise ◽  
Maximum Heart Rate ◽  
High Group ◽  
Nlrp3 Gene

Background and Objectives: The results of the studies show that the intensity and volume of aerobic exercise activity produce different responses of the immune system. This study aims to show how the signaling pathway of the inflammatory NLRP3 complex is influenced by the acute and chronic effects of moderate and high-intensity aerobic exercises in young men. Materials and Methods: Accordingly, 60 healthy (BMI = 23.56 ± 2.67) young (24.4 ± 0.4) students volunteered to participate in the study that was randomly divided into two experimental (n = 20) groups and one control (n = 20) group. The training protocol started with two intensity levels of 50% for a moderate group and 70% of maximum heart rate for high group for 30 min and then continued until reaching 70% (moderate group) and 90% (high group) of the maximum heart rate, respectively. Using Real Time-PCR method, the expression of NLRP3 gene and ELISA- were measured by IL-1β, IL-18. Results: The results showed that acute aerobic exercise with moderate intensity had no significant effect on the expression of NLRP3 gene and serum levels of IL-1β and IL-18 cytokines (p > 0.05) when acute exercise, with high intensity, begins an initiation of the activity of the inflammatory complex with elevated serum levels of IL-1β, IL-18, and NLRP3 gene expression (p < 0.05). In addition, chronic exercise with moderate intensity significantly reduced the expression of NLRP3 gene and serum levels of IL-1β, IL-18 cytokines (p < 0.05). In the case of chronic exercise with high intensity, a significant increase in expression of gene, NLRP3 and serum levels of IL-1β, IL-18 cytokines were observed (p < 0.05). Conclusions: Generally, it can be concluded that chronic exercise with moderate intensity is effective in decreasing the expression of the inflammasome and inflammation.

Interleukin 37 Levels in Relation to Serum Vitamin D Levels Among Ain Shams University Medical Students

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Randa Reda Mabrouk ◽  
Afaf Abdelalim Mostafa ◽  
Dina Aly Mohamed Aly Ragab ◽  
Fouad Mohamed Fouad zaki
Keyword(s):  
Vitamin D ◽  
Medical Students ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Group I ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Group Ii

Abstract Background The extraskeletal role of vitamin D is being increasingly recognized. This has important clinical implications, as vitamin D deficiency has reached epidemic proportions worldwide. Vitamin D has proposed anti-inflammatory properties as recent data suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers. Interleukin-37(IL-37) is an IL1 family cytokine discovered in recent years and has 5 different isoforms. As an immunosuppressive factor, IL-37 can suppress excessive immune response .IL37 plays a role in protecting the body against endotoxin shock, ischemia reperfusion injury, autoimmune diseases, and cardiovascular diseases. In addition, IL-37 has a potential antitumor effect. IL-37 and its receptors may serve as novel targets for the study, diagnosis, and treatment of immune-related diseases and tumors. Aim of the Work The aim of this study is to determine the relation between the level of interleukin-37 and 25-hydroxy Vitamin D among Ain Shams University medical students. Subjects and Methods The study was conducted at Clinical Pathology Department, Ain Shams University Hospitals. Ninety individuals, from medical students of Ain Shams University who participated in the Nutritional Assessment of Ain Shams University Medical Students (NAMESASU) Project, were selected to be in the study. The study included 2 groups: Group I: included 45 subjects selected from the NAMES-ASU project with deficient vitamin D serum levels. Group II: included 45 subjects selected from the NAMES-ASU project with sufficient vitamin D serum levels. Results There was a highly significant difference between the two groups regarding vitamin D levels. Serum IL-37 levels were significantly higher in group I subjects compared to group II subjects. No significant difference was observed between group I and group II regarding BMI, BFM, PBF and hsCRP. No significant difference was observed between the two subgroups regarding IL-37 levels and hsCRP levels. A highly significant negative correlation was observed between vitamin D levels and IL-37. A significant negative correlation was observed between hsCRP and vitamin D levels. However, no correlation was observed between hsCRP and IL-37 levels. Conclusion Data from our study showed that present study denote that in case of vitamin D deficiency, irrespective of BMI, a subclinical state of inflammation may be present as reflected by the increased hsCRP levels and this state of inflammation might induce an increase in IL-37, an anti-inflammatory cytokine, in an attempt to reduce the inflammation.

scholarly journals The Effect of Circuit Resistance Training With Varying Intensity on Selected Inflammatory Markers in Obese Men

2021 ◽  
Author(s):  
Saeid Emamdoost ◽  
Asieh Abbassi Daloii ◽  
Alireza Barari ◽  
Ayoub Saeidi
Keyword(s):  
Body Mass Index ◽  
Resistance Training ◽  
High Intensity ◽  
Inflammatory Markers ◽  
Serum Levels ◽  
Moderate Intensity ◽  
Low Intensity ◽  
Circuit Resistance Training ◽  
Circuit Resistance ◽  
Intensity Training

Obesity and associated chronic inflammation lead to insulin resistance. The aim of this study was to evaluate the effect of varying intensity circuit resistance training on metabolic and inflammatory markers in obese men. In a semi-experimental trial, 44 obese men were selected and randomly divided into four groups, including 1) Control (n=11), 2) Low-intensity circuit resistance training (n=11), 3) Moderate-intensity circuit resistance training (n=11), and 4) High-intensity circuit resistance training (n=11). Resistance training was performed at different intensities, including 1) High-intensity circuit resistance training (80% 1RM), 2) Moderate-intensity circuit resistance (60% 1RM), and 3) Low-intensity circuit resistance training (40% 1RM), three sessions per week for 12 weeks. Serum levels of Dectin-1, TLR2, TLR4, MyD88 were measured using an ELISA kit. Data were analyzed with covariance analysis at P<0.05. Twelve weeks of moderate and high-intensity circuit resistance training significantly reduced weight, body mass index, serum levels of Dectin-1, TLR2, TLR4, MyD88, and HOMA-IR (P=0.001). The reduction of weight, body mass index, serum levels of Dectin-1, TLR2, TLR4, MyD88, and HOMA-IR were significant in obese men in the high-intensity training group compared to low-intensity training (P=0.001). It seems that circuit resistance training, especially high-intensity circuit resistance training, can be used as an option to reduce the inflammatory and metabolic complications associated with obesity.  

Serum levels of gamma interferon in patients with Down's syndrome

Infection ◽  
1995 ◽  
Vol 23 (1) ◽  
pp. 66-67 ◽  
Author(s):  
D. Torre ◽  
Claudia Zeroli ◽  
G. Ferrario ◽  
R. Casalone ◽  
M. Broggini ◽  
...  
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Serum Levels ◽  
Gamma Interferon

Vitamin D receptor gene polymorphisms in persons with Down's syndrome

2006 ◽  
Vol 10 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Sara Panizo-Garcia ◽  
Eva Parisi-Capdevila ◽  
José Manuel Valdivielso-Revilla ◽  
Lluís Rosselló-Aubach ◽  
Elvira Fernández-Giraldez
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms

scholarly journals Peculiarities of Graves' disease in children and adolescents with Down's syndrome

2010 ◽  
Vol 162 (3) ◽  
pp. 591-595 ◽  
Author(s):  
Filippo De Luca ◽  
Andrea Corrias ◽  
Mariacarolina Salerno ◽  
Malgorzata Wasniewska ◽  
Roberto Gastaldi ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Children And Adolescents ◽  
Clinical Course ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Serum Levels ◽  
Graves Disease ◽  
Radioiodine Ablation ◽  
Definitive Therapy ◽  
Clinical Changes

ObjectiveTo compare the presentation and clinical course of Graves' disease (GD) in two pediatric populations consisting of 28 patients with Down's syndrome (DS) and 109 controls without DS respectively.Design and methodsThe evolution over time of GD was determined in both groups according to the clinical changes and the variations in TSH, free thyroxine, and TSH receptor autoantibodies serum levels during the entire follow-up.ResultsFemale prevalence (50 vs 81.6%; χ2=12.0, P<0.0005) and average age at GD presentation (9.9±4.4 vs 11.5±3.5 years, P<0.05) were significantly lower in DS group than in controls. Clinical responsiveness to methimazole therapy was significantly better in DS patients, as demonstrated by both the lower relapse rates after the first cycle withdrawal (7.1 vs 31.2%; χ2=7.4, P<0.005) and the higher persistent remission rates after definitive therapy withdrawal (46.4 vs 26.7%; χ2=4.1, P<0.05). Moreover, in DS group, no patients needed surgery or radioiodine ablation, whereas non-pharmacological treatment was necessary in 11% of controls (χ2=3.8, P<0.05). Antecedents of Hashimoto's thyroiditis (HT) were documented in 21.4% of DS patients and in 3.7% of controls (χ2=10.4, P<0.005). Association with other autoimmune diseases was detected in 32.1% of DS cases and in 12.8% of controls (χ2=5.94, P<0.025).ConclusionsGD in DS children and adolescents is characterized by several peculiarities: i) earlier presentation; ii) no gender predominance; iii) less severe clinical course; iv) higher frequency of documented HT antecedents; v) more frequent association with other autoimmune diseases.

scholarly journals THU0471 VITAMIN D SUPPLEMENTATION; IS IT EFFECTIVE IN FIBROMYALGIA PATIENTS?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 472.2-473 ◽  
Author(s):  
S. A. A. Tabra ◽  
M. H. Abu-Zaid ◽  
S. Hablas
Keyword(s):  
Vitamin D ◽  
Serum Levels ◽  
Vitamin D Insufficiency ◽  
Psychological Status ◽  
Once Daily ◽  
Group I ◽  
Sf 36 ◽  
Assessment Measures ◽  
Group Ii

Background:Fibromyalgia syndrome (FMS) is a chronic pain syndrome which presented by easy fatigability, widespread body pain, anxiety and tenderness points on specific anatomic regions. Fibromyalgia may be risk factor for vitamin D deficiency because of pain, poor mobility, or depression, potentially leading to less time of sun exposure or high rates of adiposity leading to decreased synthesis of vitamin D & there are conflicting results on the role of vitamin D in improving chronic nonspecific musculoskeletal pains1, 2.Objectives:Assessment of the effectiveness of vitamin D supplements as adjuvant therapy in functional status, quality of life and psychological status in fibromyalgia patients with vitamin D insufficiency.Methods:One hundred adult patients of primary FMS (according to the 2010 ACR criteria for FMS) associated with vitamin D insufficiency (21-29 ng/mL) were selected to participate in this study. Patients with secondary FMS were excluded; also we excluded patients with any psychiatric disorders and patients who had other chronic diseases interfering with calcium, phosphorus, and vitamin D metabolism. After written consent; the patients were randomly divided into 2 equal groups; group I received duloxetine (60 mg once daily for 6 months) plus 50,000 unit oral cholecalciferol weekly for 8 weeks then monthly for 16 weeks. Group II received duloxetine (60 mg once daily for 6 months) plus placebo. The patients were assessed at baseline and after 6 months of treatment by measuring serum levels of 25(OH)D, Fibromyalgia Impact Questionnaire (FIQ), Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36) & Hospital Anxiety and Depression Scale (HADS).Results:Eighty six patients completed this study. There was no significant difference between all groups in demographic data, educational status and all baseline variants except serum levels of 25(OH) D. After 6 months; there was significant improvement (P<0.05) in group I in serum levels of 25(OH) D. There was significant improvement (P<0.05) after 6 months in FIQ, SF-36 and HADS in both groups. There was significant better improvement (P<0.05) in group I than in group II in FIQ, SF-36 and HADS. The results of the study are summarized in table 1.Table 1.Pre- and post-treatment assessment measures of the patient groupsassessment measuresBaselineBaselineAfter 6 monthsAfter 6 monthsGroup IGroup IIGroup IGroup II25(OH)D25.3 ± 4.9 ng/ml26.8+5.3 ng/ml36.8+3.9 ng/ml25.6 ± 3.4 ng/mlFIQ47.5±5.446.7±6.727.5±6.138.5±7.3SF-36 (Total score)47.6±10.447.0±9.961.0±5.854.8±5.3HAD anxiety8.2±0.68.4±0.37.1±0.77.5±1.4HADS depression8.6±0.38.6±0.97.3±0.87.7±1.4Conclusion:Vitamin D supplement is effective as an adjuvant therapy in improving functional status, quality of life and psychological status in fibromyalgia patients with vitamin D insufficiency.References:[1]Abd Elghany S E et al, Regenerative injection therapy and repetitive transcranial magnetic stimulation in primary fibromyalgia treatment: A comparative study. Journal of Back and Musculoskeletal Rehabilitation -1 (2018) 1–8[2]Maria Helde-Frankling, Linda Björkhem-Bergman. Vitamin D in Pain Management. Int. J. Mol. Sci. 2017, 18, 2170Disclosure of Interests: :None declared

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