Analysis of the Research Hotspot of Drug Treatment of Tuberculosis: A Bibliometric Based on the Top 50 Cited Literatures

Objective. The objective of the current study was to analyze the research hotspot of drug treatment for tuberculosis via top literatures. Materials and Methods. A retrospective analysis was performed on June 7th, 2021. Literatures were searched on the Web of Science Core Collection to identify the top 50 cited literatures related to drug treatment of tuberculosis. The characteristics of the literatures were identified. The outcomes included authorship, journal, study type, year of publication, and institution. Cooccurrence network analysis and visualization were conducted using the VOS viewer (Version 1.6.16; Leiden University, Leiden, The Netherlands). Results. The top 50 cited literatures were cited 308 to 2689 times and were published between 1982 and 2014. The most studied drugs were the first-line drugs such as isoniazid and rifampicin ( n = 22 ), and drug-resistant tuberculosis was most frequently reported ( n = 16 ). They were published in 18 journals, and the New England Journal of Medicine published the most literatures ( n = 18 ), followed by the American Journal of Respiratory and Critical Care Medicine ( n = 7 ), and the Lancet ( n = 6 ). The authors were from 13 countries, and the authors from the USA published most of the literatures ( n = 30 ), while authors from other countries published less than five literatures. The CDC in the USA ( n = 4 ), the World Health Organization (WHO) ( n = 3 ), and the American Philosophical Society ( n = 3 ) were the leading institutions, and only two authors published at least two top-cited literatures as first authors. Conclusions. This study provides insights into the development and most important literatures on drug therapy for tuberculosis and evidence for future research on tuberculosis treatment.

Download Full-text

Evolution of COVID19 new cases in 16 countries and Scenarios for Brazil using metaphorical analysis of Board, Inverted Pyramid and Papyri

International Journal for Innovation Education and Research ◽

10.31686/ijier.vol8.iss4.2314 ◽

2020 ◽

Vol 8 (4) ◽

pp. 560-607 ◽

Cited By ~ 1

Author(s):

Jonas Gomes da Silva

Keyword(s):

World Health ◽

Future Research ◽

Business Managers ◽

Public And Private ◽

Inverted Pyramid ◽

Unified Health System ◽

The World ◽

The Usa ◽

Health Organization ◽

Metaphorical Analysis

Since the end of 2019, the world has become aware of a new virus that has emerged in China, which in February 2020 was called by the World Health Organization (WHO, 2019) as Coronavirus disease (COVID19). Due to its fast transmission, at 18:32 (GMT) on March 29, 2020, the world has officially accounted for about 710,950 new confirmed cases with 33,553 deaths and 150,734 recovered cases (Worldometers, 2020). The pandemic has become the newest challenge for several nations, especially the USA, Italy, China, Spain, Germany, Iran, for being the most affected, and since Brazil is a continental country with disabilities in its Unified Health System, it could be in the next two months among the five most affected. Thus, the main objective of the research is analyze the evolution of new cases of COVID19 in 16 countries to present short-term scenarios and recommendations for Brazil to face the pandemic. The research is applied, as its results and recommendations can be applied with adaptation by government authorities, business managers and citizens. The research is descriptive, with a qualitative and quantitative approach, based on bibliographic and documentary research, involving the study of articles, reports, manuals and other technical documents related to the subject. For the creation of scenarios, data collection focused on the number of new cases registered in 16 countries, including Brazil, as well as in the development of an approach using metaphorical analysis of the Board, the Inverted Pyramid and Papyri. The main conclusion is that even though no country is prepared to face epidemics and pandemics (NTI, JHU and EIU, 2019), among the 16 countries investigated, Thailand, Finland, Australia, South Korea, Denmark and Sweden are benchmarks that Brazil could study in order not to repeat the scenarios of China, USA, Italy and Spain. At the end, ten recommendations are made for future research and also to public and private managers.

Download Full-text

The 100 most-cited articles in the field of colorectal diseases from 1955 to 2018: A bibliometric analysis

10.7287/peerj.preprints.27602v1 ◽

2019 ◽

Author(s):

Mengqi LuoLuo ◽

Chunmei Zhang ◽

Yutang Ren ◽

Wei Peng ◽

Chunyu Zhong ◽

...

Keyword(s):

New England ◽

Science Studies ◽

Web Of Science ◽

Scientific Progress ◽

The United States ◽

Future Research ◽

Randomized Controlled ◽

Colorectal Diseases ◽

Study Type ◽

Number Of Citations

Abstract Background: The number of times that an article was cited reflected its impact. In this study, we aimed to recognize and analyze the characteristics of the most frequently cited articles in the field of colorectal diseases. Methods: We identified the 100 highest cited articles using the terms ‘colorectal’ or ‘colon’ or ‘rectal’ or ‘IBD’ or ‘ulcerative colitis’ or ‘Crohn disease’ or ‘colonoscopy’ in Web of Science. Articles were analyzed to evaluate the characteristics including number of citations, country of origin, institutions of origin based on the first author affiliation, study type and others. Results: Of the top cited publications, the number of citations ranged from 1479 to 8834 with a mean of 2304.85 citations per article. The journal with the greatest number of most-cited articles was New England Journal of Medicine (n=23), followed by Science (n=13) and Nature (n=12). These papers were published in 14 different countries, of which more than half were from the United States (n=64). The most popular field was colorectal cancer (n=51), followed by colonic tumor (n=21). Most of the papers were basic science studies (n=44) and randomized controlled trials (n=29). Conclusion: Our study could provide a historical perspective on the scientific progress in the field of colorectal diseases, which would lay a firm foundation for future research.

Download Full-text

The 100 most-cited articles in the field of colorectal diseases from 1955 to 2018: A bibliometric analysis

10.7287/peerj.preprints.27602 ◽

2019 ◽

Author(s):

Mengqi LuoLuo ◽

Chunmei Zhang ◽

Yutang Ren ◽

Wei Peng ◽

Chunyu Zhong ◽

...

Keyword(s):

New England ◽

Science Studies ◽

Web Of Science ◽

Scientific Progress ◽

The United States ◽

Future Research ◽

Randomized Controlled ◽

Colorectal Diseases ◽

Study Type ◽

Number Of Citations

Download Full-text

Drug-resistant tuberculosis: World Health Organization launches Global Response Plan 2007-2008

Weekly releases (1997–2007) ◽

10.2807/esw.12.27.03231-en ◽

2007 ◽

Vol 12 (27) ◽

Author(s):

Collective Editorial team

Keyword(s):

World Health ◽

Drug Resistant ◽

First Line ◽

Global Response ◽

Drug Resistant Tuberculosis ◽

Resistant Tuberculosis ◽

Resistant Strains ◽

Response Plan ◽

Health Organization ◽

Drug Resistant Strains

An increasing proportion of tuberculosis (TB) cases today are resistant to first line, and often also to second line anti-TB drugs. Drug-resistant strains of Mycobacterium tuberculosis are now responsible for over 400,000 cases of TB per year.

Download Full-text

Exploring Antimicrobials from the Flora and Fauna of Marine: Opportunities and Limitations

Current Drug Discovery Technologies ◽

10.2174/1570163816666190819141344 ◽

2020 ◽

Vol 17 (4) ◽

pp. 507-514 ◽

Cited By ~ 1

Author(s):

Krishnamoorthy Venkateskumar ◽

Subramani Parasuraman ◽

Leow Y. Chuen ◽

Veerasamy Ravichandran ◽

Subramani Balamurgan

Keyword(s):

Antimicrobial Resistance ◽

Bioactive Compounds ◽

Marine Environment ◽

World Health ◽

Future Research ◽

Marine Biodiversity ◽

Marine Resources ◽

Living Space ◽

Alternative Sources ◽

Health Organization

About 95% of earth living space lies deep below the ocean’s surface and it harbors extraordinary diversity of marine organisms. Marine biodiversity is an exceptional reservoir of natural products, bioactive compounds, nutraceuticals and other potential compounds of commercial value. Timeline for the development of the drug from a plant, synthetic and other alternative sources is too lengthy. Exploration of the marine environment for potential bioactive compounds has gained focus and huge opportunity lies ahead for the exploration of such vast resources in the ocean. Further, the evolution of superbugs with increasing resistance to the currently available drugs is alarming and it needs coordinated efforts to resolve them. World Health Organization recommends the need and necessity to develop effective bioactive compounds to combat problems associated with antimicrobial resistance. Based on these factors, it is imperative to shift the focus towards the marine environment for potential bioactive compounds that could be utilized to tackle antimicrobial resistance. Current research trends also indicate the huge strides in research involving marine environment for drug discovery. The objective of this review article is to provide an overview of marine resources, recently reported research from marine resources, challenges, future research prospects in the marine environment.

Download Full-text

Squamous cell carcinoma mimics small cell carcinoma of the lung: a case report

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa531 ◽

2020 ◽

Vol 2020 (12) ◽

Author(s):

Michael Kmeid ◽

Breanne Gillie ◽

Armand Asarian ◽

Philip Xiao

Keyword(s):

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Lung Tumors ◽

Small Cell ◽

World Health ◽

Lung Cancers ◽

Lung Carcinomas ◽

The Usa ◽

Health Organization

Abstract Squamous cell carcinomas (SCC) accounts for roughly 20% of lung cancers in the USA. The 2015 World Health Organization classification of lung tumors further categorizes SCC as three subtypes: keratinizing, non-keratinizing and basaloid variant. The non-keratinizing subtype is a poorly differentiated tumor that can present histologically in different ways, and one of which is a rare variant that strongly resembles small cell carcinoma. As a result, histological diagnosis alone is not sufficient to properly diagnose lung carcinomas. Immunohistochemistry has been increasingly used over the past few years to differentiate between lung tumors. The combination of morphological and immunohistochemical staining should be the mainstay for diagnosis of all lung carcinomas as more targeted therapies become more available.

Download Full-text

“How about We Give It a Go?”: A Case Study on Supporting Breastfeeding Families in an Australian Child Care Centre

Children ◽

10.3390/children7110195 ◽

2020 ◽

Vol 7 (11) ◽

pp. 195

Author(s):

Emma Woolley ◽

Shirley Wyver

Keyword(s):

Child Care ◽

World Health ◽

Future Research ◽

Care Centre ◽

Breastfeeding Support ◽

Child Care Centre ◽

Collective Case Study ◽

Instrumental Case Study ◽

Health Organization

The World Health Organization (WHO) recommends exclusive breastfeeding for six months and continuation of breastfeeding for up to two years. Formal child care has an important role in supporting breastfeeding, as many Australian infants commence care before two years of age. Currently, little is known about support or barriers in child care contexts. The present qualitative instrumental case study explores practices which protect, promote and support breastfeeding at a child care centre located in the Australian Capital Territory’s outer suburbs. Extending from a previously published collective case study, a cultural-institutional focus of analysis was used to explore the roles of proximity, flexibility and communication in supporting breastfeeding within a child care centre located close to an infant’s home. Interviews with centre staff and mothers, triangulated with observations of the centre environment and policy documents provide insight into the environment. Affirming the roles of flexibility in routine and staff rostering and two-way communication, findings suggest longer-term benefits may be derived from selecting a child care centre close to an infant’s home, provided mothers can overcome barriers to breastmilk expression in the workplace. The study recognises the role of non-lactating caregivers in the transition to formal child care, and of the support culture for educators who breastfeed. This study extends the knowledge base of breastfeeding support interventions in the child care setting to inform future research and policy.

Download Full-text

Trends in access to anti‐malarial treatment in the formal private sector in Uganda: an assessment of availability and affordability of first‐line anti‐malarials and diagnostics between 2007 and 2018

Malaria Journal ◽

10.1186/s12936-021-03680-8 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Denis Kibira ◽

Anthony Ssebagereka ◽

Hendrika A. van den Ham ◽

Jimmy Opigo ◽

Henry Katamba ◽

...

Keyword(s):

Private Sector ◽

Diagnostic Tests ◽

Malaria Treatment ◽

World Health ◽

First Line ◽

Cross Sectional ◽

Malaria Rapid Diagnostic Tests ◽

Retail Outlets ◽

Health Action ◽

Health Organization

Abstract Background Malaria is the single largest cause of illness in Uganda. Since the year 2008, the Global Fund has rolled out several funding streams for malaria control in Uganda. Among these are mechanisms aimed at increasing the availability and affordability of artemisinin-based combination therapy (ACT). This paper examines the availability and affordability of first-line malaria treatment and diagnostics in the private sector, which is the preferred first point of contact for 61% of households in Uganda between 2007 and 2018. Methods Cross-sectional surveys were conducted between 2007 and 2018, based on a standardized World Health Organization/Health Action International (WHO/HAI) methodology adapted to assess availability, patient prices, and affordability of ACT medicines in private retail outlets. A minimum of 30 outlets were surveyed per year as prescribed by the standardized methodology co-developed by the WHO and Health Action International. Availability, patient prices, and affordability of malaria rapid diagnostic tests (RDTs) was also tracked from 2012 following the rollout of the test and treat policy in 2010. The median patient prices for the artemisinin-based combinations and RDTs was calculated in US dollars (USD). Affordability was assessed by computing the number of days’ wages the lowest-paid government worker (LPGW) had to pay to purchase a treatment course for acute malaria. Results Availability of artemether/lumefantrine (A/L), the first-line ACT medicine, increased from 85 to100% in the private sector facilities during the study period. However, there was low availability of diagnostic tests in private sector facilities ranging between 13% (2012) and 37% (2018). There was a large reduction in patient prices for an adult treatment course of A/L from USD 8.8 in 2007 to USD 1.1 in 2018, while the price of diagnostics remained mostly stagnant at USD 0.5. The affordability of ACT medicines and RDTs was below one day’s wages for LPGW. Conclusions Availability of ACT medicines in the private sector medicines retail outlets increased to 100% while the availability of diagnostics remained low. Although malaria treatment was affordable, the price of diagnostics remained stagnant and increased the cumulative cost of malaria management. Malaria stakeholders should consolidate the gains made and consider the inclusion of diagnostic kits in the subsidy programme.

Download Full-text

Reflections on FDA and WHO recommendations concerning clinical trials

Psychiatry and Psychobiology ◽

10.1017/s0767399x00002960 ◽

1989 ◽

Vol 4 (2) ◽

pp. 117-122 ◽

Cited By ~ 2

Author(s):

J.-F. Dreyfus ◽

D. Cremniter ◽

J.D. Guelfi

Keyword(s):

Clinical Trials ◽

Drug Users ◽

Objective Evaluation ◽

World Health ◽

Measuring Instruments ◽

New Techniques ◽

The Usa ◽

The One ◽

Health Organization

SummaryWe are still confronted by numerous different nosographic models and problems concerning the objective evaluation of patients progress during treatment. It is interesting to consider the consequences of this situation in psychiatry which still involves a relative diversity of practical methods used in clinical trials. The recommendations of the USA Food and Drug Administration, on the one hand, constitute a highly structured and precise reference. The World Health Organization, on the other hand, promulgates general recommendations resulting from a compromise designed to satisfy the greatest number of clinicians.Despite the apparently diverse principles and the different practical methods they propose, both those sets of recommendations have been useful in inspiring clinicians to reflect upon these different methodological approaches. The qualities of the inclusion criteria used in the study of patients and the sensitivity of the different measuring instruments have allowed psychotropic drug users as well as producers to recognize the need for a certain rigour in clinical trials.The FDA and WHO guidelines have certainly improved the quality of clinical trials in psychopharmacology. However, they also represent a source of resistance to innovation.A series of consensus meetings to first reconcile US and European points of view and later to include new techniques in the recognized sets of methods would therefore be helpful.

Download Full-text

Pharmacogenetics of Metformin

Open Access Indonesian Journal of Medical Reviews ◽

10.37275/oaijmr.v1i6.573 ◽

2021 ◽

Vol 1 (6) ◽

pp. 123-129

Author(s):

Alrahman Joneri

Keyword(s):

American Diabetes Association ◽

Glucose Utilization ◽

Medical Condition ◽

World Health ◽

First Line ◽

Glucose Levels ◽

Normal Limits ◽

The World ◽

Health Organization ◽

The Individual

Hyperglycemia is a medical condition in which an increase in glucose levels in the blood exceeds normal limits. Hyperglycemia is one of the typical signs of diabetes mellitus (DM). The World Health Organization (WHO) predicts an increase in the number of people with DM which is a global health threat. Diabetes is the leading cause of kidney failure, and the leading cause of heart disease and stroke, in adults. Metformin, which is a biguanide group, is recommended by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes as the first-line oral therapy for DM and is the most widely used oral medication worldwide. Metformin can also increase peripheral glucose utilization and ultimately decrease the production of fatty acids and triglycerides. Some of the individual differences that underlie the variation in response to metformin.

Download Full-text