Pharmacogenetics of Metformin

2021 ◽  
Vol 1 (6) ◽  
pp. 123-129
Author(s):  
Alrahman Joneri
Keyword(s):  
American Diabetes Association ◽  
Glucose Utilization ◽  
Medical Condition ◽  
World Health ◽  
First Line ◽  
Glucose Levels ◽  
Normal Limits ◽  
The World ◽  
Health Organization ◽  
The Individual

Hyperglycemia is a medical condition in which an increase in glucose levels in the blood exceeds normal limits. Hyperglycemia is one of the typical signs of diabetes mellitus (DM). The World Health Organization (WHO) predicts an increase in the number of people with DM which is a global health threat. Diabetes is the leading cause of kidney failure, and the leading cause of heart disease and stroke, in adults. Metformin, which is a biguanide group, is recommended by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes as the first-line oral therapy for DM and is the most widely used oral medication worldwide. Metformin can also increase peripheral glucose utilization and ultimately decrease the production of fatty acids and triglycerides. Some of the individual differences that underlie the variation in response to metformin.

scholarly journals Pharmacogenetics of Metformin

2021 ◽  
Vol 1 (6) ◽  
pp. 123-129
Author(s):  
Alrahman Joneri
Keyword(s):  
American Diabetes Association ◽  
Glucose Utilization ◽  
Medical Condition ◽  
World Health ◽  
First Line ◽  
Glucose Levels ◽  
Normal Limits ◽  
The World ◽  
Health Organization ◽  
The Individual

Hyperglycemia is a medical condition in which an increase in glucose levels in the blood exceeds normal limits. Hyperglycemia is one of the typical signs of diabetes mellitus (DM). The World Health Organization (WHO) predicts an increase in the number of people with DM which is a global health threat. Diabetes is the leading cause of kidney failure, and the leading cause of heart disease and stroke, in adults. Metformin, which is a biguanide group, is recommended by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes as the first-line oral therapy for DM and is the most widely used oral medication worldwide. Metformin can also increase peripheral glucose utilization and ultimately decrease the production of fatty acids and triglycerides. Some of the individual differences that underlie the variation in response to metformin.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

Older people and medication management: from compliance to concordance

2004 ◽  
Vol 14 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Caroline McGraw ◽  
Vari Drennan
Keyword(s):  
Medical Profession ◽  
Medication Management ◽  
Health Care Expenditure ◽  
Chronic Illnesses ◽  
World Health ◽  
Medical Practitioners ◽  
The World ◽  
Health Organization ◽  
The Individual

The issue of not taking medicines as prescribed by medical practitioners has a history as long as the medical profession itself. The World Health Organization recently described the problem of patients diagnosed with chronic illnesses not taking their medication as prescribed as ‘a worldwide problem of striking magnitude’. Not taking medicines as prescribed has consequences not only for the individual in terms of therapeutic failure, but also for the wider society. For the individual, failure to take medication as prescribed may result in ill health, poorer quality of life, and reduced life expectancy. For the wider society, consequences include avoidable health care expenditure and the development of drug resistance.

scholarly journals Democracy Backsliding as a Danger of Sustainable Development in the Post-Pandemic Period: Social and Legal aspects of Decision

2021 ◽  
Vol 126 ◽  
pp. 06007
Author(s):  
Oleg Tkach ◽  
Оleh Batrymenko ◽  
Dmytro Nelipa ◽  
Mykola Khylko
Keyword(s):  
Human Life ◽  
Legal Aspects ◽  
World Health ◽  
Global Pandemic ◽  
The World ◽  
The Government ◽  
Democratic Principles ◽  
Health Organization ◽  
The Individual ◽  
The Right

The article considers topical issues of the threat of collapse of democracy. Examples of the democracy collapse have shown the lack of free and fair elections in the world, which threatens the independence of the judiciary, restrictions on the right to freedom of speech, which limits the ability of the political opposition to challenge the government, to prosecute, to offer alternatives to the regime. The collapse of democracy in connection with the spread of COVID-19 is being considered, as the democratic spectrum has repeatedly resorted to excessive control, discriminatory restrictions on freedoms such as movement and assembly, and arbitrary or coercive coercion. Attention is drawn to the fact that the outbreak of coronavirus COVID-19 has led to the introduction in all countries of restrictions on the rights and freedoms of the individual in order to prevent the spread of this infectious disease, declared a global pandemic by the World Health Organization. Thus, the unusual nature of the COVID - 19 coronavirus pandemic poses numerous dilemmas to the public, governments, parliaments, the judiciary, law enforcement and many other actors when it comes to the need for effective protection of health and, ultimately, human life, as well as adherence to and ensuring the fundamental democratic principles of man and society.

scholarly journals Understanding health education, health promotion and public health

2021 ◽  
Vol 9 (01) ◽  
pp. 1-7
Author(s):  
Kitty R. Van Teijlingen ◽  
Bhimsen Devkota ◽  
Flora Douglas ◽  
Padam Simkhada ◽  
Edwin R. Van Teijlingen
Keyword(s):  
Public Health ◽  
Health Promotion ◽  
Health Education ◽  
World Health ◽  
Education And Health ◽  
The World ◽  
The Difference ◽  
Health Organization ◽  
The Individual ◽  
Theoretical Overview

Across the globe, there can be confusion about the difference between the concepts of health education, health promotion and, often also, public health. This confusion does not limit itself to the individual terms but also to how these terms relate to each other. Some use terms such as health education and health promotion interchangeably; others see them clearly as different concepts. In this theoretical overview paper, we have first of all outlined our understanding of these individual terms. We suggest how the five principles of health promotion as outlined by the World Health Organization (WHO, 1984) fit into Tannahill’s (2009) model of three overlapping areas: (a) health education; (b) prevention of ill health; and (c) health protection. Our schematic overview places health education within health promotion and health promotion itself in the center of the overarching disciplines of education and public health. We hope our representation helps reduce confusion among all those interested in our discipline, including students, educators, journalists, practitioners, policymakers, politicians, and researchers.

Simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol in fixed-dose combination antituberculosis pharmaceutical formulations: a review

2018 ◽  
Vol 10 (10) ◽  
pp. 1103-1116 ◽  
Author(s):  
M. A. L. Oliveira ◽  
P. R. Chellini ◽  
T. L. Amorim
Keyword(s):  
Infectious Disease ◽  
Mycobacterium Tuberculosis ◽  
Pharmaceutical Formulations ◽  
World Health ◽  
Fixed Dose ◽  
First Line ◽  
The World ◽  
Dose Combination ◽  
Health Organization

According to the World Health Organization, rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride are the first-line drugs used to treat tuberculosis – an infectious disease caused by Mycobacterium tuberculosis.

scholarly journals d4T: keep it or abandon it?

2010 ◽  
Vol 4 (4) ◽  
pp. 541-546 ◽  
Author(s):  
Andrew Hill
Keyword(s):  
Body Weight ◽  
Adverse Events ◽  
World Health ◽  
Nucleoside Analogues ◽  
Line Treatment ◽  
First Line ◽  
The World ◽  
Dose Ranging ◽  
Health Organization ◽  
First Line Treatment

Abstract Stavudine is a nucleoside analogue used widely for first-line treatment of HIV in developing and middleincome countries. The World Health Organization recommended that all patients should switch to stavudine (30mg BID). However, there is evidence from the dose-ranging trials that patients with body weight below 60kg should use a dose of 20mg BID. For patients who show adverse events on stavudine, a switch to other nucleoside analogues can be considered. This article reviews d4T to study if it should be kept or abandoned.

scholarly journals Perception of the health-disease process: meanings and values of the Haliti-Paresí Indians

2019 ◽  
Vol 41 (1) ◽  
pp. 40262
Author(s):  
Ana Cláudia Pereira Terças ◽  
Bianca Carvalho da Graça ◽  
Josué Souza Gleriano ◽  
Vagner Ferreira do Nascimento ◽  
Thalise Yuri Hattori ◽  
...  
Keyword(s):  
Disease Process ◽  
Well Being ◽  
World Health ◽  
Food Hygiene ◽  
Ethnographic Approach ◽  
Determining Factors ◽  
The World ◽  
Data Separation ◽  
Health Organization ◽  
The Individual

Health is defined by the World Health Organization as a state of complete physical, mental and social well-being, and not merely the absence of disease. The present study aimed to know and reflect on the perception of the indigenous ethnicity Haliti-Paresí on the health-disease process. It is a research with a qualitative and ethnographic approach, in which data were collected in July 2015, through visits in the Wazare village and dialogue with the 34 residents, followed by the constitution of core meanings for data separation, according to their nature. The Paresí define health as the state of vitality in which there is energy to perform the basic activities, with food, hygiene and spirituality as determining factors. Negligence by the individual, climate change and higher forces establish the disease, with hantavirus being the main and most worrying. The health-disease process is based on the culture of this people, in which there is the figure of the shaman, elder or chief to reestablish the vital balance through rituals, offerings, teas and prayers, associated with Western medicine. There should be greater training of indigenous and non-indigenous professionals to provide comprehensive and effective assistance, as well as health education as a tool for disease prevention.

Polycythaemia vera

2020 ◽  
pp. 113-125
Author(s):  
Tiziano Barbui ◽  
Tariq I. Mughal ◽  
Guido Finazzi
Keyword(s):  
World Health ◽  
Polycythaemia Vera ◽  
First Line ◽  
First Line Therapy ◽  
Increased Risk ◽  
The World ◽  
Recent Phase ◽  
Health Organization ◽  
Cell Disorder ◽  
Acute Myeloid

Polycythaemia vera (PV) is a clonal stem cell disorder characterized by erythrocytosis and associated with burdensome symptoms, risk of thrombohaemorrhagic complications, and transformation to myelofibrosis and acute myeloid leukaemia. Diagnostic criteria are very recently revised by the World Health Organization (WHO) based on haemoglobin and haematocrit levels, bone marrow morphology consistent with trilineage proliferation and presence of the JAK2 V617 mutation. Cytoreductive therapy is indicated in patients at increased risk of thrombosis. Hydroxyurea (HU) remains the most commonly used first-line cytoreductive therapy and interferon (IFN) is used either at failure of HU or in selected patients as first-line therapy. A recent phase 3 trial has shown the superiority of the JAK1/2 inhibitor ruxolitinib in comparison to best available treatment in HU-intolerant or resistant patients.

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