Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

2017 ◽  
Vol 77 (11) ◽  
pp. 2976-2989 ◽  
Author(s):  
Mai H. Bui ◽  
Xiaoyu Lin ◽  
Daniel H. Albert ◽  
Leiming Li ◽  
Lloyd T. Lam ◽  
...  
Keyword(s):  
Therapeutic Strategies

scholarly journals Exosomes: A Forthcoming Era of Breast Cancer Therapeutics

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4672
Author(s):  
Banashree Bondhopadhyay ◽  
Sandeep Sisodiya ◽  
Faisal Abdulrahman Alzahrani ◽  
Muhammed A. Bakhrebah ◽  
Atul Chikara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapeutics ◽  
Therapeutic Strategies ◽  
Breast Cancer Patients ◽  
Liquid Biopsies ◽  
Non Invasive ◽  
Tumor Tissues ◽  
Circulating Markers

Despite the recent advancements in therapeutics and personalized medicine, breast cancer remains one of the most lethal cancers among women. The prognostic and diagnostic aids mainly include assessment of tumor tissues with conventional methods towards better therapeutic strategies. However, current era of gene-based research may influence the treatment outcome particularly as an adjunct to diagnostics by exploring the role of non-invasive liquid biopsies or circulating markers. The characterization of tumor milieu for physiological fluids has been central to identifying the role of exosomes or small extracellular vesicles (sEVs). These exosomes provide necessary communication between tumor cells in the tumor microenvironment (TME). The manipulation of exosomes in TME may provide promising diagnostic/therapeutic strategies, particularly in triple-negative breast cancer patients. This review has described and highlighted the role of exosomes in breast carcinogenesis and how they could be used or targeted by recent immunotherapeutics to achieve promising intervention strategies.

Pathogenesis of Non-Hodgkin's Lymphoma

2011 ◽  
Vol 29 (14) ◽  
pp. 1803-1811 ◽  
Author(s):  
Hendrik Nogai ◽  
Bernd Dörken ◽  
Georg Lenz
Keyword(s):  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Therapeutic Strategies ◽  
Molecular Pathogenesis ◽  
Large B Cell Lymphoma ◽  
Oncogenic Pathways ◽  
Hodgkin's Lymphomas ◽  
Identification And Characterization ◽  
Lymphoma Subtype

The understanding of the molecular pathogenesis of non-Hodgkin's lymphomas (NHL) has significantly improved in recent years. Advances in molecular biology and genetics lead to the identification and characterization of several oncogenic pathways involved in lymphomagenesis. This knowledge will ultimately lead to improved diagnostic and therapeutic strategies for patients with NHL. This review summarizes current concepts of the molecular pathogenesis of the most common NHL subtypes, with a special emphasis on diffuse large B-cell lymphoma, the most common lymphoma subtype.

Isolation and characterization of lung cancer sphere-forming cells as platforms for the development of new therapeutic strategies.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e22190-e22190
Author(s):  
Silvia Calabuig-Fariñas ◽  
Alicia Martinez-Romero ◽  
Eloisa Jantus-Lewintre ◽  
Rut Lucas ◽  
Jose Miguel Pardo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Therapeutic Strategies ◽  
Isolation And Characterization

Lysosomes and Brain Health

2018 ◽  
Vol 41 (1) ◽  
pp. 255-276 ◽  
Author(s):  
Jaiprakash Sharma ◽  
Alberto di Ronza ◽  
Parisa Lotfi ◽  
Marco Sardiello
Keyword(s):  
Neuronal Plasticity ◽  
Therapeutic Strategies ◽  
Brain Health ◽  
Developmental Needs ◽  
Fundamental Properties ◽  
System A ◽  
Lysosomal System ◽  
And Function ◽  
The Brain

One of the fundamental properties of the cell is the capability to digest and remodel its own components according to metabolic and developmental needs. This is accomplished via the autophagy-lysosome system, a pathway of critical importance in the brain, where it contributes to neuronal plasticity and must protect nonreplaceable neurons from the potentially harmful accumulation of cellular waste. The study of lysosomal biogenesis and function in the context of common and rare neurodegenerative diseases has revealed that a dysfunctional autophagy-lysosome system is the shared nexus where multiple, interconnected pathogenic events take place. The characterization of pathways and mechanisms regulating the lysosomal system and autophagic clearance offers unprecedented opportunities for the development of polyvalent therapeutic strategies based on the enhancement of the autophagy-lysosome pathway to maintain cellular homeostasis and achieve neuroprotection.

Rationelles Screening bei Nebennierentumoren

2018 ◽  
Vol 143 (17) ◽  
pp. 1227-1234
Author(s):  
Holger Willenberg ◽  
Sophie Kupfer
Keyword(s):  
Medical Imaging ◽  
Therapeutic Strategies ◽  
Endocrine Function ◽  
Adrenal Tumors ◽  
Function Tests ◽  
Diagnostic Power

AbstractThe characterization of adrenal tumors may become difficult for different reasons. Medical imaging is insufficient to establish a diagnosis, clinical symtoms may vary and medication interfers with lab analysis. Furthermore, hormonal measurements gain diagnostic power with endocrine function tests. This article reviews diagnostic and therapeutic strategies in the management of patients with adrenal tumors.

Mechanism and Inhibition of Matrix Metalloproteinases

2019 ◽  
Vol 26 (15) ◽  
pp. 2609-2633 ◽  
Author(s):  
Linda Cerofolini ◽  
Marco Fragai ◽  
Claudio Luchinat
Keyword(s):  
Matrix Metalloproteinases ◽  
Functional Characterization ◽  
Structural Data ◽  
Therapeutic Strategies ◽  
Outer Cell ◽  
Drug Candidates ◽  
The Family ◽  
Outer Cell Membrane ◽  
Membrane Bound

Matrix metalloproteinases hydrolyze proteins and glycoproteins forming the extracellular matrix, cytokines and growth factors released in the extracellular space, and membrane-bound receptors on the outer cell membrane. The pathological relevance of MMPs has prompted the structural and functional characterization of these enzymes and the development of synthetic inhibitors as possible drug candidates. Recent studies have provided a better understanding of the substrate preference of the different members of the family, and structural data on the mechanism by which these enzymes hydrolyze the substrates. Here, we report the recent advancements in the understanding of the mechanism of collagenolysis and elastolysis, and we discuss the perspectives of new therapeutic strategies for targeting MMPs.

scholarly journals Plasma Medicine Technologies

2021 ◽  
Vol 11 (10) ◽  
pp. 4584
Author(s):  
Nagendra Kumar Kaushik ◽  
Sander Bekeschus ◽  
Hiromasa Tanaka ◽  
Abraham Lin ◽  
Eun Ha Choi
Keyword(s):  
Basic Research ◽  
Therapeutic Strategies ◽  
Special Issue ◽  
Biomedical Sciences ◽  
Plasma Medicine ◽  
Interdisciplinary Field ◽  
Current Scenario ◽  
Fundamental Research ◽  
New Treatment

This Special Issue, entitled “Plasma Medicine Technologies”, covers the latest remarkable developments in the field of plasma bioscience and medicine. Plasma medicine is an interdisciplinary field that combines the principles of plasma physics, material science, bioscience, and medicine, towards the development of therapeutic strategies. A study on plasma medicine has yielded the development of new treatment opportunities in medical and dental sciences. An important aspect of this issue is the presentation of research underlying new therapeutic methods that are useful in medicine, dentistry, sterilization, and, in the current scenario, that challenge perspectives in biomedical sciences. This issue is focused on basic research on the characterization of the bioplasma sources applicable to living cells, especially to the human body, and fundamental research on the mutual interactions between bioplasma and organic–inorganic liquids, and bio or nanomaterials.

scholarly journals The trans-omics landscape of COVID-19

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Peng Wu ◽  
Dongsheng Chen ◽  
Wencheng Ding ◽  
Ping Wu ◽  
Hongyan Hou ◽  
...  
Keyword(s):  
Global Health ◽  
Critically Ill ◽  
Therapeutic Strategies ◽  
Omics Data ◽  
Blood Samples ◽  
Cell Dysfunction ◽  
Tryptophan Metabolites ◽  
T Cell Dysfunction ◽  
Critical Patients

AbstractThe outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.

scholarly journals Characterization of METTL7B to Evaluate TME and Predict Prognosis by Integrative Analysis of Multi-Omics Data in Glioma

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaochuan Chen ◽  
Chao Li ◽  
Ying Li ◽  
Shihong Wu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Biomarker ◽  
Therapeutic Strategies ◽  
Functional Enrichment ◽  
Good Prediction ◽  
Prognostic Signature ◽  
Immune Microenvironment ◽  
Prognostic Prediction ◽  
Immunosuppressive Cells

Glioma is the most common and aggressive type of primary brain malignant tumor with limited treatment approaches. Methyltransferase-like 7B (METTL7B) is associated with the pathogenesis of several diseases but is rarely studied in glioma. In this study, 1,493 glioma samples (data from our cohort, TCGA, and CGGA) expressing METTL7B were used to explore its prognostic value and mechanism in the immune microenvironment. Results showed that high expression of METTL7B is associated with poor prognosis and abundant immunosuppressive cells. Further, functional enrichment showed that METTL7B is involved in the negative regulation of immunity and carcinogenic signaling pathways. Moreover, a METTL7B-related prognostic signature constructed based on multi-omics showed a good prediction of the overall survival (OS) time of glioma patients. In conclusion, METTL7B is a potential prognostic biomarker. In addition, the prognostic prediction model constructed in this study can be used in clinical setups for the development of novel effective therapeutic strategies for glioma patients and improving overall survival.

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