Abstract 3147: Comprehensive characterization of the role of T-type calcium channels in glioblastoma

2017 ◽  
Author(s):  
Ying Zhang ◽  
Nichola Cruickshanks ◽  
Fang Yuan ◽  
Baomin Wang ◽  
Mary Pahuski ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Comprehensive Characterization

scholarly journals Conceptualizing consumption in the imagination

2017 ◽  
Vol 18 (3) ◽  
pp. 327-347 ◽  
Author(s):  
Rebecca Jenkins ◽  
Mike Molesworth
Keyword(s):  
Consumer Research ◽  
Macro Level ◽  
Market Structures ◽  
Level Of Abstraction ◽  
Temporal Location ◽  
Individual Consumption ◽  
Presence And Absence ◽  
Comprehensive Characterization

In this article we extend theory relating to the imagination and markets by reviewing explicit and implicit work in marketing, consumer research and sociology, drawing on a broader literature that provides a more comprehensive characterization of imagining. We map consumption in the imagination in order to better define the concept and to differentiate forms of imagining according to a number of characteristics that are identified in the literature. These are as follows: (1) temporal location, (2) range of emotions, (3) degree of elaboration, (4) level of abstraction (5) purpose, and (6) prompts. We also consider the role of consumption in terms of its level of presence and absence in the imagination. We then present a trajectory of consumption in the imagination that seeks to account for the relationships and movements between forms of imagining and the marketplace, noting the importance of the imagination in terms of implications for macro-level market structures and individual consumption practice.

scholarly journals Pro-biomics: Omics Technologies To Unravel the Role of Probiotics in Health and Disease

2021 ◽  
Author(s):  
Despoina Eugenia Kiousi ◽  
Marina Rathosi ◽  
Margaritis Tsifintaris ◽  
Pelagia Chondrou ◽  
Alex Galanis
Keyword(s):  
Probiotic Supplementation ◽  
Future Directions ◽  
Current Trends ◽  
Metabolomic Data ◽  
Analysis Of Results ◽  
Health And Disease ◽  
Multiple Levels ◽  
Comprehensive Characterization

ABSTRACT The comprehensive characterization of probiotic action has flourished during the past few decades, alongside the evolution of high-throughput, multiomics platforms. The integration of these platforms into probiotic animal and human studies has provided valuable insights into the holistic effects of probiotic supplementation on intestinal and extraintestinal diseases. Indeed, these methodologies have informed about global molecular changes induced in the host and residing commensals at multiple levels, providing a bulk of metagenomic, transcriptomic, proteomic, and metabolomic data. The meaningful interpretation of generated data remains a challenge; however, the maturation of the field of systems biology and artificial intelligence has supported analysis of results. In this review article, we present current literature on the use of multiomics approaches in probiotic studies, we discuss current trends in probiotic research, and examine the possibility of tailor-made probiotic supplementation. Lastly, we delve deeper into newer technologies that have been developed in the last few years, such as single-cell multiomics analyses, and provide future directions for the maximization of probiotic efficacy.

scholarly journals Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA

2021 ◽  
Author(s):  
Erik N Bergstrom ◽  
Jens-Christian Luebeck ◽  
Mia Petljak ◽  
Vineet Bafna ◽  
Paul S. Mischel ◽  
...  
Keyword(s):  
Somatic Mutations ◽  
Human Cancer ◽  
Cancer Genes ◽  
Base Substitutions ◽  
Cancer Genomes ◽  
Cancer Types ◽  
Mutational Processes ◽  
Comprehensive Characterization

Clustered somatic mutations are common in cancer genomes with prior analyses revealing several types of clustered single-base substitutions, including doublet- and multi-base substitutions, diffuse hypermutation termed omikli, and longer strand-coordinated events termed kataegis. Here, we provide a comprehensive characterization of clustered substitutions and clustered small insertions and deletions (indels) across 2,583 whole-genome sequenced cancers from 30 cancer types. While only 3.7% of substitutions and 0.9% of indels were found to be clustered, they contributed 8.4% and 6.9% of substitution and indel drivers, respectively. Multiple distinct mutational processes gave rise to clustered indels including signatures enriched in tobacco smokers and homologous-recombination deficient cancers. Doublet-base substitutions were caused by at least 12 mutational processes, while the majority of multi-base substitutions were generated by either tobacco smoking or exposure to ultraviolet light. Omikli events, previously attributed to the activity of APOBEC3 deaminases, accounted for a large proportion of clustered substitutions. However, only 16.2% of omikli matched APOBEC3 patterns with experimental validation confirming additional mutational processes giving rise to omikli. Kataegis was generated by multiple mutational processes with 76.1% of all kataegic events exhibiting AID/APOBEC3-associated mutational patterns. Co-occurrence of APOBEC3 kataegis and extrachromosomal-DNA (ecDNA) was observed in 31% of samples with ecDNA. Multiple distinct APOBEC3 kataegic events were observed on most mutated ecDNA. ecDNA containing known cancer genes exhibited both positive selection and kataegic hypermutation. Our results reveal the diversity of clustered mutational processes in human cancer and the role of APOBEC3 in recurrently mutating and fueling the evolution of ecDNA.

The role of 4-nitrobenzoic acid polymorphs in the crystallization process of organic acid–base multicomponent systems

CrystEngComm ◽  
2019 ◽  
Vol 21 (40) ◽  
pp. 6038-6047 ◽  
Author(s):  
Lilia Croitor ◽  
Mihaela F. Petric ◽  
Elisabeta I. Szerb ◽  
Gabriela Vlase ◽  
Paulina N. Bourosh ◽  
...  
Keyword(s):  
Solid State ◽  
Organic Acid ◽  
Crystallization Process ◽  
Time Dependent ◽  
Multicomponent Systems ◽  
Acid Base ◽  
Nitrobenzoic Acid ◽  
Comprehensive Characterization

An investigation of the role of 4-nitrobenzoic acid polymorphs in the crystallization process of dimethylethanolammonium 4-nitrobenzoate from solution and comprehensive characterization of time-dependent changes associated with solid-state transformations are presented.

scholarly journals A New Challenge for Radiologists: Radiomics in Breast Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Paola Crivelli ◽  
Roberta Eufrasia Ledda ◽  
Nicola Parascandolo ◽  
Alberto Fara ◽  
Daniela Soro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Clinical Trials ◽  
Molecular Subtypes ◽  
Quantitative Information ◽  
Breast Cancer Patients ◽  
Cochrane Database ◽  
Meta Analyses ◽  
Comprehensive Characterization

Introduction. Over the last decade, the field of medical imaging experienced an exponential growth, leading to the development of radiomics, with which innumerable quantitative features are obtained from digital medical images, providing a comprehensive characterization of the tumor. This review aims to assess the role of this emerging diagnostic tool in breast cancer, focusing on the ability of radiomics to predict malignancy, response to neoadjuvant chemotherapy, prognostic factors, molecular subtypes, and risk of recurrence. Evidence Acquisition. A literature search on PubMed and on Cochrane database websites to retrieve English-written systematic reviews, review articles, meta-analyses, and randomized clinical trials published from August 2013 up to July 2018 was carried out. Results. Twenty papers (19 retrospective and 1 prospective studies) conducted with different conventional imaging modalities were included. Discussion. The integration of quantitative information with clinical, histological, and genomic data could enable clinicians to provide personalized treatments for breast cancer patients. Current limitations of a routinely application of radiomics are represented by the limited knowledge of its basics concepts among radiologists and by the lack of efficient and standardized systems of feature extraction and data sharing.

scholarly journals Ukrainisation Tendencies in Luhansk Regional Printed Press of 1920-1930s

2016 ◽  
pp. 61-70
Author(s):  
Kateryna Ulyanova
Keyword(s):  
National Interests ◽  
Semantic Level ◽  
Social Nature ◽  
Scientific Analysis ◽  
The Social ◽  
Primary Focus ◽  
Comprehensive Characterization ◽  
Printed Press

The main objective of the study is to carry out a comprehensive analysis of the functioning of Luhansk regional periodicals in the scope of Ukrainisation (indigenization), which was implemented by the Bolshevists in the 1920-30s, and promoted the formation and understanding of Ukrainian national self-identification. Methods. The synchronous analysis is used to perform a comprehensive characterization of the scientific object at the particular stage of historical development. Since the study is mainly descriptive, core research methods are also descriptive, combined with various methods and procedures of scientific analysis, including comparative historical and retrospective. Results. The Ukrainisation process in media primarily affected the functioning of periodicals that were massively re-orientated to Ukrainian language. The period of 1920-30s was the most productive. Totally, there were about 100 functioning Ukrainian newspapers. However, they were only formally Ukrainian, when the semantic level of these publications absorbed the negative sides of indigenization processes, including primary focus on masses, which practically meant narrowing the role of journalism to be the ideological service of party and state policy. The course to Ukrainisation was actively supported by the national conscious people of Donbas, including clerisy, coordinated around “Zaboy” / “Literary Donbass” magazine, the only one existing at the time. The activity of the magazine in late 20s – early 30s of XX century effected rising of general cultural level of readers, impacting the modernization of national consciousness of Luhansk people. Conclusions. The study of indigenization policy and its consequences for printed press in Luhansk region reveals the social nature of journalism in general, emphasizing its creative aspect in gratification of spiritual and cultural needs of East Ukrainian community, associated with protection of Ukraine national interests.

scholarly journals Profiling of RNA N6-Methyladenosine Methylation Reveals the Critical Role of m6A in Chicken Adipose Deposition

2021 ◽  
Vol 9 ◽  
Author(s):  
Bohan Cheng ◽  
Li Leng ◽  
Ziwei Li ◽  
Weijia Wang ◽  
Yang Jing ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Biosynthesis ◽  
Critical Role ◽  
Methylation Pattern ◽  
Rna Modification ◽  
Mrna Levels ◽  
Coding Regions ◽  
Comprehensive Characterization

One of the main objectives of broiler breeding is to prevent excessive abdominal adipose deposition. The role of RNA modification in adipose deposition is not clear. This study was aimed to map m6A modification landscape in chicken adipose tissue. MeRIP-seq was performed to compare the differences in m6A methylation pattern between fat and lean broilers. We found that start codons, stop codons, coding regions, and 3′-untranslated regions were generally enriched for m6A peaks. The high m6A methylated genes (fat birds vs. lean birds) were primarily associated with fatty acid biosynthesis and fatty acid metabolism, while the low m6A methylated genes were mainly involved in processes associated with development. Furthermore, we found that the mRNA levels of many genes may be regulated by m6A modification. This is the first comprehensive characterization of m6A patterns in the chicken adipose transcriptome, and provides a basis for studying the role of m6A modification in fat deposition.

Digital x-ray mapping of nanometer-size supported bimetallic catalysts

1988 ◽  
Vol 46 ◽  
pp. 530-531
Author(s):  
L. T. Germinario
Keyword(s):  
Background Radiation ◽  
Metal Cluster ◽  
Single Element ◽  
Beam Diameter ◽  
X Rays ◽  
X Ray ◽  
Major Interest ◽  
Induced Changes

Understanding the role of metal cluster composition in determining catalytic selectivity and activity is of major interest in heterogeneous catalysis. The electron microscope is well established as a powerful tool for ultrastructural and compositional characterization of support and catalyst. Because the spatial resolution of x-ray microanalysis is defined by the smallest beam diameter into which the required number of electrons can be focused, the dedicated STEM with FEG is the instrument of choice. The main sources of errors in energy dispersive x-ray analysis (EDS) are: (1) beam-induced changes in specimen composition, (2) specimen drift, (3) instrumental factors which produce background radiation, and (4) basic statistical limitations which result in the detection of a finite number of x-ray photons. Digital beam techniques have been described for supported single-element metal clusters with spatial resolutions of about 10 nm. However, the detection of spurious characteristic x-rays away from catalyst particles produced images requiring several image processing steps.

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