MiR-22 Suppresses BMP7 in the Development of Cirrhosis

Background/Aims: New strategies for the prevention and treatment of cirrhosis are urgently needed for improving therapeutic outcome. A role of microRNAs (miRNAs) in the pathogenesis of cirrhosis has been recently acknowledged, whereas the exact involved miRNAs as well as the associated molecular signaling pathways have not been determined. Specifically, the studies on the relationship between miR-22 and bone morphogenic protein 7 (BMP7) in the development of cirrhosis are lacking. Methods: We examined the correlation of the levels of miR-22 and bone morphogenic protein 7 (BMP7) in the liver biopsies from patients with cirrhosis. We examined overexpression or suppression of miR-22 on BMP7 in hepatocytes. We examined the binding of miR-22 to the 3'-UTR of BMP7 mRNA. Finally, in a carbon tetrachloride (CCl4)-induced cirrhosis model in mice, we gave mice adeno-associated viruses carrying antisense of miR-22, and examined its effects on BMP7 levels and the hallmarks of cirrhosis. Results: The levels of miR-22 and BMP7 in the liver biopsies from patients were strongly and inversely correlated. MiR-22 inhibited BMP7 expression in hepatocytes, through directly binding the 3'-UTR of BMP7 mRNA. Expression of antisense miR-22 significantly attenuated the levels of liver fibrosis, portal hypertension and sodium retention caused by CCl4, possibly through upregulation of BMP7. Conclusions: MiR-22 promotes the development of cirrhosis through BMP7 suppression.

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Insight into the Double-Edged Role of Ferroptosis in Disease

Biomolecules ◽

10.3390/biom11121790 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1790

Author(s):

Lei Zhang ◽

Ruohan Jia ◽

Huizhen Li ◽

Huarun Yu ◽

Keke Ren ◽

...

Keyword(s):

Cell Death ◽

Digestive System ◽

Kidney Injury ◽

Oxygen Species ◽

Disease Treatment ◽

The Relationship ◽

Insight Into ◽

New Strategies ◽

Research Hotspots

Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis.

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The role of positive thinking: a study of telehealth supportive counseling for alcohol abusers

Annales Universitatis Paedagogicae Cracoviensis Studia Psychologica ◽

10.24917/20845596.13.6 ◽

2020 ◽

Vol 13 ◽

pp. 113-122

Author(s):

Hilda Maria Rodrigues Moleda Constant ◽

Helena Maria Tannhauser Barros ◽

Maristela Ferigolo ◽

Carmen Moret-Tatay

Keyword(s):

Health Professionals ◽

Positive Thinking ◽

Alcohol Abusers ◽

Negative Thinking ◽

The World ◽

Human Thinking ◽

The Relationship ◽

New Strategies ◽

Supportive Counseling

Alcohol abuse is one of the main causes of health problems in the world. In response to these alcohol-related health consequences, telehealth supportive counseling has emerged, offering new strategies of dealing with addition problems. Most of telehealth supportive counseling strategies are focused on coping more precisely with positive and negative thinking. The aim of presented study was to examine the relationships between positive thinking, and other coping strategies inherent to human thinking, to refuse alcohol. For this purpose, a total of 232 people participated in the study, all of them were users of a telehealth supportive counseling in Brazil. A batch of questionnaires was employed. This included the sociodemographic information, IDHEA-AD scores and the Coping Behaviours Inventory (CBI-20). After an analysis of mediation, the results indicated that the relationship between negative and positive thinking might be mediated by the assertiveness to refuse. These results suggest that this type of supportive counseling modality might be helpful for users and health professionals. More research is needed to examine the innumerable possibilities of the telehealth tools using as a strategy to deal with the coping variables related to quitting alcohol use.

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Role of Personalized Nutrition in Chronic-Degenerative Diseases

Nutrients ◽

10.3390/nu11081707 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1707 ◽

Cited By ~ 16

Author(s):

Laura Di Renzo ◽

Paola Gualtieri ◽

Lorenzo Romano ◽

Giulia Marrone ◽

Annalisa Noce ◽

...

Keyword(s):

Gene Expression ◽

Eating Habits ◽

Disease Status ◽

Degenerative Diseases ◽

Personalized Nutrition ◽

Therapeutic Tool ◽

Prevention And Treatment ◽

Phenotypic Transition ◽

The Relationship

Human nutrition is a branch of medicine based on foods biochemical interactions with the human body. The phenotypic transition from health to disease status can be attributed to changes in genes and/or protein expression. For this reason, a new discipline has been developed called “-omic science”. In this review, we analyzed the role of “-omics sciences” (nutrigenetics, nutrigenomics, proteomics and metabolomics) in the health status and as possible therapeutic tool in chronic degenerative diseases. In particular, we focused on the role of nutrigenetics and the relationship between eating habits, changes in the DNA sequence and the onset of nutrition-related diseases. Moreover, we examined nutrigenomics and the effect of nutrients on gene expression. We perused the role of proteomics and metabolomics in personalized nutrition. In this scenario, we analyzed also how dysbiosis of gut microbiota can influence the onset and progression of chronic degenerative diseases. Moreover, nutrients influencing and regulating gene activity, both directly and indirectly, paves the way for personalized nutrition that plays a key role in the prevention and treatment of chronic degenerative diseases.

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Facing Disruptive Innovation

Advances in Business Strategy and Competitive Advantage - Handbook of Research on Managerial Thinking in Global Business Economics ◽

10.4018/978-1-5225-7180-3.ch011 ◽

2019 ◽

pp. 196-209

Author(s):

Davide Tammam ◽

Federica Brunetta ◽

Francesca Vicentini ◽

Elvira Anna Graziano

Keyword(s):

Innovation Management ◽

Final Analysis ◽

Disruptive Innovation ◽

Journal Articles ◽

Disruptive Innovations ◽

Innovative Thinking ◽

New Challenges ◽

The Relationship ◽

New Strategies

Technological change is creating strategic and managerial challenges. This holds true in the case of disruptive innovations, which are reshaping industry boundaries, exposing organizations to new competitive logics and threats. Companies face the need of new strategies and innovative thinking capabilities. This chapter provides a systematic literature review on the role of disruptions by identifying the changes they have brought in the markets and the new challenges for managers, especially within the domain of strategic management, since disruptive innovations may modify strategic and innovative thinking. The final analysis has been conducted on 19 journal articles published between 1995 and 2018. The results show the strong interplay existing between strategy and innovation management, but they also highlight the relationship between innovative thinking, learning, human capital, and capabilities' acquisition. Furthermore, they encourage further research in the light of the multiple trajectories offered by innovation and disruptions for diverse companies and industries.

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THE RELATIONSHIP OF PLASMA VOLUME, PORTAL HYPERTENSION, ASCITES, AND RENAL SODIUM RETENTION IN CIRRHOSIS: THE OVERFLOW THEORY OF ASCITES FORMATION

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1970.tb37014.x ◽

1970 ◽

Vol 170 (1 The Hepatic C) ◽

pp. 202-212 ◽

Cited By ~ 165

Author(s):

Fred L. Lieberman ◽

Edward K. Denison ◽

Telfer B. Reynolds

Keyword(s):

Portal Hypertension ◽

Plasma Volume ◽

Sodium Retention ◽

Ascites Formation ◽

Relationship Of ◽

The Relationship

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The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review

BioMed Research International ◽

10.1155/2019/5171602 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Pan Luo ◽

Fuqiang Gao ◽

Dongsheng Niu ◽

Xichun Sun ◽

Qiang Song ◽

...

Keyword(s):

Metabolic Activity ◽

Cell Aging ◽

Research Review ◽

Normal Cartilage ◽

Delay Cell ◽

Prevention And Treatment ◽

New Ideas ◽

Chondrocyte Metabolism ◽

The Relationship

Chondrocytes are the sole cellular constituents of normal cartilage. The degeneration and apoptosis of these cells are considered the main cause of osteoarthritis (OA). Previous studies have suggested that the enhancement of autophagy in chondrocytes can delay the progression of osteoarthritis by affecting intracellular metabolic activity, i.e., by regulating the metabolism of nutrients, which can delay cell aging and death. In this review, we explored the relationship between autophagy and chondrocyte metabolism and provided new ideas for the prevention and treatment of OA.

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The Microbiome and Radiation Induced-Bowel Injury: Evidence for Potential Mechanistic Role in Disease Pathogenesis

Nutrients ◽

10.3390/nu10101405 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1405 ◽

Cited By ~ 22

Author(s):

Tomoko Kumagai ◽

Farooq Rahman ◽

Andrew Smith

Keyword(s):

Gut Microbiome ◽

Treatment Strategies ◽

Bowel Injury ◽

Pelvic Malignancy ◽

Major Drawback ◽

Prevention And Treatment ◽

Radiation Induced ◽

The Relationship ◽

Shed Light

Radiotherapy has played a major role in both the curative and palliative treatment of cancer patients for decades. However, its toxic effect to the surrounding normal healthy tissue remains a major drawback. In cases of intra-abdominal and/or pelvic malignancy, healthy bowel is inevitably included in the radiation field, causing undesirable consequences that subsequently manifest as radiation-induced bowel injury, which is associated with significant morbidity and mortality. The pathophysiology of radiation-induced bowel injury is poorly understood, although we now know that it derives from a complex interplay of epithelial injury and alterations in the enteric immune, nervous, and vascular systems in genetically predisposed individuals. Furthermore, evidence supporting a pivotal role for the gut microbiota in the development of radiation-induced bowel injury has been growing. In this review, we aim to appraise our current understanding of radiation-induced bowel injury and the role of the microbiome in its pathogenesis as well as prevention and treatment. Greater understanding of the relationship between the disease mechanism of radiation-induced bowel injury and gut microbiome might shed light on potential future prevention and treatment strategies through the modification of a patient’s gut microbiome.

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A Hypothesis for the Relationship between Depression and Cancer: Role of Ca2+/cAMP Signalling

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520620666200220113817 ◽

2020 ◽

Vol 20 (7) ◽

pp. 777-782

Author(s):

Leandro B. Bergantin

Keyword(s):

Cancer Incidence ◽

Signalling Pathways ◽

Cellular Mechanisms ◽

Camp Signalling ◽

High Prevalence ◽

Prevention And Treatment ◽

Critical Issues ◽

Risk Of Cancer ◽

The Relationship

Limitations on the pharmacotherapy and a high prevalence worldwide are critical issues related to depression and cancer. It has been discussed that a dysregulation of intracellular Ca2+ homeostasis is involved in the pathogenesis of both these diseases. In addition, depression raises the risk of cancer incidence. Consistent data support the concept that depression is an independent risk issue for cancer. However, the cellular mechanisms involved in this link between depression and cancer remain uncertain. Considering our previous reports about Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling), I herein discussed the putative contribution of Ca2+/cAMP signalling in this link between depression and cancer. Moreover, it is important to take depression into account during the process of prevention and treatment of cancer.

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