scholarly journals Commercial Rodents in America: Standard Animals, Model Animals, and Biological Diversity

2019 ◽  
Vol 93 (2-3) ◽  
pp. 70-81
Author(s):  
Cheryl A. Logan
Keyword(s):  
Large Scale ◽  
Selective Breeding ◽  
Biological Diversity ◽  
Standardized Test ◽  
Big Science ◽  
Wistar Institute ◽  
The Usa ◽  
Post War ◽  
Commercial Distribution ◽  
Evolutionary Perspectives

Rodents as standardized test animals were developed for commercial distribution in the USA between 1910 and the 1930s. The selective breeding of rats (Rattus norvegicus) and pure-bred mice (Mus musculus) at the Wistar Institute and the Jackson Memorial Laboratories eventually led to a decline in the diversity of species used in American medical and life sciences. The early driving figures, science administrator Milton Greenman and the scientists Henry Donaldson and Clarence Little, sought to standardize animals to render science and its application to humanity more precise. But their efforts were exaggerated in the USA through an expanding industrial and engineering ideal, culminating in a preference for Big Science. I explore the nineteenth century origins of this ideal in Emil Du Bois-Reymond’s neurophysiology. This foundation later merged with increasing standardization, American commercialism, and the success of Big Science to transform animal laboratory “standards” into “model animals.” Recent accounts of research with commercially bred mice reveal how findings can be co-constructed using human clinical data, as animal research is applied to humans. The neglect of evolutionary perspectives and the dominance of “models” may even have begun with the government’s post-war emphasis on funding greater species access for large-scale biomedical research.

scholarly journals Database thinking and deep description: designing a digital archive of the National Synchrotron Light Source

2019 ◽  
Vol 34 (Supplement_1) ◽  
pp. i46-i57
Author(s):  
Robert Crease ◽  
Elyse Graham ◽  
Jamie Folsom
Keyword(s):  
Phase Transition ◽  
Large Scale ◽  
Materials Science ◽  
Digital Tools ◽  
Digital Archive ◽  
Big Science ◽  
National Synchrotron Light Source ◽  
The Past ◽  
The Usa ◽  
Synchrotron Light

Abstract Over the past few years, research carried out at large-scale materials science facilities in the USA and elsewhere has undergone a phase transition that affected its character and culture. Research cultures at these facilities now resemble ecosystems, comprising of complex and evolving interactions between individuals, institutions, and the overall research environment. The outcome of this phase transition, which has been gradual and building since the 1980s, is known as the New (or Ecologic) Big Science [Crease, R. and Westfall, C. (2016). The new big science. Physics Today, 69: 30–6]. In this article, we describe this phase transition, review the practical challenges that it poses for historians, review some potential digital tools that might respond to these challenges, and then assess the theoretical implications posed by “database history’.

scholarly journals The right to comfort in the century of the self

2021 ◽  
pp. 4-7
Author(s):  
Zara Ferreira
Keyword(s):  
Social Transformation ◽  
Large Scale ◽  
Western Europe ◽  
Private Companies ◽  
The Usa ◽  
The Government ◽  
Post War ◽  
Definition Of ◽  
The Right ◽  
The City

After the war, the world was divided between two main powers, a Western capitalist bloc led by the USA, and an Eastern communist bloc, driven by the USSR. From Japan to Mexico, the post-war years were ones of prosperous economic growth and profound social transformation. It was the time of re-housing families split apart and of rebuilding destroyed cities, but it was also the time of democratic rebirth, the definition of individual and collective freedoms and rights, and of belief in the open society envisaged by Karl Popper. Simultaneously, it was the time of the biggest migrations from the countryside, revealing a large faith in the city, and of baby booms, revealing a new hope in humanity. (...) Whether through welfare state systems, as mainly evidenced in Western Europe, under the prospects launched by the Plan Marshall (1947), or through the establishment of local housing authorities funded or semi-funded by the government, or through the support of private companies, civil organizations or associations, the time had come for the large-scale application of the principles of modern architecture and engineering developed before the war. From the Spanish polígonos residenciales to the German großsiedlungen, ambitious housing programs were established in order to improve the citizens’ living conditions and health standards, as an answer to the housing shortage, and as a symbol of a new egalitarian society: comfort would no longer only be found in bourgeois houses.

The right to comfort in the century of the self

2021 ◽  
pp. 4-7
Author(s):  
Zara Ferreira
Keyword(s):  
Social Transformation ◽  
Large Scale ◽  
Western Europe ◽  
Private Companies ◽  
The Usa ◽  
The Government ◽  
Post War ◽  
Definition Of ◽  
The Right ◽  
The City

After the war, the world was divided between two main powers, a Western capitalist bloc led by the USA, and an Eastern communist bloc, driven by the USSR. From Japan to Mexico, the post-war years were ones of prosperous economic growth and profound social transformation. It was the time of re-housing families split apart and of rebuilding destroyed cities, but it was also the time of democratic rebirth, the definition of individual and collective freedoms and rights, and of belief in the open society envisaged by Karl Popper. Simultaneously, it was the time of the biggest migrations from the countryside, revealing a large faith in the city, and of baby booms, revealing a new hope in humanity. (...) Whether through welfare state systems, as mainly evidenced in Western Europe, under the prospects launched by the Plan Marshall (1947), or through the establishment of local housing authorities funded or semi-funded by the government, or through the support of private companies, civil organizations or associations, the time had come for the large-scale application of the principles of modern architecture and engineering developed before the war. From the Spanish polígonos residenciales to the German großsiedlungen, ambitious housing programs were established in order to improve the citizens’ living conditions and health standards, as an answer to the housing shortage, and as a symbol of a new egalitarian society: comfort would no longer only be found in bourgeois houses.

Scheming

2018 ◽  
Author(s):  
Seán Damer
Keyword(s):  
Social Class ◽  
Housing Policy ◽  
Large Scale ◽  
Class Structure ◽  
Local Council ◽  
Housing Scheme ◽  
Post War ◽  
First Time ◽  
The Voice ◽  
House Building

This book seeks to explain how the Corporation of Glasgow, in its large-scale council house-building programme in the inter- and post-war years, came to reproduce a hierarchical Victorian class structure. The three tiers of housing scheme which it constructed – Ordinary, Intermediate, and Slum-Clearance – effectively signified First, Second and Third Class. This came about because the Corporation uncritically reproduced the offensive and patriarchal attitudes of the Victorian bourgeoisie towards the working-class. The book shows how this worked out on the ground in Glasgow, and describes the attitudes of both authoritarian housing officials, and council tenants. This is the first time the voice of Glasgow’s council tenants has been heard. The conclusion is that local council housing policy was driven by unapologetic considerations of social class.

scholarly journals Correcting Citizens’ Misperceptions about non-Western Immigrants: Corrective Information, Interpretations, and Policy Opinions

2020 ◽  
pp. 1-10 ◽  
Author(s):  
Frederik Juhl Jørgensen ◽  
Mathias Osmundsen
Keyword(s):  
Immigration Policy ◽  
Large Scale ◽  
Total Population ◽  
Survey Experiment ◽  
Correct Information ◽  
The Usa ◽  
Large Scale Survey ◽  
Nationally Representative ◽  
Information Change ◽  
Corrective Information

Abstract Can corrective information change citizens’ misperceptions about immigrants and subsequently lead to favorable immigration opinions? While prior studies from the USA document how corrections about the size of minority populations fail to change citizens’ immigration-related opinions, they do not examine how other facts that speak to immigrants’ cultural or economic dependency rates can influence immigration policy opinions. To extend earlier work, we conducted a large-scale survey experiment fielded to a nationally representative sample of Danes. We randomly expose participants to information about non-Western immigrants’ (1) welfare dependency rate, (2) crime rate, and (3) proportion of the total population. We find that participants update their factual beliefs in light of correct information, but reinterpret the information in a highly selective fashion, ultimately failing to change their policy preferences.

scholarly journals The utility of self-rated health in population surveys: the role of bodyweight

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Robert Bozick
Keyword(s):  
Treatment Group ◽  
Large Scale ◽  
Well Being ◽  
Control Group ◽  
Self Rated Health ◽  
Risk Of Mortality ◽  
Highly Sensitive ◽  
The Usa ◽  
Group Members ◽  
Nationally Representative

Abstract Background Self-rated health (SRH) is one of the most commonly used summary measures of overall health and well-being available to population scientists due to its ease of administration in large-scale surveys and to its efficacy in predicting mortality. This paper assesses the extent to which SRH is affected by its placement before or after questions about bodyweight on a survey, and whether differences in placement on the questionnaire affects SRH’s predictive validity. Methods I assessed the validity of SRH in predicting the risk of mortality by comparing outcomes of sample members who were asked to rate their health before reporting on their bodyweight (the control group) and sample members who were asked to rate their health after reporting on their bodyweight (the treatment group). Both the control and treatment group were randomly assigned via an experiment administered as a module in a nationally representative sample of adults in the USA in 2019 (N = 2523). Results The odds of reporting a more favorable appraisal of health are 30% lower for sample members who were in the treatment group when compared with the control group. Additionally, the SRH of treatment group members is significantly associated with their risk of mortality, while the SRH of control group members is not. Conclusion The findings from this study suggest that for researchers to maximize the utility of SRH, closer attention needs to be paid to the context of the survey within which it asked. SRH is highly sensitive to the questions that precede it, and this sensitivity may in turn mischaracterize the true health of the population that the survey is intending to measure.

scholarly journals Untapped research opportunities in China: promising future avenues and potential concerns for aging companion animals

GeroScience ◽  
2021 ◽  
Author(s):  
Jessica M. Hoffman ◽  
Shanshan Song ◽  
Katharina Brugger ◽  
Teresa G. Valencak
Keyword(s):  
Large Scale ◽  
Companion Animals ◽  
Companion Animal ◽  
The European Union ◽  
Pet Ownership ◽  
Ethical Considerations ◽  
Aging Research ◽  
Agricultural Animal ◽  
The Usa ◽  
Laboratory Models

AbstractCompanion animals have recently been proposed as ideal translational models of human aging due to their shared susceptibility for certain diseases, similar environments, and sophisticated veterinary medicine diagnostics, all of which are not possible in rodent laboratory models. Here, we introduce and propose the study of companion animals in China as a largely untapped resource in academic and veterinary aging research. Pet ownership rates along with economic gains in the pet industry have skyrocketed over the last decade in China. Yet, the majority of research institutions still focus on agricultural animal research, not companion animals. In this perspective, we compare available pet ownership rates between the USA, the European Union, and China before focusing on the potential of companion animal aging research in China. In addition, we highlight some ethical considerations that must be addressed before large-scale companion animal aging research can be completed.

scholarly journals Botulinum Toxin in WW2 German and Allied Armies: Failures and Myths of Weaponization

2021 ◽  
pp. 1-8
Author(s):  
Laurent Tatu ◽  
Jean-Paul Feugeas
Keyword(s):  
Botulinum Toxin ◽  
Biological Weapon ◽  
Military Research ◽  
Intelligence Services ◽  
National Archives ◽  
The Usa ◽  
Post War ◽  
The 19Th Century ◽  
The Military ◽  
Second World

Botulinum toxin is nowadays approved as an effective medication for various neurological disorders. The extreme toxicity of this toxin-inducing botulism, a severe lethal muscle-paralyzing illness, has been well known since the seminal works of the end of the 19th century. Because of this toxicity, botulinum toxin was one of the first agents to be considered for use as a biological weapon. The Second World War was a crucial period for the first attempts to weaponize this toxin even if many unknown factors about botulinum toxin still existed at the outbreak of the war. Using documents from the British National Archives and other published sources, we discuss the main points of the attempts to weaponize this toxin in German and Allied armies. During WW2, Allied intelligence services regularly reported a major German threat related to the potential use of botulinum toxin as a biological weapon, especially during the preparation of <i>Operation Overlord</i>, the Allied invasion to liberate Europe. All these reports would ultimately prove to be inaccurate: botulinum toxin was not part of the German military arsenal even if some German scientists tried to use the results of the French pre-war military research. Misinformation spread by intelligence services stimulated military research at Porton Down facilities in England and at Camp Detrick in the USA. These studies led to a succession of failures and myths about the weaponization of botulinum toxin. Nevertheless, major progress (purification, toxoid) arose from the military research, providing useful data for the first steps of the therapeutic use of botulinum toxin in the post-war years.

scholarly journals Solar Thermochemical Hydrogen Production in the USA

2021 ◽  
Vol 13 (14) ◽  
pp. 7804
Author(s):  
Christoph Falter ◽  
Andreas Sizmann
Keyword(s):  
Hydrogen Production ◽  
Large Scale ◽  
Low Cost ◽  
The United States ◽  
Solar Irradiation ◽  
Transport Sector ◽  
Fossil Energy ◽  
The Us ◽  
The Usa ◽  
Solar Thermochemical

Hydrogen produced from renewable energy has the potential to decarbonize parts of the transport sector and many other industries. For a sustainable replacement of fossil energy carriers, both the environmental and economic performance of its production are important. Here, the solar thermochemical hydrogen pathway is characterized with a techno-economic and life-cycle analysis. Assuming a further increase of conversion efficiency and a reduction of investment costs, it is found that hydrogen can be produced in the United States of America at costs of 2.1–3.2 EUR/kg (2.4–3.6 USD/kg) at specific greenhouse gas emissions of 1.4 kg CO2-eq/kg. A geographical potential analysis shows that a maximum of 8.4 × 1011 kg per year can be produced, which corresponds to about twelve times the current global and about 80 times the current US hydrogen production. The best locations are found in the Southwest of the US, which have a high solar irradiation and short distances to the sea, which is beneficial for access to desalinated water. Unlike for petrochemical products, the transport of hydrogen could potentially present an obstacle in terms of cost and emissions under unfavorable circumstances. Given a large-scale deployment, low-cost transport seems, however, feasible.

scholarly journals Resource allocation in the Covid-19 health crisis: are Covid-19 preventive measures consistent with the Rule of Rescue?

2021 ◽  
Author(s):  
Julian W. März ◽  
Søren Holm ◽  
Michael Schlander
Keyword(s):  
Resource Allocation ◽  
Large Scale ◽  
Preventive Measures ◽  
Risk Groups ◽  
Healthcare Resources ◽  
Health Crisis ◽  
Rule Of Rescue ◽  
Post War ◽  
Vaccination Campaigns ◽  
N95 Respirators

AbstractThe Covid-19 pandemic has led to a health crisis of a scale unprecedented in post-war Europe. In response, a large amount of healthcare resources have been redirected to Covid-19 preventive measures, for instance population-wide vaccination campaigns, large-scale SARS-CoV-2 testing, and the large-scale distribution of protective equipment (e.g., N95 respirators) to high-risk groups and hospitals and nursing homes. Despite the importance of these measures in epidemiological and economic terms, health economists and medical ethicists have been relatively silent about the ethical rationales underlying the large-scale allocation of healthcare resources to these measures. The present paper seeks to encourage this debate by demonstrating how the resource allocation to Covid-19 preventive measures can be understood through the paradigm of the Rule of Rescue, without claiming that the Rule of Rescue is the sole rationale of resource allocation in the Covid-19 pandemic.

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