Zentrale Schlafapnoe bei Patienten mit Herzinsuffizienz: Physiologische Auswirkungen der periodischen Beatmung

2020 ◽  
Vol 8 (1) ◽  
pp. 30-32
Author(s):  
Simon Dominik Herkenrath
Keyword(s):  
Healthy Volunteers ◽  
Healthy Subjects ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Periodic Breathing ◽  
Frequency Component ◽  
High Frequency Component ◽  
Zentrale Schlafapnoe ◽  
Voluntary Hyperventilation ◽  
Positive Effects

Background: The effects of hyperventilation and hyperventilation in the context of periodic breathing (PB) on sympatho-vagal balance (SVB) and hemodynamics in conditions of decreased cardiac output and feedback resetting, such as heart failure (HF) or pulmonary arterial hypertension (PAH), are not completely understood. Objectives: To investigate the effects of voluntary hyperventilation and simulated PB on hemodynamics and SVB in healthy subjects, in patients with systolic HF and reduced or mid-range ejection fraction (HFrEF and HFmrEF) and in patients with PAH. Methods: Study participants (n = 20 per group) underwent non-invasive recording of diastolic blood pressure, heart rate variability (HRV), baroreceptor-reflex sensitivity (BRS), total peripheral resistance index (TPRI) and cardiac index (CI). All measurements were performed at baseline, during voluntary hyperventilation and during simulated PB with different length of the hyperventilation phase. Results: In healthy subjects, voluntary hyperventilation led to a 50% decrease in the mean BRS slope and a 29% increase in CI compared to baseline values (p < 0.01 and p < 0.05). Simulated PB did not alter TPRI or CI and showed heterogeneous effects on BRS, but analysis of dPBV revealed decreased sympathetic drive in healthy volunteers depending on PB cycle length (p < 0.05). In HF patients, hyperventilation did not affect BRS and TPRI but increased the CI by 10% (p < 0.05). In HF patients, simulated PB left all of these parameters unaffected. In PAH patients, voluntary hyperventilation led to a 15% decrease in the high-frequency component of HRV (p < 0.05) and a 5% increase in CI (p < 0.05). Simulated PB exerted neutral effects on both SVB and hemodynamic parameters. Conclusions: Voluntary hyperventilation was associated with sympathetic predominance and CI increase in healthy volunteers, but only with minor hemodynamic and SVB effects in patients with HF and PAH. Simulated PB had positive effects on SVB in healthy volunteers but neutral effects on SVB and hemodynamics in patients with HF or PAH.

Apnea central del sueño en pacientes con insuficiencia cardiaca: Efectos fisiológicos de la ventilación periódica

2021 ◽  
Vol 3 (1) ◽  
pp. 23-25
Author(s):  
Simon-Dominik Herkenrath
Keyword(s):  
Healthy Volunteers ◽  
Healthy Subjects ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Periodic Breathing ◽  
Frequency Component ◽  
High Frequency Component ◽  
Voluntary Hyperventilation ◽  
Positive Effects ◽  
Heterogeneous Effects

<b>Background:</b> The effects of hyperventilation and hyperventilation in the context of periodic breathing (PB) on sympatho-vagal balance (SVB) and hemodynamics in conditions of decreased cardiac output and feedback resetting, such as heart failure (HF) or pulmonary arterial hypertension (PAH), are not completely understood. Objectives: To investigate the effects of voluntary hyperventilation and simulated PB on hemodynamics and SVB in healthy subjects, in patients with systolic HF and reduced or mid-range ejection fraction (HFrEF and HFmrEF) and in patients with PAH. <b>Methods:</b> Study participants (n = 20 per group) underwent non-invasive recording of diastolic blood pressure, heart rate variability (HRV), baroreceptor-reflex sensitivity (BRS), total peripheral resistance index (TPRI) and cardiac index (CI). All measurements were performed at baseline, during voluntary hyperventilation and during simulated PB with different length of the hyperventilation phase. <b>Results:</b> In healthy subjects, voluntary hyperventilation led to a 50% decrease in the mean BRS slope and a 29% increase in CI compared to baseline values (<i>p</i> &#x3c; 0.01 and <i>p</i> &#x3c; 0.05). Simulated PB did not alter TPRI or CI and showed heterogeneous effects on BRS, but analysis of dPBV revealed decreased sympathetic drive in healthy volunteers depending on PB cycle length (<i>p</i> &#x3c; 0.05). In HF patients, hyperventilation did not affect BRS and TPRI but increased the CI by 10% (<i>p</i> &#x3c; 0.05). In HF patients, simulated PB left all of these parameters unaffected. In PAH patients, voluntary hyperventilation led to a 15% decrease in the high-frequency component of HRV (<i>p</i> &#x3c; 0.05) and a 5% increase in CI (<i>p</i> &#x3c; 0.05). Simulated PB exerted neutral effects on both SVB and hemodynamic parameters. <b>Conclusions:</b> Voluntary hyperventilation was associated with sympathetic predominance and CI increase in healthy volunteers, but only with minor hemodynamic and SVB effects in patients with HF and PAH. Simulated PB had positive effects on SVB in healthy volunteers but neutral effects on SVB and hemodynamics in patients with HF or PAH.

Age and gender dependency of baroreflex sensitivity in healthy subjects

1998 ◽  
Vol 84 (2) ◽  
pp. 576-583 ◽  
Author(s):  
Tomi Laitinen ◽  
Juha Hartikainen ◽  
Esko Vanninen ◽  
Leo Niskanen ◽  
Ghislaine Geelen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Healthy Subjects ◽  
Baroreflex Sensitivity ◽  
Plasma Renin ◽  
Frequency Component ◽  
High Frequency Component ◽  
Plasma Norepinephrine ◽  
Age And Gender ◽  
And Gender

Laitinen, Tomi, Juha Hartikainen, Esko Vanninen, Leo Niskanen, Ghislaine Geelen, and Esko Länsimies. Age and gender dependency of baroreflex sensitivity in healthy subjects. J. Appl. Physiol. 84(2): 576–583, 1998.—We evaluated the correlates of baroreflex sensitivity (BRS) in healthy subjects. The study consisted of 117 healthy, normal-weight, nonsmoking male and female subjects aged 23–77 yr. Baroreflex control of heart rate was measured by using the phenylephrine bolus-injection technique. Frequency- and time-domain analysis of heart rate variability and an exercise test were performed. Plasma norepinephrine, epinephrine, insulin, and arginine vasopressin concentrations and plasma renin activity were measured. In the univariate analysis, BRS correlated with age ( r = −0.65, P < 0.001), diastolic blood pressure ( r = −0.47, P < 0.001), exercise capacity ( r = 0.60, P < 0.001), and the high-frequency component of heart rate variability ( r= 0.64, P < 0.001). There was also a significant correlation between BRS and plasma norepinephrine concentration ( r = −0.22, P < 0.05) and plasma renin activity ( r = 0.32, P < 0.001). According to the multivariate analysis, age and gender were the most important physiological correlates of BRS. They accounted for 52% of interindividual BRS variation. In addition, diastolic blood pressure and high-frequency component of heart rate variability were significant independent correlates of BRS. BRS was significantly higher in men than in women (15.0 ± 1.2 vs. 10.2 ± 1.1 ms/mmHg, respectively; P < 0.01). Twenty-four percent of women >40 yr old and 18% of men >60 yr old had markedly depressed BRS (<3 ms/mmHg). We conclude that physiological factors, particularly age and gender, have significant impact on BRS in healthy subjects. In addition, we demonstrate that BRS values that have been proposed to be useful in identifying postinfarction patients at high risk of sudden death are frequently found in healthy subjects.

scholarly journals A single dose of dark chocolate increases parasympathetic modulation and heart rate variability in healthy subjects

2016 ◽  
Vol 29 (6) ◽  
pp. 765-773 ◽  
Author(s):  
Ana Amélia Machado DUARTE ◽  
Cristiano MOSTARDA ◽  
Maria Claudia IRIGOYEN ◽  
Katya RIGATTO
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Single Dose ◽  
Standard Deviation ◽  
Healthy Subjects ◽  
Frequency Component ◽  
Dark Chocolate ◽  
High Frequency Component ◽  
Rr Intervals

ABSTRACT Objective: The aim of this study was to investigate the acute effect of a single dose of dark chocolate (70% cocoa) on blood pressure and heart rate variability. Methods: Thirty-one healthy subjects (aged 18-25 years; both sexes) were divided into two groups: 10 subjects in the white chocolate (7.4 g) group and 21 in the dark chocolate (10 g) group; measurements were performed at the university's physiology lab. An electrocardiogram measured the sympathovagal balance by spectral and symbolic analysis. Results: A single dose of dark chocolate significantly reduced systolic blood pressure and heart rate. After consuming 10 g of dark chocolate, significant increases were observed for heart rate variability, standard deviation of RR intervals standard deviation of all NN intervals, square root of the mean squared differences between adjacent normal RR intervals root mean square of successive differences, and an increase in the high frequency component in absolute values, representing the parasympathetic modulation. Conclusion: In conclusion the importance of our results lies in the magnitude of the response provoked by a single dose of cocoa. Just 10 g of cocoa triggered a significant increase in parasympathetic modulation and heart rate variability. These combined effects can potentially increase life expectancy because a reduction in heart rate variability is associated with several cardiovascular diseases and higher mortality.

Ultrasound features of peripheral angiodistonic syndrome of the upper extremities in vibration disease

2020 ◽  
Vol 60 (11) ◽  
pp. 815-817
Author(s):  
Nadezhda I. Kuprina ◽  
Ekaterina V. Ulanovskaya ◽  
Olga A. Kochetova
Keyword(s):  
Blood Flow ◽  
Heart Defects ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Ulnar Artery ◽  
Upper Extremities ◽  
Disease Stage ◽  
Peripheral Blood Flow ◽  
Pronounced Increase ◽  
Vibration Disease

Introduction. Vibration disease (VD) is an example of the most common pathology due to the systematic exposure of the worker to intense vibration with sufficient work experience, the main manifestation of which is peripheral angiodystonic syndrome. The aim of study was to learn the features of peripheral blood flow in the arteries of the forearm in vibration disease using the ultrasound method. Materials and methods. The radial and ulnar arteries in patients with vibration disease were examined by ultrasound in B- and PW-mode. These materials present the results of an ultrasound assessment of the speed indicators of the main arteries of the forearm in vibration disease stages 1 and 2. The selection criteria for patients in the study ware the presence of pronounced clinical manifestations of angiodystonic syndrome in vibration disease, confirmed by instrumental research methods and data on the sanitary and hygienic characteristics of working conditions, the absence of cardiovascular chronic diseases (ischemic heart disease, heart defects, rhythm and conduction disturbances), rheumatic, oncological, infectious diseases, osteo-traumatic changes in the upper extremities. Results. The groups of patients with the established diagnosis of vibration disease of 1 and 2 degrees were studied. With vibration disease stage 1 a decrease in the pulse velocity of blood flow was observed in isolation on the ulnar artery and an increase in peripheral resistance (pulsation index and resistance index) in the radial and ulnar arteries symmetrically on both upper extremities. The second stage of vibration disease differed from the first by a more significant decrease in speed indicators both on the ulnar and radial arteries on both sides, symmetrically in combination with a more pronounced increase in peripheral resistance indicators on both main arteries of the forearm (pulsation index and resistance index). The revealed changes were determined with the same frequency in men and women. Conclusions. A significant decrease in speed indicators on the ulnar artery and an increase in peripheral resistance indicators are detected already at the initial stages of vibration disease. Thus, the method of ultrasound examination of the main arteries of the middle caliber of the upper extremities is currently the only available and objective method for examining the vascular system in vibration disease.

RATIONALIZATION FOR THE DIFFERENTIAL DIAGNOSIS OF OVARIAN CANCER AND CHRONIC SALPINGOOPHORITIS IN THE PARAMETERS OF DISINTEGRATION AND NETWORK MODELING CHANGES OF BLOOD FLOW IN UTERINE AND OVARIAN ARTERIES AND VEINS

2017 ◽  
Vol 63 (5) ◽  
pp. 766-769
Author(s):  
Nikolay Agarkov ◽  
Pavel Tkachenko ◽  
Dmitriy Kicha ◽  
Vitaliy Aksenov ◽  
Aleksandr Ivanov ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Blood Flow ◽  
Diagnostic Criteria ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Diagnostic Process ◽  
Venous Outflow ◽  
Flow Changes ◽  
Arteries And Veins ◽  
Selection Of

Analysis of ultrasonic blood flow changes in uterine and ovarian arteries and veins in 92 patients with ovarian cancer and 87 patients with chronic salpingoophoritis has allowed to identify the leading differential diagnostic criteria, which include minimum diastolic blood flow velocity, resistance index, while fast hyperemia, the index of venous outflow diastolic index and index of peripheral resistance. Based on a selection of leading differential diagnostic criteria for ovarian cancer and chronic salpingoophoritis developed a network model of differentiation of these groups of patients, streamlining the differential diagnostic process

scholarly journals Effects of nasal high flow on nocturnal hypercapnia, sleep, and sympathovagal balance in patients with neuromuscular disorders

2020 ◽  
Author(s):  
Anna Christina Meyer ◽  
Jens Spiesshoefer ◽  
Nina Christina Siebers ◽  
Anna Heidbreder ◽  
Christian Thiedemann ◽  
...  
Keyword(s):  
Neuromuscular Disorders ◽  
Ventilatory Support ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
High Flow ◽  
Apnea Hypopnea Index ◽  
Sympathovagal Balance ◽  
Peripheral Oxygen Saturation ◽  
Depth Analysis ◽  
Nasal High Flow Therapy

Abstract Purpose In neuromuscular disorders (NMD), inspiratory muscle weakness may cause sleep-related hypoventilation requiring non-invasive ventilation (NIV). Alternatively, nasal high flow therapy (NHF) may ameliorate mild nocturnal hypercapnia (NH) through washout of anatomical dead space and generation of positive airway pressure. Ventilatory support by NIV or NHF might have favourable short-term effects on sympathovagal balance (SVB). This study comparatively investigated the effects of NHF and NIV on sleep-related breathing and SVB in NMD patients with evolving NH. Methods Transcutaneous CO2 (ptcCO2), peripheral oxygen saturation (SpO2), sleep outcomes and SVB (spectral analysis of heart rate, diastolic blood pressure variability) along with haemodynamic measures (cardiac index, total peripheral resistance index) were evaluated overnight in 17 patients. Polysomnographies (PSG) were randomly split into equal parts with no treatment, NIV and NHF at different flow rates (20 l/min vs. 50 l/min). In-depth analysis of SVB and haemodynamics was performed on 10-min segments of stable N2 sleep taken from each intervention. Results Compared with no treatment, NHF20 and NHF50 did not significantly change ptcCO2, SpO2 or the apnea hypopnea index (AHI). NHF50 was poorly tolerated. In contrast, NIV significantly improved both gas exchange and AHI without adversely affecting sleep. During daytime, NHF20 and NHF50 had neutral effects on ventilation and oxygenation whereas NIV improved ptcCO2 and SpO2. Effects of NIV and NHF on SVB and haemodynamics were neutral during both night and daytime. Conclusions NHF does not correct sleep-disordered breathing in NMD patients with NH. Both NHF and NIV exert no immediate effects on SVB.

scholarly journals Mask-Type Sensor for Pulse Wave and Respiration Measurements and Eye Blink Detection

Sensors ◽  
2021 ◽  
Vol 21 (14) ◽  
pp. 4895
Author(s):  
Thanh-Vinh Nguyen ◽  
Masaaki Ichiki
Keyword(s):  
Pulse Wave ◽  
Pressure Change ◽  
Frequency Component ◽  
High Frequency Component ◽  
Sensing Element ◽  
Eye Blink ◽  
Mask Type ◽  
Blink Detection ◽  
The Subject ◽  
Air Bag

This paper reports on a mask-type sensor for simultaneous pulse wave and respiration measurements and eye blink detection that uses only one sensing element. In the proposed sensor, a flexible air bag-shaped chamber whose inner pressure change can be measured by a microelectromechanical system-based piezoresistive cantilever was used as the sensing element. The air bag-shaped chamber is fabricated by wrapping a sponge pad with plastic film and polyimide tape. The polyimide tape has a hole to which the substrate with the piezoresistive cantilever adheres. By attaching the sensor device to a mask where it contacts the nose of the subject, the sensor can detect the pulses and eye blinks of the subject by detecting the vibration and displacement of the nose skin caused by these physiological parameters. Moreover, the respiration of the subject causes pressure changes in the space between the mask and the face of the subject as well as slight vibrations of the mask. Therefore, information about the respiration of the subject can be extracted from the sensor signal using either the low-frequency component (<1 Hz) or the high-frequency component (>100 Hz). This paper describes the sensor fabrication and provides demonstrations of the pulse wave and respiration measurements as well as eye blink detection using the fabricated sensor.

scholarly journals Combined Effect of Arginine, Valine, and Serine on Exercise-Induced Fatigue in Healthy Volunteers: A Randomized, Double-Blinded, Placebo-Controlled Crossover Study

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 862 ◽  
Author(s):  
Yuichi Tsuda ◽  
Makoto Yamaguchi ◽  
Teruyuki Noma ◽  
Eiji Okaya ◽  
Hiroyuki Itoh
Keyword(s):  
Amino Acids ◽  
Healthy Volunteers ◽  
Perceived Exertion ◽  
Ketone Bodies ◽  
Blood Analysis ◽  
Rating Of Perceived Exertion ◽  
Physical Parameters ◽  
Positive Effects ◽  
Exercise Induced ◽  
Double Blinded

Although several kinds of amino acids (AAs) are known to affect physiological actions during exercise, little is known about the combined effects of a mixture of several AAs on fatigue during exercise. The aim of the present study was to investigate the effect of an AA mixture supplement containing arginine, valine, and serine on exercise-induced fatigue in healthy volunteers. These AAs were selected because they were expected to reduce fatigue during exercise by acting the positive effects synergistically. A randomized, double-blinded, placebo-controlled crossover trial was conducted. Thirty-nine males ingested an AA mixture containing 3600 mg of arginine, 2200 mg of valine, and 200 mg of serine or a placebo each day for 14 days. On the 14th day, the participants completed an exercise trial on a cycle ergometer at 50% of VO2max for 120 min. After the two-week washout period, the participants repeated the same trial with the other test sample. The participant’s feeling of fatigue based on a visual analog scale (VAS) and a rating of perceived exertion (RPE), as well as blood and physical parameters were evaluated. The feeling of fatigue based on VAS and RPE were significantly improved in AA compared to those in placebo. In the blood analysis, the increase in serum total ketone bodies during exercise and plasma tryptophan/branched-chain amino acids were significantly lower in AA than those in placebo. The present study demonstrated that supplementation with an AA mixture containing arginine, valine, and serine reduced the feeling of fatigue during exercise. The AA mixture also changed several blood parameters, which may contribute to the anti-fatigue effect.

Laser-Generated Ultrasonic Technique for Inspecting Delamination in CFRP

2006 ◽  
Vol 321-323 ◽  
pp. 968-971
Author(s):  
Won Su Park ◽  
Sang Woo Choi ◽  
Joon Hyun Lee ◽  
Kyeong Cheol Seo ◽  
Joon Hyung Byun
Keyword(s):  
High Frequency ◽  
Ultrasonic Method ◽  
Piezoelectric Sensor ◽  
Frequency Component ◽  
Guided Wave ◽  
Center Frequency ◽  
High Frequency Component ◽  
Ultrasonic Technique ◽  
Non Destructive Evaluation ◽  
Non Destructive

For improving quality of a carbon fiber reinforced composite material (CFRP) by preventing defects such as delamination and void, it should be inspected in fabrication process. Novel non-contacting evaluation technique is required because the transducer should be contacted on the CFRP in conventional ultrasonic technique during the non-destructive evaluation and these conventional contact techniques can not be applied in a novel fiber placement system. For the non-destructive evaluation of delamination in CFRP, various methods for the generation and reception of laser-generated ultrasound are applied using piezoelectric transducer, air-coupled transducer, wavelet transform technique etc. The high frequency component of laser-generated guided wave received with piezoelectric sensor disappeared after propagating through delamination region. Air-coupled transducer was tried to be adopted in reception of laser-generated guided wave generated by using linear slit array in order to generate high frequency guided wave with a frequency of 1.1 MHz. Nevertheless, it was failed to receive high frequency guided wave in using air-coupled transducer and linear slit array. Transmitted laser-generated ultrasonic wave was received on back-wall and its frequency was analyzed to establish inspecting technique to detect delamination by non-contact ultrasonic method. In a frequency spectrum analysis, intensity ratio of low frequency and center frequency was approvable parameter to detect delamination.

Hierarchal Predefined Codebook for High-Frequency Component Augmentation Image Enlargement

2010 ◽  
Author(s):  
Hakaru Tamukoh ◽  
Hideaki Kawano ◽  
Noriaki Suetake ◽  
Masatoshi Sekine ◽  
Byungki Cha ◽  
...  
Keyword(s):  
High Frequency ◽  
Frequency Component ◽  
High Frequency Component ◽  
Image Enlargement
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