Circulating irisin levels in preadolescents and adolescents born preterm

2021 ◽  
Author(s):  
Arsinoi Koutroumpa ◽  
Christina Kanaka Gantenbein ◽  
Aimilia Mantzou ◽  
Artemis Doulgeraki ◽  
Flora Bacopoulou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Density Lipoprotein ◽  
Full Term ◽  
Central Adiposity ◽  
Arterial Blood ◽  
Skin Fold ◽  
Triceps Skin Fold ◽  
And Gender ◽  
Preterm Born ◽  
Circulating Levels

Introduction. Prematurity is associated with increased cardiometabolic risk later in life. The adipomyokine irisin has been acknowledged as a modulator of energy metabolism and insulin sensitivity. The aim of this study was to investigate circulating levels of irisin and their relation to anthropometric measurements and cardiometabolic phenotype in a population of preterm-born children vs. full-term-born peers. Methods. A total of 160 children (87 born preterm aged 8.1-14.8 years and 73 born full-term of similar age and gender distribution) were studied. Arterial blood pressure, anthropometry, body composition assessments with dual energy X-ray absorptiometry (DXA) and skin fold measurements were performed. Blood biochemistry and circulating levels of irisin, insulin, cortisol, leptin, and adiponectin were also determined. Results. The preterm group had higher diastolic blood pressure, triceps skin fold, subscapular skin fold (SSF) and abdominal skin fold measurements and more central adiposity than the full-term group. Irisin was significantly lower (p=0.002), whereas leptin was higher (p=0.03), in the preterm than the full-term group. Irisin correlated positively with gestational age (r=0.19, p=0.01), birthweight (r=0.23, p=0.003) and high-density lipoprotein cholesterol (r=0.20, p=0.01), and negatively with SSSF (r=-0.25 p=0.003) and chronological age (r=-0.21, p=0.008). Conclusion. Lower levels of irisin and a slightly unhealthy adiposity and cardiometabolic pattern were detected in preterm-born children in comparison to their full-term-born peers. Whether low irisin levels in preadolescents and adolescents born prematurely could be of prognostic value for the development of cardiometabolic sequelae later in life remains to be further studied.

scholarly journals To Determine the Correlation between Anthropometric Variables of Obesity and Hypertension at NGMC: A Tertiary Care Hospital

2018 ◽  
Vol 14 (2) ◽  
pp. 70-74
Author(s):  
Bhawana Neupane Pant ◽  
Manoj Pant ◽  
Rajesh Kumar Goit ◽  
Ashish Neupane ◽  
Ganesh Prasad Neupane ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Tertiary Care ◽  
Morbidity And Mortality ◽  
Care Hospital ◽  
Hip Circumference ◽  
Specific Population ◽  
Anthropometric Indices ◽  
Arterial Blood ◽  
Skin Fold ◽  
Scientific Validation

Aim: Obesity is associated with the metabolic risk factors such as high blood pressure, body fat abnormality, and glucose intolerance which may influence the morbidity and mortality due to cardiovascular diseases. The present study is to determine the correlation of common anthropometric indices of obesity with blood pressure among population in mid-western region of Nepal. The result will provide us insight on relevant anthropometric indices for predicting hypertension based on linear correlation calculated from our data. Methods: We screened 500 healthy subjects to study the correlation between anthropometric indices and blood pressure.Result: Our result showed strong correlation between Sum of Skin fold, waist circumference, and waist hip ratio with blood pressure (systolic blood pressure, diastolic blood pressure and mean arterial blood pressure). However some of the anthropometric indices like hip circumference and body mass index did not have significant correlation with blood pressure. Conclusion: Provided obesity related morbidity and mortality is burgeoning in our society it is imperative to identify right indicators of cardiovascular disease for specific population. Relevant anthropometric indices can serve as excellent indicators if used based of scientific validation. JNGMC, Vol. 14 No. 2 December 2016, Page:70-74

Effect of docosahexaenoic acid monoacylglyceride on systemic hypertension and cardiovascular dysfunction

2015 ◽  
Vol 309 (1) ◽  
pp. H93-H102 ◽  
Author(s):  
Caroline Morin ◽  
Eric Rousseau ◽  
Pierre U. Blier ◽  
Samuel Fortin
Keyword(s):  
Blood Pressure ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Lipid Analysis ◽  
Profile Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Systemic Hypertension ◽  
Arterial Blood

ω-3 Fatty acid supplementation has been associated with lower blood pressure. Cardiovascular diseases are also known to be linked directly to an increase in ω-6 and a reduction in ω-3 fatty acid levels in blood circulation and tissues. To determine the effect of docosahexaenoic acid monoglycerides (MAG-DHA) on blood pressure, lipid profiles, and vascular remodeling in rats fed a high-fat/high-carbohydrate (HFHC) diet. Studies were performed in male rats subjected to 8 wk of HFHC diet supplemented or not with 3 g/day MAG-DHA. After 8 wk of daily MAG-DHA treatment, rats in the HFHC + MAG-DHA group had lower arterial blood pressure and heart rate compared with the HFHC group. Moreover, MAG-DHA prevented the increase aortic wall thickness, whereas lipid analysis of aortic tissues revealed an increase in DHA/AA ratio correlated with the production of resolvin D2 and D3 metabolites. Histological analysis revealed that MAG-DHA prevented the development of LVH in the HFHC group. Serum lipid profile analysis further showed a decrease in total cholesterol (TC) and LDL, including very low-density lipoprotein (VLDL) and triglyceride (TG) levels, together with an increase in HDL levels after 8 wk of MAG-DHA treatment compared with the HFHC group. Furthermore, daily MAG-DHA treatment resulted in reduced proinflammatory marker levels such as CRP, IL-6, TNFα, and IL-1β. Altogether, these findings revealed that per os administration of MAG-DHA prevents HFHC-diet induced hypertension and LVH in rats.

scholarly journals Use of Global Risk Score for Cardiovascular Evaluation of Rural Workers in Southern Brazil

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Marta Regina Cezar-Vaz ◽  
Clarice Alves Bonow ◽  
Marlise Capa Verde Almeida de Mello ◽  
Daiani Modernel Xavier ◽  
Jordana Cezar Vaz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Risk Score ◽  
Southern Brazil ◽  
Global Risk ◽  
Rural Workers ◽  
Arterial Blood ◽  
And Gender ◽  
Cardiovascular Evaluation

The objectives of the present study were to classify the cardiovascular evaluation of rural workers through the Global Risk Score and analyze the intensity of the relationship between the classification and the variables of the score. A descriptive study was developed with 38 rural workers from the extreme southern Brazil. Data collection was performed through an interview and verification of anthropometric measurements and arterial blood pressure. Data were analyzed descriptively and inferentially using the Spearman correlation test. The overall 10-year cardiovascular risk classification using the Framingham global score showed a predominance of low risk (n=22; 57.9%); however, 11 rural workers (28.9%) had a high cardiovascular risk. Spearman’s correlation analysis showed significance between the Global Risk Score and gender (rho = 0.623, p≤0.001), age (rho = 0.783, p≤0.001), systolic blood pressure (rho = 0.545, p≤0.001), and smoking (rho = 0.483, p=0.002). These results show that rural workers need attention with regard to components that may put them at risk for cardiovascular disease. This study may help in the early diagnosis and more effective actions on the risk factors for cardiovascular disease.

scholarly journals Blood Pressure Morphology Assessment from Photoplethysmogram and Demographic Information Using Deep Learning with Attention Mechanism

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2167 ◽  
Author(s):  
Nicolas Aguirre ◽  
Edith Grall-Maës ◽  
Leandro J. Cymberknop ◽  
Ricardo L. Armentano
Keyword(s):  
Blood Pressure ◽  
Deep Learning ◽  
Attention Mechanism ◽  
Wireless Devices ◽  
Demographic Information ◽  
Use Of Data ◽  
Arterial Blood ◽  
The Mean ◽  
And Gender ◽  
Deep Learning Model

Arterial blood pressure (ABP) is an important vital sign from which it can be extracted valuable information about the subject’s health. After studying its morphology it is possible to diagnose cardiovascular diseases such as hypertension, so ABP routine control is recommended. The most common method of controlling ABP is the cuff-based method, from which it is obtained only the systolic and diastolic blood pressure (SBP and DBP, respectively). This paper proposes a cuff-free method to estimate the morphology of the average ABP pulse (ABPM¯) through a deep learning model based on a seq2seq architecture with attention mechanism. It only needs raw photoplethysmogram signals (PPG) from the finger and includes the capacity to integrate both categorical and continuous demographic information (DI). The experiments were performed on more than 1100 subjects from the MIMIC database for which their corresponding age and gender were consulted. Without allowing the use of data from the same subjects to train and test, the mean absolute errors (MAE) were 6.57 ± 0.20 and 14.39 ± 0.42 mmHg for DBP and SBP, respectively. For ABPM¯, R correlation coefficient and the MAE were 0.98 ± 0.001 and 8.89 ± 0.10 mmHg. In summary, this methodology is capable of transforming PPG into an ABP pulse, which obtains better results when DI of the subjects is used, potentially useful in times when wireless devices are becoming more popular.

scholarly journals Body fat indices for identifying risk of hypertension in Indian children

2019 ◽  
Vol 6 (5) ◽  
pp. 2116
Author(s):  
Vairamuthu G. S. ◽  
Thangavel A.
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Body Fat ◽  
Height Ratio ◽  
Indian Children ◽  
Skin Fold Thickness ◽  
Skin Fold ◽  
Triceps Skin Fold ◽  
Waist To Height Ratio ◽  
Triceps Skin Fold Thickness

Background: Studies in India shown high body fat indices were strongly associated with hypertension in Indian children, but such studies mostly not done in southern states of India. So, authors include children in Tamilnadu measure body fat indices and blood pressure to find which body fat index correlates closely with hypertension.Methods: Standing height was measured using stadiometer. Weight was measured using electronic scale. WC measured in standing position, by a stretch resistant.  WC above 90th centile will be considered as Adipose. Waist to height ratio optimal cut-off value is 0.44 for children. TSFT recorded using Harpenden caliper, on the non-dominant upper arm. Wrist circumference measured using stretch resistant tape.Results: In this study 2000 children were participated. More hypertensives are seen in 10 to 12 years(62) and 16 to 18 years(31).Increased weight correlated with hypertension. Study indicates waist circumference is significantly correlated with systolic BP p<0.003, diastolic BP p<0.000. This study shows significant correlation p<0.003 for systolic and p<0.000 for diastolic BP with triceps skin fold thickness estimation. In multivariate analysis with systolic blood pressure and diastolic blood pressure shows very strong correlation with waist circumference, waist to height ratio and triceps skin fold thickness.Conclusions: In this study we investigate the correlation between body fat indices and blood pressure correlation was statistically analyzed which shows that waist circumference, waist to height ratio and triceps skin fold thickness were strongly correlated with systolic and diastolic BP.

Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes

2014 ◽  
Vol 0 (0) ◽  
Author(s):  
Gustavo F. Gonzales ◽  
Vilma Tapia
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
High Altitude ◽  
Venous Blood ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
P Value ◽  
Physiological Variables ◽  
Arterial Blood ◽  
Liver And Kidney

AbstractCurrently there are no studies on γ-glutamyltransferase (γGT) levels at high altitude or on the relationship between γGT, uric acid and several dysfunctions. The aim of the study was to determine the association between serum γGT and uric acid levels in subjects at high altitude with hemoglobin, glycemia, and lipidic, hepatic and kidney markers.The present study was performed in 487 subjects aged 30–75 years living at 4100 m of altitude. A venous blood sample was drawn from each subject to measure hemoglobin, glucose, and lipid levels and markers of liver and kidney function. Quartiles for serum γGT and uric acid were calculated and associated with different physiological variables. A p-value <0.05 was considered statistically significant.Serum γGT values were higher in men (38.35± 2.54 IU/L) than in women (30.33±1.76 IU/L) (p<0.01). Similarly, serum uric acid levels were higher in men (5.78± 0.12 mg/dL) than in women (4.29±0.08 mg/dL; p<0.001). Serum γGT levels in the top quartile were associated with higher glycemia, overweight/obesity, increased levels of non-high-density lipoprotein (non-HDL) cholesterol, triglycerides, alanine aminotransferase, alkaline phosphatase, uric acid, creatinine, and hemoglobin. Levels of uric acid in the top quartile were associated with overweight/obesity, elevated non-HDL cholesterol, triglycerides, creatinine, γGT and hemoglobin. Higher arterial blood pressure was associated with high levels of uric acid but not with γGT levels.At high altitude, increased γGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease.

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