scholarly journals Структурні та морфометричні зміни печінки при експериментальній термічній травмі

2015 ◽  
Author(s):  
Л. Д Тупол
Keyword(s):  
Key Words ◽  
Blood Vessels ◽  
The Body ◽  
Key Words Liver ◽  
Thermal Trauma

СТРУКТУРНІ ТА МОРФОМЕТРИЧНІ ЗМІНИ ПЕЧІНКИ ПРИ ЕКСПЕРИМЕНТАЛЬНІЙ ТЕРМІЧНІЙ ТРАВМІ - В експерименті на морських свинках проведено мікроскопічні та морфометричні дослідження печінки в динаміці. Після тяжкої термічної травми встановлено, що у стадії токсемії були характерні зміни судин та паренхіми органа, що носять пристосувально-компенсаторний характер. У пізні терміни після опіку (стадії пізньої токсемії та септикотоксеміі) виявлено значну деструкцію вен, судин тріад та гемокапілярів, вміст темних клітин у часточках зростає, в темних і світлих гепатоцитах значно змінюються ядерно-цитоплазматичні співвідношення, що свідчить про пригнічення процесів регенерації.<br />СТРУКТУРНЫЕ И МОРФОМЕТРИЧЕСКИЕ ИЗМЕНЕНИЯ ПЕЧЕНИ ПРИ ЭКСПЕРИМЕНТАЛЬНОЙ ТЕРМИЧЕСКОЙ ТРАВМЕ - В эксперименте на морских свинках проведены микроскопические и морфометрические исследования печени в динамике. После тяжелой термической травмы установили, что в стадии токсемии были характерные изменения сосудов и паренхимы органа и носят приспособительно-компенсаторный характер. В поздние сроки после ожога (стадии поздней токсемии и септикотоксемии) обнаружена значительная деструкция вен, сосудов триад и гемокапилляров, количество темных клеток в дольках растет, в темных и светлых гепатоцитах значительно меняются ядерно-цитоплазматические соотношения, что свидетельствует об угнетении процессов регенерации.<br />STRUCTURAL AND MORPHOMETRIC CHANGES OF LIVER IN EXPERIMENTAL THERMAL TRAUMA - Іп experiment on gvinea pigs with thermal ingury of skin was investigated the histological and morphometrical changes of liver. The obtained results showed in toxemia stage changes in blood vessels and parenchyma of the body that are adaptative-compensatory character. In later stages after the burn (stage late toxemia and septicotoxemia) found significant degradation veins, vascular triads and hemocahilares, namber of dark hepatocytes increases. In dark and light hepatocytes canges nuclear-cytoplasmic ratio, which means inhibition of regeneration.<br />Ключові слова: печінка, гістологічні та морфометричні зміни, термічна травма.<br />Ключевые слова: печень, гистологические и морфометрические изменения, термическая травма.<br />Key words: liver, histological and morphometrical changes, thermal trauma.

COMPARISON OF ANTIHYPERTENSIVE EFFECT OF MOXONIDINE VERSUS CLONIDINE IN RENAL FAILURE PATIENTS.

2018 ◽  
Vol 6 (9) ◽  
Author(s):  
DR.MATHEW GEORGE ◽  
DR.LINCY JOSEPH ◽  
MRS.DEEPTHI MATHEW ◽  
ALISHA MARIA SHAJI ◽  
BIJI JOSEPH ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Blood Flow ◽  
Blood Vessel ◽  
Blood Vessels ◽  
High Blood Pressure ◽  
Antihypertensive Effect ◽  
The Body ◽  
Ability To Work ◽  
Blood Flows

Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called hypertension, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged(1). High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.

Harnessing clay nano-particles for stem-cell driven tissue regeneration, EPSRC

Impact ◽  
2018 ◽  
Vol 2018 (3) ◽  
pp. 26-28
Author(s):  
Jonathan Dawson ◽  
Richard Oreffo
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Blood Vessels ◽  
The Body ◽  
Biological Molecules ◽  
Nano Particles ◽  
Clay Particles ◽  
Clay Nanoparticles ◽  
Signalling Molecules ◽  
The Right

Gels made from clay could provide an environment able to stimulate stem-cells due to their ability to bind biological molecules. That molecules stick to clay has been known by scientists since the 1960s. Doctors observed that absorption into the blood stream of certain drugs was severely reduced when patients were also receiving clay-based antacid or anti-diarrhoeal treatments. This curious phenomenon was realized to be due to binding of the drugs by clay particles. This interaction is now routinely harnessed in the design of tablets to carefully control the release and action of a drug. Dr Dawson now proposes to use this property of clay to create micro-environments that could stimulate stem cells to regenerate damaged tissues such as bone, cartilage or skin. The rich electrostatic properties of nano (1 millionth of a millimetre) -scale clay particles which mediate these interactions could allow two hurdles facing the development of stem-cell based regenerative therapies to be overcome simultaneously. The first challenge - to deliver and hold stem cells at the right location in the body - is met by the ability of clays to self-organise into gels via the electrostatic interactions of the particles with each other. Cells mixed with a low concentration (less than 4%) of clay particles can be injected into the body and held in the right place by the gel, eliminating, in many situations, the need for surgery. Clay particles can also interact with large structural molecules (polymers) which are frequently used in the development of materials (or 'scaffolds'), designed to host stem cells. These interactions can greatly improve the strength of such structures and could be applied to preserve their stability at the site of injury until regeneration is complete. While several gels and scaffold materials have been designed to deliver and hold stem cells at the site of regeneration, the ability of clay nanoparticles to overcome a second critical hurdle facing stem-cell therapy is what makes them especially exciting. Essential to directing the activity of stem-cells is the carefully controlled provision of key biological signalling molecules. However, the open structures of conventional scaffolds or gels, while essential for the diffusion of nutrients to the cells, means their ability to hold the signalling molecules in the same location as the cells is limited. The ability of clay nano-particles to bind biological molecules presents a unique opportunity to create local environments at a site of injury or disease that can stimulate and control stem-cell driven repair. Dr Dawson's early studies investigated the ability of clay gels to stimulate the growth of new blood vessels by incorporating a key molecular signal that stimulates this process, vascular endothelial growth factor (VEGF). In a manner reminiscent of the observations made in the 60s, Dr Dawson and colleagues observed that adding a drop of clay gel to a solution containing VEGF caused, after a few hours, the disappearance of VEGF from the solution as it became bound to the gel. When placed in an experimental injury model, the gel-bound VEGF stimulated a cluster of new blood vessels to form. These exciting results indicate the potential of clay nanoparticles to create tailor-made micro-environments to foster stem cell regeneration. Dr Dawson is developing this approach as a means of first exploring the biological signals necessary to successfully control stem cell behaviour for regeneration and then, using the same approach, to provide stem cells with these signals to stimulate regeneration in the body. The project will seek to test this approach to regenerate bone lost to cancer or hip replacement failure. If successful the same technology may be applied to harness stem cells for the treatment of a whole host of different scenarios, from burn victims to those suffering with diabetes or Parkinson's.

Extase scopique, sédimentation langagičre et inscription corporelle. Les images dans la civilisation contemporaine

PARADIGMI ◽  
2009 ◽  
pp. 71-83
Author(s):  
Jean-Jacques Wunenburger
Keyword(s):  
Key Words ◽  
The Body ◽  
Pathological Conditions ◽  
Image Informatics

- Linguistic Sedimentation, and Bodily Inscription At present, we are exposed to an excessive offer of images, which raises a problem of assimilation. Subjects are increasingly passive, in ways that can border on pathological conditions. Yet, it is not so much a question of condemning this situation as of finding a way of re-symbolizing images, saving them from mere contemplation and inserting them in a process of contextualisation. Such a process requires an understanding of the role of the body and of the incorporation of images along the lines of Bachelard's intuition of the "resisting" nature of images. This raises the possibility of an education to images suited to the present age.Key words: Alienation, Education, Embodiment, Image, Informatics, Symbolisation.Parole chiave: Alienazione, Educazione, Immagine, Incorporazione, Informatica, Simbolizzazione.

scholarly journals The Importance of Anatomy

2020 ◽  
Vol 8 ◽  
Author(s):  
Kelly Stanford ◽  
Sharon Rutland ◽  
Craig J. Sturrock ◽  
Catrin Sian Rutland
Keyword(s):  
Blood Vessels ◽  
Health Professionals ◽  
The Body ◽  
Veterinary Surgeons ◽  
The Future ◽  
Anatomical Information

Anatomy is the knowledge about the structure of the bodies of animals and people. This includes information about blood vessels, organs, the skeleton, and nerves. But have you ever wondered where the anatomical information in science books and websites comes from? When did our fascination with the body begin and why do people still study it now? Who teaches doctors, nurses, veterinary surgeons, and other health professionals about the body? How has anatomy inspired art, and vice versa? This paper looks at the amazing world of anatomy: what anatomy is; why it is needed; why it is important; who studies, teaches, and researches anatomy; and what the future holds for this fascinating science.

scholarly journals Sepakbola: Kapasitas Vital Paru dan Tingkat Kebugaran Jasmani

2020 ◽  
Vol 5 (1) ◽  
pp. 30-39
Author(s):  
Rusmanto ◽  
Rola Angga Lardika ◽  
Novri Gazali
Keyword(s):  
Physical Fitness ◽  
Blood Vessels ◽  
Vital Capacity ◽  
The Body ◽  
Process Data ◽  
Fitness Level ◽  
Physiological Conditions ◽  
The Status ◽  
T Distribution

Lung vital capacity is the status of physiological conditions associated with the ability to treat respiration together with the increasing of physical fitness, so lung vital capacity is a process involving the mechanism of the heart and blood vessels and blood which aims to provide O2 to cells in the body and transport CO2 out of body. The purpose of this study is to determine the correlation between lung vital capacity and the physical fitness level of Pendor Football Athletes from Universitas Riau. The collecting of data in this study is data from lung vital capacity tests and physical fitness with a sample of 20 athletes. Analysis of the data that used to process data is Product Moment correlation. For determining the significance of data, it uses formulation of t distribution. The results that obtained from lung vital capacity have a significant correlation with the level of physical fitness, this is indicated by the results obtained by r count (0622) > r table (α = 0.05) = 0.456. Meanwhile, t distribution test is obtained the result of t count (3,369) > t  table (1,734). So H0 is refused  and Ha is accepted. Thus it can be concluded that there is a significant correlation between the lung vital capacity (x) and the level of physical fitness (y).

scholarly journals Morphofunctional and immunohistochemical characteristics of the large omentum in ovarian cancer

2020 ◽  
Vol 9 (3) ◽  
pp. 64-71
Author(s):  
N. N. Shevlyuk ◽  
L. V. Khalikova ◽  
A. A. Khalikov
Keyword(s):  
Ovarian Cancer ◽  
Connective Tissue ◽  
Protein Expression ◽  
Blood Vessels ◽  
Lymphoid Tissue ◽  
P53 Protein ◽  
Individual Variability ◽  
The Body ◽  
Great Omentum ◽  
Low Grade

The aim of the study was to establish morphofunctional and immunohistochemical characteristics of large omentum in women with ovarian cancer.Material and methods. The large omenta of 48 women with ovarian cancer (low-grade differentiated seropapillary adenocarcinoma of high-grade malignancy) of II stage (n=20) and III stage (n=28) were studied. Histological sections were stained with overview histological and immunohistochemical methods (to reveal ki67, P53, CD34, CD7, CD4, CD8, CD61 proteins expression). Results. In patients, the size of the large omentum was characterized by high individual variability; in the presence of metastasis, the size of the omentum was reduced. Intensive development of blood vessels in the organ was noted, but in the presence of metastases stasis of blood corpuscles, leucocytic infiltration, and moderate edema of connective tissue were observed in the organ’s vessels. Areas of lymphoid tissue, both small lymphatic follicles and diffusely located lymphoid tissue, were revealed in the omentum. In most follicles, reactive centers were not marked, and the number of follicles was reduced in the presence of metastases in the omentum. The analysis of CD34+ cells distribution showed that they were identified both in the tumor and in the areas of the omentum adjacent to the tumor, which indicates a pronounced angiogenesis. An irregular distribution of CD7+ and CD8+ and CD4+ cells was revealed in the tumor tissues, as well as in the surroundings. Simultaneously with the expression of P53 protein, ki67 protein expression is revealed in the significant number of tumor cells (including endothelial cells of tumor blood vessels). The proportion of ki67+ cells in the tumor cell population was 60.1±3.3%. The presence of a large number of ki67+cells in the presence of P53 protein expression in them indicates the aggressiveness of the tumor, as well as a disturbance of apoptosis regulatory mechanisms in the cells. Ki67 expression was low in the omentum areas unaffected by metastases, and it was revealed in the certain areas of connective tissue in fibroblastic programmed differentiation cells. Conclusion. The results obtained indicate significant plasticity and reactivity of great omentum in the presence of tumor process in the body and confirm the important role of great omentum in protective reactions.

Oligophrenia associated with various pathogenesis

2020 ◽  
Vol 56 (07) ◽  
pp. 73-76
Author(s):  
Afat Afar Israfilova ◽  
Keyword(s):  
Mental Retardation ◽  
Key Words ◽  
Metabolic Disorders ◽  
Genetic Disorders ◽  
Physical Illness ◽  
The Body ◽  
Negative Effect

The causes of pathology are different. There are various inherited genetic disorders of the body, which are metabolic disorders, chromosome deficiency leads to various pathologies. Other factors have a negative effect on embryonic pathogenesis in the intrauterine stage. As a result, the baby does not develop properly in the womb. Key words: Pathology, physical illness, infection, mental retardation

Pregnancy and velvet

2021 ◽  
Vol 65 (04) ◽  
pp. 86-88
Author(s):  
Sevinc Nadir qızı Kerimova ◽  
Keyword(s):  
Immune Response ◽  
Laboratory Test ◽  
Key Words ◽  
Rubella Virus ◽  
The Body ◽  
Key Words Pregnancy ◽  
Specific Antibodies ◽  
Rubella Infection

The main prevention of rubella infection during pregnancy is to be vaccinated against this disease in preparation for pregnancy. Before you decide to get vaccinated against rubella, you need to have a special laboratory test to detect antibodies to the rubella virus in your blood to check if you are immune to this infection. The fact is that in some cases it is impossible to determine whether you are sick with rubella. Because in many cases, the disease can be latent or with a very limited number of symptoms, in which case, naturally, the body develops specific antibodies against the virus. Doctors believe that in this case, the body's immune response will be strengthened. It is recommended that the velvet vaccine be given at least 3 months before the planned date of pregnancy. Key words: pregnancy, rubella, fetus, infection

Development of an experimental setup for intraoperative angiography system

2021 ◽  
Author(s):  
I.A. Kudashov ◽  
N.V. Kalmykov ◽  
A.R. Alexandrov ◽  
P.G. Ryazantsev ◽  
S.I. Shchukin ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Intraoperative Imaging ◽  
Objective Assessment ◽  
Locally Advanced ◽  
Practical Importance ◽  
Clinical Problem ◽  
The Body ◽  
Experimental Setup ◽  
Intraoperative Angiography ◽  
Vessel Imaging

The treatment of locally advanced tumors of the head and neck presents serious difficulties due to the difficulty of localizing growths, namely the proximity to vital organs and systems of the body (brain, large blood vessels) and the small size of the areas of intervention limits the choice of treatment methods. So, the development of helper methods and hardware of intraoperative visualization of blood vessels is relevant. So, the development of auxiliary methods and hardware means of intraoperative blood vessel imaging for objective assessment of adequacy of blood supply and differentiated recognition of anatomical structures is especially relevant in biomedical optics. The aim of the work is to create an experimental setup for the development, testing and modification of the algorithms for improving the quality of the image of blood vessels against the background of surrounding tissues by optical method. The article is devoted to technological and program features of developing and creating an experimental setup for intraoperative imaging. Clinical problem of the necessity of vessel imaging has been established. Current state of intraoperative vessel imaging has been analyzed. Structure of the setup has been determined. The requirements for parts of the setup have been formulated. Usage of the chlorophyll as a new liquid for blood substitution has been experimentally justified. A MATLAB-based model for quality evaluation of functions of the setup has been developed. The experimental results obtained in the article are of great practical importance for the development of a biotechnological system for intraoperative vessel imaging.

scholarly journals Chondrolipoma of tongue

1970 ◽  
Vol 6 (4) ◽  
pp. 505-507 ◽  
Author(s):  
G Goel ◽  
UN Khadilkar ◽  
S Kumar
Keyword(s):  
Medical Journal ◽  
Oral Cavity ◽  
Key Words ◽  
Rare Variant ◽  
The Body

Although lipomas can occur in any part of the body, they are found infrequently in the oral cavity. Variants of lipoma have been described according to the type of tissue present; a lipoma with cartilaginous metaplasia is a chondrolipoma which is a rare variant. We describe a chondrolipoma of tongue in a 36 year old lady. Key words: Tongue, Chondrolipoma doi: 10.3126/kumj.v6i4.1745     Kathmandu University Medical Journal (2008), Vol. 6, No. 4, Issue 24, 505-507

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