Human papillomavirus (HPV) testing on self-collected specimens: perceptions among HIV positive women attending rural and urban clinics in South Africa

In Botswana, where human immunodeficiency virus (HIV) prevalence remains high, cervical cancer is the leading cause of cancer deaths in women. Multiple organizations recommend high-risk human papillomavirus (hr-HPV) testing as a screening tool; however, high coverage may not be feasible with provider-collected samples. We conducted the first assessment of self- versus provider-collected samples for hr-HPV testing in HIV-positive women in Botswana and report prevalence of hr-HPV and histological outcomes. We recruited HIV-positive women ≥25 years attending an HIV clinic in Gaborone. Self- and provider-collected samples from participants were tested for hr-HPV using Cepheid GeneXpert. Women testing positive for any hr-HPV returned for colposcopy. We used unweighted κ statistics to determine hr-HPV agreement. We report that 31 (30%) of 103 women tested positive for any hr-HPV. The most common genotypes were HPV 31/33/35/52/58. Overall agreement between self- and provider-collected samples for any hr-HPV was 92% with a κ of 0.80. Ten of the 30 hr-HPV-positive women attending colposcopy had CIN2+ (33%). In conclusion, in this HIV-positive population, there was excellent agreement between self and provider samples, and self-sampling may play an important role in screening programs in high HIV burden settings with limited resources like Botswana.

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Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2020.02.051 ◽

2020 ◽

Vol 95 ◽

pp. 176-182 ◽

Cited By ~ 1

Author(s):

Ongeziwe Taku ◽

Charles B. Businge ◽

Mana L. Mdaka ◽

Keletso Phohlo ◽

Wisdom Basera ◽

...

Keyword(s):

Risk Factors ◽

South Africa ◽

Human Papillomavirus ◽

Hiv Positive ◽

Eastern Cape ◽

Hiv Positive Women ◽

Hiv Negative

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Faculty Opinions recommendation of Carcinogenicity of Human Papillomavirus (HPV) Types in HIV-Positive Women: A Meta-Analysis From HPV Infection to Cervical Cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727565191.793546767 ◽

2018 ◽

Author(s):

Santosh Kumar

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Meta Analysis ◽

Hpv Infection ◽

Hiv Positive ◽

Hiv Positive Women ◽

Hpv Types

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High prevalence of human papillomavirus and European variants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women

PLoS ONE ◽

10.1371/journal.pone.0227900 ◽

2020 ◽

Vol 15 (4) ◽

pp. e0227900

Author(s):

Milagros Pérez-Quintanilla ◽

Rocío Méndez-Martínez ◽

Salvador Vázquez-Vega ◽

Raquel Espinosa-Romero ◽

Rita Sotelo-Regil ◽

...

Keyword(s):

Human Papillomavirus ◽

Oral Cavity ◽

Hiv Positive ◽

Hpv 16 ◽

Hiv Positive Women ◽

High Prevalence

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Spatiotemporal modelling and mapping of cervical cancer incidence among HIV positive women in South Africa: a nationwide study

International Journal of Health Geographics ◽

10.1186/s12942-021-00283-z ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Dhokotera Tafadzwa ◽

Riou Julien ◽

Bartels Lina ◽

Rohner Eliane ◽

Chammartin Frederique ◽

...

Keyword(s):

South Africa ◽

Health Care ◽

Cervical Cancer ◽

South African ◽

Access To Health Care ◽

Health Facilities ◽

Hiv Positive ◽

The South ◽

Hiv Positive Women ◽

Access To Health

Abstract Background Disparities in invasive cervical cancer (ICC) incidence exist globally, particularly in HIV positive women who are at elevated risk compared to HIV negative women. We aimed to determine the spatial, temporal, and spatiotemporal incidence of ICC and the potential risk factors among HIV positive women in South Africa. Methods We included ICC cases in women diagnosed with HIV from the South African HIV cancer match study during 2004–2014. We used the Thembisa model, a mathematical model of the South African HIV epidemic to estimate women diagnosed with HIV per municipality, age group and calendar year. We fitted Bayesian hierarchical models, using a reparameterization of the Besag-York-Mollié to capture spatial autocorrelation, to estimate the spatiotemporal distribution of ICC incidence among women diagnosed with HIV. We also examined the association of deprivation, access to health (using the number of health facilities per municipality) and urbanicity with ICC incidence. We corrected our estimates to account for ICC case underascertainment, missing data and data errors. Results We included 17,821 ICC cases and demonstrated a decreasing trend in ICC incidence, from 306 to 312 in 2004 and from 160 to 191 in 2014 per 100,000 person-years across all municipalities and corrections. The spatial relative rate (RR) ranged from 0.27 to 4.43 in the model without any covariates. In the model adjusting for covariates, the most affluent municipalities had a RR of 3.18 (95% Credible Interval 1.82, 5.57) compared to the least affluent ones, and municipalities with better access to health care had a RR of 1.52 (1.03, 2.27) compared to municipalities with worse access to health. Conclusions The results show an increased incidence of cervical cancer in affluent municipalities and in those with more health facilities. This is likely driven by better access to health care in more affluent areas. More efforts should be made to ensure equitable access to health services, including mitigating physical barriers, such as transportation to health centres and strengthening of screening programmes.

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Social and Demographic Factors Associated with Postnatal Depression Symptoms among HIV-Positive Women in Primary Healthcare Facilities, South Africa

Healthcare ◽

10.3390/healthcare9010065 ◽

2021 ◽

Vol 9 (1) ◽

pp. 65

Author(s):

Kebogile Elizabeth Mokwena ◽

Nontokozo Lilian Mbatha

Keyword(s):

South Africa ◽

Primary Healthcare ◽

Postnatal Depression ◽

Hiv Positive ◽

P Value ◽

Depression Symptoms ◽

Healthcare Facilities ◽

Factors Associated ◽

Hiv Positive Women ◽

Kwazulu Natal

Background: Mothers living with HIV are at risk for mental health problems, which may have a negative impact on the management of their HIV condition and care of their children. Although South Africa has a high prevalence of HIV, there is a dearth of studies on sociodemographic predictors of postnatal depression (PND) among HIV-positive women in South Africa, even in KwaZulu Natal, a province with the highest prevalence of HIV in the country. Objective: The objective of the study was to determine sociodemographic factors associated with the prevalence of postnatal depression symptoms among a sample of HIV-positive women attending health services from primary healthcare facilities in Umhlathuze District, KwaZulu Natal. Methods: A quantitative cross-sectional survey was used to collect data from 386 HIV-positive women who had infants aged between 1 and 12 weeks. The Edinburgh Postnatal Depression Scale (EPNDS), to which sociodemographic questions were added, was used to collect data. Results: The prevalence of PND symptoms among this sample of 386 HIV-positive women was 42.5%. The age of the mothers ranged from 16 to 42 years, with a mean of 29 years. The majority of the mothers were single or never married (85.5%; n = 330), living in a rural setting (81.9%; n = 316%), with a household income of less than R 2000 (estimated 125 USD) per month (64.9%; n = 120). The government child support grant was the main source of income for most of the mothers (53%; n = 183). PND symptoms were significantly associated with the participant’s partner having other sexual partners (p-value < 0.001), adverse life events (p-value = 0.001), low monthly income (p-value = 0.015), and being financially dependent on others (p-value = 0.023). Conclusion: The prevalence of PND symptoms among the sample is high, with a number of social and demographic factors found to be significantly associated with PND. This requires the consideration of sociodemographic information in the overall management of both HIV and postnatal depression. Addressing the impact of these factors can positively influence the health outcomes of both the mother and the baby.

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Effectiveness of the WHO/UNICEF guidelines on infant feeding for HIV-positive women: results from a prospective cohort study in South Africa

AIDS ◽

10.1097/qad.0b013e32827b1462 ◽

2007 ◽

Vol 21 (13) ◽

pp. 1791-1797 ◽

Cited By ~ 70

Author(s):

Tanya Doherty ◽

Mickey Chopra ◽

Debra Jackson ◽

Ameena Goga ◽

Mark Colvin ◽

...

Keyword(s):

South Africa ◽

Cohort Study ◽

Infant Feeding ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Hiv Positive ◽

Hiv Positive Women

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Cervical cancer risk and impact of Pap-based screening in HIV-positive women on antiretroviral therapy in Johannesburg, South Africa

International Journal of Cancer ◽

10.1002/ijc.30749 ◽

2017 ◽

Vol 141 (3) ◽

pp. 488-496 ◽

Cited By ~ 9

Author(s):

Eliane Rohner ◽

Mazvita Sengayi ◽

Bridgette Goeieman ◽

Pamela Michelow ◽

Cynthia Firnhaber ◽

...

Keyword(s):

South Africa ◽

Cervical Cancer ◽

Antiretroviral Therapy ◽

Cancer Risk ◽

Hiv Positive ◽

Cervical Cancer Risk ◽

Hiv Positive Women

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Identification of Genetic Variants of Human Papillomavirus in a Group of Mexican HIV/AIDS Patients and Their Possible Association with Cervical Cancer

Polish Journal of Microbiology ◽

10.33073/pjm-2021-047 ◽

2021 ◽

Vol 70 (4) ◽

pp. 501-509

Author(s):

FELIPE ORTIZ-GUTIÉRREZ ◽

LILIA SÁNCHEZ-MINUTTI ◽

JOSÉ F. MARTÍNEZ-HERRERA ◽

INDIANA D. TORRES-ESCOBAR ◽

ELIAS B. PEZZAT-SAID ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Genetic Variants ◽

Direct Relationship ◽

Low Risk ◽

Hiv Positive ◽

Hiv Positive Women ◽

Immunodeficiency Virus ◽

Regional Population ◽

Polymerase Chain

Infections caused by the human immunodeficiency virus (HIV) and human papillomavirus (HPV) cause thousands of deaths worldwide each year. So far, there has been no consensus on whether there is a direct relationship between the incidence of neoplasms and the immunosuppression caused by HIV that could help understand if coinfection increases the likelihood of cervical cancer. The objective of the study was to identify the presence of genetic variants of HPV in a group of HIV-positive women and their possible association with cervical cancer. Cervical samples were taken from HIV-positive patients for cytological analysis to identify the HPV genotype by polymerase chain reaction (PCR) and sequencing. The most preva¬lent L1 capsid protein mutations in the HPV genotype were ana¬lyzed in silico. Various types of HPV were identified, both high-risk (HR) and low-risk (LR). The most prevalent genotype was HPV51. Analysis of the L1 gene sequences of HPV51 isolates showed nucleo¬tide variations. Of the samples analyzed in Puebla, Mexico, HPV51 had the highest incidence (17.5%, 7/40). Different mutations, which could be used as population markers, were detected in this area, and they have not been reported in the L1 databases for HPV51 in Mexico. Genotypes 6, 14, 86, 87, 89, and 91, not detected or reported in samples from patients with HPV in Mexico, were also identified. Data from the population analyzed suggest no direct relationship between HIV immunosuppression and cervical cancer, regardless of the high- or low-risk HPV genotype. Furthermore, it is possible to develop regional population markers for the detection of HPV based on the mutations that occur in the sequence of nucleotides analyzed.

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