Moderate/high resistance exercise is better to reduce blood glucose and blood pressure in middle-aged diabetic subjects

Type 2 diabetes (T2D) main feature is insulin resistance. Hypertension is a comorbidity linked to T2D. Resistance exercise (RE) is an important non-pharmacological tool to contribute to managing blood glucose and blood pressure (BP), but there is not a common sense about acute effects. The aim of this study was to evaluate the acute physiological effects after two different RE sessions using different intensities at middle-aged hypertensive T2D subjects. There were 40 middle-aged men (20 nondiabetics; 20 diabetics), who underwent an exercise protocol with the same volume at 60% or 75% of the one maximum repetition test (1RM), consisting in: bench press, triceps pulley, rowing machine, barbell curl, lateral raise with dumbbells and barbell squat. Physiological changes were evaluated through BP, glycemia, creatine kinase, lactate dehydrogenase, C reactive protein (C-RP), testosterone and cortisol.For non-diabetics, both intensities promoted blood glucose uptake (8.2% to 11.1%, p<0.05), and only the 75%1RM session induced blood glucose uptake in 5.7% in the diabetics. Post-exercise hypotension was significant after RE at 75%1RM for systolic BP (SBP) and after both intensities for diastolic BP (DBP) in non-diabetics, while the SBP and DPB reduced after both intensities for diabetics. RE at 75%1RM resulted in better blood glucose uptake, and both intensities reduced the BP in diabetic subjects. After 75%1RM there was a higher indirect muscle damage result. The alterations in hormones, C-RP, and indirect muscle damage markers indicated an adequate acute anabolic recovery with no significant inflammation in both intensities. Acute RE at 60%1RM or 75%1RM can used as an extra tool to manage both pathologic conditions.

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Moderate/high resistance exercise is better to reduce blood glucose and blood pressure in middle-aged diabetic subjects

Revista Brasileira de Educação Física e Esporte ◽

10.11606/issn.1981-4690.v34i1p165-175 ◽

2020 ◽

Vol 34 (1) ◽

pp. 165-175 ◽

Cited By ~ 2

Author(s):

Ricardo Augusto Leoni de Sousa ◽

Karinn Faro Hagenbeck ◽

Gisela Arsa ◽

Emerson Pardono

Keyword(s):

Blood Pressure ◽

Blood Glucose ◽

Resistance Exercise ◽

Glucose Uptake ◽

Muscle Damage ◽

Middle Aged ◽

Reactive Protein ◽

Reduce Blood Glucose ◽

Lactate Dehydrogenase C ◽

The One

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Effects of Resistance Exercise Using Elastic Band on Liver Function and Blood Glucose in Middle-Aged Women

Korean Journal of Sports Science ◽

10.35159/kjss.2019.02.28.1.1239 ◽

2019 ◽

Vol 28 (1) ◽

pp. 1239-1244

Author(s):

Young-Hwan Seo

Keyword(s):

Blood Glucose ◽

Liver Function ◽

Resistance Exercise ◽

Middle Aged ◽

Elastic Band

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Association between C reactive protein and obesity: a study in a tertiary care hospital

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20194212 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1535

Author(s):

Lavanya Mandli

Keyword(s):

Blood Pressure ◽

Blood Glucose ◽

Cardiovascular Diseases ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Obese Patients ◽

Elevated Blood ◽

C Reactive Protein ◽

Reactive Protein

Background: Obesity and dyslipidemia, especially in children and adolescents coupled with impaired blood glucose metabolism and elevated blood pressure may result in atherosclerosis in the older ages. This study was conducted to assess the association between high levels of CRP with obesity.Methods: Details including height and weight for BMI and serum for C reactive protein estimation was collected for all 134 patients.Results: 60.4% were females and 49.6% were males. Among the obese patients, clinically raised CRP levels was observed in 29.2% and elevated CRP levels in 45.8% levels, while in overweight patients, 21.4% had clinically raised CRP and 46.4% has elevated CRP levels. In normal BMI patients, elevated CRP was seen in 22% and clinically raised in 1.9%.Conclusion: Detection of CRP levels in overweight and obese patients is imperative in the early stages itself to prevent cardiovascular diseases.

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Abstract T P345: Cardiovascular Health Metrics and All-cause and Cardiovascular Disease Mortality among Middle Aged Men in Korea: The Seoul Male Cohort Study

Stroke ◽

10.1161/str.45.suppl_1.tp345 ◽

2014 ◽

Vol 45 (suppl_1) ◽

Author(s):

Ji Young Kim ◽

Chul Woo Rhee ◽

Young-Jin Ko ◽

Byung-Joo Park ◽

Dong-Hyun Kim ◽

...

Keyword(s):

Blood Pressure ◽

Blood Glucose ◽

Health Behaviors ◽

Cardiovascular Health ◽

Fasting Blood Glucose ◽

Asian Population ◽

Heart Association ◽

Middle Aged ◽

Ideal Cardiovascular Health ◽

Cvd Mortality

Background: In Korea, Cerebrovascular and cardiovascular diseases (CVD) were the second leading cause of deaths in 2011. In 2010, the American Heart Association (AHA) published cardiovascular health metrics (CVHM) aimed at reducing deaths from all CVDs and stroke, and improving the cardiovascular health of the population as a whole. Despite their implications, the AHA’s metrics have not been broadly studied or previously applied to an Asian population. Objectives: This study estimated the combined association of cardiovascular health behaviors on the risk of all-cause and CVD mortality in middle-aged men in Korea. Methods: In total, 14,533 men aged 40-59 years were enrolled in 1993 and followed-up through 2011. CVHM defined the following lifestyles proposed by the AHA: smoking, physical activity, BMI, healthy diet score, total cholesterol, blood pressure, and fasting blood glucose. The CVHMs score was calculated as a single categorical variable, by assigning 1 point to each ideal healthy behavior vs. 0 points otherwise. All subjects were classified as meeting 0-7 CVHM. The principal outcome variables were all-cause and CVD mortality. The Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of cardiovascular health behavior, and CVHMs score. PARs were calculated from significant CVHMs. Results: During 266,482.8 person-years of follow-up, there were 1,314 deaths in total. Current smoking, blood pressure, and fasting blood glucose were significantly associated with all-cause and CVD mortality. The adjusted PARs for the 3 significant metrics combined were 81% (95% CI, 50-94%) and 96% (66-99%) for all-cause and CVD mortality, respectively. More ideal CVHM was significantly associated with lower risks of all-cause and CVD mortality ( p-trend<.0001 ). The adjusted HRs of the groups with 6-7 vs. 0-2 ideal CVHM were 0.49 (0.35-0.70) and 0.23 (0.10-0.57) for all-cause and CVD mortality, respectively. Conclusions: Among ideal cardiovascular health behaviors, non-smoking, normal blood pressure, and recommended fasting blood glucose levels associated with reduced risks of all-cause and total CVD mortality. There was a strong trend towards decreased all-cause and CVD mortality risk with increasing the number of ideal CVHMs.

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Fasting Blood Glucose Predicts Incidence of Hypertension Independent of HbA1c Levels and Insulin Resistance in Middle-Aged Japanese: The Saku Study

American Journal of Hypertension ◽

10.1093/ajh/hpz123 ◽

2019 ◽

Vol 32 (12) ◽

pp. 1178-1185 ◽

Cited By ~ 2

Author(s):

Yukako Tatsumi ◽

Akiko Morimoto ◽

Kei Asayama ◽

Nao Sonoda ◽

Naomi Miyamatsu ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Insulin Secretion ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Model Assessment ◽

Middle Aged ◽

Impaired Insulin Secretion ◽

Impaired Insulin ◽

Hba1c Levels

Abstract BACKGROUND Relationships between blood glucose (BG) levels and insulin action, and incidence of hypertension have not been well known epidemiologically. This study aimed to investigate the association between indices of diabetes and the incidence of hypertension and compare the predictive powers of these indices in middle-aged Japanese. METHODS This 5-year cohort study included 2,210 Japanese aged 30–64 years without hypertension. Hazard ratios of high fasting blood glucose (FBG) levels, high post-loaded BG levels, high glycated hemoglobin (HbA1c) levels, insulin resistance (defined by homeostasis model assessment of insulin resistance [HOMA-IR]) and impaired insulin secretion at baseline for the incidence of hypertension were estimated using multivariable-adjusted Cox proportional hazard models. Hypertension was defined as blood pressure ≥ 140/90 mm Hg or receiving antihypertensive treatment. RESULTS During the follow-up, 456 participants developed hypertension. After adjustment for HbA1c and HOMA-IR, FBG was independently and significantly associated with hypertension. The hazard ratio of participants with FBG ≥ 7.0 mmol/l was 1.79 compared with those with FBG < 5.6 mmol/l. Even among those with HbA1c < 6.5%, HOMA-IR < 2.5, body mass index < 25 kg/m2, age < 55 years old, blood pressure < 130/80 mm Hg or non- and moderate drinking, the results were similar. High 120-minute BG level and impaired insulin secretion did not increase the risk for hypertension. CONCLUSIONS FBG was a predictable index for future incidence of hypertension in middle-aged Japanese men and women. This is the first study comparing predictive powers of indices of diabetes for the incidence of hypertension.

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What is New in COVID-19 and What We Need to Do Against This Pandemic Infection? A Comparative Review

RADS Journal of Pharmacy and Pharmaceutical Sciences ◽

10.37962/jpps.v8i2.393 ◽

2020 ◽

Vol 8 (2) ◽

pp. 116-125

Author(s):

Sadaf Naeem ◽

Yousra Shafiq ◽

Muhammad Arif Asghar

Keyword(s):

Preventive Measures ◽

World Health ◽

Laboratory Findings ◽

Reactive Protein ◽

Comparative Review ◽

Lactate Dehydrogenase C ◽

The Many ◽

The One ◽

Health Organization ◽

Corona Viruses

Background: Initially, large number of COVID-19 cases reported from Wuhan City, China, reflected that this is likely the zoonotic origin of COVID-19. In March, 2020; it has since been declared a serious pandemic infection by the World Health Organization (WHO). Objective: The main objective of this review was to addressed what gaps still exist. Many researchers have reported the many common characteristics of COVID-19 virus in comparison with other pandemic viruses, while the major differences are discussed in this review. Method: In this review, we investigated the general characteristics of COVID-19 its diagnosis and other preventive measures in comparison with other pandemic viruses that we know or we need to know. Results: All reported corona viruses belong to the one genus and family Coronavirus and Coronaviridae. The COVID-19 virus spreads easily and exponentially multiple times compares to other viruses. It can be divided into four antigenic groups, HKU1, NL63, 229E and OC43. The case mortality rate of this pandemic is 1.68%, compared to other pandemics in their first outbreaks, including the great pandemic influenza (0.2%), SARS-CoV (10%), MERS-CoV (34%), and Ebola (50%). Laboratory findings related to COVID-19 include elevated levels of D-dimer, Alanine transaminase (ALT), LDH (lactate dehydrogenase), C-reactive protein (CRP), creatine kinase and prothrombin times. Conclusion: This comparison based review will help to understand the biology, potential risk and preventive measures of COVID-19 and provide cognizance about what we need to do against this pandemic which victimized more than 200 countries up to the present time.

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Attenuated Increases in Blood Pressure by Dynamic Resistance Exercise in Middle-Aged Men

Hypertension Research ◽

10.1291/hypres.31.1045 ◽

2008 ◽

Vol 31 (5) ◽

pp. 1045-1053 ◽

Cited By ~ 9

Author(s):

Hiroshi KAWANO ◽

Hitomi NAKAGAWA ◽

Sho ONODERA ◽

Mitsuru HIGUCHI ◽

Motohiko MIYACHI

Keyword(s):

Blood Pressure ◽

Resistance Exercise ◽

Dynamic Resistance ◽

Middle Aged

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Links between High-Sensitivity C-Reactive Protein and Pulse Wave Analysis in Middle-Aged Patients with Hypertension and High Normal Blood Pressure

Disease Markers ◽

10.1155/2019/2568069 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Ioana Mozos ◽

Daniela Jianu ◽

Cristina Gug ◽

Dana Stoian

Keyword(s):

Blood Pressure ◽

Vitamin D ◽

Pulse Wave ◽

Oxidized Ldl ◽

High Sensitivity ◽

Normal Blood Pressure ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Arterial Aging

Arterial stiffness and arterial age provide valuable prognostic cardiovascular information. The present study aimed at assessing the levels of vitamin D, high-sensitivity C-reactive protein (hsCRP), low-density lipoprotein cholesterol (LDL), and oxidized LDL (oxLDL) in a group of middle-aged hypertensive patients and their relationship with pulse wave velocity (PWV), central blood pressure, and early arterial aging (EAA), respectively. A total of 56 patients, aged 48±6 years, 57% males, with hypertension and high normal blood pressure (HNBP), were investigated using a Mobile-O-Graph, to assess central and peripheral blood pressure, PWV, and arterial age. Additionally, hsCRP, LDL, oxLDL, and 25-hydroxy vitamin D3 were assessed. PWV, 25-hydroxy vitamin D3, hsCRP, oxLDL, and LDL levels were 7.26±0.69 m/s, 25.99±11.17 microg/l, 0.48±0.44 mg/dl, 261.37±421 ng/ml, and 145.73±39.53 mg/dl, respectively. Significant correlations were obtained between oxLDL and pulse pressure amplification (rS=−0.347, p=0.028) and between hsCRP and LDL levels with PWV and EAA, respectively. ROC curve analysis revealed that hsCRP is a sensitive and specific predictor of EAA and increased PWV values. Concluding, vitamin D deficiency and increased hsCRP and LDL values are very common, and high oxidized LDL is related to pulse pressure amplification in patients with elevated blood pressure. Vitamin D level and high-sensitivity C-reactive protein and LDL provide valuable information in middle-aged hypertensive and HNBP patients related to arterial stiffness and early arterial aging, but only hsCRP is a sensitive predictor of EAA and PWV.

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