Association Between Elevated Liver Enzymes and C-Reactive Protein

Hypoxemia is a hallmark of coronavirus disease 2019 (COVID-19) severity. We sought to determine predictors of hypoxemia and related adverse outcomes among patients hospitalized with COVID-19 in the two largest hospitals in Jerusalem, Israel, from 9 March through 16 July 2020. Patients were categorized as those who developed reduced (<94%) vs. preserved (≥94%) arterial oxygen saturation (SpO2) within the first 48 h after arrival to the emergency department. Overall, 492 hospitalized patients with COVID-19 were retrospectively analyzed. Patients with reduced SpO2 were significantly older, had more comorbidities, higher body surface area (BSA) and body mass index (BMI), lower lymphocyte counts, impaired renal function, and elevated liver enzymes, c-reactive protein (CRP), and D-dimer levels as compared to those with preserved SpO2. In the multivariable regression analysis, older age (odds ratio (OR) 1.02 per year, p < 0.001), higher BSA (OR 1.16 per 0.10 m2, p = 0.003) or BMI (OR 1.05 per 1 kg/m2, p = 0.011), lower lymphocyte counts (OR 1.72 per 1 × 103/μL decrease, p = 0.002), and elevated CRP (1.11 per 1 mg/dL increase, p < 0.001) were found to be independent predictors of low SpO2. Severe hypoxemia requiring ventilatory support, older age, and pre-existing comorbidities, including underlying renal dysfunction and heart failure, were found to be significantly associated with in-hospital mortality. These findings suggest that assessment of predictors of hypoxemia early at the time of hospitalization with COVID-19 may be helpful in risk stratification and management.

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Een geriatrische patiënte met een perirectaal abces, pyleflebitis en multipele pyogene leverabcessen: een gevalsbespreking

Tijdschrift voor Geneeskunde ◽

10.47671/tvg.77.21.133 ◽

2021 ◽

Author(s):

K. VAN GEYT ◽

M. PETROVIC ◽

W. JANSSENS

Keyword(s):

Geriatric Patient ◽

Liver Enzymes ◽

C Reactive Protein ◽

Perirectal Abscess ◽

Reactive Protein ◽

Non Invasive ◽

Elevated Liver Enzymes ◽

Invasive Diagnostics ◽

Very High

A geriatric patient with a perirectal abscess, pylephlebitis and multiple pyogenic liver abscesses: a case-report. In this case study, an 86-year-old patient is presented with fever, anorexia and drowsiness, a very high C-reactive protein (CRP) level and elevated liver enzymes. Given the frailty of the patient, a non-invasive diagnostic approach was chosen. Initially, a pancreatic carcinoma with liver metastases was suspected, but the presence of positive blood cultures raised doubts about the initially suggested diagnosis. Ultimately, a perirectal abscess with Streptococcus intermedius bacteremia, pylephlebitis and multiple liver and pancreatic abscesses were diagnosed. After a course of 9 weeks of antibiotics, the patient's condition improved. The vague complaints in this geriatric patient and the lack of invasive diagnostics pose a challenge for the clinician in recognizing this disease.

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The Effect of Concurrent Training and Chlorogenic Acid Intake on Liver Enzymes and C-reactive Protein in Obese Women

Journal of Ardabil University of Medical Sciences ◽

10.29252/jarums.19.3.284 ◽

2019 ◽

Vol 19 (3) ◽

pp. 284-293

Author(s):

Lale Naderi ◽

Allahyar Arabmomeni ◽

◽

Keyword(s):

Chlorogenic Acid ◽

Liver Enzymes ◽

Concurrent Training ◽

Obese Women ◽

C Reactive Protein ◽

Reactive Protein ◽

Acid Intake

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Acute painless pancreatitis as an unusual presentation of leptospirosis in a low-incidence country

BMJ Case Reports ◽

10.1136/bcr-2020-234988 ◽

2020 ◽

Vol 13 (8) ◽

pp. e234988

Author(s):

Ami Schattner ◽

Ina Dubin ◽

Yair Glick ◽

Elizabeth Nissim

Keyword(s):

Acute Pancreatitis ◽

Serum Amylase ◽

Liver Enzymes ◽

Elevated Serum ◽

Kidney Injury ◽

C Reactive Protein ◽

Diagnostic Challenge ◽

Reactive Protein ◽

Animal Contact ◽

Low Incidence

A healthy, urban-dwelling man presented with lassitude, jaundice without increased liver enzymes or obstructive features on imaging, brief acute kidney injury, leucocytosis with near-normal C reactive protein and markedly increased serum amylase and lipase. Leptospirosis was not considered for 10 days because of the low incidence of the disease in the country, absent animal contact and physicians’ low index of suspicion. Presentation without fever and without the commonly associated abdominal pain, myalgia, headache, thrombocytopaenia or elevated serum creatine kinase added to the diagnostic challenge. Once an infectious cause of acute pancreatitis was contemplated, leptospirosis was immediately sought and diagnosed by PCR of urine and microscopic agglutination test, and he fully recovered on ceftriaxone. Physicians in countries with a low incidence of leptospirosis should be more aware of the possibility of the disease even when several key features such as fever or pain are missing and the patient has a rare infectious acute pancreatitis.

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Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients

Nutrition Research ◽

10.1016/j.nutres.2013.11.005 ◽

2014 ◽

Vol 34 (2) ◽

pp. 143-148 ◽

Cited By ~ 61

Author(s):

Faezeh Askari ◽

Bahram Rashidkhani ◽

Azita Hekmatdoost

Keyword(s):

Insulin Resistance ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Liver Enzymes ◽

High Sensitivity ◽

C Reactive Protein ◽

Nonalcoholic Fatty Liver ◽

Reactive Protein ◽

Therapeutic Benefits

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Intravenous Infusion of N-acetylcysteine in cirrhotic patients undergoing liver resection attenuates the postoperative increase in liver enzymes, C reactive protein and intercellular adhesion molecule 1. A randomized controlled trial

10.26226/morressier.58f5b030d462b80296c9e6a0 ◽

2017 ◽

Author(s):

Khaled Yassen

Keyword(s):

Randomized Controlled Trial ◽

Liver Resection ◽

Liver Enzymes ◽

Controlled Trial ◽

Intercellular Adhesion Molecule ◽

C Reactive Protein ◽

Intercellular Adhesion Molecule 1 ◽

Reactive Protein ◽

Randomized Controlled ◽

Cirrhotic Patients

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Effects of Long-Term Testosterone Therapy on Patients with “Diabesity”: Results of Observational Studies of Pooled Analyses in Obese Hypogonadal Men with Type 2 Diabetes

International Journal of Endocrinology ◽

10.1155/2014/683515 ◽

2014 ◽

Vol 2014 ◽

pp. 1-15 ◽

Cited By ~ 54

Author(s):

Ahmad Haider ◽

Aksam Yassin ◽

Gheorghe Doros ◽

Farid Saad

Keyword(s):

Blood Pressure ◽

Type 2 Diabetes ◽

Liver Enzymes ◽

Fasting Blood Glucose ◽

Glycated Haemoglobin ◽

C Reactive Protein ◽

Reactive Protein ◽

Obesity And Diabetes

To investigate effects of long-term testosterone (T) therapy in obese men with T deficiency (TD) and type 2 diabetes mellitus (T2DM), data were collected from two observational, prospective, and cumulative registry studies of 561 men with TD receiving T therapy for up to 6 years. A subgroup of obese hypogonadal men with T2DM was analyzed. Weight, height, waist circumference (WC), fasting blood glucose (FBG), glycated haemoglobin (HbA1c) blood pressure, lipid profile, C-reactive protein (CRP), and liver enzymes were measured. A total of 156 obese, diabetic men with T deficiency, aged 61.17 ± 6.18 years, fulfilled selection criteria. Subsequent to T therapy, WC decreased by 11.56 cm and weight declined by 17.49 kg (15.04%). Fasting glucose declined from 7.06 ± 1.74 to 5.59 ± 0.94 mmol/L (P<0.0001for all).HbA1cdecreased from 8.08 to 6.14%, with a mean change of 1.93%. Systolic and diastolic blood pressure, lipid profiles including total cholesterol: HDL ratio, CRP, and liver enzymes all improved (P<0.0001). Long-term T therapy for up to 6 years resulted in significant and sustained improvements in weight, T2DM, and other cardiometabolic risk factors in obese, diabetic men with TD and this therapy may play an important role in the management of obesity and diabetes (diabesity) in men with T deficiency.

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