Ethnicity, CVD Risk Factor Clustering and the Progression of Microvascular Disease: The Insulin Resistance and Atherosclerosis Study

P31 Ethnic disparities in cardiovascular disease (CVD) and end-stage renal disease exist in the US, with African Americans (AAs) and Hispanic Americans (HAs) being at greater risk compared to non-Hispanic whites (NHWs). This maybe related to variations in individual and/or clusters of CVD risk factors across ethnic groups. We have previously shown ethnic differences in cross-sectional analyses from the Insulin Resistance and Atherosclerosis Study (IRAS) data in the effect of CVD risk factor clustering, with AAs being more greatly affected for nephropathy risk, and NHWs being more affected for CVD. We examined the effect of CVD risk factor clustering on the 5-year progression of albuminuria, which itself is a known CVD risk factor. Data were analyzed from the IRAS study, a multi-center epidemiologic cohort study that included roughly similar numbers of persons with normal and impaired glucose tolerance and type 2 diabetes, at baseline and 5-year follow-up. Comparisons were made forAAs and NHWs (Oakland/LAclinics), and for HAs and NHWs (San Antonio/San Luis Valley clinics). Data were available on 1256 IRAS subjects on nephropathy progression status, of which about 10% progressed from normal, defined as albumin/creatinine ratio less than 30 mg/g, to microalbuminuria (ACR of ≥30 and < 300) or macroalbuminuria (ACR ≥300) or from microalbuminuria to macroalbuminuria. CVD risk factors (dyslipidemia, BMI, waist-hip ratio, PAI-1, hypertension, diabetes status) at baseline were dichotomized, and subjects were classified as having high (≥ risk factors) or low (< 3 risk factors) risk. Overall 30.9% of the sample were classified as high risk. After adjusting for age, gender, and baseline nephropathy status, risk factor clustering predicted nephropathy progression in both ethnic comparisons (OR 2.24, p< 0.001 in AAs/NHWs group; OR 2.81, p< 0.001 in the HAs/NHWs group). With risk status in the model, HAs were at no greater risk for progression compared to NHWs, but risk was about 80% greater for AAs compared to NHWs (p < 0.05). These data indicate a risk of nephropathy among AAs that extends beyond the traditional CVD risk factor clusters.

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Trends in cardiovascular disease risk factors by body mass index category among adults in England 2003-18: analysis of repeated cross-sectional national health surveys

10.1101/2020.09.02.20186619 ◽

2020 ◽

Cited By ~ 1

Author(s):

Shaun Scholes ◽

Linda Ng Fat ◽

Jennifer S Mindell

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Risk Factor ◽

Total Cholesterol ◽

Normal Weight ◽

Overweight And Obesity ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Risk Factor Prevalence

Objective. Favourable trends in cardiovascular disease (CVD) risk factors at the population level potentially mask differences within high- and low-risk groups. Data from annual, repeated cross-sectional surveys (Health Survey for England 2003-18) was used to examine trends in the prevalence of key CVD risk factors by body mass index (BMI) category among adults aged 16 years or older (n=115,860). Methods. Six risk factors were investigated: (i) current cigarette smoking; (ii) physical inactivity (<30 minutes of moderate-to-vigorous physical activity per week); (iii) drinking above recommended daily alcohol limits; (iv) hypertension (measured blood pressure ≥140/90mmHg or use of medicine prescribed for high blood pressure); (v) total diabetes (reported diagnosed or elevated glycated haemoglobin); and (vi) raised total cholesterol (≥5mmol/L). Age-standardised risk factor prevalence was computed in each four-year time period (2003-06; 2007-10; 2011-14; 2015-18) in all adults and by BMI category (normal-weight; overweight; obesity). Change in risk factor prevalence on the absolute scale was computed as the difference between the first and last time-periods, expressed in percentage points (PP). Results. Risk factor change varied by BMI category in a number of cases. Current smoking prevalence fell more sharply for normal-weight men (-8.1 PP; 95% CI: -10.3, -5.8) versus men with obesity (-3.8 PP; 95% CI: -6.2, -1.4). Hypertension remained at a stable level among normal-weight men but decreased among men with obesity (-4.1 PP; 95% CI: -7.1, -1.0). Total diabetes remained at a stable level among normal-weight adults, but increased among adults with obesity (men: 3.5 PP; 95% CI: 1.2, 5.7; women: 3.6 PP; 95% CI: 1.8, 5.4). Raised total cholesterol decreased in all BMI groups, but fell more sharply among women with obesity (-21 PP; 95% CI: -25, -17) versus their normal-weight counterparts (-16 PP; 95% CI: -18, -14). Conclusions. Relative to adults with normal weight, greater reductions in hypertension and raised total cholesterol among adults with overweight and obesity reflect at least in part improvements in screening, treatment and control among those at highest cardiovascular risk. Higher levels of risk factor prevalence among adults with overweight and obesity, in parallel with rising diabetes, highlight the importance of national prevention efforts to combat the public health impact of excess adiposity.

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Self-Reported Modifiable Risk Factors of Cardiovascular Disease among Seafarers: A Cross-Sectional Study of Prevalence and Clustering

Journal of Personalized Medicine ◽

10.3390/jpm11060512 ◽

2021 ◽

Vol 11 (6) ◽

pp. 512

Author(s):

Getu Gamo Sagaro ◽

Gopi Battineni ◽

Marzio Di Canio ◽

Francesco Amenta

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Cross Sectional Study ◽

Categorical Variables ◽

Modifiable Risk Factors ◽

Sectional Study ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Job Duration

Background: Cardiovascular diseases (CVD) are the major cause of work-related mortality from diseases onboard ships in seafarers. CVD burden derives mainly from modifiable risk factors. To reduce the risk factors and the burden of CVD onboard ships in seafarers, it is important to understand the up-to-date prevalence of modifiable risk factors. The primary purpose of this study was to assess the prevalence and clustering of self-reported modifiable CVD risk factors among seafarers. We have also explored the association between socio-demographic and occupational characteristics and reported modifiable CVD risk factor clustering. Materials and methods: A cross-sectional study was conducted among seafarers from November to December 2020 on board ships. In total, 8125 seafarers aged 18 to 70 were selected from 400 ships. Data were collected using a standardized and anonymous self-reported questionnaire. The prevalence value for categorical variables and mean differences for continuous variables were compared using chi-square and independent sample t-tests. Multinomial logistic regression models were performed to identify independent predictors for modifiable CVD risk factor clustering. Results: Out of a total of 8125 seafarers aged ≥18 years on selected vessels, 4648 seafarers volunteered to participate in the survey, with a response rate of 57.2%. Out of 4318 participants included in analysis, 44.7% and 55.3% were officers and non-officers, respectively. The prevalence of reported hypertension, diabetes, current smoking and overweight or obesity were 20.8%, 8.5%, 32.5%, and 44.7%, respectively. Overall, 40%, 20.9%, 6% and 1.3% of the study participants respectively had one, two, three and four modifiable CVD risk factors. Older age (51+ years) (odds ratio (OR): 3.92, 95% confidence interval (CI): 2.44–6.29), being non-officers (OR: 1.36, 95% CI: 1.09–1.70), job duration (10–20 years) (OR: 2.73, 95% CI: 2.09–3.57), job duration (21+ years) (OR: 2.60, 95% CI: 1.79–3.78), working 57–70 h per week (OR: 2.03, 95% CI: 1.65–2.49) and working 71+ h per week (OR: 3.08, 95% CI: 2.42–3.92) were independent predictors for at least two self-reported modifiable CVD risk factor clustering. Conclusion: The results of our study demonstrate that more than four in six (68.5%) seafarers aged between 19 and 70 years have at least one of the modifiable CVD risk factors. Therefore, CVD prevention and modifiable risk factors reduction strategies targeting high-risk groups should be designed and implemented on board ships.

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Association of Plasma Branched Chain Amino Acid with Biomarkers of Inflammation and Lipid Metabolism in Women

Circulation Genomic and Precision Medicine ◽

10.1161/circgen.121.003330 ◽

2021 ◽

Author(s):

Rikuta Hamaya ◽

Samia Mora ◽

Patrick R. Lawler ◽

Nancy R. Cook ◽

Paul M. Ridker ◽

...

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Health Study ◽

Cardiometabolic Health ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Blood Draw ◽

Isoleucine Leucine ◽

Cross Sectional ◽

Branched Chain

Backgrounds - Branched-chain amino acids (BCAAs; isoleucine, leucine and valine) correlate with insulin resistance and poor glucose control, which may in part explain associations between type 2 diabetes (T2D) and cardiovascular disease (CVD). However, the relationships of BCAAs with other cardiometabolic pathways, including inflammation and dyslipidemia, are unclear. We hypothesized that plasma BCAAs would correlate with multiple pathways of cardiometabolic dysfunction. Methods - We conducted a cross-sectional analysis among 19,472 participants (mean age=54.9 years, SD=7.2 years) in the Women's Health Study without a history of T2D, CVD, or cancer. We quantified the concentrations of individual biomarkers of inflammation and lipids, across quartiles of BCAAs, adjusting for age, smoking, BMI, physical activity, and other established CVD risk factors at blood draw. Results - Women in the highest vs. lowest quartiles of plasma BCAAs had higher inflammatory markers including high-sensitivity C-reactive protein (multivariable-adjusted means: 1.96 vs. 1.43 mg/L), fibrinogen (367 vs. 362 mg/dL), soluble intercellular cell adhesion molecule-1 (361 vs. 353 ng/mL), and glycoprotein acetylation (407 vs. 371 µmol/L) (p-trend=0.0002 for fibrinogen; p<0.0001 for others). Similarly for lipids, women with higher BCAAs had lower HDL-c (49.0 vs. 55.0 mg/dL), and higher triglycerides (143 vs. 114 mg/dL), LDL-c (133 vs. 124 mg/dL), and lipoprotein insulin resistance score (52.6 vs. 37.3) (all: p<0.0001). Similar associations with these biomarkers were observed in isoleucine, leucine and valine, respectively. Conclusions - Higher circulating BCAA concentrations are associated with adverse profiles of biomarkers of inflammation and dyslipidemia independent of established CVD risk factors, and thus may reflect poorer cardiometabolic health through multiple pathways.

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Cardiovascular risk factors are negatively associated with rheumatoid arthritis disease outcomes

Therapeutic Advances in Musculoskeletal Disease ◽

10.1177/1759720x20981217 ◽

2021 ◽

Vol 13 ◽

pp. 1759720X2098121

Author(s):

Kangping Cui ◽

Mohammad Movahedi ◽

Claire Bombardier ◽

Bindee Kuriya

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Risk Factor ◽

Disease Activity ◽

Activity Index ◽

Disease Activity Index ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Rheumatoid Arthritis Disease

Aims: Rheumatoid arthritis (RA) is associated with cardiovascular disease (CVD), but the influence of CVD risk factors on RA outcomes is limited. We examined if CVD risk factors alone are associated with RA disease activity and disability. Methods: We performed a cross-sectional analysis of participants in the Ontario Best Practices Research Initiative, RA registry. Patients were categorized into mutually exclusive CVD categories: (1) No established CVD and no CVD risk factors; (2) CVD risk factors only including ⩾1 of hypertension, dyslipidemia, diabetes, or smoking; or (3) history of established CVD event. Multivariable regression analyses examined the effect of CVD status on Disease Activity Score 28 (DAS28-ESR), Clinical Disease Activity Index (CDAI), and Health Assessment Questionnaire Disability Index (HAQ-DI) scores at baseline. Results: Of 2033 patients, 50% had at least 1 CVD risk factor, even in the absence of established CVD. The presence of ⩾1 CVD risk factor was independently associated with higher CDAI [β coefficient 1.59, 95% confidence interval (CI) 0.29–2.90, p = 0.02], DAS28-ESR (β coefficient 0.20, 95% CI 0.06–0.34, p = 0.01) and HAQ-DI scores (β coefficient 0.15, 95% CI 0.08–0.22, p < 0.0001). The total number of CVD risk factors displayed a dose response, as >1 CVD risk factor was associated with higher disease activity and disability, compared with having one or no CVD risk factors. Conclusion: CVD risk factors alone, or in combination, are associated with higher disease activity and disability in RA. This emphasizes the importance of risk factor recognition and management, not only to prevent CVD, but also to improve potential RA outcomes.

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Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study

BMC Cardiovascular Disorders ◽

10.1186/s12872-020-01826-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Svein Ivar Bekkelund

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Alanine Aminotransferase ◽

Maximum Level ◽

Glycated Haemoglobin ◽

Caucasian Population ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Serum Alanine Aminotransferase

Abstract Background High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population. Methods Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP). Results Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88–1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86–0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found. Conclusion This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies.

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Is night-time light intensity associated with cardiovascular disease risk factors among adults in early-stage urbanisation in South India? A cross-sectional study of the Andhra Pradesh Children and Parents Study

BMJ Open ◽

10.1136/bmjopen-2019-036213 ◽

2020 ◽

Vol 10 (11) ◽

pp. e036213

Author(s):

Tina Bonde Sorensen ◽

Robin Wilson ◽

John Gregson ◽

Bhavani Shankar ◽

Alan D Dangour ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Andhra Pradesh ◽

South India ◽

Early Stage ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Night Time ◽

Cross Sectional ◽

Children And Parents

ObjectivesTo explore associations of night-time light intensity (NTLI), a novel proxy for continuous urbanisation levels, with mean systolic blood pressure (SBP), body mass index (BMI), fasting serum low-density lipoprotein (LDL) and fasting plasma glucose (FPG), among adults in early-stage urbanisation in Telangana, South India.DesignCross-sectional analysis of the third wave of the Andhra Pradesh Children and Parents Study cohort.Setting28 villages representing a continuum of urbanisation levels, ranging from rural settlement to medium-sized town in Telangana, South India.ParticipantsData were available from 6944 participants, 6236 of whom were eligible after excluding pregnant women, participants younger than 18 years of age and participants missing data for age. Participants were excluded if they did not provide fasting blood samples, had implausible or missing outcome values, were medicated for hypertension or diabetes or had triglyceride levels invalidating derived LDL. The analysis included 5924 participants for BMI, 5752 participants for SBP, 5287 participants for LDL and 5328 participants for FPG.ResultsIncreasing NTLI was positively associated with mean BMI, SBP and LDL but not FPG. Adjusted mean differences across the range of village-level NTLI were 1.0 kg/m2 (95% CI 0.01 to 1.9) for BMI; 4.2 mm Hg (95% CI 1.0 to 7.4) for SBP; 0.3 mmol/L (95% CI −0.01 to 0.7) for LDL; and −0.01 mmol/L (95% CI −0.4 to 0.4) for FPG. Associations of NTLI with BMI and SBP were stronger in older age groups.ConclusionThe association of NTLI with cardiovascular disease (CVD) risk factors identify NTLI as a potentially important tool for exploring urbanisation-related health. Consistent associations of moderate increases in urbanisation levels with important CVD risk factors warrant prevention strategies to curb expected large public health impacts from continued and rapid urbanisation in India.

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Abstract P200: Elevated Triacylglycerols and Diacylglycerols Had Association With Increased Carotid Arterial Stiffness, Independent of Cvd Risk Factors, in Women With or at High Risk of HIV Infection

Circulation ◽

10.1161/circ.137.suppl_1.p200 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Renato Quispe ◽

Simin Hua ◽

Clary Clish ◽

Justin Scott ◽

Amy Deik ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Hiv Infection ◽

Carbon Number ◽

Nonpolar Lipid ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Arterial Distensibility ◽

Carotid Stiffness ◽

Carotid Arterial

Background: Metabolomics has provided new insights into mechanistic knowledge of CVD. However, this approach has limited use for studying arterial disease in high-risk women with and without HIV infection. Methods: Using liquid chromatography-tandem mass spectrometry, we profiled plasma levels of 114 cationic polar and 211 nonpolar lipid metabolites among 411 women (72% HIV+; 60% Black and 31% Hispanic) aged 35-50 from the Women’s Interagency HIV Study. Carotid arterial distensibility, a direct measure of carotid stiffness, was calculated from ultrasound measurements of the right common carotid artery diameter at systole and diastole and brachial artery pulse pressure measured. We performed partial least squares discriminant analysis (PLS-DA) to identify metabolite clusters associated with carotid stiffness (lowest vs. the other 3 quartiles of distensibility index). We used multivariate linear regression models to examine associations of individual metabolites with the distensibility index. Results: PLS-DA identified two major metabolite clusters associated with carotid stiffness. In the lipid metabolite cluster, triacylglycerols (TAGs 52:3, 52:4, 54:4), diacylglycerols (DAGs 36:2, 36:3) and sphingomyelins (16:1, 18:1, 18:2) were associated with decreased distensibility, while lysophosphatidylcholines (18:2, 20:5) were associated with increased distensibility. In the cationic polar metabolite cluster, urate, C4-OH carnitine, C5-DC carnitine, pseudouridine and 1-methyladenosine were associated with decreased distensibility. The associations of TAGs 52:3, 52:4, 54:4 and DAG 36:3 with carotid stiffness remained significant after further adjustment for conventional CVD risk factors ( Table ). No interaction by HIV infection was found. Conclusions: Among women with or at risk of HIV infection from predominantly race-ethnic minority groups, plasma TAGs and DAG of higher carbon number and double bond content are associated with carotid stiffness independent of conventional CVD risk factors.

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Abstract P284: The Association Of Oral Hypofunction And Increased Arterial Stiffness

Hypertension ◽

10.1161/hyp.78.suppl_1.p284 ◽

2021 ◽

Vol 78 (Suppl_1) ◽

Author(s):

Chisa Matsumoto ◽

Hirofumi Tomiyama ◽

Mari Matsuura ◽

Takayuki Nakai ◽

Daichi Chikazu ◽

...

Keyword(s):

Risk Factors ◽

Arterial Stiffness ◽

Subgroup Analysis ◽

Linear Regression Analysis ◽

Tongue Pressure ◽

Multivariate Linear Regression Analysis ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Swallowing Function ◽

Cross Sectional

Background: Frailty is associated with higher risk of cardiovascular disease (CVD) and mortality. Recently, oral hypofunction, a disease in which the oral function is complexly reduced not only by ageing but also by a variety of factors, is regarded as a major risk factor for frailty, as it develops malnutrition and sarcopenia. However, no studies have evaluated the association of oral hypofunction and arterial stiffness, a marker for CVD. Hypothesis: We hypothesized that subjects with oral hypofunction have increased arterial stiffness compared to those without oral hypofunction. Methods: Japanese subjects above 50 years old who underwent annual health checkup were enrolled in this cross-sectional study. Subjects with history of CVD and dementia were excluded. Arterial stiffness was evaluated by brachial-ancle pulse wave velocity (baPWV). Oral hypofunction was evaluated based on the guidance by the Japanese Association for Dental Science. Seven oral factors, oral hygiene, oral moisture, occlusal force, tongue-lip motor function, tongue pressure, masticatory function, and swallowing function were assessed. Oral hypofunction was diagnosed if more than 3 factors showed deterioration. The association of oral hypofunction and baPWV was evaluated by multivariate linear regression analysis adjusted for conventional CVD risk factors. We also performed subgroup analysis stratified by age. (<60, ≧60 years). Results: Among 148 subjects (mean age: 59±7 years), 34 subjects (23%) had oral hypofunction. BaPWV in subjects with oral hypofunction was significantly higher than subjects without oral hypofunction (mean baPWV: 1539±312 v.s. 1416±260cm/sec, p=0.02). However, after adjustment for CVD risk factors, oral hypofunction did not significantly associate with baPWV (β=46±49, p=0.35). On the other hand, in subgroup analysis, oral hypofunction was significantly associated with increased baPWV among subjects in subjects younger than 60 years old even after adjustment of CVD risk factors (β=135±67, p=0.046), but this association was not observed in subjects over 60s. Conclusion: Oral hypofunction was associated with increased arterial stiffness, especially in subjects younger than 60s. Further research on oral hypofunction and CVD is warranted.

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Neck circumference and clustered cardiovascular risk factors in children and adolescents: cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2017-016048 ◽

2017 ◽

Vol 7 (9) ◽

pp. e016048 ◽

Cited By ~ 10

Author(s):

José Castro-Piñero ◽

Alvaro Delgado-Alfonso ◽

Luis Gracia-Marco ◽

Sonia Gómez-Martínez ◽

Irene Esteban-Cornejo ◽

...

Keyword(s):

Risk Factors ◽

Body Composition ◽

Children And Adolescents ◽

Screening Tool ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Sectional Study ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional

ObjectiveEarly detection of cardiovascular disease (CVD) risk factors, such as obesity, is crucial to prevent adverse long-term effects on individuals’ health. Therefore, the aims were: (1) to explore the robustness of neck circumference (NC) as a predictor of CVD and examine its association with numerous anthropometric and body composition indices and (2) to release sex and age-specific NC cut-off values to classify youths as overweight/obese.DesignCross-sectional study.Setting23 primary schools and 17 secondary schools from Spain.Participants2198 students (1060 girls), grades 1–4 and 7–10.MeasuresPubertal development, anthropometric and body composition indices, systolic and diastolic blood pressure (SBP and DBP, respectively), cardiorespiratory fitness, blood sampling triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), glucose and inflammatory markers. Homoeostasis model assessment (HOMA-IR) and cluster of CVD risk factors were calculated.ResultsNC was positively correlated with all anthropometric and body composition indices. NC was negatively associated with maximum oxygen consumption (R2=0.231, p<0.001 for boys; R2=0.018, p<0.001 for girls) and positively associated with SBP, DBP, TC/HDL-c, TG, HOMA, complement factors C-3 and C-4, leptin, adiponectin and clustered CVD risk factor in both sexes (R2from 0.035 to 0.353, p<0.01 for boys; R2from 0.024 to 0.215, p<0.001 for girls). Moreover, NC was positively associated with serum C reactive protein, LDL-c and visfatin only in boys (R2from 0.013 to 0.107, p<0.05).ConclusionNC is a simple, low-cost and practical screening tool of excess of upper body obesity and CVD risk factors in children and adolescents. Paediatricians can easily use it as a screening tool for overweight/obesity in children and adolescents. For this purpose, sex and age-specific thresholds to classify children and adolescents as normal weight or overweight/obese are provided.

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Dinner consumption and cardiovascular disease risk factors among a nationally representative sample of Iranian adolescents: the CASPIAN-III Study

Journal of Cardiovascular and Thoracic Research ◽

10.15171/jcvtr.2019.24 ◽

2019 ◽

Vol 11 (2) ◽

pp. 138-146

Author(s):

Leila Azadbakht ◽

Fahime Akbari ◽

Mostafa Qorbani ◽

Mohammad Esmaeil Motlagh ◽

Gelayol Ardalan ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Representative Sample ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Cluster Sampling ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Nationally Representative

Introduction: This cross-sectional study aimed to assess the association between cardiovascular disease (CVD) risk factors and dinner consumption in a nationally representative sample of Iranian adolescents. Methods: The present study was conducted on 5642 adolescents aged 10-18 years old in 27 provinces in Iran. The subjects were included applying by multistage random cluster sampling. Participants who ate ≥5 dinners during a week were considered as a dinner consumer. Results: Among 5642 subjects, 1412 (25%) did not consume dinner. Dinner consumers were less likely to be overweight or obese (P < 0.001) and abdominally obese (P < 0.001) as well as to have an abnormal level of HDL-C (P = 0.02). Dinner skipper youths had a higher risk for overweight or obesity (odds ratio [OR]: 1.62; 95% CI: 1.39-1.89) and abdominal obesity (OR: 1.59; 95% CI: 1.36-1.85) which remained significant after adjusting confounding factors (P <0001). No relationship was observed between dinner consumption and the rest of the CVD risk factors, neither in crude nor in adjusted models. A higher proportion of dinner-consumer adolescents had no CVD risk factors in comparison to dinner-skipper subjects (31.1% vs. 28%). Conclusion: Eating dinner might be inversely associated with some CVD risk factors among Iranian adolescents. Further prospective studies will need to prove this theory.

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