Abstract P244: Relations Between Residential Fast-food Environment and Individual Risk of Cardiovascular Disease

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Ilonca Vaartjes ◽  
Ilonca Vaartjes ◽  
Maartje Poelman ◽  
Maartje Poelman

Background: The food environment has been hypothesized to influence cardiovascular diseases (CVD) such as hypertension and coronary heart disease (CHD). This study determines the relation between fast-food outlet density (FFD) and the individual risk for CVD, among a nationwide Dutch sample. Methods: After linkage of three national registers , a cohort of 2,472,004 adults (≥35 year), free from CVD at January 1 st 2009, and living at the same address for ≥15 years was constructed. Participants were followed for one year to determine incidence of CVD, including CHD, stroke and heart failure. FFD within 500m, 1000m and 3000m from residential addresses was related to CVD using logistic regression, stratifying models by degree of urbanisation and adjusting for age, sex, ethnicity, marital status, comorbidity, neighbourhood-level income and population density. Results: In urban areas, fully adjusted models indicated that the incidence of CVD and CHD was significantly higher within 500m buffers containing one or more fast food outlets compared to areas without outlets. An elevated FFD within 1000m was associated with a significantly increased incidence of CVD and CHD. Evidence was less pronounced for 3000m buffers, or for stroke and heart-failure incidence. Conclusions: Elevated FFD in the urban residential environment (≤1000m) was related with an increased incidence of CVD and CHD. To better understand how FFD is associated with CVD, future studies should account for a wider range of lifestyle and environmental confounders than was achieved in this study.

2018 ◽  
Vol 25 (13) ◽  
pp. 1397-1405 ◽  
Author(s):  
Maartje Poelman ◽  
Maciej Strak ◽  
Oliver Schmitz ◽  
Gerard Hoek ◽  
Derek Karssenberg ◽  
...  

Background The food environment has been hypothesized to influence cardiovascular diseases such as hypertension and coronary heart disease. This study determines the relation between fast-food outlet density (FFD) and the individual risk for cardiovascular disease, among a nationwide Dutch sample. Methods After linkage of three national registers, a cohort of 2,472,004 adults (≥35 years), free from cardiovascular disease at January 1st 2009 and living at the same address for ≥15 years was constructed. Participants were followed for one year to determine incidence of cardiovascular disease, including coronary heart disease, stroke and heart failure. Street network-based buffers of 500 m, 1000 m and 3000 m around residential addresses were calculated, while FFD was determined using a retail outlet database. Logistic regression analyses were conducted. Models were stratified by degree of urbanization and adjusted for age, sex, ethnicity, marital status, comorbidity, neighbourhood-level income and population density. Results In urban areas, fully adjusted models indicated that the incidence of cardiovascular disease and coronary heart disease was significantly higher within 500 m buffers with one or more fast-food outlets as compared with areas with no fast-food outlets. An elevated FFD within 1000 m was associated with an significantly increased incidence of cardiovascular disease and coronary heart disease. Evidence was less pronounced for 3000 m buffers, or for stroke and heart-failure incidence. Conclusions Elevated FFD in the urban residential environment (≤1000 m) was related to an increased incidence of cardiovascular heart disease and coronary heart disease. To better understand how FFD is associated with cardiovascular disease, future studies should account for a wider range of lifestyle and environmental confounders than was achieved in this study.


1997 ◽  
Vol 33 (4) ◽  
pp. 364-368 ◽  
Author(s):  
A Tidholm ◽  
H Svensson ◽  
C Sylven

A survival analysis was performed using the case records of 189 dogs, including 38 breeds, with congestive heart failure caused by dilated cardiomyopathy (DCM). Overall prognosis was poor, with survival rates of 17.5% at one year and 7.5% at two years. Prognosis in the individual case of DCM proved to be difficult to predict at the time of initial examination. Only three of 27 tested independent predictors of survival were identified. The most significant predictive variables were age at onset of clinical signs, followed by dyspnea and ascites (as noted on the physical examination).


2020 ◽  
pp. 1-20
Author(s):  
Laura A. van der Velde ◽  
Femke M. P. Zitman ◽  
Joreintje D. Mackenbach ◽  
Mattijs E. Numans ◽  
Jessica C. Kiefte-de Jong

Abstract Objective The current study aimed to explore the interplay between food insecurity, fast-food outlet exposure, and dietary quality in disadvantaged neighbourhoods. Design In this cross-sectional study, main associations between fast-food outlet density and proximity, food insecurity status and dietary quality were assessed using Generalized Estimating Equation analyses. We assessed potential moderation by fast-food outlet exposure in the association between food insecurity status and dietary quality by testing for effect modification between food insecurity status and fast-food outlet density and proximity. Setting A deprived urban area in the Netherlands. Participants We included 226 adult participants with at least one child below the age of 18 years living at home. Results Fast-food outlet exposure was not associated with experiencing food insecurity (fast-food outlet density: b=-0.026, 95%CI=-0.076; 0.024; fast-food outlet proximity: b=-0.003, 95%CI=-0.033; 0.026). Experiencing food insecurity was associated with lower dietary quality (b=-0.48 per unit increase, 95%CI=-0.94; -0.012). This association was moderated by fast-food outlet proximity (p-interaction=0.008), and stratified results revealed that the adverse effect of food insecurity on dietary quality was more pronounced for those with the nearest fast-food outlet located closer to the home. Conclusions Food insecurity but not fast-food outlet density is associated with dietary quality. However, the association between food insecurity and dietary quality may be modified by the food environment. These findings could inform policy-makers to promote a healthier food environment including less fast-food outlets, with particular emphasis on areas with high percentages of food insecure households.


2016 ◽  
pp. 45-49
Author(s):  
P.N. Veropotvelyan ◽  
◽  
I.S. Tsehmistrenko ◽  
N.P. Veropotvelyan ◽  
N.S. Rusak ◽  
...  

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.


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