Abstract 17260: Body Mass Index, Waist Circumference and the 6-Year Risk of Coronary Heart Disease in 708,544 Thai Men and Women: HCUR Study

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Parinya Chamnan ◽  
Weera Mahawanakul ◽  
Wichai Aekplakorn ◽  
Wannee Nitiyanant ◽  
Prasert Boongird ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Waist Circumference ◽  
Body Mass ◽  
Retrospective Cohort ◽  
Central Obesity ◽  
Men And Women ◽  
Chd Risk ◽  
Different Levels

Introduction: Body mass index (BMI) and waist circumference has been reported to have a positive association with risk of coronary heart disease (CHD) and their optimal levels have been proposed. However, the association was less well described in Asian population. Hypothesis: This study aimed to examine the risk of developing CHD across different levels of BMI and waist circumference in a large retrospective cohort of Thai general population. Methods: This retrospective cohort was derived from the linkage of 2006 health checks data with diagnostic information from electronic health records of 708,544 men and women aged 20 years and above residing in Ubon Ratchathani. We examined the incidence of CHD over 6 years of follow-up in individuals with different levels of BMI defined by the WHO Asia-Pacific cut-offs and central obesity defined as waist circumference higher than half of each individual’s height. Corresponding hazard ratios were computed using Cox proportional hazards regression. Results: Over 3,514,681 person-years, 2,562 CHD cases developed, an overall incidence of 0.73 (95%CI 0.70-0.76) per 1,000 person-years. BMI had a J-shape association with CHD risk, with those with a BMI of 20-22.4 kg/m2 showing the lowest CHD incidence. Waist circumference had a curvilinear relationship with CHD risk, with CHD risk starting to increase after waist circumference of 80 and 85 cm in women and men respectively. CHD risk increased with higher levels of BMI and waist circumference (Table 1). Compared to those with BMI of 20.0-22.9 kg/m 2 and without central obesity, those with BMI higher than 30 kg/m 2 and with and without central obesity had a 1.8 and 2.4 fold increased risk of CHD (Adjusted hazards ratio 1.80 (1.46-2.24) and 2.39 (1.38-4.13) respectively). Conclusions: Different levels of BMI and waist circumference conferred different CHD risk. Change in optimal cut-off of BMI and waist circumference for the Thai population should be considered.

scholarly journals Body mass index, waist circumference, and risk of coronary heart disease: A prospective study among men and women

2010 ◽  
Vol 4 (3) ◽  
pp. e171-e181 ◽  
Author(s):  
Alan J. Flint ◽  
Kathryn M. Rexrode ◽  
Frank B. Hu ◽  
Robert J. Glynn ◽  
Hervé Caspard ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Waist Circumference ◽  
Prospective Study ◽  
Body Mass ◽  
Men And Women ◽  
A Prospective Study

scholarly journals Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ahryoung Ko ◽  
Kyuwoong Kim ◽  
Joung Sik Son ◽  
Yu Jin Cho ◽  
Sang Min Park ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cancer Survivors ◽  
Body Mass ◽  
Proportional Hazards Model ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Cancer Site ◽  
Chd Risk

AbstractAssociation between body mass index (BMI) and coronary heart disease (CHD) in cancer survivors is not clearly established. This study analyzed the prediagnosis BMI-CHD association by examining 13,500 cancer survivors identified from the National Health Insurance Service-Health Screening Cohort from January 1, 2004 to December 31, 2009 including the patients who were free of cardiovascular disease at enrollment. The Cox proportional hazards model (adjusted for socioeconomic, health behavior, health status, and medical characteristics) was used for calculating hazard ratios (HR) and 95% confidence intervals (95% CI) for CHD in each prediagnosis BMI category among cancer survivors. Compared to cancer survivors with a prediagnosis BMI between 18.5 and 22.9 kg/m2, those with a prediagnosis BMI of 23.0–24.9 kg/m2 and ≥ 25.0 kg/m2 had significantly higher CHD risk (HR = 1.51; 95% CI: 1.13–2.01 and HR = 1.38; 95% CI: 1.04–1.84, respectively). Cancer survivors with a low prediagnosis BMI (< 18.5 kg/m2) also had significantly higher CHD risk (HR = 1.97; 95% CI: 1.20–3.24) compared to those with a BMI of 18.5–22.9 kg/m2. Similar associations were found after stratifying analyses based on first cancer site and sociodemographic and medical characteristic subgroups. Our study suggests that prediagnosis underweight among patients with cancer is a predictor of CHD risk.

scholarly journals Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258395
Author(s):  
Susanna Calling ◽  
Sven-Erik Johansson ◽  
Veronica Milos Nymberg ◽  
Jan Sundquist ◽  
Kristina Sundquist
Keyword(s):  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Life Course ◽  
Body Mass ◽  
Normal Weight ◽  
World Health ◽  
Chd Risk ◽  
Increased Risk ◽  
Overweight Or Obesity

Objective Obesity is a well-known risk factor for coronary heart disease (CHD), but there is little evidence on the effect of long-term trajectories of body mass index (BMI) over the life course. By using repeated assessments, the aim was to study the risk of CHD in adults during 38 years in different trajectories of BMI. Methods A sample of 2129 men and women, aged 20–59 years at baseline, took part in four repeated interviews between 1980 and 2005. Data on BMI, medical history, lifestyle and socioeconomy were collected. Based on the World Health Organization categories of BMI, life course trajectories of stable normal weight, stable overweight, stable obesity, increasing BMI and fluctuating BMI were created. The individuals were followed through national registers for first hospitalization of CHD (389 events) until the end of 2017, and Hazard Ratios (HRs) were calculated, adjusted for age, sex, socioeconomic factors, lifestyle factors and metabolic comorbidities. Results Stable normal weight in all assessments was the reference group. Those who had an increase in BMI from normal weight in the first assessment to overweight or obesity in later assessments had no increased risk of CHD, HR 1.04 (95% CI: 0.70–1.53). The HR for individuals with fluctuating BMI was 1.25 (0.97–1.61), for stable overweight 1.43 (1.03–1.98), for stable obesity 1.50 (0.92–2.55), and for stable overweight or obesity 1.45 (1.07–1.97), after full adjustments. Conclusion Having a stable overweight or obesity throughout adult life was associated with increased CHD risk but changing from normal weight at baseline to overweight or obesity was not associated with increased CHD risk. Prevention of obesity early in life may be particularly important to reduce CHD risk.

Coronary heart disease incidence in women by waist circumference within categories of body mass index

2013 ◽  
Vol 20 (5) ◽  
pp. 759-762 ◽  
Author(s):  
Dexter Canoy ◽  
Benjamin J Cairns ◽  
Angela Balkwill ◽  
F Lucy Wright ◽  
Jane Green ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Waist Circumference ◽  
Body Mass ◽  
Disease Incidence ◽  
Coronary Heart Disease Incidence

scholarly journals The N363S Polymorphism of the Glucocorticoid Receptor: Potential Contribution to Central Obesity in Men and Lack of Association with Other Risk Factors for Coronary Heart Disease and Diabetes Mellitus1

2001 ◽  
Vol 86 (5) ◽  
pp. 2270-2274 ◽  
Author(s):  
Mark G. Dobson ◽  
Christopher P. F. Redfern ◽  
Nigel Unwin ◽  
Jolanta U. Weaver
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Glucocorticoid Receptor ◽  
Body Mass ◽  
Central Obesity ◽  
Density Lipoprotein

Considerable evidence suggests that diabetes mellitus and hypertension are influenced by genetic factors. Studies in humans have associated glucocorticoid receptor (GR) polymorphisms with high blood pressure, insulin sensitivity, body mass index, increased visceral fat, and variations in tissue-specific steroid sensitivity. The N363S polymorphism of the GR results in an asparagine to serine amino acid substitution in a modulatory region of the receptor. Phosphorylation of serine residues in this region has been shown to enhance transactivation of GR responsive genes. The aim of this study was to investigate the association between the 363S allele and risk factors for coronary heart disease and diabetes mellitus in a population of European origin living in the northeast of the United Kingdom. Blood samples from 135 males and 240 females were characterized for 363 allele status. The overall frequency of the 363S allele was 3.0%, 23 heterozygotes (7 males and 16 females) but no 363S homozygotes were identified. The data show a significant association of the 363S allele with increased waist to hip ratio in males but not females. This allele was not associated with blood pressure, body mass index, serum cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein cholesterol levels, and glucose tolerance status. The results of this study suggest that this GR polymorphism may contribute to central obesity in men. Further studies are required to elucidate the properties of GR363S at a molecular level.

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