scholarly journals How do Red Blood Cells Dilate Blood Vessels?—Reply

2004 ◽  
Vol 95 (3) ◽  
Author(s):  
Daniel B. Kim-Shapiro ◽  
Rakesh P. Patel ◽  
Alan N. Schechter ◽  
Mark T. Gladwin ◽  
Richard O. Cannon ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Vessels ◽  
Blood Cells

scholarly journals Pengamatan histopatologis pulpa gigi M. nemestrina yang terpapar getah J. curcas

2008 ◽  
Vol 7 (1) ◽  
pp. 19
Author(s):  
Indrya Kirana Mattulada
Keyword(s):  
Red Blood Cells ◽  
Blood Vessels ◽  
Chronic Inflammation ◽  
Blood Cells ◽  
Chronic Condition ◽  
Acute Inflammation ◽  
Anti Inflammation

Tooth pain can be overcame by analgetics oraly or topically applied in the toothcavity. One of the topical analgetic is latex of J. Curcas. The purpose of this study wasto evaluate the anti inflammation effect of the latex of J. Curcas under histopathologicobservation. Twenty two teeth of M. Nemestrina were prepared until perforation,then applied the lyophilized latex of J. Curcas into the cavity and covered bytemporary filling.Eugenol was used as comparison. Evaluation was carried out after3, 6 and 24 hours. Monkeys were euthanized and the teeth were extracted. Antiinflammation effect was evaluated under histopathology observation. The result of thisstudy show red blood cells and acute inflammation were found under 3 and 6 hoursobservation, while odontoblastvacuolization cells and lysis of the blood vessels. Theconclusion was chronic inflammation occured might explain pulp pain relieved due tothe the chronic condition followed

Blood vessels and red blood cells preserved in dinosaur bones

1998 ◽  
Vol 180 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Roman Pawlicki ◽  
Maria Nowogrodzka-Zagórska
Keyword(s):  
Red Blood Cells ◽  
Blood Vessels ◽  
Blood Cells

scholarly journals Localisation of Lactate Transporters in Rat and Rabbit Placentae

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Nigel P. Moore ◽  
Catherine A. Picut ◽  
Jeffrey H. Charlap
Keyword(s):  
Red Blood Cells ◽  
Blood Vessels ◽  
Blood Cells ◽  
Opposite Polarity ◽  
Monocarboxylate Transporter ◽  
Sprague Dawley ◽  
Nucleated Red Blood Cells ◽  
Sprague Dawley Rats ◽  
New Zealand White Rabbits ◽  
Pyruvic Acids

The distribution of monocarboxylate transporter (MCT) isoforms 1 and 4, which mediate the plasmalemmal transport of l-lactic and pyruvic acids, has been identified in the placentae of rats and rabbits at different ages of gestation. Groups of three pregnant Sprague-Dawley rats and New Zealand White rabbits were sacrificed on gestation days (GD) 11, 14, 18, or 20 and on GD 13, 18, or 28, respectively. Placentae were removed and processed for immunohistochemical detection of MCT1 and MCT4. In the rat, staining for MCT1 was associated with lakes and blood vessels containing enucleated red blood cells (maternal vessels) while staining for MCT4 was associated with vessels containing nucleated red blood cells (embryofoetal vessels). In the rabbit, staining for MCT1 was associated with blood vessels containing nucleated red blood cells while staining for MCT4 was associated with vessels containing enucleated red blood cells. Strength of staining for MCT1 decreased during gestation in both species, but that for MCT4 was stronger than that for MCT1 and was consistent between gestation days. The results imply an opposite polarity of MCT1 and MCT4 across the trophoblast between rat and rabbit.

scholarly journals PO-277 Nitric oxide generation in red blood cells induced by exercise

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Zhenghui Zha ◽  
Yuli Zhang
Keyword(s):  
Nitric Oxide ◽  
Shear Stress ◽  
Red Blood Cells ◽  
Blood Vessels ◽  
Blood Cells ◽  
White Blood Cells ◽  
Pi3k Pathway ◽  
No Production ◽  
Hemodynamic Changes ◽  
Enzyme Source

Objective Vascular endothelial nitric oxide synthase (NOS) is considered to be the main enzyme source for NO production in blood vessels, and studies have shown that RBC may also express NOS and produce NO. The purpose of this study was to summarize the expression of NOS in vascular red blood cells caused by changes in hemodynamics, and to improve the bioavailability of NO, and to lay a theoretical foundation for exploring the mechanism of exercise to improve vasodilation. Methods A literature review method was used to analyze related studies on exercise and RBC-NOS published in recent years. Results Intravascular NO is one of the most important vascular signaling molecules, which has the function of relaxing blood vessels. NO is produced during the conversion of L-arginine into L-citrulline, which is mainly dependent on the regulation of vascular eNOS. RBC can express NOS under certain action, and RBC-NOS is mainly located on RBC membrane and cytoplasm; The regulatory mechanisms of RBC-NOS and eNOS have similarities and differences: RBC-NOS and eNOS are both dependent on Ca2+ regulation and phosphorylation of Serine 1177  via the PI3K pathway; however, since red blood cells do not have nuclei, endoplasmic reticulum and Golgi, they do not have other mechanisms of action of eNOS. Therefore, the vascular endothelium is not the only source of NO production. Red blood cells, white blood cells and platelets can produce NO. The amount of NO produced by red blood cells is significantly higher than that of white blood cells and platelets，it is another major source of NO production in blood vessels.The level of wall shear stress is the main determinant of NOS expression in blood vessels: On the one hand, exercise training can cause hemodynamic changes, increased shear stress, and induce changes in eNOS and RBC-NOS levels, increase NO bioavailability, and participate in the regulation of vasodilation.On the other hand, moderate-intensity exercise causes NO produced by RBC to increase red blood cell deformability and participate in vascular regulation. Conclusions 1.Erythrocyte is an enzyme source that relies on hemodynamics to release NO from the blood vessel wall. It is regulated by Ca2+ and phosphorylates ser1177 through the PI3K pathway to participate in the regulation of the body. 2.Hemodynamic changes caused by exercise training can simultaneously induce the expression of eNOS and RBC-NOS, increase the bioavailability of NO, and jointly mediate vasodilation.

Binding Analysis of a Novel Peptide to Plasmodium falciparum Knob-Associated Histidine Rich Protein (KAHRP)

2007 ◽  
Vol 1 (1) ◽  
Author(s):  
J. Preston ◽  
L. Zeng ◽  
C. G. Takoudis ◽  
X. Li ◽  
A. Chishti
Keyword(s):  
Plasmodium Falciparum ◽  
Amino Acid ◽  
Red Blood Cells ◽  
Blood Vessels ◽  
Real Time ◽  
Optical Sensor ◽  
Blood Cells ◽  
Specific Binding ◽  
Binding Interaction ◽  
The Real

Knob-associated histidine rich protein (KAHRP) is secreted by Plasmodium falciparum in infected red blood cells. This protein is required for the production of surface protrusions called knobs, which have been shown to be crucial for the adherence of P. falciparum-infected erythrocytes (Pf-IRBC) to the endothelia of small blood vessels. KP-AP, a 10-amino acid (AA) peptide (FITRANDTSK), binds specifically with KAHRP in preliminary studies. KP-AP is expected to disrupt knob formation and prohibit adherence of Pf-IRBC to blood vessels and greatly reduce the pathogenicity of the parasite. This paper describes an investigation into the binding interaction between biotinylated KP-AP (Biotin-AP) and a segment of KAHRP. ELISA and the real-time bio-interaction optical sensor, BIAcore are the methods of detection. The specific binding was confirmed with ELISA and the KD value was estimated to be 1.2 μM. Binding was not detected with BIAcore, most likely due to the reduced flexibility of Biotin-AP while immobilized on the sensor chip.

scholarly journals Effectiveness of Sansavieria trifasciata Extract Bracelet in Absorbing Carbon Monoxide (Co) in Cigarette Smoke

Jurnal Biota ◽  
1970 ◽  
Vol 5 (2) ◽  
pp. 96-103
Author(s):  
Gendis Siti Rahmawati ◽  
Resti Nuraeni ◽  
Lu’lu Robiatul Fajrin ◽  
Sistiana Windyariani
Keyword(s):  
Carbon Monoxide ◽  
Red Blood Cells ◽  
Experimental Method ◽  
Blood Vessels ◽  
Cigarette Smoke ◽  
Blood Cells ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Randomized Design ◽  
Completely Randomized Design

Carbon monoxide (CO) contained in cigarette smoke is a very strong poison, if it is smoked by the lungs it will be easier to bind hemoglobin, so that red blood cells will lack oxygen, which can cause damage to blood vessels. with the process of atherosclerosis (narrowing). Sansevieria trifasciata has the ability to absorb poisons such as CO. This study aims to determine the effectiveness of Sansevieria trifasciata leaf extract in absorbing CO contained in cigarette smoke and assessing the amount of CO absorbed by Sansevieria trifasciata leaf extract. The method used is a pure experimental method using a Completely Randomized Design (CRD) consisting of 3 different treatments and 3 repetitions. The results of the 3 treatments showed that P1 (Sanseviera trifasciata wet extract) had the ability to absorb CO an average of 12.67 ppm every 15 minutes, in contrast to P2 (ethanol extract of Sanseviera trifasciata) which absorbs CO. 91.11 ppm every 15 minutes P3 (ethanol extract and CMC leaves from Sansevieria trifasciata) has the ability to absorb CO by 37.89 ppm every 15 minutes. The highest absorption effectiveness was obtained by ethanol extract and bracelets containing ethanol extract with the addition of CMC.

scholarly journals Retinal Changes in Cerebral Malaria among Sudanese patient in Khartoum State, Sudan 2019

2020 ◽  
pp. 15-18
Author(s):  
Abbasher Hussien ◽  
Khabab Abbasher ◽  
Radi Tofaha Alhusseini ◽  
Mohammed Hamad Malik Al-Dar ◽  
Yousif F.O. Altayeb ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Red Blood Cells ◽  
Cerebral Malaria ◽  
Blood Vessels ◽  
Blood Cells ◽  
Neurological Manifestations ◽  
Cross Sectional ◽  
Infected Blood ◽  
Malarial Retinopathy ◽  
The Brain

Introduction: It is thought that Malaria parasites live in red blood cells and make them stick to the inside of small blood vessels, particularly in the brain and also the eye. The light-sensitive tissue in the eye is also affected because the parasites disrupt the supply of oxygen and nutrients These changes, known as malarial retinopathy, include white, opaque patches, whitening of the infected blood vessels, bleeding into the retina and swelling of the optic nerve. Objectives: Our study was aimed to demonstrate malarial retinopathy in patients presented with neurological manifestations of malaria. Methodology: A cross-sectional Hospital based study included all patients with malaria seen during the period between 1-1-2019 and 25-4-2019

scholarly journals THE PATHOGENESIS OF ERYTHROBLASTOSIS FETALIS

Blood ◽  
1949 ◽  
Vol 4 (11) ◽  
pp. 1249-1255 ◽  
Author(s):  
B. S. KLINE
Keyword(s):  
Red Blood Cells ◽  
Blood Vessels ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Maternal Blood ◽  
Fetal Blood ◽  
Fetal Circulation ◽  
Nucleated Red Blood Cells

Abstract The mechanism of transfer, in cases of erythroblastosis fetalis, of incompatible fetal red blood cells to the mother and of maternal blood with antibody to the fetus, was observed especially well in 2 cases in which the infants were born alive. The two placentas showed occlusion of peripheral blood vessels of many villi and trunks by agglutinated red blood cells and fibrin. Associated with the vascular thromboses, there were, in places, necrosis of the walls and of regional tissues with rupture and hemorrhage of fetal blood, containing numerous intact nucleated red blood cells, into regional intervillous spaces. Through the broken surfaces, adjacent maternal blood was in contact with the fetal circulation. A more accurate designation for "erythroblastosis fetalis" would be "transplacental erythrocytotoxic anemia."

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