Abstract 145: Is the Rate of Ischemic Stroke Incidence Changing Differentially Over Time for Women and Men?

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Jane C Khoury ◽  
Brett Kissela ◽  
Heidi Sucharew ◽  
Kathleen Alwell ◽  
Charles Moomaw ◽  
...  
Keyword(s):  
Age Groups ◽  
Population Based ◽  
Incidence Rates ◽  
Age And Gender ◽  
Stroke Incidence ◽  
Men And Women ◽  
Stroke Prevalence ◽  
And Gender ◽  
Gender Specific ◽  
Over Time

Background: A surge of midlife (age 55-64 years) stroke in women, and not in men, has previously been reported using prevalence data from NHANES. However it is not clear if this same finding would be seen within age- and gender-specific incidence rates of stroke. We sought to examine the incidence of ischemic (IS) stroke and the gender-specific trends over time in a population-based study of stroke epidemiology. Methods: Data from the population-based Greater Cincinnati and Northern Kentucky epidemiology of stroke study for adults (≥ 20 years) was used from three collection periods; 7/1993 to 6/1994, 1999, and 2005. We compared the IS stroke incidence rates in women versus men between the three study periods, in particular for the ages 35 to 65 years. Sex specific age, and race adjusted incidence rates and race adjusted, age and gender specific incidence rates were estimated and adjusted to the 2000 US population. Results: A total of 5166 incident IS strokes were identified: 1709 from 7/1993 to 6/1994, 1778 from 1999, and 1679 from 2005. These were 56% female, 18% black; mean age was 71.4 (13.7) years. Overall, IS stroke incidence declined in both women and men in 2005 compared to the previous time periods (p<0.01). However, there was a significant increase over time in stroke incidence seen in both men and women in the younger age groups in 2005, compared with 1993/94 (p<0.05). Conclusions: We found that stroke incidence is not changing differently over time for men and women. There has been an increase in IS stroke incidence in the young, but this is found in both men and women. The previously reported “surge” in middle-aged stroke prevalence may be related in part to increased rates of stroke in the young, with survival to middle-age, but our incidence findings do not explain the reported difference in prevalence found between women and men in the NHANES cohort.

scholarly journals Gender difference in the incidence of shingles

2004 ◽  
Vol 132 (1) ◽  
pp. 1-5 ◽  
Author(s):  
D. M. FLEMING ◽  
K. W. CROSS ◽  
W. A. COBB ◽  
R. S. CHAPMAN
Keyword(s):  
Herpes Simplex ◽  
Age Groups ◽  
Incidence Rates ◽  
Age Group ◽  
Age And Gender ◽  
Relative Risks ◽  
And Gender ◽  
Incident Cases ◽  
Gender Specific ◽  
Practice Network

We investigated age- and gender-specific incidence of shingles reported in a large sentinel practice network monitoring a defined population over the years 1994–2001. In total, 5915 male and 8617 female incident cases were studied. For each age group, we calculated the relative risk of females to males presenting with shingles. Incidence rates of chickenpox and herpes simplex were examined similarly. Shingles incidence was greater in females in each age group (except for 15–24 years). Relative risks (female to male) were greatest in age groups 45–64 years (1·48) and 0–14 years (1·43). There were no gender differences in the incidence of chickenpox except in the 15–24 years age group (female excess): for herpes simplex there were female excesses in all age groups. Gender-specific age-standardized incidence rates of shingles were calculated for each year and showed a consistent female excess in each of the 8 years (average annual excess 28%).

scholarly journals Population-Level Projections for Multiple Myeloma Patients By Line of Therapy in the USA

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 2-3
Author(s):  
Gena Kanas ◽  
Otavio Clark ◽  
Katie Keeven ◽  
Knar Nersesyan ◽  
Leah Sansbury ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Incidence Rates ◽  
Publicly Traded ◽  
Age And Gender ◽  
Combining Data ◽  
The Usa ◽  
And Gender ◽  
Line Of Therapy ◽  
Gender Specific ◽  
Over Time

Introduction: Treatment for multiple myeloma (MM) has evolved over time, leading to improved survival outcomes for patients. However, information on real world clinical practice, such as the proportion of patients receiving each treatment regimen or the number of patients eligible for a given line of therapy (LOT), is limited. The purpose of this analysis is to report the results of a patient epidemiology model for MM treatment by LOT in the USA. Methods: This study was a retrospective, population-based, secondary data analysis of MM in the USA combining data from the Surveillance, Epidemiology, and End Results (SEER) registry and physician survey results from the CancerMPact® (CMP) database. Age- and gender-specific incidence rates were obtained from SEER for all available years through 2016 using the ICD-O-3 histology codes of 9731 (solitary plasmacytoma of bone), 9732 (plasma cell myeloma), and 9734 (extraosseous plasmacytoma). Based on the observed trend in the historical incidence rates through 2016, the incidence rates were projected to 2025. These projected rates were multiplied by the respective age- and gender-specific USA population from the 2010 U.S. Census, moderate projection to calculate the estimated number of incident MM patients between 2020-2025. Complete prevalence was calculated using the National Cancer Institute's Complete Prevalence (ComPrev) software. Annual prevalent patients by LOT were defined as the number of MM patients who received a line therapy at any point in the given year, and who had not yet progressed to the next LOT. To calculate the number of unique patients during a given year who were on a specific LOT, the mean progression-free survival (PFS) of the LOT in months was calculated based on data from the 2018-2019 CMP Treatment Architecture (TA) physician surveys. The total estimate of MM patients on a LOT among prevalent patients was calculated using the annual estimate of patients initiating a line by year, divided by total months per year, then multiplied by the average PFS in months for that line. Results: Projected complete MM prevalence in the USA in 2020 was estimated at 144,922, further increasing to 162,339 by 2025. Projected unique MM patients by LOT in 2020 was estimated as 53,176 (1st LOT), 19,407 (2nd LOT), 6,481 (3rd LOT), 1,649 (4th LOT), and 426 (5th LOT) (refer to Table 1 for ranges). It is estimated the number of unique prevalent patients will increase over time for each line (total of 13% across 5 years). Conclusions: With different treatment options available, the choice of therapeutic approach for MM patients is an increasingly complex process. As more new anti-neoplastic agents are introduced and survival duration for patients with MM continues to increase with longer intervals between disease progression, patients are potentially able to receive multiple lines of therapy. In this study, the proportion of prevalent cases by line decreased with each additional LOT. The current study estimated overall lower proportions than previous studies for third line and beyond (Ruzafa 2016, Raab 2018). These differences can be attributed to the underlying assumptions and different methodologies used. The physicians responding to the TA survey are basing their responses on their own recall and clinical experience across all the multiple myeloma patients they treated over the past 6 months. Few published studies have reported on contemporary proportions of treated MM patients by LOT combining data from both registry sources and physician surveys in an epidemiology model. The results of this study show that incidence and prevalence by LOT for MM patients in the USA are estimated to increase between 2020-2025. While several factors can contribute to the increase of MM incidence and treated patients projected into the future, a key consideration is the underlying aging of the population (Vespa 2020). Between 2020-2025, the total incidence as well as the total unique patients treated by line increased substantially and the assumption is that this trend will continue. Funding: GSK (study: 213443). Disclosures Kanas: Kantar: Consultancy. Clark:Kantar: Consultancy, Current Employment, Honoraria. Keeven:Kantar: Consultancy, Current Employment. Nersesyan:Kantar: Consultancy, Current Employment. Sansbury:GSK: Current Employment, Current equity holder in publicly-traded company. Hoggea:GSK: Current Employment, Current equity holder in publicly-traded company.

scholarly journals Secular trends in the incidence and prevalence of gout in Denmark from 1995 to 2015: a nationwide register-based study

Rheumatology ◽  
2018 ◽  
Vol 58 (5) ◽  
pp. 836-839 ◽  
Author(s):  
Kristian Zobbe ◽  
Daniel Prieto-Alhambra ◽  
René Cordtz ◽  
Pil Højgaard ◽  
Jens Skøt Hindrup ◽  
...  
Keyword(s):  
Temporal Trends ◽  
Incidence Rates ◽  
Secular Trends ◽  
Annual Incidence Rate ◽  
Danish Population ◽  
Age And Gender ◽  
National Patient Registry ◽  
National Patient ◽  
And Gender ◽  
Gender Specific

Abstract Objective To investigate temporal trends in the incidence and prevalence of gout in the adult Danish population. Methods Using the nationwide Danish National Patient Registry, we calculated the number of incident gout patients (per 100 000 person-years) within each 1 year period from 1995 to 2015 and the prevalence of gout in 2000 and 2015. Further, we calculated age- and gender-specific incidence rates of gout from 1995 to 2015. Results We identified a total of 45 685 incident gout patients (72.9% males) with a mean age of 65 years (s.d. 16) at diagnosis. In both genders, an increase in age-standardized incidence rates was observed from 32.3/100 000 (95% CI 30.7, 33.9) in 1995 to 57.5/100 000 (95% CI 55.6, 59.5) in 2015 (P < 0.001). Similar trends were observed for 8950 cases diagnosed in rheumatology departments. We likewise observed an increase in the prevalence of gout from 0.29% (95% CI 0.29, 0.30) in 2000 to 0.68% (95% CI 0.68, 0.69) in 2015. Conclusions The annual incidence rate of gout increased by almost 80% in Denmark between 1995 and 2015. The prevalence increased by nearly 130% between 2000 and 2015. Reasons for this are unknown but may include an increase in risk factors (e.g. obesity, diabetes mellitus), longer life expectancy and increased awareness of the disease among patients and/or health professionals.

P5309Age and gender distributions of coronary artery calcium in the Dutch adult population: preliminary results of the ImaLife study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Xia ◽  
M Rook ◽  
G J Pelgrim ◽  
J N Van Bolhuis ◽  
P M A Van Ooijen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Reference Values ◽  
Coronary Artery Calcium ◽  
Adult Population ◽  
Age Groups ◽  
Population Based ◽  
Imaging Biomarkers ◽  
Dutch Population ◽  
Age And Gender ◽  
And Gender

Abstract Background Coronary artery calcium (CAC) scoring is a promising tool for cardiovascular risk classification. Population-based reference values are important for the clinical interpretation of CAC scores. Purpose To establish standards of CAC distributions by age and gender in an unselected Dutch population, which can be used to determine reference values. Methods ImaLife (Imaging in Lifelines) is a computed tomography (CT) based substudy of the Lifelines cohort, with a primary aim to establish reference values of imaging biomarkers for early stages of coronary artery disease in adults (above 45 years old). In total, 12,000 participants will be enrolled from an unselected adult population in the northern Netherlands for CAC scoring with third generation dual-source CT. CAC is quantified with dedicated commercial software using the Agatston method. Results Included so far were 3,702 participants (57.5% females, mean age 54 years, range 45–82 years). CAC was present in 39.2% of participants, with a higher prevalence of CAC in men (55.3%) than in women (27.3%). CAC scores increased with increasing age in both genders. The percentiles of CAC scores by age and gender groups are summarized in the table. Agatston CAC score percentiles by age and gender Percentiles Women – Age, years Men – Age, years 45–49 50–54 55–59 60–64 65∼ 45–49 50–54 55–59 60–64 65∼ N 505 634 719 260 10 355 473 543 185 18 25th 0 0 0 0 0 0 0 0 1 75 50th 0 0 0 0 4 0 1 6 22 556 75th 0 0 6 33 386 6 21 72 129 751 90th 4 26 77 120 1037 49 154 242 500 1803 Conclusion This preliminary result presents CAC distribution by age and gender in a middle-aged unselected Dutch population. Compared with the Heinz Nixdorf Recall study, CAC scores in our cohort for both genders were lower in the 5-year age groups between 45 and 64 years. Based on the overall data, expected within 2 years, reference values of CAC for the Dutch population can be established.

scholarly journals Differences in drinking patterns between men and women in Brazil

2011 ◽  
Vol 33 (4) ◽  
pp. 367-373 ◽  
Author(s):  
Cynthia C Wolle ◽  
Marcos Sanches ◽  
Monica L Zilberman ◽  
Raul Caetano ◽  
Marcos Zaleski ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Binge Drinking ◽  
Negative Binomial ◽  
Age Groups ◽  
Negative Binomial Regression ◽  
Treatment Programs ◽  
Drinking Patterns ◽  
Age And Gender ◽  
Men And Women ◽  
And Gender

OBJECTIVE: To examine sex differences in alcohol consumption according to age groups, and to assess gender and age effects on several aspects of alcohol consumption patterns. METHOD: Based on a Brazilian nationwide representative sample (n = 3,007), we analysed the differences in drinking patterns between genders. We also assessed the effects of gender, age, and gender by age interaction for alcohol consumption dimensions (frequent drinking, usual intake, binge drinking, and frequent binge drinking), using logistic and negative binomial regression models. RESULTS: Gender, age, and gender by age interaction had significant effects on the predictive models for all studied drinking patterns, except for the 'usual' dosage. The effect of gender on drinking patterns varies with age. While gender has a greater effect in older age groups, the difference between men and women decreased in the younger age groups. CONCLUSIONS: Gender convergence regarding alcohol use is a trend that might be influenced by environmental factors and should be addressed in prevention and treatment programs, as well as in public health policies.

Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument

2012 ◽  
Vol 50 (5) ◽  
Author(s):  
Peter Ridefelt ◽  
Mattias Aldrimer ◽  
Per-Olof Rödöö ◽  
Frank Niklasson ◽  
Leif Jansson ◽  
...  
Keyword(s):  
Clinical Chemistry ◽  
Population Based ◽  
Reference Intervals ◽  
Healthy Children ◽  
Age And Gender ◽  
Sodium Potassium ◽  
Daycare Centers ◽  
And Gender ◽  
Gender Specific ◽  
Abbott Architect

AbstractReference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete.Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid.Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles.The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.

scholarly journals Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study

2020 ◽  
Author(s):  
Peng Shi ◽  
Xiaobo Zhang ◽  
Lijuan Liu ◽  
Liangfeng Tang ◽  
Jing Li ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Respiratory Infections ◽  
Age Groups ◽  
Childhood Mortality ◽  
Teaching Hospitals ◽  
Annual Growth Rate ◽  
Age And Gender ◽  
Outpatient Visits ◽  
And Gender ◽  
Gender Specific

Abstract Background: Respiratory infections are one of three leading causes of childhood mortality, and worldwide increase and recent plateau in childhood asthma has been reported. However, data on trends of respiratory diseases over long period of time is limited. This study aimed to determine the trends of respiratory disease outpatient visits (ROVs) and diagnoses (RODs) in one of the largest children’s teaching hospitals in China between 2009 and 2018. Methods: A retrospective study based on routine administrative data was designed and implemented according to the RECORD statement. Demographic details and diagnoses of the outpatients <18 years visiting the respiratory department of the hospital were extracted from the Hospital Information System. Age- and gender-specific trends were illustrated by calculating average annual growth rate (AAGR) for ROVs and comparing change of proportion for different RODs over time. Results: There were 698054 ROVs from 285574 children (40.4% female). AAGR of ROVs was 15.2%. Children aged 4 to < 7 years had a faster increase than other age groups. Bronchitis (27.6%), pneumonia (18.5%), pneumonia affecting other systems (18.4%), asthma and status asthmaticus (10.7%), and vasomotor and allergic rhinitis (9.2%) accounted for 84.4% of all RODs. The proportion of bronchitis decreased across years, with the concomitant increasing trend in the proportion of pneumonia. Age-specific trend in diagnoses showed greater proportion of asthma in all visits for the children aged 7 to < 18 years than younger children. Gender-specific trend in diagnoses showed the proportion of asthma was greater for males but the AAGR was greater for females. Conclusion: The persistent upward trend in ROVs was observed among children at different ages and a gender difference was also seen. In contrast to what has been reported, burden of asthma and allergies diseases continues to increase locally.

scholarly journals Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016

2021 ◽  
Vol 27 ◽  
Author(s):  
Lilla Tamási ◽  
Krisztián Horváth ◽  
Zoltán Kiss ◽  
Krisztina Bogos ◽  
Gyula Ostoros ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Age Groups ◽  
Age Group ◽  
Lung Cancer Incidence ◽  
Age And Gender ◽  
Female Population ◽  
Incidence And Mortality ◽  
Icd 10 ◽  
And Gender ◽  
Gender Specific

Objective: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungary based on a retrospective analysis of the National Health Insurance Fund database.Methods: This longitudinal study included patients aged ≥20 years with LC diagnosis (ICD-10 C34) between January 1, 2011 and December 31, 2016. Patients with different cancer-related codes 6 months before or 12 months after LC diagnosis or having any cancer treatment other than lung cancer protocols were excluded.Results: Lung cancer incidence and mortality increased with age, peaking in the 70–79 age group (375.0/100,000 person-years) among males, while at 60–69 age group for females (148.1/100,000 person-years). The male-to-female incidence rate ratio reached 2.46–3.01 (p &lt; 0.0001) among the 70–79 age group. We found 2–11% decrease in male incidence rate at most age groups, while a significant 1–3% increase was observed in older females (&gt;60) annually during the study period.Conclusion: This nationwide epidemiology study demonstrated that LC incidence and mortality in Hungary decreased in younger male and female population, however we found significant increase of incidence in older female population, similar to international trends. Incidence rates peaked in younger age-groups compared to Western countries, most likely due to higher smoking prevalence in these cohorts, while lower age LC incidence could be attributed to higher competing cardiovascular risk resulting in earlier mortality in smoking population.

Age and Gender Patterns of Sport Involvement among the Swiss Labor Force

1996 ◽  
Vol 13 (3) ◽  
pp. 274-287 ◽  
Author(s):  
Markus Lamprecht ◽  
Hanspeter Stamm
Keyword(s):  
Labor Force ◽  
Leisure Time ◽  
Age Groups ◽  
Age And Gender ◽  
Time Activity ◽  
Men And Women ◽  
Gender And Age ◽  
New Meanings ◽  
Gender Patterns ◽  
And Gender

Under the influence of the Sport for All movement the sport system in Switzerland has changed. Sport has become a leisure-time activity for an increasing number of people and has gained new meanings and forms. Many traditional limitations to participation appear to have been removed. By focusing on gender and age, this study, based on a survey of 1,103 employees, explores the extent to which particularisms and inequalities in contemporary recreational Swiss sport still exist. Although the involvement in sport by men and women, and involvement of different age groups, are quite similar in terms of frequency, their forms and meanings remain different. Using correspondence analysis we identify different sports fields and different sporting patterns by gender and age in terms of motives, places, and activities.

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