Abstract 62: Recovery-based Prediction of Who Is Using a G-tube at 6 Weeks Post-stroke

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Andria L Ford ◽  
Christopher Leon-Guerrero ◽  
Jasmin Chua ◽  
Lynda Loehr ◽  
David Carpenter ◽  
...  
Keyword(s):  
Speech Therapy ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Tube Placement ◽  
Icu Admission ◽  
Post Stroke ◽  
Standard Clinical Practice ◽  
Point G ◽  
Dysphagic Patients

Background: Decision-making regarding gastrostomy tube (G-tube) placement prolongs hospital stay in the inpatient stroke setting. Studies have predicted who receives G-tube placement at discharge, but have not assessed which factors predict who is actually using a G-tube long-term by assessing dysphagia recovery and G-tube needs in follow-up. Methods: Stroke patients from an inpatient stroke service were prospectively recruited if dysphagia was identified on the clinical speech therapy dysphagia test, defined as Mann Assessment of Swallowing Ability (MASA) score < 178. Variables associated with dysphagia were prospectively collected. G-tubes were placed in patients according to standard clinical practice based on speech therapy recommendations and family discussion. Follow-up included a 6 week swallowing quality of life survey (SWAL-QOL, 12 items including if a G-tube is currently being used). Univariate predictors of G-tube use at 6 weeks were assessed allowing calculation of a “G-tube Score” for prediction of who required a G-tube at 6 weeks. Score performance was measured by receiver operating characteristic (ROC) curves and area under the curve (AUC). Results: Of 146 dysphagic patients (median NIHSS=15), 31% were discharged with a G-tube. Of those completing 6 week SWAL-QOL (N=61), 26% of patients who had received a G-tube, no longer needed a G-tube. Univariate predictors of needing a G-tube included: age ≥ 70 (p=0.017), NIHSS ≥ 18 (p=0.006), ICU admission (p=0.007), respiratory failure requiring intubation (p=0.001), and MASA score < 110 (p<0.0001). 4 and 5 point G-tube scores performed well in predicting 6 week G-tube needs (AUCs 0.88 and 0.92, respectively). The optimal cut-off for both scores, preserving sensitivity and maintaining specificity, was a score of 2 points (Fig). Conclusion: Carrying 2 of the following early factors: age ≥ 70, NIHSS ≥ 18, ICU admission, and intubation, yields a high likelihood of requiring a G-tube beyond 6 weeks post-stroke.

Ambulant erworbene Pneumonie: Die Mortalität nachhaltig senken

2020 ◽  
Vol 8 (5) ◽  
pp. 252-253
Author(s):  
Stefan Krüger
Keyword(s):  
Operating Characteristic ◽  
Distress Syndrome ◽  
Area Under The Curve ◽  
Scoring Systems ◽  
Roc Curves ◽  
Community Acquired Pneumonia ◽  
Ambulant Erworbene Pneumonie ◽  
Icu Admission ◽  
Failure Assessment

Background: The study aimed to investigate the predictive value of the quick sequential organ failure assessment (qSOFA) for clinical outcomes in emergency patients with community-acquired pneumonia (CAP). Methods: A total of 742 CAP cases from the emergency department (ED) were enrolled in this study. The scoring systems including the qSOFA, SOFA and CURB-65 (confusion, urea, respiratory rate, blood pressure and age) were used to predict the prognostic outcomes of CAP in ICU-admission, acute respiratory distress syndrome (ARDS) and 28-day mortality. According to the area under the curve (AUC) of the receiver operating characteristic (ROC) curves, the accuracies of prediction of the scoring systems were analyzed among CAP patients. Results: The AUC values of the qSOFA, SOFA and CURB-65 scores for ICU-admission among CAP patients were 0.712 (95%CI: 0.678–0.745, P < 0.001), 0.744 (95%CI: 0.711–0.775, P < 0.001) and 0.705 (95%CI: 0.671–0.738, P < 0.001), respectively. For ARDS, the AUC values of the qSOFA, SOFA and CURB-65 scores were 0.730 (95%CI: 0.697–0.762, P < 0.001), 0.724 (95%CI: 0.690–0.756, P < 0.001) and 0.749 (95%CI: 0.716–0.780, P < 0.001), respectively. After 28 days of follow-up, the AUC values of the qSOFA, SOFA and CURB-65 scores for 28-day mortality were 0.602 (95%CI: 0.566–0.638, P < 0.001), 0.587 (95%CI: 0.551–0.623, P < 0.001) and 0.614 (95%CI: 0.577–0.649, P < 0.001) in turn. There were no statistical differences between qSOFA and SOFA scores for predicting ICU-admission (Z = 1.482, P = 0.138), ARDS (Z = 0.321, P = 0.748) and 28-day mortality (Z = 0.573, P = 0.567). Moreover, we found no differences to predict the ICU-admission (Z = 0.370, P = 0.712), ARDS (Z = 0.900, P = 0.368) and 28-day mortality (Z = 0.768, P = 0.442) using qSOFA or CURB-65 scores. Conclusion: qSOFA was not inferior to SOFA or CURB-65 scores in predicting the ICU-admission, ARDS and 28-day mortality of patients presenting in the ED with CAP.

scholarly journals A novel predictor of clinical progression in patients on active surveillance for prostate cancer

2019 ◽  
Vol 13 (8) ◽  
Author(s):  
Guan Hee Tan ◽  
Antonio Finelli ◽  
Ardalan Ahmad ◽  
Marian Wettstein ◽  
Alexandre Zlotta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Active Surveillance ◽  
Cox Regression ◽  
Area Under The Curve ◽  
Progression Free Survival ◽  
Roc Curves ◽  
Standard Of Care ◽  
Low Risk ◽  
Clinical Progression

Introduction: Active surveillance (AS) is standard of care in low-risk prostate cancer (PC). This study describes a novel total cancer location (TCLo) density metric and aims to determine its performance in predicting clinical progression (CP) and grade progression (GP).     Methods: This was a retrospective study of patients on AS after confirmatory biopsy (CBx). We excluded patients with Gleason ≥7 at CBx and <2 years follow-up. TCLo was the number of locations with positive cores at diagnosis (DBx) and CBx. TCLo density was TCLo / prostate volume (PV). CP was progression to any active treatment while GP occurred if Gleason ≥7 was identified on repeat biopsy or surgical pathology. Independent predictors of time to CP or GP were estimated with Cox regression. Kaplan-Meier analysis compared progression-free survival curves between TCLo density groups. Test characteristics of TCLo were explored with receiver operating characteristic (ROC) curves.     Results: We included 181 patients who had CBx between 2012-2015, and met inclusion criteria. The mean age of patients was 62.58 years (SD=7.13) and median follow-up was 60.9 months (IQR=23.4). A high TCLo density score (>0.05) was independently associated with time to CP (HR 4.70, 95% CI: 2.62-8.42, p<0.001), and GP (HR 3.85, 95% CI: 1.91-7.73, p<0.001). ROC curves showed TCLo density has greater area under the curve than number of positive cores at CBx in predicting progression.     Conclusion: TCLo density is able to stratify patients on AS for risk of CP and GP. With further validation, it could be added to the decision-making algorithm in AS for low-risk localized PC.

scholarly journals Efeitos da Terapia da Fala em Pacientes Internados com Disfagia Pós-Acidente Cerebrovascular: Revisão Sistemática de Estudos Observacionais

2017 ◽  
Vol 30 (12) ◽  
pp. 870 ◽  
Author(s):  
Joice Santos Andrade ◽  
Wagner Walter Oliveira de Jesus Souza ◽  
Luiz Renato Paranhos ◽  
Danielle Ramos Domenis ◽  
Carla Patrícia Hernandez Alves Ribeiro César
Keyword(s):  
Early Intervention ◽  
Recovery Time ◽  
Speech Therapy ◽  
Oropharyngeal Dysphagia ◽  
Control Group ◽  
Loss To Follow Up ◽  
Post Stroke ◽  
Swallowing Rehabilitation ◽  
Hospital Bed

Introduction: Since dysphagia may be one of the brain post-stroke consequences, the objective of this study was to analyze the average recovery time of patients with cerebrovascular accident and dysphagia subjected to speech therapy in a hospital bed.Material and Methods: Systematic review performed following the ‘Preferred Reporting Items is Systematic Reviews and MetaAnalyses’ instructions. The search was performed in different electronic databases, without restriction of time and language. The studies were evaluated regarding their methodological quality.Results: Of 5671 titles, five studies were included. 176 patients with stroke and dysphagia were obtained (aged between 22 and 91 years old – average: 68.95), with no preference regarding gender. Improvement occurred in 84.26% of the subjects and the recovery time was between one and ninety days (average: 22 days). Randomization, blinding, loss to follow-up and withdrawal were not performed with control group in any study.Discussion: The success of rehabilitation of oropharyngeal dysphagia as a post-stroke sequela will depend on the extent, location of the neurological lesion and early intervention in the hospital bed. Despite the recognition of health professionals about the importance of swallowing rehabilitation for these patients, there is a lack of studies that support an evidence-based practice, although the results point to improvements in this regard.Conclusion: Speech therapy in hospital bed in post-stroke hospitalized patients with dysphagia seems to bring satisfactory results in the short-term, revealing the importance of diagnosis and early intervention in these cases.

scholarly journals Laboratory Predictors for COVID-19 ICU Admissions in a Caribbean Territory.

2020 ◽  
Author(s):  
Chavin Gopaul ◽  
Dale Ventour ◽  
Davlin Thomas
Keyword(s):  
Univariate Analysis ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Good Test ◽  
Icu Patients ◽  
High Odds ◽  
Icu Admission ◽  
Admission Data ◽  
Significant Area ◽  
Life Threatening

Abstract Introduction. Understanding the symptoms associated with COVID-19 cases that require intensive care unit (ICU) attention is important in management of the life threatening case of the disease. Method : This study was carried out with the aim of determining the laboratory indicators of ICU admission. Data from 126 COVID-19 patients (ICU patients, n = 18, Non-ICU, n = 98) were analyzed from a Caribbean Territory.Results: The median age for the non-ICU patients was 59.0 (IQR = 23.5) years while the ICU patients had a median age of 62.5 (IQR = 17.5). The univariate analysis indicted that laboratory indicators that were significantly associated with ICU admission included WBC (P = 0.037), lymphocyte (P = 0.016), LDH (P = 0.002), AST (P = 0.005) and CRP (P = 0.0001). However, multivariate analysis that included WBC, neutrophil, lymphocyte, PLT, AST, LDH, ALT, and CRP indicated that only AST was associated with high odds of patients being admitted to ICU (OR .002, 95% CI 0.000-.004, P = 0.017). Statistically significant area under the curve (AUC) were obtained for Neutrophil (AUC = 0.704, P = 0.007), CRP (AUC = 0.81, p= 0.00) and LDH (AUC=0.766, P= 0.00) and AST (AUC= 0.729, P= 0.003). Conclusion: The findings indicate that neutrophils, AST and LDH’s ROC curves are good tests while CRP curve is a very good test. However, lymphocyte curve is a poor test for determining COVID-19 patient for ICU admission. Neutrophil, AST, LDH and CRP are suitable predictors of COVID-19 patients that should receive ICU care

scholarly journals Reading the Future

2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0002
Author(s):  
Ashlee MacDonald ◽  
Jeff Houck ◽  
Judith Baumhauer
Keyword(s):  
Hallux Valgus ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Measurement Information ◽  
Foot And Ankle ◽  
Assessment Scores ◽  
Operative Outcomes ◽  
Patient Reported ◽  
D Values

Category: Bunion, Midfoot/Forefoot Introduction/Purpose: Hallux valgus is a common condition of the foot with 4.4 million patients seeking care yearly for this condition. A previous study suggested specific pre-operative cut-off scores based on Patient Reported Outcomes Measurement Information System (PROMIS) physical function (PF), pain interference (PI), and depression (D) values could predict post-operative outcomes in foot and ankle surgery. Though hallux valgus correction, among other procedures, were identified as one of the most common surgeries in the previous study, specific conditions were not considered separately. The purpose of this study was to evaluate the validity of applying a published comprehensive pre-surgical PROMIS profile of PF, PI and D to patients undergoing bunionectomy surgery. Methods: PROMIS scores were prospectively obtained from patients evaluated in a specialty foot and ankle clinic between February 2015 and November 2016. Using ICD-9/10 and CPT codes, a total of 65 patients with hallux valgus who underwent a bunionectomy by a single surgeon were identified. Those with less than two-month follow-up, multiple procedures during the follow-up period, and incomplete PROMIS assessment scores were excluded, resulting in 42 patients. Using pre-operative scores and scores at the last follow-up visit, minimally clinically important differences (MCID), receiver operating characteristic (ROC) curves, and area under the curve (AUC) were obtained to determine if pre-operative PROMIS scores predicted achieving MCID with 95% specificity or failing to achieve a MCID with 95% sensitivity. New cut-off values were then compared to the previous study. Results: The AUC for PF (p=0.01) and Mood (p=0.03) were significant. However, PI AUC was not significant (p=0.14). The PF cut off for 95% specificity of exceeding MCID was 39.6 and 50.2 for 95% sensitivity for failing to achieve MCID. The D cut off for 95% specificity of exceeding MCID was 39.4 and 58.1 for 95% sensitivity for failing to achieve MCID. Patients below the 50.2 threshold (n=27) had significantly greater improvements on PF (2.3 95% CI 0.5 to 4.3) and PI (-3.8 95% CI -6.9 to -0.7) but not D. Patients above the 50.2 cut off (n=15) were significantly worse on PF (-7.3 95% CI -12.0 to -2.7) at this short follow up and were statistically unchanged on PI and D. Conclusion: This data confirms that pre-surgical PROMIS PF and Depression scores are significant post-surgical predictors. However, cut-off scores for 95% sensitivity/specificity were one standard deviation higher for PROMIS PF (>50.2 versus previous study >42) and similar for Depression (<39.4 versus previous study <41.5) as compared to all foot and ankle surgeries. Patients meeting the new cut-off (>50.2) experienced significantly better outcomes on all PROMIS scales and patients not meeting the cut- off (~30%) were significantly worse. Although longer term follow-up is desirable, this short term follow up suggests a significant clinical impact of using PROMIS scores for pre-surgical decisions.

A conservative approach to the management of otitis media with effusion in cleft palate children

1992 ◽  
Vol 106 (9) ◽  
pp. 788-792 ◽  
Author(s):  
A. K. Robson ◽  
J. D. Blanshard ◽  
K. Jones ◽  
E. H. Albery ◽  
I. M. Smith ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Otitis Media ◽  
Speech Therapy ◽  
Otitis Media With Effusion ◽  
Treated Group ◽  
Speech Development ◽  
Tube Placement ◽  
Tube Insertion ◽  
Clinical Indications

AbstractOtitis media with effusion (OME) is almost universal in children born with a cleft palate. Early placement of a ventilation tube to alleviate hearing problems is common. A retrospective study has been carried out to assess whether the practice of tube placement only for definite clinical indications is successful in terms of subsequent hearing levels and speech and language development. This was assessed by a case note review, analysis of speech therapy data and by means of a special follow-up clinic.There was no difference in speech development between those treated with tube insertion for OME and those untreated. Audiological thresholds were worse in the treated group. A similar number in each group required regular speech therapy. More abnormal otological findings were present at follow up in those who had tubes inserted, some of these were directly attributable to the presence of tubes.A conservative management of OME in cleft palate children, with tube insertion for only definite clinical indications, is an appropriate management, and will lead to fewer otological complications of tube insertion.

scholarly journals “Stifflammation” in hypertension is a predictor of future cardiovascular hospitalizations

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
D Terentes-Printzios ◽  
G Christopoulou ◽  
L Korogiannis ◽  
N Ioakeimidis ◽  
K Aznaouridis ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Confidence Intervals ◽  
Venous Blood ◽  
Area Under The Curve ◽  
High Sensitivity ◽  
Roc Curves ◽  
Left Ventricular ◽  
Multivariable Logistic Regression Analysis

Abstract Background/Introduction Hypertension is associated with increased cardiovascular risk, inflammation and arterial stiffness. Purpose We sought to investigate the role of inflammation and arterial stiffness in the prognosis of cardiovascular hospitalizations in hypertensive patients over an extended follow-up. Methods One hundred and seventy-three patients (mean age 52.5±13.2 years, 57% males) untreated hypertensives at baseline without cardiovascular disease, were included in the study. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (PWV). High-sensitivity C-reactive protein (hsCRP) was measured in venous blood samples. Other markers of subclinical organ damage [left ventricular mass index (LVMI) by echocardiography and estimated glomerular filtration rate (eGFR)] were also evaluated in all patients. Results During 13.6±0.4 years of follow-up, forty-four patients (25.4%) patients were admitted in hospital due to cardiovascular causes. In multivariable logistic regression analysis, only higher hsCRP (Odds Ratio [OR] = 3.34, 95% Confidence intervals [CI]: 1.22–9.51, P=0.02) and increased PWV (OR = 1.48, 95% Confidence intervals [CI]: 1.03–2.12, P=0.036) were associated with higher risk of cardiovascular hospitalizations, which was independent of age, gender, systolic blood pressure, LVMI and presence of diabetes. In further analysis, receiver operating characteristic (ROC) curves were generated to evaluate the ability of hsCRP and PWV to discriminate subjects with cardiovascular hospitalization. The area under the curve (AUC) and 95% CIs of the ROC curves were AUC=0.69 (95% CI: 0.59–0.78, p&lt;0.001) for hsCRP and AUC=0.74 (95% CI: 0.65–0.83, P&lt;0.001) for PWV (Figure). Conclusions Our study shows the independent complimentary prognostic role of inflammation and arterial stiffness in the prognosis of hypertensives even in studies with extended follow-up. FUNDunding Acknowledgement Type of funding sources: None. ROC curves for the prediction of outcome

Quantifying copy number variations in cell-free DNA for potential clinical utility from a large prostate cancer cohort.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 5072-5072
Author(s):  
Ekkehard Schütz ◽  
Mohammad R Akbari ◽  
Julia Beck ◽  
Howard B. Urnovitz ◽  
William Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Copy Number ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Copy Number Variations ◽  
Male Population ◽  
Cell Free Dna ◽  
Free Dna ◽  
Statistical Separation

5072 Background: Prostate cancer (PrCa) is the most frequent non-dermatological malignancy in the male population. Genomic instability resulting in copy number variation (CNV) is a hallmark of malignant transformation. CNV traces from tumors in cell-free DNA (cfDNA) of prostate cancer patients may be identified through massive parallel sequencing (MPS) of serum DNA. These CNV traces may be biomarkers of cancer with clinical applications for screening and follow-up. Methods: DNA was extracted from serum of 205 PrCa patients (Gleason 2 to10), 207 age matched male controls (HC), 10 men with benign hyperplasia (BPH) and 10 with prostatitis (PiS). DNA was amplified using random primers, tagged with a unique molecular identifier per sample, sequenced on a SOLiD system and aligned to the human genome (Build 37). Hits were counted in sliding 100kbp intervals and normalized. Using a random-resampling procedure, genomic regions showing copy number variations in cfDNA that distinguish PrCa from HC were selected. A model using 20 cfDNA regions was cross-validated and used as cfDNA biomarker. Receiver operator characteristics (ROC) curves were calculated for assessment of diagnostic performance by means of area under the curve (AUC). Results: To assess whether CNVs in cfDNA are indicative of PrCa, the number of regions with significant CNV deviation was counted in a first subset of 82 PrCa. Using only the number of regions as measure resulted in an AUC of 0.81 (0.7 – 0.9, p<0.001). Therefore, all samples were used to select regions (n=80) in random resampling (50/50). These regions were used to define a highly significant 20-regions model using five rounds of 10-fold cross-validation (AUC: 0.85±0.7; p< 10-7). This final model discriminated between PrCa and HC with an AUC of 0.92 (0.87 – 0.95) reaching a calculated accuracy of 83%. Both BPH and PiS could be distinguished from PrCa using the cfDNA CNV biomarker with a predicted accuracy of 90%. Conclusions: MPS revealed that only a limited number of chromosomal regions showing CNVs are necessary to achieve statistical separation between prostate cancer and controls. This technique may prove to be clinically useful for screening and follow up of men with prostate cancer.

Facilitating Parental Involvement in Speech Therapy for Children With Speech Sound Disorders: A Survey of Speech-Language Pathologists' Practices, Perspectives, and Strategies

2020 ◽  
Vol 29 (4) ◽  
pp. 1987-1996
Author(s):  
Sherine R. Tambyraja
Keyword(s):  
Parental Involvement ◽  
Online Survey ◽  
Speech Therapy ◽  
Speech Sound ◽  
Speech Sound Disorders ◽  
Speech Sound Disorder ◽  
Speech Language Pathologists ◽  
School Based ◽  
Homework Completion

Purpose This study investigated the extent to which speech-language pathologists (SLPs) facilitate parents' completion of homework activities for children with speech sound disorder (SSD). In addition, this study explored factors related to more consistent communication about homework completion and strategies considered particularly effective for supporting this element of parental involvement. Method Licensed SLPs serving at least one child with SSD were invited to participate in an online survey. Questions relevant to this study gathered information regarding (a) frequency of communication about homework distribution and follow-up, (b) demographic and workplace characteristics, and (c) an open-ended question about the specific strategies used to support parental involvement and completion of homework activities. Results Descriptive results indicated considerable variability with respect to how frequently SLPs engaged in communication about homework completion, but that school-based SLPs were significantly less likely to engage in this type of follow-up. Strategies considered effective, however, were similar across therapy contexts. Conclusion These results suggest potentially important differences between school-based services and therapy in other contexts with respect to this particular aspect of service provision for children with SSD.

Therapy of post-stroke depression – a systematic review

2013 ◽  
Vol 10 (02) ◽  
pp. 108-129 ◽  
Author(s):  
W. Gaebel ◽  
W. Wannagat ◽  
J. Zielasek
Keyword(s):  
Systematic Review ◽  
Large Scale ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Placebo Control ◽  
Post Stroke ◽  
Pharmacological Studies ◽  
Post Stroke Depression ◽  
Control Procedures ◽  
Antidepressant Pharmacotherapy

SummaryWe performed a systematic review of randomized placebo-controlled pharmacological and non-pharmacological trials for the therapy and prevention of post-stroke depression that have been published between 1980 and 2011. We initially identified 2 260 records of which 28 studies were finally included into this review. A meta-analytic approach was hampered by considerable differences regarding the kinds of therapeutic regimens and the study durations. Modest effects favoring treatment of post-stroke depression could be found for pharmacological treatment as well as repetitive transcranial magnetic stimulation. For the prevention of post-stroke depression, antidepressant pharmacotherapy showed promising results. However, large-scale studies with better standardized study populations, optimized placebo control procedures in non-pharmacological studies, and replication in larger follow-up studies are still necessary to find the optimal therapeutic regimens to prevent and treat post-stroke depression.

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