Abstract P782: Bioimpedance as a Means to Quantify Clot Composition and Guide Selection of Thrombectomy Devices

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Yang Liu ◽  
Ankur Bhambri ◽  
Arjun Adapa ◽  
Albert Shih ◽  
Aditya Pandey
Keyword(s):  
Real Time ◽  
Gold Electrode ◽  
Low Voltage ◽  
Pearson Correlation ◽  
Excitation Frequency ◽  
Unmet Need ◽  
In Vitro Test ◽  
Test Bed ◽  
Vessel Occlusion ◽  
Human Rbcs

Introduction: Recent studies suggest that suction based thrombectomy leads to better recanalization with RBC-rich clots while stent-retrievers perform better with fibrin-rich clots. The ability to determine real-time histology of clots, in the setting of large vessel occlusion (LVO), could potentially lead to improved recanalization and better clinical outcomes while simultaneously reducing procedural costs. There is an unmet need for technology that would allow for accurate assessment of real-time clot histology in LVOs. Hypothesis: Bioimpedance measurements can be used to predict real-time clot histology. Methods: We constructed an in vitro test bed to measure the bioimpedance of clot analogs with different RBC percentages. The test bed includes a cylindrical chamber with a gold electrode embedded at the bottom. A mixture of human RBCs and plasma was injected into the chamber and coagulation was induced by adding calcium chloride solution. After coagulation, another gold electrode was used to sandwich the clot. Both electrodes were connected to an inductance, capacitance, and resistance (LCR) meter and a low-voltage (10 mV) excitation was sent to the clot at 1 to 201 kHz. We fabricated 5 types of clot analogs by mixing human RBCs and plasma with different RBC percentages (10%, 30%, 50%, 70%, and 90%). Clot types were measured 3 times. The Pearson correlation coefficient was calculated and used to evaluate the relationship between clot bioimpedance and RBC percentage. Results and Conclusions: Clot impedance decreases with the excitation frequency and clots with higher RBC percentages had higher impedance at all excitation frequencies (Fig. 1). The impedance was strongly and positively related to the RBC percentage ( r = .996, p = .0004). By minimizing the electrode size and integrating them into catheters, stents, or wires, such technology could inform clinicians of clot composition and guide device selection for optimum recanalization.

scholarly journals Implementation and intelligent gain tuning feedback–based optimal torque control of a rotary parallel robot

2021 ◽  
pp. 107754632110191
Author(s):  
Farzam Tajdari ◽  
Naeim Ebrahimi Toulkani
Keyword(s):  
Real Time ◽  
Tracking Error ◽  
Parallel Robot ◽  
Torque Control ◽  
Test Bed ◽  
Linear Quadratic ◽  
Control Effort ◽  
The Real ◽  
Unknown Disturbances ◽  
Quadratic Integral

Aiming at operating optimally minimizing error of tracking and designing control effort, this study presents a novel generalizable methodology of an optimal torque control for a 6-degree-of-freedom Stewart platform with rotary actuators. In the proposed approach, a linear quadratic integral regulator with the least sensitivity to controller parameter choices is designed, associated with an online artificial neural network gain tuning. The nonlinear system is implemented in ADAMS, and the controller is formulated in MATLAB to minimize the real-time tracking error robustly. To validate the controller performance, MATLAB and ADAMS are linked together and the performance of the controller on the simulated system is validated as real time. Practically, the Stewart robot is fabricated and the proposed controller is implemented. The method is assessed by simulation experiments, exhibiting the viability of the developed methodology and highlighting an improvement of 45% averagely, from the optimum and zero-error convergence points of view. Consequently, the experiment results allow demonstrating the robustness of the controller method, in the presence of the motor torque saturation, the uncertainties, and unknown disturbances such as intrinsic properties of the real test bed.

scholarly journals Emulation of grid-forming inverters using real-time PC and 4-quadrant voltage amplifier

2021 ◽  
Author(s):  
Wolf Schulze ◽  
Maurizio Zajadatz ◽  
Michael Suriyah ◽  
Thomas Leibfried
Keyword(s):  
Real Time ◽  
Control Method ◽  
Current Control ◽  
Control Methods ◽  
Test Bed ◽  
Test Scenario ◽  
Power Semiconductors ◽  
Voltage Amplifier ◽  
Grid Side ◽  
Virtual Synchronous Machine

AbstractA test bed for the evaluation of novel control methods of inverters for renewable power generation is presented. The behavior of grid-following and grid-forming control in a test scenario is studied and compared.Using a real-time capable control platform with a cycle time of 50 µs, control methods developed with Matlab/Simulink can be implemented. For simplicity, a three-phase 4‑quadrant voltage amplifier is used instead of an inverter. Thus, the use of modulation and switched power semiconductors can be avoided. In order to show a realistic behavior of a grid-side filter, passive components can be automatically connected as L‑, LC- or LCL-filter. The test bed has a nominal active power of 43.6 kW and a nominal voltage of 400 V.As state-of-the-art grid-following control method, a current control in the d/q-system is implemented in the test bed. A virtual synchronous machine, the Synchronverter, is used as grid-forming control method. In combination with a frequency-variable grid emulation, the behavior of both control methods is studied in the event of a load connection in an island grid environment.

scholarly journals Microfluidic Airborne Metal Particle Sensor Using Oil Microcirculation for Real-Time and Continuous Monitoring of Metal Particle Emission

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 825
Author(s):  
Jong-Seo Yoon ◽  
Jiwon Park ◽  
Hye-Rin Ahn ◽  
Seong-Jae Yoo ◽  
Yong-Jun Kim
Keyword(s):  
Real Time ◽  
Metal Particle ◽  
Continuous Monitoring ◽  
Metal Particles ◽  
Minimum Size ◽  
Capacitive Sensing ◽  
Test Bed ◽  
Optimal Frequency ◽  
Site Monitoring ◽  
Cost Efficient

Airborne metal particles (MPs; particle size > 10 μm) in workplaces result in a loss in production yield if not detected in time. The demand for compact and cost-efficient MP sensors to monitor airborne MP generation is increasing. However, contemporary instruments and laboratory-grade sensors exhibit certain limitations in real-time and on-site monitoring of airborne MPs. This paper presents a microfluidic MP detection chip to address these limitations. By combining the proposed system with microcirculation-based particle-to-liquid collection and a capacitive sensing method, the continuous detection of airborne MPs can be achieved. A few microfabrication processes were realized, resulting in a compact system, which can be easily replaced after contamination with a low-priced microfluidic chip. In our experiments, the frequency-dependent capacitive changes were characterized using MP (aluminum) samples (sizes ranging from 10 μm to 40 μm). Performance evaluation of the proposed system under test-bed conditions indicated that it is capable of real-time and continuous monitoring of airborne MPs (minimum size 10 μm) under an optimal frequency, with superior sensitivity and responsivity. Therefore, the proposed system can be used as an on-site MP sensor for unexpected airborne MP generation in precise manufacturing facilities where metal sources are used.

scholarly journals Construction of a comprehensive endovascular test bed for research and device development in mechanical thrombectomy in stroke

2020 ◽  
pp. 1-8 ◽  
Author(s):  
Adithya S. Reddy ◽  
Yang Liu ◽  
Joshua Cockrum ◽  
Daniel Gebrezgiabhier ◽  
Evan Davis ◽  
...  
Keyword(s):  
Flow Rate ◽  
Hydraulic System ◽  
Mechanical Thrombectomy ◽  
Low Cost ◽  
Quality Analysis ◽  
Test Bed ◽  
Vessel Occlusion ◽  
Physiological Flow ◽  
3D Printed ◽  
Device Interaction

OBJECTIVEThe development of new endovascular technologies and techniques for mechanical thrombectomy in stroke has greatly relied on benchtop simulators. This paper presents an affordable, versatile, and realistic benchtop simulation model for stroke.METHODSA test bed for embolic occlusion of cerebrovascular arteries and mechanical thrombectomy was developed with 3D-printed and commercially available cerebrovascular phantoms, a customized hydraulic system to generate physiological flow rate and pressure, and 2 types of embolus analogs (elastic and fragment-prone) capable of causing embolic occlusions under physiological flow.RESULTSThe test bed was highly versatile and allowed realistic, radiation-free mechanical thrombectomy for stroke due to large-vessel occlusion with rapid exchange of geometries and phantom types. Of the transparent cerebrovascular phantoms tested, the 3D-printed phantom was the easiest to manufacture, the glass model offered the best visibility of the interaction between embolus and thrombectomy device, and the flexible model most accurately mimicked the endovascular system during device navigation. None of the phantoms modeled branches smaller than 1 mm or perforating arteries, and none underwent realistic deformation or luminal collapse from device manipulation or vacuum. The hydraulic system created physiological flow rate and pressure leading to iatrogenic embolization during thrombectomy in all phantoms. Embolus analogs with known fabrication technique, structure, and tensile strength were introduced and consistently occluded the middle cerebral artery bifurcation under physiological flow, and their interaction with the device was accurately visualized.CONCLUSIONSThe test bed presented in this study is a low-cost, comprehensive, realistic, and versatile platform that enabled high-quality analysis of embolus–device interaction in multiple cerebrovascular phantoms and embolus analogs.

scholarly journals Distribution of Artificial Thrombi Candidates Through Patient-Specific Aortic-Arch Phantoms under Pulsatile Flow Conditions

2021 ◽  
Author(s):  
Marco Testaguzza ◽  
Mehdi Benhassine ◽  
Haroun Frid ◽  
Laurence Gebhart ◽  
Karim Zouaoui Boudjeltia ◽  
...  
Keyword(s):  
Aortic Arch ◽  
Pulsatile Flow ◽  
Patient Specific ◽  
Flow Profile ◽  
In Vitro Test ◽  
Flow Conditions ◽  
Test Bed ◽  
Arch Models ◽  
Artificial Emboli

Abstract Ischemic Stroke is the most frequent type of stroke and is subject to many studies investigating prevention means. Avoiding the difficulties and ethical problems of experimental in-vivo research, in-vitro testing is a convenient way of studying in controlled conditions the morphological impact and mechanical aspects of emboli dynamics. This in-vitro study was performed with two realistic silicone aortic-arch phantoms submitted to physiological pulsatile flow conditions. In the in-vitro test bed, using automatic image tracking and analysis, it was made possible detecting and tracking artificial spherical emboli candidates circulating in the anatomic aortic-arch models under a realistic based-patient blood flow profile. The emboli trajectories as well as their repartition in the different supra-aortic branches are presented for the two aortic-arch geometries obtained from CT scans. Through a statistical analysis performed with several artificial emboli sizes, the experimental study shows that the repartition percentages of the emboli closely follow the flowrate repartition percentages for both aortic-arch models, suggesting that higher flowrates lead to higher concentrations of emboli in a given artery. Sets of human thrombi were also injected and the repartition percentages have been established, giving the same trend as for artificial emboli.

scholarly journals Thin-film chemical expansion of ceria based solid solutions: laser vibrometry study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Hendrik Wulfmeier ◽  
Dhyan Kohlmann ◽  
Thomas Defferriere ◽  
Carsten Steiner ◽  
Ralf Moos ◽  
...  
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
High Temperature ◽  
Film Thickness ◽  
Solid Solutions ◽  
Low Voltage ◽  
Excitation Frequency ◽  
Dimensional Change ◽  
Potential Core ◽  
Chemical Expansion

Abstract The chemical expansion of Pr0.1Ce0.9O2–δ (PCO) and CeO2–δ thin films is investigated in the temperature range between 600 °C and 800 °C by laser Doppler vibrometry (LDV). It enables non-contact determination of nanometer scale changes in film thickness at high temperatures. The present study is the first systematic and detailed investigation of chemical expansion of doped and undoped ceria thin films at temperatures above 650 °C. The thin films were deposited on yttria stabilized zirconia substrates (YSZ), operated as an electrochemical oxygen pump, to periodically adjust the oxygen activity in the films, leading to reversible expansion and contraction of the film. This further leads to stresses in the underlying YSZ substrates, accompanied by bending of the overall devices. Film thickness changes and sample bending are found to reach up to 10 and several hundred nanometers, respectively, at excitation frequencies from 0.1 to 10 Hz and applied voltages from 0–0.75 V for PCO and 0–1 V for ceria. At low frequencies, equilibrium conditions are approached. As a consequence maximum thin-film expansion of PCO is expected due to full reduction of the Pr ions. The lower detection limit for displacements is found to be in the subnanometer range. At 800 °C and an excitation frequency of 1 Hz, the LDV shows a remarkable resolution of 0.3 nm which allows, for example, the characterization of materials with small levels of expansion, such as undoped ceria at high oxygen partial pressure. As the correlation between film expansion and sample bending is obtained through this study, a dimensional change of a free body consisting of the same material can be calculated using the high resolution characteristics of this system. A minimum detectable dimensional change of 5 pm is estimated even under challenging high-temperature conditions at 800 °C opening up opportunities to investigate electro-chemo-mechanical phenomena heretofore impossible to investigate. The expansion data are correlated with previous results on the oxygen nonstoichiometry of PCO thin films, and a defect model for bulk ceria solid solutions is adopted to calculate the cation and anion radii changes in the constrained films during chemical expansion. The constrained films exhibit anisotropic volume expansion with displacements perpendicular to the substrate plane nearly double that of bulk samples. The PCO films used here generate high total displacements of several 100 nm’s with high reproducibility. Consequently, PCO films are identified to be a potential core component of high-temperature actuators. They benefit not only from high displacements at temperatures where most piezoelectric materials no longer operate while exhibiting, low voltage operation and low energy consumption.

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