Upper Airways Bacterial Microbiota Profiling In A Case/Control Study Of Early Onset Wheezing Infants And Healthy Controls From The Tropics Of Ecuador

Background:Cardiovascular disease (CV) is the most frequent cause of death in rheumatoid arthritis (RA) patients. It is well known that RA acts as an independent cardiovascular risk factor.Objectives:To assess the CV risk in RA patients using carotid ultrasonography (US) additionally to the traditional CV risk factors.Methods:A prospective transversal case control study was performed, including adult RA patients who fulfilled ACR/EULAR 2010 criteria and healthy controls matched according to CV risk factors. Population over 75 years old, patients with established CV disease and/or chronic kidney failure (from III stage) were excluded. The US evaluator was blinded to the case/control condition and evaluated the presence of plaques and the intima-media thickness. Statistical analysis was performed with R (3.6.1 version) and included a multivariate variance analysis (MANOVA) and a negative binomial regression adjusted by confounding factors (age, sex and CV risk factors).Results:A total of 200 cases and 111 healthy controls were included in the study. Demographical, clinical and US data are exposed in table 1. Not any difference was detected in terms of CV risk factors between the cases and controls. In both groups a relationship between age, BMI and high blood pressure was detected (p<0.001).Table 1.Table 2.RA basal characteristicsDisease duration (years)16,98 (11,38)Erosions (X-Ray of hands/feet)163 (81,5%)Seropositive (RF/anti-CCP)146 (73%)Extra-articular symptoms44 (22%)Intersticial difusse lung disease10 (5%)Rheumatoid nodules14 (7%)Prednisone use103 (51,5%)Median dose of Prednisone last year (mg)2,34 (2,84)sDMARDsMethotrexate104 (52%)Leflunomide29 (14,5%)Hydroxycloroquine9 (4,5%)bDMARDs89 (44,5%) TNFi41 (20,5%) Abatacept15 (7,5%) IL6i22 (11%) RTX11 (5,5%)JAKi26 (13%) Baricitinib11 (5,5%) Tofacitinib15 (7,5%)DAS 28-ESR3,1 (2,3, 3,9)SDAI7,85 (4,04, 13,41)HAQ0,88 (0,22, 1,5)RF (U/mL)51 (15, 164,25)Anti-CCP (U/mL)173 (22, 340)Patients showed higher intima-media (both right and left) thickness compared to controls (p<0.006). Moreover it was also related to the disease duration and DAS28 score (p<0.001). A higher plaque account was noted in cases(p<0.004) and it was also related to the disease duration (p<0.001).Conclusion:RA implies a higher CV risk. Traditional CV risk factors explains only partially the global risk. These findings support that RA acts as an independent cardiovascular risk factor.Disclosure of Interests:None declared

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Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study

BioMed Research International ◽

10.1155/2015/817427 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Mahmut Alpayci ◽

Aysel Milanlioglu ◽

Veysel Delen ◽

Mehmet Nuri Aydin ◽

Huseyin Guducuoglu ◽

...

Keyword(s):

Case Control Study ◽

Critical Role ◽

Positive Association ◽

Case Control ◽

Enzyme Linked Immunosorbent Assay ◽

Healthy Controls ◽

Citrullinated Proteins ◽

Antibody Levels ◽

Citrullinated Peptide ◽

Control Study

Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 ± 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 ± 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 ± 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls(P<0.001). Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores(r=-0.250). In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.

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Serum p53 protein and anti-p53 antibodies are associated with increased cancer risk: a case–control study of 569 patients and 879 healthy controls

Molecular Biology Reports ◽

10.1007/s11033-009-9744-7 ◽

2009 ◽

Vol 37 (1) ◽

pp. 339-343 ◽

Cited By ~ 38

Author(s):

Min Wu ◽

Chen Mao ◽

Qing Chen ◽

Xin-Wei Cu ◽

Wei-Seng Zhang

Keyword(s):

Cancer Risk ◽

Case Control Study ◽

P53 Protein ◽

Case Control ◽

Healthy Controls ◽

P53 Antibodies ◽

Serum P53 ◽

Control Study

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Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study

European Journal of Cancer Prevention ◽

10.1097/cej.0000000000000037 ◽

2014 ◽

Vol 23 (4) ◽

pp. 296-302 ◽

Cited By ~ 19

Author(s):

Leah M. Ferrucci ◽

Brenda Cartmel ◽

Annette M. Molinaro ◽

David J. Leffell ◽

Allen E. Bale ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Early Onset ◽

Case Control Study ◽

Case Control ◽

Control Study

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Inflammatory and oxidative parameters in cord blood as diagnostic of early-onset neonatal sepsis: A case-control study

Pediatric Critical Care Medicine ◽

10.1097/pcc.0b013e318198b0e3 ◽

2009 ◽

Vol 10 (4) ◽

pp. 467-471 ◽

Cited By ~ 30

Author(s):

Ana Carolina Cancelier ◽

Fabricia Petronilho ◽

Adalisa Reinke ◽

Larissa Constantino ◽

Roberta Machado ◽

...

Keyword(s):

Cord Blood ◽

Neonatal Sepsis ◽

Early Onset ◽

Case Control Study ◽

Case Control ◽

Control Study

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Body mass index, height and early-onset basal cell carcinoma in a case-control study

Dermatology Online Journal ◽

10.5070/d3229032524 ◽

2016 ◽

Vol 22 (9) ◽

Author(s):

Yanchang Zhang ◽

Brenda Cartmel ◽

Courtney C Choy ◽

Annette M Molinaro ◽

David J Leffell ◽

...

Keyword(s):

Body Mass Index ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Body Mass ◽

Basal Cell ◽

Early Onset ◽

Case Control Study ◽

Case Control ◽

Control Study

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Ethnic differences in CAPN10 SNP-19 in type 2 diabetes: a North-West Indian case control study and evidence from meta-analysis

Genetics Research ◽

10.1017/s0016672313000207 ◽

2013 ◽

Vol 95 (5) ◽

pp. 146-155 ◽

Cited By ~ 4

Author(s):

RUBINA SHARMA ◽

KAWALJIT MATHAROO ◽

ROHIT KAPOOR ◽

HIMANSHI CHOPRA ◽

AJS BHANWER

Keyword(s):

Indian Population ◽

Case Control Study ◽

Meta Analysis ◽

West Indian ◽

Case Control ◽

Healthy Controls ◽

North West ◽

The North ◽

Control Study

SummaryCalpain 10 (CAPN10) variants have been associated with the genetic susceptibility to type 2 diabetes (T2D). In the present case-control study, we analysed the distribution of SNP-19 insertion/deletion (I/D) polymorphism in a total of 607 samples (103 T2D cases and 102 healthy controls) from Brahmin; (100 T2D cases and 100 healthy controls) from Bania and (100 T2D cases and 102 healthy controls) from Jat Sikh ethnic groups of the North-West Indian population. Increased frequency of I allele and II genotype was found in T2D in Brahmin ethnic group [P = 0·003, OR = 2·83 (1·43–5·61 at 95% CI)]. Significant correlation between II genotype and body mass index (BMI) was also observed [P = 0·003, OR = 3·31 (1·52–7·20 at 95% CI)]. No association for the genotypes and alleles was seen in Banias and Jat Sikhs. Our data suggests that SNP-19 I/D variation in the CAPN10 gene is modulated by ethnicity and influences the susceptibility to T2D in the North-West Indian population. We also performed a meta-analysis of relevant studies to assess the validity of this association. Data from 13 case-control studies with 15 760 samples comprising of 8395 T2D cases and 7365 controls were finally analysed. Significant heterogeneity between individual studies was evident in dominant and codominant models. The results of present meta-analysis indicate an association of T2D with carriers of DD genotype of CAPN10 I/D polymorphism. However, further analyses on a larger sample size are required to establish a conclusive association in meta-analysis.

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Salivary Cortisol Levels in Patients with Oral Lichen Planus—A Pilot Case-Control Study

Dentistry Journal ◽

10.3390/dj7020059 ◽

2019 ◽

Vol 7 (2) ◽

pp. 59 ◽

Cited By ~ 1

Author(s):

Ivana Skrinjar ◽

Valentina Vidranski ◽

Bozana Loncar Brzak ◽

Danica Vidovic Juras ◽

Ana Andabak Rogulj ◽

...

Keyword(s):

Lichen Planus ◽

Salivary Cortisol ◽

Oral Lichen Planus ◽

Case Control Study ◽

Case Control ◽

Healthy Controls ◽

Unstimulated Saliva ◽

Cortisol Levels ◽

Oral Lichen ◽

Control Study

It is known that cortisol level increases in stress situations. The aim of the study was to measure the levels of salivary cortisol in patients with oral lichen planus (OLP) and healthy controls. This was a case-control pilot study which included seven patients with reticular (non-symptomatic) OLP, eight patients with atrophic/erosive (symptomatic) OLP, and nine healthy controls. We hypothesized that patients with an atrophic/erosive type of OLP have higher levels of cortisol compared to patients with the reticular type of OLP and healthy controls. In each participant, unstimulated saliva was collected in order to determine cortisol levels by using commercially available ELISA kit. Our results have shown no differences between levels of salivary cortisol in OLP patients and healthy controls. We can conclude that further research with a larger number of OLP patients is needed to determine the correlation between OLP and stress.

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