Serum p53 protein and anti-p53 antibodies are associated with increased cancer risk: a case–control study of 569 patients and 879 healthy controls

AbstractDietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.

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Missing and decayed teeth, oral hygiene and dental staining in relation to esophageal cancer risk: ESCCAPE case‐control study in Kilimanjaro, Tanzania

International Journal of Cancer ◽

10.1002/ijc.33433 ◽

2020 ◽

Author(s):

Blandina T. Mmbaga ◽

Amos Mwasamwaja ◽

Godfrey Mushi ◽

Alex Mremi ◽

Gissela Nyakunga ◽

...

Keyword(s):

Esophageal Cancer ◽

Cancer Risk ◽

Oral Hygiene ◽

Case Control Study ◽

Case Control ◽

Control Study

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SAT0077 CARDIOVASCULAR RISK ASSESSMENT WITH CAROTID ULTRASONOGRAPHY IN ADDITION TO THE TRADITIONAL CARDIOVASCULAR RISK FACTORS IN RHEUMATOID ARTHRITIS PATIENTS: A CASE CONTROL STUDY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.6420 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 973-973

Author(s):

R. Gonzalez Mazario ◽

J. J. Fragio-Gil ◽

P. Martinez Calabuig ◽

E. Grau García ◽

M. De la Rubia Navarro ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Risk Factor ◽

Cardiovascular Risk ◽

Disease Duration ◽

Case Control Study ◽

Case Control ◽

Healthy Controls ◽

Carotid Ultrasonography ◽

Control Study

Background:Cardiovascular disease (CV) is the most frequent cause of death in rheumatoid arthritis (RA) patients. It is well known that RA acts as an independent cardiovascular risk factor.Objectives:To assess the CV risk in RA patients using carotid ultrasonography (US) additionally to the traditional CV risk factors.Methods:A prospective transversal case control study was performed, including adult RA patients who fulfilled ACR/EULAR 2010 criteria and healthy controls matched according to CV risk factors. Population over 75 years old, patients with established CV disease and/or chronic kidney failure (from III stage) were excluded. The US evaluator was blinded to the case/control condition and evaluated the presence of plaques and the intima-media thickness. Statistical analysis was performed with R (3.6.1 version) and included a multivariate variance analysis (MANOVA) and a negative binomial regression adjusted by confounding factors (age, sex and CV risk factors).Results:A total of 200 cases and 111 healthy controls were included in the study. Demographical, clinical and US data are exposed in table 1. Not any difference was detected in terms of CV risk factors between the cases and controls. In both groups a relationship between age, BMI and high blood pressure was detected (p<0.001).Table 1.Table 2.RA basal characteristicsDisease duration (years)16,98 (11,38)Erosions (X-Ray of hands/feet)163 (81,5%)Seropositive (RF/anti-CCP)146 (73%)Extra-articular symptoms44 (22%)Intersticial difusse lung disease10 (5%)Rheumatoid nodules14 (7%)Prednisone use103 (51,5%)Median dose of Prednisone last year (mg)2,34 (2,84)sDMARDsMethotrexate104 (52%)Leflunomide29 (14,5%)Hydroxycloroquine9 (4,5%)bDMARDs89 (44,5%) TNFi41 (20,5%) Abatacept15 (7,5%) IL6i22 (11%) RTX11 (5,5%)JAKi26 (13%) Baricitinib11 (5,5%) Tofacitinib15 (7,5%)DAS 28-ESR3,1 (2,3, 3,9)SDAI7,85 (4,04, 13,41)HAQ0,88 (0,22, 1,5)RF (U/mL)51 (15, 164,25)Anti-CCP (U/mL)173 (22, 340)Patients showed higher intima-media (both right and left) thickness compared to controls (p<0.006). Moreover it was also related to the disease duration and DAS28 score (p<0.001). A higher plaque account was noted in cases(p<0.004) and it was also related to the disease duration (p<0.001).Conclusion:RA implies a higher CV risk. Traditional CV risk factors explains only partially the global risk. These findings support that RA acts as an independent cardiovascular risk factor.Disclosure of Interests:None declared

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Food groups and endometrial cancer risk: a case-control study from Italy

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2008.09.015 ◽

2009 ◽

Vol 200 (3) ◽

pp. 293.e1-293.e7 ◽

Cited By ~ 27

Author(s):

Francesca Bravi ◽

Lorenza Scotti ◽

Cristina Bosetti ◽

Antonella Zucchetto ◽

Renato Talamini ◽

...

Keyword(s):

Endometrial Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Case Control ◽

Food Groups ◽

Endometrial Cancer Risk ◽

Control Study

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Methodological approaches to the study of cancer risk in the vicinity of pollution sources: the experience of a population-based case–control study of childhood cancer

International Journal of Health Geographics ◽

10.1186/s12942-019-0176-x ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 2

Author(s):

Javier García-Pérez ◽

Diana Gómez-Barroso ◽

Ibon Tamayo-Uria ◽

Rebeca Ramis

Keyword(s):

Cancer Risk ◽

Childhood Cancer ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Pollution Sources ◽

Methodological Approaches ◽

Control Study

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Trajectories of physical activity, from young adulthood to older adulthood, and pancreatic cancer risk; a population-based case-control study in Ontario, Canada

BMC Cancer ◽

10.1186/s12885-020-6627-8 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Jaspreet Sandhu ◽

Vanessa De Rubeis ◽

Michelle Cotterchio ◽

Brendan T. Smith ◽

Lauren E. Griffith ◽

...

Keyword(s):

Physical Activity ◽

Pancreatic Cancer ◽

Cancer Risk ◽

Young Adulthood ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Older Adulthood ◽

Pancreatic Cancer Risk ◽

Control Study

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Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study

BioMed Research International ◽

10.1155/2015/817427 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Mahmut Alpayci ◽

Aysel Milanlioglu ◽

Veysel Delen ◽

Mehmet Nuri Aydin ◽

Huseyin Guducuoglu ◽

...

Keyword(s):

Case Control Study ◽

Critical Role ◽

Positive Association ◽

Case Control ◽

Enzyme Linked Immunosorbent Assay ◽

Healthy Controls ◽

Citrullinated Proteins ◽

Antibody Levels ◽

Citrullinated Peptide ◽

Control Study

Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 ± 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 ± 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 ± 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls(P<0.001). Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores(r=-0.250). In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.

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