Synthesis and Antimicrobial Properties of Zinc Oxide Nanoparticles

2020 ◽  
Vol 20 (10) ◽  
pp. 5977-5996 ◽  
Author(s):  
Saee Gharpure ◽  
Balaprasad Ankamwar
Keyword(s):  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Metal Oxide Nanoparticles ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Physical Contact ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Promising Alternative

With increase in incidence of multidrug resistant pathogens, there is a demand to adapt newer approaches in order to combat these diseases as traditional therapy is insufficient for their treatment. Use of nanotechnology provides a promising alternative as antimicrobial agents as against traditional antibiotics. Metal oxides have been exploited for a long times for their antimicrobial properties. Zinc oxide nanoparticles (ZnO NPs) are preferred over other metal oxide nanoparticles because of their bio-compatible nature and excellent antibacterial potentials. The basic mechanism of bactericidal nature of ZnO nanoparticles includes physical contact between ZnO nanoparticles and the bacterial cell wall, generation of reactive oxygen species (ROS) as well as free radicals and release of Zn2+ ions. This review focuses on different synthesis methods of ZnO nanoparticles, various analytical techniques frequently used for testing antibacterial properties, mechanism explaining antibacterial nature of ZnO nanoparticles as well as different factors affecting the antibacterial properties.

Green Route for the Fabrication of ZnO Nanoparticles and Potential Functionalization with Chitosan Using Cross-linkers: A Review

2021 ◽  
Vol 3 (1) ◽  
pp. 1-25
Author(s):  
Hemra Hamrayev ◽  
Kamyar Shameli ◽  
Mostafa Yusefi ◽  
Serdar Korpayev
Keyword(s):  
Zinc Oxide ◽  
Metal Oxide ◽  
Green Synthesis ◽  
Zno Nanoparticles ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Zno Nps ◽  
Biological Sources ◽  
Physical And Chemical

Zinc oxide is of significant importance for many industries due to its versatile properties, which have been enhanced with the production of this material in the nanoscale. Recent interest in the preparation of metal oxide nanoparticles using biological approaches has been reported in the literature. This technique known as “green synthesis” is an environmentally benign process than conventional methods like physical and chemical synthesis methods. Zinc oxide nanoparticles (ZnO-NPs) have been successfully obtained by green synthesis using different biological substrates like chitosan. Chitosan is biocompatible, biodegradable polymer having exclusive physical and chemical properties. Chitosan/metal oxide nanocomposite is a promising nanomaterial with enhanced properties for multiple functionalities. Therefore, this review discusses favorable approach in the formation of cross-linked Chitosan/ZnO nanocomposites attracting significant attention in various fields such biomedical due to their unique biodegradable, biocompatible, non-toxic nature. The use of biological sources, fabrication of green synthesized ZnO nanoparticles and its applications is briefly discussed. Overall, this review is a comprehensive study for the synthesis of ZnO-NPs using biological sources counting on their features and applications.

scholarly journals Green versus Chemical Precipitation Methods of Preparing Zinc Oxide Nanoparticles and Investigation of Antimicrobial Properties

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Bulcha Bekele ◽  
Anatol Degefa ◽  
Fikadu Tesgera ◽  
Leta Tesfaye Jule ◽  
R. Shanmugam ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Chemical Synthesis ◽  
Zinc Oxide Nanoparticles ◽  
Antimicrobial Properties ◽  
Chemical Precipitation ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Zno Nps ◽  
Precipitation Synthesis

Comparison of green and chemical precipitation method syntheses of zinc oxide nanoparticles (ZnO NPs) was performed, and antimicrobial properties were investigated. Avocado, mango, and papaya fruit extracts were carried out for the green synthesising methods, while the chemical precipitation method was chosen from chemical synthesis methods. Zinc nitrate was used as a salt precursor, whereas leaf extract was served as a reducing agent for green synthesising methods. In addition, sodium hydroxide, polyvinyl alcohol, and potassium hydroxide were used as reducing agents in the case of chemical precipitation synthesis methods. ZnO NPs were characterised by characterizing techniques such as Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The antimicrobial activities of prepared nanoparticles were evaluated on Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), and Salmonella typhimurium (S. typhimurium). The particle sizes of the prepared samples which were evaluated by the Scherrer equation were in the range of 11-21 nm for green synthesis, while 30-40 nm for chemical precipitation synthesis methods. Small agglomerations were observed from SEM results of prepared ZnO NPs from both methods. Prepared ZnO NPs were showed strong antimicrobial properties. From the result, the inhibition zone was in the range of 15-24 mm for the green route and 7–15 mm for chemical precipitation methods, where the standard drugs have 25 mm of the zone of inhibition. A green synthesised method of preparing ZnO NPs gives promising antimicrobial properties compared to chemical synthesis and is also eco-friendly and safe compared to the chemical synthesis.

scholarly journals Mechanistic Study of Antibacterial Properties of Chemically Synthesize Zinc Oxide Nanoparticles

2019 ◽  
Vol 2 (1) ◽  
pp. 42-52
Author(s):  
Abdur Rehman ◽  
Saira Ahmad ◽  
Abdul Mateen ◽  
Huma Qamar ◽  
Mudaber Ahmad Mubashar ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Bacterial Strain ◽  
Zinc Oxide Nanoparticles ◽  
Sol Gel ◽  
Antibacterial Properties ◽  
Mechanistic Study ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Wide Range

Nanotechnology is the science, engineering and technology conducted at the scale that ranges between 1-100 nanometers. For the bio-application, evolution of nanotechnology is creating the concern of scientists towards the synthesis of nanoparticles. The nanoparticles have unique characteristics as compare to bulk materials. Zinc oxide (ZnO) is a matchless semiconductor and it has been under investigation due to its wide range of applications in various areas like biomedical, electronics, material science and optics. In the present work synthesis of ZnO nanoparticles was carried out by using simple chemical approach, Sol-gel method for being effective and inexpensive, by employing zinc acetate dehydrate Zn (CH3CO2)2.2H2O as a precursor and sodium hydroxide (NaOH) starch as a constant agent. The structural properties of resultant zinc oxide nanoparticles were investigated by X-ray diffraction (XRD) technique. The XRD data confirmed the hexagonal wurtzite structure of ZnO powder confirmed by JCPDS 36-1451 data. Particles size was calculated by Scherrer formula and calculated size was 30.14 nm. These nanoparticles were investigated for inhibition zone of bacterial strain Escherichia coli, a gram-negative microbe, at various concentrations of ZnO nanoparticles. Zinc oxide nanoparticles were very proficient for inhibition of growth of bacterial strain E. coli. The mechanism of ZnO NPs for antibacterial activity is release of reactive oxygen species which not only hydrolyze cell wall but cell membrane and cellular components as well providing a potential bactericidal effect.

scholarly journals Analysis of Antimicrobial Properties of PVA-Based Coatings with Silver and Zinc Oxide Nanoparticles

2021 ◽  
Author(s):  
Jolanta Pulit-Prociak ◽  
Anita Staroń ◽  
Magdalena Prokopowicz ◽  
Karolina Magielska ◽  
Marcin Banach
Keyword(s):  
Zinc Oxide ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Zinc Oxide Nanoparticles ◽  
Metal Oxide Nanoparticles ◽  
Antimicrobial Properties ◽  
Oxide Nanoparticles ◽  
Public Places ◽  
Growth Area ◽  
Nanoparticles Concentration

Abstract Public places such as swimming pools, saunas and jacuzzis are at high risk of developing microorganisms and are a potential source of disease. Above all, increased temperature and humidity favour this. A relatively new but effective way to combat microorganisms is to subject them to metal or metal oxide nanoparticles. The paper presents a method of obtaining nanocompositions for direct application at the place of occurrence of the microorganisms. The advantage of nanocompositions is that they can easily be removed from the infected surface in the form of a film containing dead organic matter. The article investigates the biocidal properties against common microorganisms such as Aspergillus niger and Candida albicans of nanocompositions containing silver nanoparticles and nanometric zinc oxide. The physicochemical properties of the nanocompositions were characterised and the antifungal properties of the preparations obtained determined using the suspension method. The results showed that the PVA-based compositions obtained were able effectively to inhibit the growth of the tested strains. Elongation of contact time between microorganism and nanoparticles which was changed from 5 to 60 min resulted in higher antimicrobial activity. It was manifested in reduced growth area. The same observation was made when the concentration of used nanoparticles was increased. When the concentration of nanosilver raised from 12.5 up to 200 ppm, the development of Aspergillus niger was slower. Increasing of zinc oxide nanoparticles concentration resulted in growth inhibition of Candida albicans strain. Graphic Abstract

Antibacterial zinc oxide nanoparticles in polymer biomaterial composites

2011 ◽  
Vol 1316 ◽  
Author(s):  
Justin T. Seil ◽  
Thomas J. Webster
Keyword(s):  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Antibacterial Properties ◽  
Oxide Nanoparticles ◽  
Zno Nanoparticle ◽  
Crystal Violet Staining ◽  
Antibiotic Resistant ◽  
Endotracheal Tubes

ABSTRACTParticulate zinc oxide (ZnO) is a known antibacterial agent. Studies have shown that reducing the size of ZnO particles to nanoscale dimensions further enhances their antibacterial properties. Polymers, like all biomaterials, run the risk of harboring bacteria which may produce an antibiotic-resistant biofilm. The addition of ZnO nanoparticles, to form a composite material, may reduce undesirable bacteria activity. The purpose of the present in vitro study was to investigate the antibacterial properties of ZnO nanoparticles when incorporated into a polymer biomaterial. Staphylococcus aureus were seeded at a known cell density onto coverslips coated in a film of polyvinyl chloride (PVC) with varying concentrations of ZnO nanoparticles. Samples were cultured for 24 or 72 h. Methods of analysis, including optical density readings and crystal violet staining, indicated a reduced presence of biofilm on ZnO nanoparticle and polymer composites compared to polymer control. Live/dead assays provided images to confirm reduced presence of active bacteria on samples with zinc oxide nanoparticles. Development of this technology may improve biomaterial effectiveness for applications, such as endotracheal tubes and implanted biomaterials, which are prone to bacterial infection.

scholarly journals Single-Step Antimicrobial And Moisture Management Finishing Of Pc Fabric Using Zno Nanoparticles

2017 ◽  
Vol 17 (3) ◽  
pp. 259-262 ◽  
Author(s):  
Munir Ashraf ◽  
Muhammad Irfan Siyal ◽  
Ahsan Nazir ◽  
Abdur Rehman
Keyword(s):  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Metal Oxide Nanoparticles ◽  
Sol Gel ◽  
Standard Test ◽  
Woven Fabrics ◽  
Single Step ◽  
Oxide Nanoparticles ◽  
Moisture Management

AbstractFunctionalization of textile fabrics with metal oxide nanoparticles can be used to add antibacterial and moisture management properties to them. Current work focuses on the development of these properties on polyester/cotton woven fabrics by treating them with zinc oxide nanoparticles for workwear and sportswear applications. Zinc oxide nanoparticles, prepared by sol-gel method, were applied on fabric samples, which were then tested for antibacterial and moisture management properties using standard test methods AATCC 147 with Staphylococcus aureus and AATCC 195, respectively. It was found that application of ZnO nanoparticles improved both these properties with smaller particle imparting larger effects on both of them.

Microbiote shift in sequencing batch reactors in response to antimicrobial ZnO nanoparticles

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 110108-110111 ◽  
Author(s):  
Zhenghui Liu ◽  
Huifang Zhou ◽  
Jiefeng Liu ◽  
Xudong Yin ◽  
Yufeng Mao ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Wastewater Treatment ◽  
Adverse Effects ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Wastewater Treatment Plants ◽  
Oxide Nanoparticles ◽  
Batch Reactors ◽  
Sequencing Batch Reactors ◽  
Zno Nps

Zinc oxide nanoparticles (ZnO NPs) have been monitored in wastewater treatment plants as their potential adverse effects on functional microorganisms have been causing increasing concern.

Raspberry-like morphology of polyvinyl chloride/zinc oxide nanoparticles induced by surface interaction and formation of nanoporous foam

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36845-36857 ◽  
Author(s):  
Tingting Ren ◽  
Jie Wang ◽  
Jinfeng Yuan ◽  
Mingwang Pan ◽  
Gang Liu ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Polyvinyl Chloride ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Surface Interaction ◽  
Oxide Nanoparticles ◽  
Nano Coating ◽  
Coating Method

P(VC-co-AAEM)/ZnO nanoparticles are prepared by a nano-coating method, and the morphology of the raspberry-like particles is adjusted by hydrophilicity and NaOH concentration.

scholarly journals Antibacterial Activity of The Iron-Zinc Oxide Nanoparticles Synthesized Via Electric Discharge Method

2021 ◽  
Author(s):  
Fereshteh Shahbazi ◽  
Reza Ahmadi ◽  
Mohammad Noghani ◽  
Gholamreza Karimi
Keyword(s):  
Zinc Oxide ◽  
Electrical Discharge ◽  
Zinc Oxide Nanoparticles ◽  
Viral Infections ◽  
Antibacterial Properties ◽  
Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Discharge Method ◽  
Electric Discharge Method ◽  
Novel Antibiotics

Abstract With the increase in diseases caused by bacterial and viral infections, the need for antibiotics has increased. On the other hand, by creating drug resistance to organicmoietiesbased antibiotics, novel antibiotics have attracted the attention of researchers.Nano-scale metal oxides are increasingly being considered for medical applications, especially as antibacterial agents.In this study, iron oxide nanoparticles (IONPs) and zinc oxide nanoparticles (ZONPs) were prepared via electrical discharge method in liquid medium by changing parameters such as wire diameter and electric current intensity. Synthesized NPs were evaluated by XRD, UV_Visible, FE_SEM, EDS, HR_TEM and TEM analyzes. Also, the antibacterial properties of these nanoparticles were evaluated in different ways against gram-positive and gram-negative bacteria.

scholarly journals Photocatalytic activity of biogenic zinc oxide nanoparticles: In vitro antimicrobial, biocompatibility, and molecular docking studies

2021 ◽  
Vol 10 (1) ◽  
pp. 1079-1091
Author(s):  
Mahboob Alam
Keyword(s):  
Zinc Oxide ◽  
Molecular Docking ◽  
Zinc Oxide Nanoparticles ◽  
Dye Degradation ◽  
Antimicrobial Properties ◽  
Morphological Properties ◽  
Diffusion Method ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Receptor Binding Site

Abstract The biogenic synthesis of zinc oxide nanoparticles (ZnO NPs) with pinecone extract (PCE) as a reducing agent and antibacterial agent was explored. The current study aims to investigate the biosynthesis of ZnO NPs and their effect on photocatalytic dye degradation and antimicrobial properties. The physical, chemical, and morphological properties of biogenic ZnO NPs synthesized using PCE were investigated using advanced spectroscopy techniques such as Fourier transform infrared spectroscopy (FTIR), UV-visible spectroscopy, transmission electron microscopy (TEM) analysis, selected area electron diffraction (SAED), and X-ray diffraction (XRD) techniques. The photocatalytic degradation of methylene blue was measured spectrophotometrically using biogenic ZnO NPs as nanocatalysts, and decolonization of solution indicates dye degradation gradually as exposure duration increases. The antimicrobial properties of ZnONPs against the tested pathogenic strains were demonstrated using the disc diffusion method. The antimicrobial efficacy of ZnONPs was further explained using molecular docking analysis. Confirmation of the lowest binding energy was used to predict receptor binding site with NPs in order to understand the mechanistic approach. ZnONPs are likely to interact with pathogens via mechanical enfolding, which could be one of the major toxicity actions of ZnONPs against strains. Furthermore, the nontoxicity and biocompatibility of ZnO NPs were studied, revealing impressive hemocompatibility with red blood cells (RBCs) and no significant toxicity to Brine shrimps at lower ZnONP concentrations.

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