Identification and localization tasks reveal the role of strength of association in Stroop and reverse Stroop effects

Background The prognostic significance of the expression of the miR-221/222 family in cancer remains controversial. We here performed a meta-analysis of published data investigating the effects of miR-221/222 expression on both overall survival (OS) and disease-free survival (DFS) among patients with cancer. Methods A systematic search of the PubMed, Embase, Cochrane, and CNKI databases was performed with the last search being updated on March 15, 2013. The hazard ratio (HR) and its 95% confidence interval (95% CI) were used to assess the strength of association. Results A total of 17 studies involving 1,204 subjects were included in this meta-analysis. When assessing the prognostic significance of miR-221 expression, the pooled HR was 1.91 (95% CI: 1.28-2.85, p=0.002) for OS and 1.36 (95% CI: 0.88-2.09, p=0.163) for DFS. When assessing the prognostic significance of miR-222 expression, the pooled HR was 2.15 (95% CI: 1.51-3.06, p<0.0001) for OS and 1.37 (95% CI: 0.45-4.13, p=0.581) for DFS. We also found that an elevated miR-221 expression was significantly associated with poor OS when stratifying by ethnicity, cancer type, statistical methodology, sample, and quality assessment. There was no evidence of publication bias. Conclusion The meta-analysis demonstrates that the elevated expression of miR-221 and miR-222 is associated with poor OS in patients with cancer. The miR-221/222 cluster might be used as a potential therapeutic strategy in clinical practice. More work is required to fully elucidate the role of the miR-221/222 family in human tumors.

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Study of Asssociation of Concha Bullosa with Rhinosinusitis

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2016.v24i3.87 ◽

2016 ◽

Vol 24 (3) ◽

pp. 111-116

Author(s):

Shrikrishna B H ◽

Jyothi A C

Keyword(s):

Chronic Rhinosinusitis ◽

Ct Scans ◽

Radiological Assessment ◽

Concha Bullosa ◽

Cross Sectional ◽

Relationship Of ◽

The Relationship ◽

Strength Of Association ◽

Larger Sample

Introduction There are several studies with contradictory findings about the role of concha bullosa with predisposition to rhinosinusitis. This study was conducted to assess the relationship of osteomeatal unit blockage with concha bullosa. Materials and method A cross-sectional observational study by radiological assessment of prevalence of chronic rhinosinusitis and blockage of ipsilateral osteomeatal unit was done on 100 cases of concha bullosa detected on computed tomography to determine the prevalence of chronic rhinosinusitis in subjects with concha bullosa and to examine the latter’s relationship to osteomeatal unit blockage, which is a precursor for rhinosinusitis. Result One hundred cases of concha bullosa were studied in a total of 87 CT scan films depicting concha bullosa. Some CT scans showed unilateral concha bullosa while few scans showed bilateral concha bullosa. Ipsilateral rhinosinusitis was found in only 31% of the sides in scans of subjects with concha bullosa. Of the total 100 concha bullosae studied, extensive type was the commonest followed by bulbous and lamellar variety. Discussion Although rhinosinusitis was more predominant in the extensive type of concha bullosa compared to other types, it was statistically not significant and there was no statistically significant association between any type of concha bullosa with ipsilateral rhinosinusitis either in right side or left side. Conclusion This study has found no statistically significant association between any type of concha bullosa with rhinosinusitis. A bigger study with larger sample size is required to better assess the strength of association between concha bullosa and rhinosinusitis.

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Unlucky at work, unlucky in love: job loss and marital stability

Review of Economics of the Household ◽

10.1007/s11150-020-09506-x ◽

2020 ◽

Author(s):

Carina Keldenich ◽

Christine Luecke

Keyword(s):

Relative Risk ◽

Employment Status ◽

Job Loss ◽

Marital Dissolution ◽

Working Hours ◽

Marital Stability ◽

Plant Closures ◽

The Relationship ◽

Strength Of Association

Abstract This paper analyses the relationship between a husband’s job loss and marital stability, focusing on involuntary employment terminations due to plant closures or dismissals. Using discrete survival analysis techniques on data from the German Socio-Economic Panel, we find plant closures and dismissals to be associated with a 54 and 74% higher risk of marital dissolution respectively, though the strength of association varies significantly by how long ago the change in employment status occurred. We extend the previous literature by considering heterogeneity in the relationship depending on whether new employment was found. Our analysis shows that the dissolution risk remains elevated even in couples where the husband has taken up a new position. Surprisingly, the relative risk of dissolution following the first period in a new job after a job loss is about the same as the relative risk of dissolution following the first period without employment. The relationship between finding a new job and marital dissolution appears to be mediated by changes in working hours as well as wages. In two extensions, we also consider the role of the wife’s employment status in moderating the relationship and show that a wife’s job loss is not associated with a similar increase in the probability of divorce as a husband’s.

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Investigation of ATG16L1 rs2241880 Polymorphism with Cancer Risk: A Meta-Analysis

Medicina ◽

10.3390/medicina55080425 ◽

2019 ◽

Vol 55 (8) ◽

pp. 425 ◽

Cited By ~ 2

Author(s):

Moazeni-Roodi ◽

Tabasi ◽

Ghavami ◽

Hashemi

Keyword(s):

Cancer Risk ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Genetic Models ◽

Case Control Studies ◽

Study Population ◽

Cancer Types ◽

The Impact ◽

Strength Of Association

Background and Objectives: Previous studies have investigated the impact of the ATG16L1 rs2241880 (Thr300Ala) polymorphism on individual susceptibility to cancer, but the conclusions are still controversial. To get a more precise evaluation of the correlation between ATG16L1 rs2241880 polymorphism and cancer susceptibility, we performed a meta-analysis of the association of all eligible studies. Materials and Methods: Searches were performed in the Web of Science, PubMed, Scopus and Google Scholar databases up to November 2018. A total of 12 case-control studies from 9 articles comprising 2254 cases and 4974 controls were included. Statistical analysis was achieved by STATA 14.1 and Review Manager 5.3 software. The odds ratios (ORs) with 95% confidence intervals (95% CIs) under five genetic models were used to determine the strength of association among rs2241880 polymorphism and cancer susceptibility. Results: The findings did not support an association between the rs2241880 variant in either the overall study population or the subgroups, based on cancer types and ethnicity in any of the genetic models. As far as we know, our study is the first meta-analysis of the association between rs2241880 polymorphism and cancer risk. Conclusions: In conclusion, the findings of this meta-analysis proposes that the ATG16L1 rs2241880 polymorphism may not play a role in cancer development. Further well-designed studies are necessary to clarify the precise role of the ATG16L1 rs2241880 polymorphism on cancer risk.

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Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1604285113 ◽

2016 ◽

Vol 113 (33) ◽

pp. 9256-9261 ◽

Cited By ~ 21

Author(s):

Yina Ma ◽

Shiyi Li ◽

Chenbo Wang ◽

Yi Liu ◽

Wenxin Li ◽

...

Keyword(s):

Estimation Error ◽

Confidence Judgment ◽

Social Adaptation ◽

Belief Updating ◽

Double Blind ◽

Functional Roles ◽

First Order ◽

Strength Of Association ◽

Better Than

Humans update their beliefs upon feedback and, accordingly, modify their behaviors to adapt to the complex, changing social environment. However, people tend to incorporate desirable (better than expected) feedback into their beliefs but to discount undesirable (worse than expected) feedback. Such optimistic updating has evolved as an advantageous mechanism for social adaptation. Here, we examine the role of oxytocin (OT)―an evolutionary ancient neuropeptide pivotal for social adaptation―in belief updating upon desirable and undesirable feedback in three studies (n = 320). Using a double-blind, placebo-controlled between-subjects design, we show that intranasally administered OT (IN-OT) augments optimistic belief updating by facilitating updates of desirable feedback but impairing updates of undesirable feedback. The IN-OT–induced impairment in belief updating upon undesirable feedback is more salient in individuals with high, rather than with low, depression or anxiety traits. IN-OT selectively enhances learning rate (the strength of association between estimation error and subsequent update) of desirable feedback. IN-OT also increases participants’ confidence in their estimates after receiving desirable but not undesirable feedback, and the OT effect on confidence updating upon desirable feedback mediates the effect of IN-OT on optimistic belief updating. Our findings reveal distinct functional roles of OT in updating the first-order estimation and second-order confidence judgment in response to desirable and undesirable feedback, suggesting a molecular substrate for optimistic belief updating.

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Evaluation of TOPS score as predictor for outcome in sick newborns

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20202129 ◽

2020 ◽

Vol 7 (6) ◽

pp. 1249

Author(s):

Nirali Maheshbhai Sheth ◽

Nimisha Pandya

Keyword(s):

P Value ◽

Efficient Score ◽

Medical College ◽

Multiple Parameters ◽

Blood Glucose Reading ◽

Study Population ◽

Strength Of Association ◽

Hypoxic Group ◽

Glucose Reading

Background: Multiple parameters have been developed to prognosticate the outcomes of critically ill newborns admitted in NICUs. The objective of this study is to predict the outcome of newborns admitted in NICU using a simple but efficient score, TOPS score, involving alteration of physiological parameters. Aim of this study was to evaluate role of TOPS score in predicting mortality in sick neonates.Methods: The variables assessed under TOPS score on arrival for all subjects were: Temperature, Oxygen Saturation, Perfusion and blood glucose reading <45 mg/dl. All affected neonates were given treatment as per NICU protocol and outcome was assessed in terms of mortality or discharge using TOPS score. It was prospective study conducted at NICU, Department of Pediatrics, GMERS medical college and general hospital, Gotri, Vadodara. Study population was all admitted neonates aged <28 days at NICU.Results: Mean age of presentation of all cases was 2.8±3.58 days. Hypothermia on admission was observed in 63.3% cases. 40.8% cases had hypoxia. 26.5% neonates recorded poor perfusion. Mortality observed in hypoxic group was 51.7% followed by hypothermic group (46.9%). Highest strength of association was found for poor perfusion, mortality (87.5%) and OR-33.406. TOPS score was observed to be statistically significant (X2 value is 63.27, p < 0.05) as predictor of mortality. Thus, mortality rate increased with increasing no. of altered TOPS parameters. Regression analysis showed three factors (hypothermia, hypoxia, prolonged CRT) which are consistently associated with p value ≤ 0.05 for each variable and can be used to predict mortality.Conclusions: All parameters in TOPS score are physiologically important and each parameter carries an independent risk associated with mortality. It is important to note that multiple parameters affected increases the risk. TOPS score is a simple, basic and effective tool to guide about the condition of new born at admission and outcome. of neonatal mortality.

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Practical Postmoderns

The Twentysomething Soul ◽

10.1093/oso/9780190931353.003.0007 ◽

2019 ◽

pp. 163-184

Author(s):

Tim Clydesdale ◽

Kathleen Garces-Foley

Keyword(s):

Life Course ◽

Multivariate Analyses ◽

Religious Affiliation ◽

National Study ◽

Adolescent Religiosity ◽

The Future ◽

The Life Course ◽

Strength Of Association ◽

Religiously Unaffiliated

The concluding chapter summarizes the book’s findings on the religious, spiritual, and secular lives of American twentysomethings. It compares the findings from the National Study of American Twentysomethings with research on adolescent religiosity and analyses the role of spirituality in the lives of Christian and religiously unaffiliated Twentysomethings. Chapter 7 also includes multivariate analyses of the strength of association between religion, spirituality, and eight life statuses. Lastly, this chapter discusses the importance of the 20s to understanding the life course as well as thinking about what the future holds for America’s Christian traditions and the growing number of adults with no religious affiliation.

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Morphometry of talar trochlear surface and its correlation

National Journal of Clinical Anatomy ◽

10.1055/s-0040-1701725 ◽

2018 ◽

Vol 7 (03) ◽

pp. 123-127

Author(s):

Suresh Narayanan ◽

Vljisha Phalgunan ◽

Nachiket Shankar

Keyword(s):

Body Weight ◽

Standard Deviation ◽

Correlation Coefficient ◽

Load Transmission ◽

Articular Surfaces ◽

The Mean ◽

Strength Of Association ◽

Surface Length ◽

Surface Angle

Abstract Background and objectives: The morphometry of talus represents its biomechanical role in transmission of body weight. The objective of the study was to find the shape of trochlea and its correlation with other articular surfaces. Methodology: A total of 160 dry Tali of unknown sex were utilised for this study, its trochlear surface length-anterior, middle and posterior breadth [TSL, TSAB, TSMB and TSPB], calcaneal surface length & breadth [CSL and CSB] and navicular surface length & breadth [NSL and NSB] were measured using digital vernier caliper. Trochlear surface angle [TSA] and depth angle [DA] were calculated using image J software. The mean and standard deviation of the parameters were calculated. Side differences between the parameters were calculated by independent sample t test and the strength of association between the parameters was calculated by Pearson's correlation coefficient. Results: The results were trochlear surface length, anterior, middle and posterior breadth [29.6 ± 2.7, 31 ± 2.5, 28.2 ± 2.6 and21.4± 2.1mm], navicular surface length & breadth [29.7 ± 2.5 & 20.5 ± 1.7mm] and calcaneal surface length & breadth [30 ± 2.4 &19.8 ± 1.6mm]. The mean trochlear surface and depth angle were 9.7 ± 3.3 and 156 ± 5.1 degrees. There was significant correlation between the parameters of the articular surfaces. Conclusion: The present study helps in understanding the morphology of talus and the role of articular surfaces in load transmission.

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Association between P2X7 Polymorphisms and Susceptibility to Tuberculosis: An Updated Meta-Analysis of Case-Control Studies

Medicina ◽

10.3390/medicina55060298 ◽

2019 ◽

Vol 55 (6) ◽

pp. 298 ◽

Cited By ~ 1

Author(s):

Taheri ◽

Sarani ◽

Moazeni-Roodi ◽

Naderi ◽

Hashemi

Keyword(s):

Meta Analysis ◽

Extrapulmonary Tuberculosis ◽

Asian Population ◽

Genetic Models ◽

Case Control Studies ◽

Increased Risk ◽

Stratified Analysis ◽

The Impact ◽

Strength Of Association

Background and Objectives: Several studies inspected the impact of P2X7 polymorphisms on individual susceptibility to tuberculosis (TB), but the findings are still controversial and inconclusive. To achieve a more precise estimation, we conducted a meta-analysis of all eligible studies on the association between P2X7 polymorphisms and TB risk. Materials and Methods: Relevant studies were identified by searching the PubMed, Web of Science, Scopus and Google scholar databases up to November 2018. Twenty-four full-text articles were included in our meta-analysis. The strength of association between P2X7 polymorphisms and TB risk was evaluated by odds ratios (ORs) and 95% confidence intervals (95% CIs) under five genetic models. Results: The findings of this meta-analysis revealed that the rs3751143 variant significantly increased the risk of TB in heterozygous codominant (OR = 1.44, 95%CI = 1.17−1.78, p = 0.0006, AC vs. AA), homozygous codominant (OR = 1.87, 95% CI = 1.40−2.49, p = 0.0004, CC vs. AA), dominant (OR = 1.50, 95% CI = 1.22−1.85, p = 0.0002, AC + CC vs. AA), recessive (OR = 1.61, 95% CI = 1.25−2.07, p = 0.001, CC vs. AC + AA), and allele (OR = 1.41, 95% CI = 1.19−1.67, p < 0.0001, C vs. A) genetic models. Stratified analysis showed that rs3751143 increased the risk of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in all genetic models. Furthermore, the rs3751143 increased risk of TB in the Asian population. The findings did not support an association between the rs2393799, rs1718119, rs208294, rs7958311, and rs2230911 polymorphisms of P2X7 and TB risk. Conclusions: The findings of this meta-analysis suggest that P2X7 rs3751143 polymorphism may play a role in susceptibility to TB in the Asian population. More well-designed studies are required to elucidate the exact role of P2X7 polymorphisms on TB development.

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Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽

10.1001/jama.195.12.1005 ◽

1966 ◽

Vol 195 (12) ◽

pp. 1005-1009 ◽

Cited By ~ 18

Author(s):

D. J. Fernbach

Keyword(s):

Wilms Tumor

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